Patterns of stressful life events and polygenic scores for five mental disorders and neuroticism among adults with depression DOI Creative Commons
Jacob J. Crouse, Shin Park, Enda M. Byrne

et al.

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: April 4, 2024

Abstract The dominant (‘general’) version of the diathesis-stress theory depression views stressors and genetic vulnerability as independent risks. In Australian Genetics Depression Study ( N = 14,146; 75% female), we tested whether polygenic scores (PGS) for major depression, bipolar disorder, schizophrenia, anxiety, ADHD, neuroticism were associated with reported exposure to 32 childhood, past-year, lifetime, accumulated stressful life events (SLEs). false discovery rate-corrected models, clearest PGS-SLE relationships ADHD- depression-PGSs, a lesser extent, anxiety- schizophrenia-PGSs. We describe associations childhood SLEs, 2–3 strongest past-year/lifetime SLE associations. Higher ADHD-PGS was all SLEs (emotional abuse, emotional neglect, physical neglect; ORs 1.09–1.14; p’s < 1.3 × 10 − 5 ), more sudden violent death (OR 1.23; p 3.6 legal troubles 1.15; 0.003), accidental 1.14; 0.006). depression-PGS (ORs 1.07–1.12; 0.013), severe human suffering 1.17; assault weapon 1.12; living in unpleasant surroundings 1.11; 0.001). anxiety-PGS abuse 1.08; 1.6 4 serious accident 0.004), 2.2 transportation 1.07; schizophrenia-PGS 1.12–1.19; 9.3 8 1.16; 0.003). neuroticism-PGS 1.09; 0.007) financial 1.06; 0.014). A reversed pattern seen bipolar-PGS, lower odds 0.95; 0.014), 0.93; 0.92; 0.007). Genetic risk several mental disorders influences among adults moderately severe, recurrent depression. Our findings emphasise that diatheses are inter-dependent challenge diagnosis subtyping (e.g., reactive/endogenous) based on events.

Language: Английский

Depression in young people DOI
Anita Thapar, Olga Eyre, Vikram Patel

et al.

The Lancet, Journal Year: 2022, Volume and Issue: 400(10352), P. 617 - 631

Published: Aug. 1, 2022

Language: Английский

Citations

445
Major depressive disorder DOI
Wolfgang Marx, Brenda W.J.H. Penninx, Marco Solmi

et al.

Nature Reviews Disease Primers, Journal Year: 2023, Volume and Issue: 9(1)

Published: Aug. 24, 2023

Language: Английский

Citations

251
The multiple roles of life stress in metabolic disorders DOI
Mika Kivimäki, Alessandro Bartolomucci, Ichiro Kawachi

et al.

Nature Reviews Endocrinology, Journal Year: 2022, Volume and Issue: 19(1), P. 10 - 27

Published: Oct. 12, 2022

Language: Английский

Citations

131
Childhood Maltreatment and Mental Health Problems: A Systematic Review and Meta-Analysis of Quasi-Experimental Studies DOI
Jessie R. Baldwin, Biyao Wang, Lucy Karwatowska

et al.

American Journal of Psychiatry, Journal Year: 2023, Volume and Issue: 180(2), P. 117 - 126

Published: Jan. 11, 2023

Childhood maltreatment is associated with mental health problems, but the extent to which this relationship causal remains unclear. To strengthen inference, authors conducted a systematic review and meta-analysis of quasi-experimental studies examining between childhood problems.

Language: Английский

Citations

111
Genetic correlates of phenotypic heterogeneity in autism DOI Creative Commons
Varun Warrier, Xinhe Zhang,

Patrick Reed

et al.

Nature Genetics, Journal Year: 2022, Volume and Issue: 54(9), P. 1293 - 1304

Published: June 2, 2022

The substantial phenotypic heterogeneity in autism limits our understanding of its genetic etiology. To address this gap, here we investigated differences between autistic individuals (n

Language: Английский

Citations

104
Neurobiology of early life adversity: A systematic review of meta-analyses towards an integrative account of its neurobiological trajectories to mental disorders DOI Creative Commons
Yuko Hakamata,

Yuhki Suzuki,

Hajime Kobashikawa

et al.

Frontiers in Neuroendocrinology, Journal Year: 2022, Volume and Issue: 65, P. 100994 - 100994

Published: March 21, 2022

Adverse childhood experiences (ACEs) may leave long-lasting neurobiological scars, increasing the risk of developing mental disorders in later life. However, no review has comprehensively integrated existing evidence across fields: hypothalamic-pituitary-adrenal axis, immune/inflammatory system, neuroimaging, and genetics/epigenetics. We thus systematically reviewed previous meta-analyses towards an integrative account ACE-related alterations. Following Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) guideline, a total 27 until October 2021 were identified. This found that individuals with ACEs possess blunted cortisol response to psychosocial stressors, low-grade inflammation evinced by increased C-reactive protein levels, exaggerated amygdalar emotionally negative information, diminished hippocampal gray matter volume. Importantly, these alterations consistently observed those without psychiatric diagnosis. These findings discussed schematic model Future longitudinal research based on multidisciplinary approach is imperative disorders' prevention treatment.

Language: Английский

Citations

82
Robust estimation of cortical similarity networks from brain MRI DOI Creative Commons
Isaac Sebenius, Jakob Seidlitz, Varun Warrier

et al.

Nature Neuroscience, Journal Year: 2023, Volume and Issue: 26(8), P. 1461 - 1471

Published: July 17, 2023

Abstract Structural similarity is a growing focus for magnetic resonance imaging (MRI) of connectomes. Here we propose Morphometric INverse Divergence (MIND), new method to estimate within-subject between cortical areas based on the divergence their multivariate distributions multiple MRI features. Compared prior approach morphometric networks (MSNs) n > 11,000 scans spanning three human datasets and one macaque dataset, MIND were more reliable, consistent with cytoarchitectonics symmetry correlated tract-tracing measures axonal connectivity. derived from T1-weighted sensitive age-related changes than MSNs or by tractography diffusion-weighted MRI. Gene co-expression was strongly coupled tractography. network phenotypes also heritable, especially edges structurally differentiated areas. analysis provides biologically validated lens connectomics using readily available data.

Language: Английский

Citations

48
Genetic insights into human cortical organization and development through genome-wide analyses of 2,347 neuroimaging phenotypes DOI
Varun Warrier, Eva-Maria Stauffer, Qin Qin Huang

et al.

Nature Genetics, Journal Year: 2023, Volume and Issue: 55(9), P. 1483 - 1493

Published: Aug. 17, 2023

Language: Английский

Citations

47
Gene–environment interactions in human health DOI

Esther Herrera-Luis,

Kelly S. Benke, Heather E. Volk

et al.

Nature Reviews Genetics, Journal Year: 2024, Volume and Issue: 25(11), P. 768 - 784

Published: May 28, 2024

Language: Английский

Citations

21
Social Functioning in Individuals Affected by Childhood Maltreatment: Establishing a Research Agenda to Inform Interventions DOI Creative Commons
Monique C. Pfaltz, Sarah L. Halligan, Shilat Haim-Nachum

et al.

Psychotherapy and Psychosomatics, Journal Year: 2022, Volume and Issue: 91(4), P. 238 - 251

Published: Jan. 1, 2022

Childhood maltreatment (CM) is linked to impairments in various domains of social functioning. Here, we argue that it critical identify factors underlie impaired functioning as well processes mediate the beneficial health effects positive relationships individuals exposed CM. Key research recommendations are presented, focusing on: (1) identifying attachment-related alterations specific inter- and intrapersonal (e.g., regulation closeness distance) problems broader lack perceived support) affected by CM; (2) internal current emotional state) external situational cultural factors, presence close others) modulate processes; (3) mechanisms explain intact Methodological include: assessing through interactive (close to) real-life assessments inside outside laboratory; adopting an interdisciplinary, lifespan perspective assess processes, using multi-method assessments; establishing global collaborations account for influences on enable replications across laboratories countries. The proposed line will contribute globally develop refine interventions prevent CM further relationships, which - likely buffering chronic stress corresponding allostatic load foster resilience improve mental physical health, thereby reducing personal suffering societal economic costs its consequences. Interventions targeting euthymia psychological well-being promising therapeutic concepts this context.

Language: Английский

Citations

54