Chimeric Antigen Receptor Cells Solid Tumor Immunotherapy Assisted by Biomaterials Tools DOI
Yujun Song, Yifan Wang,

Jianping Man

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

Chimeric antigen receptor (CAR) immune cell therapies have revolutionized oncology, particularly in hematological malignancies, yet their efficacy against solid tumors remains limited due to challenges such as dense stromal barriers and immunosuppressive microenvironments. With advancements nanobiotechnology, researchers developed various strategies methods enhance the CAR tumor treatment. In this Review, we first outline structure mechanism of CAR-T (T, T cell), CAR-NK (NK, natural killer), CAR-M (M, macrophage) deeply analyze potential these cells treatment they face. Next, explore how biomaterials can optimize treatments by improving microenvironment, controlling release, promoting infiltration, enhancing efficacy. Finally, summarize current solutions, emphasize effective combination therapy, look forward its future clinical application strategies. This Review provides important theoretical perspectives practical guidance for development more

Language: Английский

Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions DOI Creative Commons

Peilin Lu,

Dongxue Ruan,

Meiqi Huang

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: July 1, 2024

The applications of hydrogels have expanded significantly due to their versatile, highly tunable properties and breakthroughs in biomaterial technologies. In this review, we cover the major achievements potential therapeutic applications, focusing primarily on two areas: emerging cell-based therapies promising non-cell modalities. Within context cell therapy, discuss capacity overcome existing translational challenges faced by mainstream therapy paradigms, provide a detailed discussion advantages principal design considerations for boosting efficacy as well list specific examples different disease scenarios. We then explore drug delivery, physical intervention therapies, other areas (e.g., bioadhesives, artificial tissues, biosensors), emphasizing utility beyond mere delivery vehicles. Additionally, complement our latest progress clinical application outline future research directions, particularly terms integration with advanced biomanufacturing This review aims present comprehensive view critical insights into selection both tailored meet requirements diverse diseases situations.

Language: Английский

Citations

94
Sequential Targeting Hybrid Nanovesicles Composed of Chimeric Antigen Receptor T-Cell-Derived Exosomes and Liposomes for Enhanced Cancer Immunochemotherapy DOI
Tianchuan Zhu, Zhenxing Chen, Guanmin Jiang

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(17), P. 16770 - 16786

Published: Aug. 25, 2023

Paclitaxel (PTX)-based chemotherapy remains the main approach to treating lung cancer but systemic toxicity limits its use. As chimeric antigen receptor-T (CAR-T) cell-derived exosomes contain tumor-targeted CARs and cytotoxic granules (granzyme B perforin), they are considered potential delivery vehicles for PTX. However, low drug-loading capacity hepatotropic properties of obstacles their application extrahepatic cancer. Here, a hybrid nanovesicle named Lip-CExo@PTX was designed immunochemotherapy by fusing derived from bispecific CAR-T cells targeting both mesothelin (MSLN) programmed death ligand-1 (PD-L1) with lung-targeted liposomes. Due lung-targeting ability liposomes, over 95% intravenously administered accumulated in tissue. In addition, help anti-MSLN single-chain variable fragment (scFv), PTX inside were further delivered into MSLN-positive tumors. Notably, anti-PD-L1 scFv on blocked PD-L1 tumors avoid T cell exhaustion promoted PTX-induced immunogenic death. Furthermore, prolonged survival time tumor-bearing mice CT-26 metastatic model. Therefore, may deliver tumor through sequential targeted enhance antitumor effects, providing promising strategy

Language: Английский

Citations

55
A Distinctive Insight into Inorganic Sonosensitizers: Design Principles and Application Domains DOI
Wen Qin, Qiaoling Yang, Chunyan Zhu

et al.

Small, Journal Year: 2024, Volume and Issue: 20(25)

Published: Jan. 15, 2024

Abstract Sonodynamic therapy (SDT) as a promising non‐invasive anti‐tumor means features the preferable penetration depth, which nevertheless, usually can't work without sonosensitizers. Sonosensitizers produce reactive oxygen species (ROS) in presence of ultrasound to directly kill tumor cells, and concurrently activate immunity especially after integration with microenvironment (TME)‐engineered nanobiotechnologies combined therapy. Current sonosensitizers are classified into organic inorganic ones, current most reviews only cover highlighted their applications. However, there have few specific that focus on including design principles, regulation, etc. In this review, first according rationales rather than composition, action underlying chemistry highlighted. Afterward, what how TME is regulated based sonosensitizers‐based SDT nanoplatform an emphasis targets‐engineered elucidated. Additionally, applications non‐cancer diseases also outlined. Finally, setbacks challenges, proposed potential solutions future directions pointed out. This review provides comprehensive detailed horizon sonosensitizers, will arouse more attentions SDT.

Language: Английский

Citations

30
Wrecking neutrophil extracellular traps and antagonizing cancer-associated neurotransmitters by interpenetrating network hydrogels prevent postsurgical cancer relapse and metastases DOI Creative Commons
Hang Zhou, Chunyan Zhu, Qing Zhao

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 39, P. 14 - 24

Published: May 14, 2024

Tumor-promoting niche after incomplete surgery resection (SR) can lead to more aggressive local progression and distant metastasis with augmented angiogenesis-immunosuppressive tumor microenvironment (TME). Herein, elevated neutrophil extracellular traps (NETs) cancer-associated neurotransmitters (CANTs, e.g., catecholamines) are firstly identified as two of the dominant inducements. Further, an injectable fibrin-alginate hydrogel high tissue adhesion has been constructed specifically co-deliver NETs inhibitor (DNase I)-encapsulated PLGA nanoparticles unselective β-adrenergic receptor blocker (propranolol). The components (i.e., fibrin alginate) respond triggers (thrombin Ca2+, respectively) in postoperative bleeding gelate, shaping into interpenetrating network (IPN) featuring strength. continuous release DNase I PR wreck antagonize catecholamines decrease microvessel density, blockade myeloid-derived suppressor cells, secrete various proinflammatory cytokines, potentiate natural killer cell function hamper cytotoxic T exhaustion. reprogrammed TME significantly suppress locally residual tumors, induce strong immune memory effects thus inhibit lung metastasis. Thus, targetedly degrading blocking CANTs enabled by this in-situ IPN-based drug depot provides a simple efficient approach against SR-induced cancer recurrence

Language: Английский

Citations

21
Nanomedicine-Unlocked Radiofrequency Dynamic Therapy Dampens Incomplete Radiofrequency Ablation-Arised Immunosuppression to Suppress Cancer Relapse DOI
Yan Fang,

Feixiang Hu,

Weiwei Ren

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 317, P. 123087 - 123087

Published: Jan. 2, 2025

Language: Английский

Citations

2
Multichannel Sonocatalysis Amplifiers Target IDH1‐Mutated Tumor Plasticity and Attenuate Ros Tolerance to Repress Malignant Cholangiocarcinoma DOI
Duo Wang, Xiaoqi Zhu, Xiaobo Wang

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(48)

Published: July 11, 2023

Abstract Tumor adaptation‐originated tumor tolerance that compensatory mechanisms (e.g., isocitrate dehydrogenase (IDH) mutation) jointly shape is the dominant obstacle of ROS therapy. Currently, targeting a single pathway fails to fundamentally reverse complex milieu and diminish adaptation. Herein, multichannel sonocatalysis amplifier engineered via one‐pot gas diffusion method attenuate IDH1‐mutated cholangiocarcinoma plasticity therapy, wherein triptolide IR780 are co‐loaded in DSPE‐mPEG‐modified CaCO 3 nanoparticles. Triptolide can blockade Nrf2 cut off glutathione biosynthesis blockading proteomic communication, disrupt redox homeostasis potentiate IR780‐mediated sonocatalytic production. ROS‐induced mitochondria damages Ca 2+ turn aggravate accumulation, which cooperates with reprogram mitochondrial energy substance metabolism adenosine triphosphatase glutathione), hinder DNA self‐repair, impair IDH1‐mutation‐asired tolerance. Systematic experiments support these actions such amplifiers indeed /redox disarm robust IDH1‐mutation‐induced therapy against progression. Briefly, pave comprehensive avenue metabolism, target vulnerability, genomic instability‐raised treatment

Language: Английский

Citations

24
Biomaterials to enhance adoptive cell therapy DOI
Noah Eckman, Anahita Nejatfard,

Romola Cavet

et al.

Nature Reviews Bioengineering, Journal Year: 2024, Volume and Issue: 2(5), P. 408 - 424

Published: Jan. 26, 2024

Language: Английский

Citations

16
Dual‐ROS Sensitive Moieties Conjugate Inhibits Curcumin Oxidative Degradation for Colitis Precise Therapy DOI

Dunsheng Liang,

Xiaofan Shen,

Lu Han

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(13)

Published: March 3, 2024

Abstract Curcumin, a natural bioactive polyphenol with diverse molecular targets, is well known for its anti‐oxidation and anti‐inflammatory potential. However, curcumin exhibits low solubility (<1 µg mL −1 ), poor tissue‐targeting ability, rapid oxidative degradation, resulting in bioavailability stability inflammatory therapy. Here, poly(diselenide‐oxalate‐curcumin) nanoparticle (SeOC‐NP) dual‐reactive oxygen species (ROS) sensitive chemical moieties (diselenide peroxalate ester bonds) fabricated by one‐step synthetic strategy. The results confirmed that dual‐ROS endowed SeOC‐NP the ability of targeted delivery significantly suppress degradation high‐efficiency In detail, amount SeOC about 4‐fold lower than free an microenvironment. As result, enhanced antioxidant activity efficacy vitro analysis scavenging intracellular ROS suppressing secretion nitric oxide pro‐inflammatory cytokines. mouse colitis models, orally administered can remarkably alleviate symptoms IBD maintain homeostasis gut microbiota. This work provided simple effective strategy to fabricate ROS‐responsive micellar enhance oxidation medicine precise therapeutic inflammation.

Language: Английский

Citations

12
Biomaterials to regulate tumor extracellular matrix in immunotherapy DOI
Yujie Zhang,

Xuexue Dong,

Yanxiang Zhang

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 376, P. 149 - 166

Published: Oct. 11, 2024

Language: Английский

Citations

12
Sonocatalytic oncolysis microbiota curb intrinsic microbiota lactate metabolism and blockade CD24-Siglec10 immune escape to revitalize immunological surveillance DOI

Xiulin Dong,

Hui Liu, Chao Fang

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 311, P. 122662 - 122662

Published: June 12, 2024

Language: Английский

Citations

11