Polyphyllin VII promotes hepatic stellate cell ferroptosis via the HIC1/CX3CL1/GPX4 axis DOI Creative Commons
Feng Jiang, Xinmiao Li, Mengyuan Li

et al.

Journal of Pharmaceutical Analysis, Journal Year: 2024, Volume and Issue: unknown, P. 101147 - 101147

Published: Nov. 1, 2024

Language: Английский

Esculin inhibits hepatic stellate cell activation and CCl4-induced liver fibrosis by activating the Nrf2/GPX4 signaling pathway DOI

Shuoxi Xu,

Yonger Chen,

Jindian Miao

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 128, P. 155465 - 155465

Published: Feb. 17, 2024

Language: Английский

Citations

23
Myricetin Induces Ferroptosis and Inhibits Gastric Cancer Progression by Targeting NOX4 DOI
Yi Lu, Jingguo Sun, Mingyue Yang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(12), P. 6178 - 6188

Published: March 14, 2024

Ferroptosis holds great potential as a therapeutic approach for gastric cancer (GC), prevalent and deadly malignant tumor associated with high rates of incidence mortality. Myricetin, well-known its multifaceted biomedical attributes, particularly anticancer properties, has yet to be thoroughly investigated regarding involvement in ferroptosis. The aim this research was elucidate the impact myricetin on ferroptosis GC progression. present study observed that could trigger cells by enhancing malondialdehyde production Fe2+ accumulation while suppressing glutathione levels. Mechanistically, directly interacted NADPH oxidase 4 (NOX4), influencing stability inhibiting ubiquitin degradation. Moreover, regulated inhibition induced Helicobacter pylori cytotoxin-associated gene A (CagA) through NOX4/NRF2/GPX4 pathway. In vivo experiments demonstrated treatment significantly inhibited growth subcutaneous tumors BALB/c nude mice. It accompanied increased NOX4 expression tissue suppression NRF2/GPX4 antioxidant Therefore, underscores novel inducer interaction NOX4. is promising candidate treatment.

Language: Английский

Citations

11
Crosstalk between ROS-inflammatory gene expression axis in the progression of lung disorders DOI
Sumel Ashique, Neeraj Mishra, Shubhrajit Mantry

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 28, 2024

Language: Английский

Citations

10
Ruscogenin attenuates cartilage destruction in osteoarthritis through suppressing chondrocyte ferroptosis via Nrf2/SLC7A11/GPX4 signaling pathway DOI

Qing Ruan,

Cuijie Wang,

Yunfeng Zhang

et al.

Chemico-Biological Interactions, Journal Year: 2023, Volume and Issue: 388, P. 110835 - 110835

Published: Dec. 18, 2023

Language: Английский

Citations

16
Natural flavonoids act as potent ferroptosis inhibitors and their potentials in the treatment of ferroptosis-associated diseases DOI Creative Commons
Lu Liu, Lun Wang,

Ying Xiao

et al.

Pharmacological Research - Modern Chinese Medicine, Journal Year: 2024, Volume and Issue: 10, P. 100377 - 100377

Published: Jan. 26, 2024

Ferroptosis, an iron-dependent cell death characterized by lethal lipid peroxidation, has been involved in the pathogenesis of various diseases, such as ischemia/reperfusion injury, neurodegenerative and inflammatory disorders. Pharmacological inhibition ferroptosis represents a promising strategy for treatment above diseases. Flavonoids, class natural products found medicinal plants functional foods, are known numerous activities, especially newly discovered anti-ferroptotic activity. Our review aims to expand our understanding flavonoids' activity on multiple biological systems highlight importance utilizing flavonoids ferroptosis-associated A systematic literature search was conducted using Google Scholar, PubMed, Web Science, ScienceDirect, Springer Link. The following keywords: flavonoids, products, ferroptosis, mechanism, available information comprehensively studied compiled. We recent advances molecular mechanisms its roles diverse further systematically summarize inhibitory underlying suggest that ROS accumulation labile Fe2+ availability well activation Nrf2 signaling responsible inhibition. also discuss their clinical applications ferroptosis-related Taken together, exhibit prospect This is expected not only facilitate design development flavonoid-based inhibitors, but diseases therapies.

Language: Английский

Citations

5
Ferroptosis in Liver Disease: Natural Active Compounds and Therapeutic Implications DOI Creative Commons

Zhili Wu,

Yanru Zhu,

Wen‐Chao Liu

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(3), P. 352 - 352

Published: March 15, 2024

Ferroptosis is an emerging type of regulated cell death usually accompanied by the accumulation ferrous ions (Fe2+) and lipid peroxides. As metabolic hub body, liver crucial for iron storage metabolism. The seems to be closely related ferroptosis through Liver disease greatly threatens host health, exploring effective interventions essential. Mounting studies have demonstrated that one possible pathogenic mechanisms involved in disease. Targeting may provide a promising opportunity treating However, drugs targeting are extremely limited. Therefore, it urgent need develop new safe regulators. Natural active compounds (NAC), especially those derived from traditional Chinese medicine, recently shown great therapeutic potential via modulating ferroptosis-related genes or pathways. Here, we outline molecular mechanism systematically summarize regulatory function NAC on Finally, discuss application prospects problems concerning as regulators managing

Language: Английский

Citations

5
Cloning, Expression, and Functional Characterization of Two Highly Efficient Flavonoid-di-O-glycosyltransferases ZmUGT84A1 and ZmUGT84A2 from Maize (Zea mays L.) DOI
Xiaorong Sun, Ke Zhao,

Dengyu Zheng

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(13), P. 7354 - 7363

Published: March 21, 2024

The maize (Zea mays L.) glycosyltransferase family 1 comprises many uridine diphosphate (UGT) members. However, UGT activities and biochemical functions have seldom been revealed. In this study, the genes of two flavonoid di-O-glycosyltransferases ZmUGT84A1 ZmUGT84A2 were cloned from plant expressed in Escherichia coli. Phylogenetic analysis showed that enzymes homologous to AtUGT84A1 AtUGT84A3. recombinant a high conversion rate luteolin its glucosides, mainly 4′,7-di-O-glucoside minorly 3′,7-di-O-glucoside two-step glycosylation reactions vitro. Moreover, had broad substrate spectrum, converting eriodictyol, naringenin, apigenin, quercetin, kaempferol monoglucosides diglucosides. highly efficient may be used as tool for effective synthesis various O-glycosides markers crop breeding increase O-glycosyl content food.

Language: Английский

Citations

5
Ferroptosis: Potential opportunities for natural products in cancer therapy DOI

Anzheng Nie,

Chaozan Shen,

Zheng Zhou

et al.

Phytotherapy Research, Journal Year: 2023, Volume and Issue: 38(3), P. 1173 - 1190

Published: Dec. 20, 2023

Abstract Cancer cells often exhibit defects in the execution of cell death, resulting poor clinical outcomes for patients with many cancer types. Ferroptosis is a newly discovered form programmed death characterized by intracellular iron overload and lipid peroxidation membrane. Increasing evidence suggests that ferroptosis closely associated wide variety physiological pathological processes, particularly cancer. Notably, various bioactive natural products have been shown to induce initiation cells, thereby exerting anticancer effects. In this review, we summarize core regulatory mechanisms multifaceted roles Importantly, focus on regulate such as terpenoids, polyphenols, alkaloids, steroids, quinones, polysaccharides. The efficacy, adverse effects, drug–drug interactions these need be evaluated further high‐quality studies accelerate their application treatment.

Language: Английский

Citations

10
Licochalcone A mitigates aflatoxin B1-induced immunotoxicity via ferroptosis in bursa of broilers and macrophages DOI Creative Commons

Shijie Xia,

Yuxi He,

Songya Yang

et al.

Poultry Science, Journal Year: 2024, Volume and Issue: 103(10), P. 104080 - 104080

Published: July 10, 2024

Aflatoxin B

Language: Английский

Citations

3
A new strategy for the treatment of intracerebral hemorrhage: Ferroptosis DOI

Ke Yao Sun,

Xin Yue Bai,

Lei Zhang

et al.

Experimental Neurology, Journal Year: 2024, Volume and Issue: 382, P. 114961 - 114961

Published: Sept. 15, 2024

Language: Английский

Citations

3