Materials Today Bio, Год журнала: 2025, Номер 31, С. 101616 - 101616
Опубликована: Фев. 26, 2025
Язык: Английский
Applied Surface Science Advances, Год журнала: 2021, Номер 6, С. 100163 - 100163
Опубликована: Сен. 14, 2021
Biomedical applications with emphasis on the design of smart materials, specifically magnetic nanoparticles (MNPs) are considered to have technological benefits because they can be manipulated using fields. Magnetic NPs been widely used in hyperthermia, target drug delivery system, imaging, and extraction biomolecules, postulating them also as an important tool cancer treatment. Morphological structures materials drawn tremendous attention from diverse scientific fields due their unique surface chemistry, nontoxicity, biocompatibility, particularly inducible moment. This review features recent research accomplishments made biomedical field nanoparticles. The first part gives a comprehensive overview treatment chronic diseases targeting. second includes role electrochemical, optical-based immunoassays. outlines current challenges future perspectives for fostering advanced high-performance applications.
Язык: Английский
Процитировано
297
Magnetochemistry, Год журнала: 2022, Номер 8(9), С. 107 - 107
Опубликована: Сен. 17, 2022
The use of magnetic nanoparticles has greatly expanded for numerous biomedical applications over the past two decades due to their high surface area, size-dependent superparamagnetic properties, precision tunability, and easy modification. Magnetic can be engineered manipulated with other functional compounds form multi-modal systems useful in theragnosis. However, superior biocompatibility, loading efficacy, regulated drug release, vitro vivo stability are necessary efficient incorporation these into physiological systems. In recent years, considerable advancements have been made reported both synthesis application, given broad range biomedical-related prospective uses nanoparticles. Here, this review, we highlighted some essential works, specifically related application delivery, hyperthermia, resonance imaging, particle biosensors, tissue engineering.
Язык: Английский
Процитировано
85
Coordination Chemistry Reviews, Год журнала: 2023, Номер 480, С. 215027 - 215027
Опубликована: Янв. 16, 2023
Язык: Английский
Процитировано
53
Chemical Society Reviews, Год журнала: 2022, Номер 51(23), С. 9759 - 9830
Опубликована: Янв. 1, 2022
Radiotherapy (RT), including external beam RT and internal radiation therapy, uses high-energy ionizing to kill tumor cells.
Язык: Английский
Процитировано
67
Biomedicines, Год журнала: 2022, Номер 10(5), С. 1072 - 1072
Опубликована: Май 5, 2022
Metal ion homeostasis is fundamental for life. Specifically, transition metals iron, manganese and zinc play a pivotal role in mitochondrial metabolism energy generation, anti-oxidation defense, transcriptional regulation the immune response. The misregulation of expression or mutations carriers corresponding changes Mn2+ Zn2+ levels suggest that these ions cancer progression. Moreover, coordinated have been detected, suggesting particular mechanisms influenced by both might be required growth cells, metastasis evasion. Here, we present review pathophysiology cooperatively regulate cancerogenesis. Zn Mn effects converge on mitochondria-induced apoptosis, cGAS-STING signaling pathway, mediating Both influence progression impact treatment efficacy animal models clinical trials. We predict novel strategies targeting will complement current therapeutic strategies.
Язык: Английский
Процитировано
44
Journal of Controlled Release, Год журнала: 2022, Номер 347, С. 89 - 103
Опубликована: Май 6, 2022
Nanoparticle mediated hyperthermia has been explored as a method to increase cancer treatment efficacy by heating tumours inside-out. With that purpose, nanoparticles have designed and their properties tailored respond external stimuli convert the supplied energy into heat, therefore inducing damage tumour cells. Moreover, combination of with chemotherapy described more effective strategy due synergy between high temperature drug's effects, also associated remote controlled on-demand drug release. In this review, methods behind nanoparticle hyperthermia, namely material design, response conversion will be discussed critically analysed. We address most relevant studies on triggered release for treatment. Finally, advantages, difficulties challenges therapeutic discussed, while giving insight future developments.
Язык: Английский
Процитировано
42
Biomaterials, Год журнала: 2023, Номер 302, С. 122321 - 122321
Опубликована: Сен. 11, 2023
Язык: Английский
Процитировано
26
Journal of Controlled Release, Год журнала: 2024, Номер 372, С. 751 - 777
Опубликована: Июль 4, 2024
Despite significant advances, cancer remains a leading global cause of death. Current therapies often fail due to incomplete tumor removal and nonspecific targeting, spurring interest in alternative treatments. Hyperthermia, which uses elevated temperatures kill cells or boost their sensitivity radio/chemotherapy, has emerged as promising alternative. Recent advancements employ nanoparticles (NPs) heat mediators for selective cell destruction, minimizing damage healthy tissues. This approach, known NP hyperthermia, falls into two categories: photothermal (PTT) magnetothermal (MTT). PTT utilizes NPs that convert light heat, while MTT magnetic activated by alternating fields (AMF), both achieving localized damage. These methods offer advantages like precise minimal invasiveness, reduced systemic toxicity. However, the efficacy hyperthermia depends on many factors, particular, properties, microenvironment (TME), TME-NP interactions. Optimizing this treatment requires accurate monitoring strategies, such nanothermometry biologically relevant screening models can better mimic physiological features human body. review explores state-of-the-art NP-mediated discussing available nanomaterials, strengths weaknesses, characterization methods, future directions. Our particular focus lies preclinical techniques, providing an updated perspective relevance journey towards clinical trials.
Язык: Английский
Процитировано
10
The Innovation Materials, Год журнала: 2024, Номер 2(1), С. 100051 - 100051
Опубликована: Янв. 1, 2024
<p>Magnetic nanoparticle-mediated hyperthermia (MHT) is a promising tumor theranostic technology due to its noninvasive nature and ability penetrate deep tissues without greatly damaging normal tissues. To advance the clinical translation application of MHT, we present comprehensive overview topics related including basic physical heating principles, magnetic nanoparticle design, biological effects applications. First, fundamental principles through which nanoparticles mediate are reviewed in detail. Subsequently, strategies increase magnetothermal effect MHT highlighted. Then, multitechnology integration applications precision diagnosis treatment introduced. Finally, key challenges outlooks for purposes discussed.</p>
Язык: Английский
Процитировано
8
Materials Science and Engineering C, Год журнала: 2020, Номер 116, С. 111163 - 111163
Опубликована: Июнь 6, 2020
Язык: Английский
Процитировано
51