Molecular Psychiatry, Journal Year: 2024, Volume and Issue: unknown
Published: May 14, 2024
Language: Английский
Molecular Psychiatry, Journal Year: 2024, Volume and Issue: unknown
Published: May 14, 2024
Language: Английский
The Lancet, Journal Year: 2022, Volume and Issue: 400(10352), P. 617 - 631
Published: Aug. 1, 2022
Language: Английский
Citations
427Nature Reviews Disease Primers, Journal Year: 2023, Volume and Issue: 9(1)
Published: Aug. 24, 2023
Language: Английский
Citations
241Nature Reviews Endocrinology, Journal Year: 2022, Volume and Issue: 19(1), P. 10 - 27
Published: Oct. 12, 2022
Language: Английский
Citations
125American Journal of Psychiatry, Journal Year: 2023, Volume and Issue: 180(2), P. 117 - 126
Published: Jan. 11, 2023
Childhood maltreatment is associated with mental health problems, but the extent to which this relationship causal remains unclear. To strengthen inference, authors conducted a systematic review and meta-analysis of quasi-experimental studies examining between childhood problems.
Language: Английский
Citations
108Nature Genetics, Journal Year: 2022, Volume and Issue: 54(9), P. 1293 - 1304
Published: June 2, 2022
The substantial phenotypic heterogeneity in autism limits our understanding of its genetic etiology. To address this gap, here we investigated differences between autistic individuals (n
Language: Английский
Citations
102Frontiers in Neuroendocrinology, Journal Year: 2022, Volume and Issue: 65, P. 100994 - 100994
Published: March 21, 2022
Adverse childhood experiences (ACEs) may leave long-lasting neurobiological scars, increasing the risk of developing mental disorders in later life. However, no review has comprehensively integrated existing evidence across fields: hypothalamic-pituitary-adrenal axis, immune/inflammatory system, neuroimaging, and genetics/epigenetics. We thus systematically reviewed previous meta-analyses towards an integrative account ACE-related alterations. Following Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) guideline, a total 27 until October 2021 were identified. This found that individuals with ACEs possess blunted cortisol response to psychosocial stressors, low-grade inflammation evinced by increased C-reactive protein levels, exaggerated amygdalar emotionally negative information, diminished hippocampal gray matter volume. Importantly, these alterations consistently observed those without psychiatric diagnosis. These findings discussed schematic model Future longitudinal research based on multidisciplinary approach is imperative disorders' prevention treatment.
Language: Английский
Citations
81Nature Neuroscience, Journal Year: 2023, Volume and Issue: 26(8), P. 1461 - 1471
Published: July 17, 2023
Abstract Structural similarity is a growing focus for magnetic resonance imaging (MRI) of connectomes. Here we propose Morphometric INverse Divergence (MIND), new method to estimate within-subject between cortical areas based on the divergence their multivariate distributions multiple MRI features. Compared prior approach morphometric networks (MSNs) n > 11,000 scans spanning three human datasets and one macaque dataset, MIND were more reliable, consistent with cytoarchitectonics symmetry correlated tract-tracing measures axonal connectivity. derived from T1-weighted sensitive age-related changes than MSNs or by tractography diffusion-weighted MRI. Gene co-expression was strongly coupled tractography. network phenotypes also heritable, especially edges structurally differentiated areas. analysis provides biologically validated lens connectomics using readily available data.
Language: Английский
Citations
45Nature Genetics, Journal Year: 2023, Volume and Issue: 55(9), P. 1483 - 1493
Published: Aug. 17, 2023
Language: Английский
Citations
44Nature Reviews Genetics, Journal Year: 2024, Volume and Issue: 25(11), P. 768 - 784
Published: May 28, 2024
Language: Английский
Citations
19Psychotherapy and Psychosomatics, Journal Year: 2022, Volume and Issue: 91(4), P. 238 - 251
Published: Jan. 1, 2022
Childhood maltreatment (CM) is linked to impairments in various domains of social functioning. Here, we argue that it critical identify factors underlie impaired functioning as well processes mediate the beneficial health effects positive relationships individuals exposed CM. Key research recommendations are presented, focusing on: (1) identifying attachment-related alterations specific inter- and intrapersonal (e.g., regulation closeness distance) problems broader lack perceived support) affected by CM; (2) internal current emotional state) external situational cultural factors, presence close others) modulate processes; (3) mechanisms explain intact Methodological include: assessing through interactive (close to) real-life assessments inside outside laboratory; adopting an interdisciplinary, lifespan perspective assess processes, using multi-method assessments; establishing global collaborations account for influences on enable replications across laboratories countries. The proposed line will contribute globally develop refine interventions prevent CM further relationships, which - likely buffering chronic stress corresponding allostatic load foster resilience improve mental physical health, thereby reducing personal suffering societal economic costs its consequences. Interventions targeting euthymia psychological well-being promising therapeutic concepts this context.
Language: Английский
Citations
54