Strategies for enhancing cancer chemodynamic therapy performance

Exploration, Год журнала: 2022, Номер 2(2)

Опубликована: Март 7, 2022

Chemodynamic therapy (CDT) has emerged to be a frontrunner amongst reactive oxygen species-based cancer treatment modalities. CDT utilizes endogenous H

Язык: Английский

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Immunogenic Cell Death Augmented by Manganese Zinc Sulfide Nanoparticles for Metastatic Melanoma Immunotherapy

ACS Nano, Год журнала: 2022, Номер 16(9), С. 15471 - 15483

Опубликована: Авг. 18, 2022

Both T-cell deprivation and insufficient tumor immunogenicity seriously hinder the efficacy of immune-mediated destruction in melanoma. In this work, an amphiphilic polyethylene glycol-poly(2-hexoxy-2-oxo-1,3,2-dioxaphospholane) copolymer with a thermally sensitive flowable core (mPEG-b-PHEP) was chosen to incorporate IR780 dye manganese zinc sulfide nanoparticles (ZMS) form polymer micelles (denoted PPIR780-ZMS), which precisely controlled release ZMS after being triggered by near-infrared light (NIR). Mn2+-mediated chemodynamic therapy (CDT) photothermal trigger boosted generation reactive oxygen species (ROS), making PPIR780-ZMS smart bomblets vivo. It demonstrated that could maximize immunogenic cell death (ICD) cancer, is characterized abundant damage-associated molecular pattern (DAMP) exposure. As result, cytotoxic T cells (CD8+) helper (CD4+) expanded infiltrated neoplastic foci, further reprogrammed suppressive microenvironment (TME) against primary pulmonary metastases safe systemic cytokine expression. addition, cGAS-STING signaling pathway activation enhanced antitumor immunity nanocomposite, providing practical strategy for expanding use Mn-based nanostructures.

Язык: Английский

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Recent advances on modulation of H2O2 in tumor microenvironment for enhanced cancer therapeutic efficacy

Coordination Chemistry Reviews, Год журнала: 2023, Номер 481, С. 215049 - 215049

Опубликована: Фев. 9, 2023

Язык: Английский

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Copper-doped MOF-based nanocomposite for GSH depleted chemo/photothermal/chemodynamic combination therapy

Chemical Engineering Journal, Год журнала: 2022, Номер 438, С. 135567 - 135567

Опубликована: Март 1, 2022

Язык: Английский

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Unraveling mitochondria‐targeting reactive oxygen species modulation and their implementations in cancer therapy by nanomaterials

Exploration, Год журнала: 2023, Номер 3(2)

Опубликована: Апрель 1, 2023

Abstract Functional subcellular organelle mitochondria are emerging as a crucial player and driver of cancer. For maintaining the sites cellular respiration, experience production, accumulation reactive oxygen species (ROS) underlying oxidative damage in electron transport chain carriers. Precision medicine targeting can change nutrient availability redox homeostasis cancer cells, which might represent promising strategy for suppressing tumor growth. Herein, this review highlights how modification capable manipulating nanomaterials ROS generation strategies influence or compensate state mitochondrial homeostasis. We propose foresight to guide research innovation with an overview seminal work discuss future challenges our perspective on commercialization novel mitochondria‐targeting agents.

Язык: Английский

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Tumor Microenvironment-Activable Manganese-Boosted Catalytic Immunotherapy Combined with PD-1 Checkpoint Blockade

ACS Nano, Год журнала: 2022, Номер 16(12), С. 20400 - 20418

Опубликована: Ноя. 28, 2022

Immune checkpoint blockade (ICB) therapy has attracted widespread attention in cancer treatment. Due to the low immunogenicity and immune suppression state tumor microenvironment (TME), therapeutic effects are only moderate. Herein, a TME-activable manganese-boosted catalytic immunotherapy is designed for synergism with ICB kill tumors efficiently. The cell membrane (CM)-wrapping multienzyme-mimic manganese oxide (MnOx) nanozyme termed CM@Mn showed intrinsic peroxidase oxidase-like activities an acidic TME. These can generate toxic hydroxyl (•OH) superoxide radicals (•O2-) killing evoking immunogenic death (ICD). Furthermore, TME-responsive release of Mn2+ directly promotes dendritic maturation macrophage M1 repolarization, resulting reversal immunosuppressive TME into immune-activating environment. Additionally, hypoxia relief caused by catalase-like activity also contributes process reversal. Finally, robust tumor-specific T cell-mediated antitumor response occurs support PD-1 blockade. proliferation primary metastatic was inhibited, long-term memory effect induced. strategy outlined here may serve as promising candidate tumor-integrated

Язык: Английский

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Reactive oxygen species-powered cancer immunotherapy: Current status and challenges

Journal of Controlled Release, Год журнала: 2023, Номер 356, С. 623 - 648

Опубликована: Март 21, 2023

Язык: Английский

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Smart polydopamine-based nanoplatforms for biomedical applications: state-of-art and further perspectives

Coordination Chemistry Reviews, Год журнала: 2023, Номер 488, С. 215153 - 215153

Опубликована: Апрель 27, 2023

Язык: Английский

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Tumor microenvironment-responsive manganese-based nanomaterials for cancer treatment

Coordination Chemistry Reviews, Год журнала: 2023, Номер 480, С. 215027 - 215027

Опубликована: Янв. 16, 2023

Язык: Английский

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Spatially Asymmetric Nanoparticles for Boosting Ferroptosis in Tumor Therapy

Nano Letters, Год журнала: 2024, Номер 24(4), С. 1284 - 1293

Опубликована: Янв. 17, 2024

Despite its effectiveness in eliminating cancer cells, ferroptosis is hindered by the high natural antioxidant glutathione (GSH) levels tumor microenvironment. Herein, we developed a spatially asymmetric nanoparticle, Fe3O4@DMS&PDA@MnO2-SRF, for enhanced ferroptosis. It consists of two subunits: Fe3O4 nanoparticles coated with dendritic mesoporous silica (DMS) and PDA@MnO2 (PDA: polydopamine) loaded sorafenib (SRF). The spatial isolation Fe3O4@DMS PDA@MnO2-SRF subunits enhances synergistic effect between GSH-scavengers ferroptosis-related components. First, increased exposure subunit Fenton reaction, leading to production reactive oxygen species. Furthermore, effectively depletes GSH, thereby inducing inactivation glutathione-dependent peroxidases 4. Moreover, SRF blocks Xc– transport augmenting GSH depletion capabilities. dual Fe3O4@DMS&PDA@MnO2-SRF significantly weakens antioxidative system, boosting chemodynamic performance cells.

Язык: Английский

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