Depression in young people

The Lancet, Год журнала: 2022, Номер 400(10352), С. 617 - 631

Опубликована: Авг. 1, 2022

Язык: Английский

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Major depressive disorder

Nature Reviews Disease Primers, Год журнала: 2023, Номер 9(1)

Опубликована: Авг. 24, 2023

Язык: Английский

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The multiple roles of life stress in metabolic disorders

Nature Reviews Endocrinology, Год журнала: 2022, Номер 19(1), С. 10 - 27

Опубликована: Окт. 12, 2022

Язык: Английский

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Childhood Maltreatment and Mental Health Problems: A Systematic Review and Meta-Analysis of Quasi-Experimental Studies

American Journal of Psychiatry, Год журнала: 2023, Номер 180(2), С. 117 - 126

Опубликована: Янв. 11, 2023

Childhood maltreatment is associated with mental health problems, but the extent to which this relationship causal remains unclear. To strengthen inference, authors conducted a systematic review and meta-analysis of quasi-experimental studies examining between childhood problems.

Язык: Английский

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Genetic correlates of phenotypic heterogeneity in autism

Nature Genetics, Год журнала: 2022, Номер 54(9), С. 1293 - 1304

Опубликована: Июнь 2, 2022

The substantial phenotypic heterogeneity in autism limits our understanding of its genetic etiology. To address this gap, here we investigated differences between autistic individuals (n

Язык: Английский

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Neurobiology of early life adversity: A systematic review of meta-analyses towards an integrative account of its neurobiological trajectories to mental disorders

Frontiers in Neuroendocrinology, Год журнала: 2022, Номер 65, С. 100994 - 100994

Опубликована: Март 21, 2022

Adverse childhood experiences (ACEs) may leave long-lasting neurobiological scars, increasing the risk of developing mental disorders in later life. However, no review has comprehensively integrated existing evidence across fields: hypothalamic-pituitary-adrenal axis, immune/inflammatory system, neuroimaging, and genetics/epigenetics. We thus systematically reviewed previous meta-analyses towards an integrative account ACE-related alterations. Following Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) guideline, a total 27 until October 2021 were identified. This found that individuals with ACEs possess blunted cortisol response to psychosocial stressors, low-grade inflammation evinced by increased C-reactive protein levels, exaggerated amygdalar emotionally negative information, diminished hippocampal gray matter volume. Importantly, these alterations consistently observed those without psychiatric diagnosis. These findings discussed schematic model Future longitudinal research based on multidisciplinary approach is imperative disorders' prevention treatment.

Язык: Английский

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Robust estimation of cortical similarity networks from brain MRI

Nature Neuroscience, Год журнала: 2023, Номер 26(8), С. 1461 - 1471

Опубликована: Июль 17, 2023

Abstract Structural similarity is a growing focus for magnetic resonance imaging (MRI) of connectomes. Here we propose Morphometric INverse Divergence (MIND), new method to estimate within-subject between cortical areas based on the divergence their multivariate distributions multiple MRI features. Compared prior approach morphometric networks (MSNs) n > 11,000 scans spanning three human datasets and one macaque dataset, MIND were more reliable, consistent with cytoarchitectonics symmetry correlated tract-tracing measures axonal connectivity. derived from T1-weighted sensitive age-related changes than MSNs or by tractography diffusion-weighted MRI. Gene co-expression was strongly coupled tractography. network phenotypes also heritable, especially edges structurally differentiated areas. analysis provides biologically validated lens connectomics using readily available data.

Язык: Английский

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Genetic insights into human cortical organization and development through genome-wide analyses of 2,347 neuroimaging phenotypes

Nature Genetics, Год журнала: 2023, Номер 55(9), С. 1483 - 1493

Опубликована: Авг. 17, 2023

Язык: Английский

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Gene–environment interactions in human health

Nature Reviews Genetics, Год журнала: 2024, Номер 25(11), С. 768 - 784

Опубликована: Май 28, 2024

Язык: Английский

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Social Functioning in Individuals Affected by Childhood Maltreatment: Establishing a Research Agenda to Inform Interventions

Psychotherapy and Psychosomatics, Год журнала: 2022, Номер 91(4), С. 238 - 251

Опубликована: Янв. 1, 2022

Childhood maltreatment (CM) is linked to impairments in various domains of social functioning. Here, we argue that it critical identify factors underlie impaired functioning as well processes mediate the beneficial health effects positive relationships individuals exposed CM. Key research recommendations are presented, focusing on: (1) identifying attachment-related alterations specific inter- and intrapersonal (e.g., regulation closeness distance) problems broader lack perceived support) affected by CM; (2) internal current emotional state) external situational cultural factors, presence close others) modulate processes; (3) mechanisms explain intact Methodological include: assessing through interactive (close to) real-life assessments inside outside laboratory; adopting an interdisciplinary, lifespan perspective assess processes, using multi-method assessments; establishing global collaborations account for influences on enable replications across laboratories countries. The proposed line will contribute globally develop refine interventions prevent CM further relationships, which - likely buffering chronic stress corresponding allostatic load foster resilience improve mental physical health, thereby reducing personal suffering societal economic costs its consequences. Interventions targeting euthymia psychological well-being promising therapeutic concepts this context.

Язык: Английский

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