Multifunctional Metal–Phenolic Composites Promote Efficient Periodontitis Treatment via Antibacterial and Osteogenic Properties

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(11), С. 13573 - 13584

Опубликована: Март 5, 2024

Periodontitis, a complex inflammatory disease initiated by bacterial infections, presents significant challenge in public health. The increased levels of reactive oxygen species and the subsequent exaggerated immune response associated with periodontitis often lead to alveolar bone resorption tooth loss. Herein, we develop multifunctional metal–phenolic composites (i.e., Au@MPN-BMP2) address nature periodontitis, where gold nanoparticles (AuNPs) are coated networks (MPNs) morphogenetic protein 2 (BMP2). In this design, MPNs exhibit remarkable antibacterial antioxidant properties, AuNPs BMP2 promote osteogenic differentiation marrow mesenchymal stem cells under conditions. rat model treatment Au@MPN-BMP2 leads notable therapeutic outcomes, including mitigated oxidative stress, reduced progression inflammation, prevention These results highlight multifunctionality as promising approach for addressing both microbial causative factors an overactivated response. We envision that rational design will provide versatile nanoplatforms tissue regeneration potential clinical applications.

Язык: Английский

---

Structurally Oriented Carbon Dots as ROS Nanomodulators for Dynamic Chronic Inflammation and Infection Elimination

ACS Nano, Год журнала: 2024, Номер 18(33), С. 22055 - 22070

Опубликована: Авг. 8, 2024

The selective elimination of cytotoxic ROS while retaining essential ones is pivotal in the management chronic inflammation. Co-occurring bacterial infection further complicates conditions, necessitating precision and an efficacious treatment strategy. Herein, dynamic nanomodulators are rationally constructed through regulating surface states herbal carbon dots (CDs) for on-demand inflammation or elimination. phenolic OH containing CDs derived from honeysuckle (HOCD) dandelion (DACD) demonstrated appropriate redox potentials, ensuring their ability to scavenge such as ·OH ONOO–, invalidity toward O2·–, H2O2, NO. This enables efficient without affecting signal pathways. C–N/C═N taxus leaves (TACD) DACD renders them with suitable band structures, facilitating absorption red region generation O2·– upon light irradiation sterilization. Specifically, facilely prepared demonstrates fascinating modulating ability, making it highly addressing concurrent infection, diabetic wound infection. regulation strategy facilitates realization precise minimal side effects, holding immense potential clinical practice.

Язык: Английский

---

Nanozyme-Enhanced Probiotic Spores Regulate the Intestinal Microenvironment for Targeted Acute Gastroenteritis Therapy

Nano Letters, Год журнала: 2024, Номер 24(7), С. 2289 - 2298

Опубликована: Фев. 11, 2024

Antibiotic therapeutics to combat intestinal pathogen infections often exacerbate microbiota dysbiosis and impair mucosal barrier functions. Probiotics are promising strategies, because they inhibit colonization improve imbalance. Nevertheless, their limited targeting ability susceptibility oxidative stress have hindered therapeutic potential. To tackle these challenges, Ces3 is synthesized by in situ growth of CeO2 nanozymes with positive charges on probiotic spores, facilitating electrostatic interactions negatively charged pathogens possessing a high reactive oxygen species (ROS) scavenging activity. Importantly, can resist the harsh environment gastrointestinal tract. In mice S. Typhimurium-infected acute gastroenteritis, shows potent anti-S. Typhimurium activity, thereby alleviating dissemination into other organs. Additionally, owing its O2 deprivation capacity, promotes proliferation anaerobic probiotics, reshaping healthy microbiota. This work demonstrates promise combining antibacterial, anti-inflammatory, content regulation properties for gastroenteritis therapy.

Язык: Английский

---

Integration of a biocompatible metal-phenolic network and fluorescence microspheres as labels for sensitive and stable detection of carbendazim with a lateral flow immunoassay

Food Chemistry, Год журнала: 2024, Номер 450, С. 139260 - 139260

Опубликована: Апрель 4, 2024

Язык: Английский

---

Nanoclay Mediated Self‐Promoted Reactive Oxygen Species Releasing Enables Efficient Antimicrobial

Advanced Functional Materials, Год журнала: 2024, Номер 34(45)

Опубликована: Май 28, 2024

Abstract Reactive oxygen species (ROS) releasing materials are increasingly used in nanomedicines due to their effectiveness against a broad spectrum of microbes. However, most ROS‐releasing rely on external stimuli such as photoirradiation, either through photodynamic or photocatalytic processes, which limits practical applications. Herein, this work presents novel nanoclay mediated self‐promoted ROS material called vacancies‐rich ZnO/kaolinite (O v ‐rich ZnO/Kaol). Both experiments and density functional theory (DFT) calculations reveal that the introduction kaolinite increases content O ZnO, change electronic structure promotes process adsorption activation, resulting generation · 2 − reduction without photoirradiation. Molecular dynamics simulations confirm enhances interaction between bacterial membrane, promoting bacterial‐killing effect . More importantly, ZnO/Kaol is successfully prepared pilot scale manufacture antibacterial gauze, showed at least 99% activity both Escherichia coli ( E. ) Staphylococcus aureus S. absence light. The as‐prepared also exhibited satisfactory biocompatibility biosafety. This method can offer more benign approach address limitations traditional photoirradiation‐dependent photosensitizers for antimicrobial gauze.

Язык: Английский

---

Dual‐Polymer Functionalized Melanin‐AgNPs Nanocomposite with Hydroxyapatite Binding Ability to Penetrate and Retain in Biofilm Sequentially Treating Periodontitis

Small, Год журнала: 2024, Номер unknown

Опубликована: Май 15, 2024

Abstract Periodontitis is the leading cause of adult tooth missing. Thorny bacterial biofilm and high reactive oxygen species (ROS) levels in tissue are key elements for periodontitis process. It meaningful to develop an advanced therapeutic system with sequential antibacterial/ antioxidant ability meet overall goals therapy. Herein, a dual‐polymer functionalized melanin‐AgNPs (P/D‐MNP‐Ag) penetration, hydroxyapatite binding, sequentially treatment fabricated. Polymer enriched 2‐(Dimethylamino)ethyl methacrylate (D), can be protonated acid environment enhanced positive charge, promoting penetration biofilm. The other polymer rich phosphate group (P) chelate Ca 2+ , adhere surface. Melanin has good ROS scavenging photothermal abilities, after situ reduction Ag, composite transitioned between antibacterial antioxidative due heat accelerated Ag + release. released have synergistic effects killing. With consumption, MNP recovers scavenge inflammatory area. When applied model, P/D‐MNP‐Ag therapeutical ablate biofilm, relieve inflammation state, reduce alveolar bone loss. provides reference developing oral eradication systems.

Язык: Английский

---

Ultrasound-triggered piezoelectric polyetheretherketone with boosted osteogenesis via regulating Akt/GSK3β/β-catenin pathway

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Сен. 5, 2024

Язык: Английский

---

Marine‐Derived Nanozyme‐Crosslinked Self‐Adaptive Hydrogels for Programmed Regulating the Regeneration Process

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Июнь 16, 2024

Abstract Self‐adaptive hydrogels that can specifically respond to pathological cues and match the highly ordered tissue regeneration process are significantly on‐demand for effective wound management. Herein, multifunctional marine‐derived gold clusterzyme (AuNCs)‐based self‐adaptive with microenvironment triggered release behavior elaborately fabricated antioxidant, anti‐inflammatory immunoregulation. The marine mussel‐derived catechol ligands (L‐3,4‐dihydroxyphenylalanine) endow AuNCs enhanced superoxide dismutase‐mimic activity due their high affinity anion free radical (O 2 − •) unique electron transfer mechanism, leading 100% inhibition of O •. Upon uniformly crosslinking phenylboronic acid‐modified sodium alginate (PBA‐Sa), obtained AuNCs@PBA‐Sa exhibit outstanding self‐healing property, tunable degradation good removability. Meanwhile, greatly enhance mechanical property confer hydrogel favorable adhesion rapid hemostasis. Furthermore, injectable not only adapt shape irregular wound, but also smartly microstructure physiological diabetic responsive upon break boronate ester bonds. released clusterzymes actively induce generation M2‐macrophage, demonstrating an pro‐regeneration effect. Therefore, present clusterzyme‐based hold great potential remolding dynamic smart

Язык: Английский

---

Artificial Bacteriophages for Treating Oral Infectious Disease via Localized Bacterial Capture and Enhanced Catalytic Sterilization

Advanced Science, Год журнала: 2024, Номер 11(41)

Опубликована: Авг. 19, 2024

Abstract With the rapid emergence of antibiotic‐resistant pathogens, nanomaterial‐assisted catalytic sterilization has been well developed to combat pathogenic bacteria by elevating level reactive oxygen species including hydroxyl radical (·OH). Although promising, ultra‐short lifetime and limited diffusion distance ·OH severely limit their practical antibacterial usage. Herein, rational design preparation novel virus‐like copper silicate hollow spheres (CSHSs) are reported, as applications robust artificial bacteriophages for localized bacterial capture enhanced in treatment oral infectious diseases. During whole process killing, CSHSs can efficiently via shortening between CSHSs, produce massive around bacteria, further iinducing admirable effect inhibition. By using mucosal infection periodontitis typical diseases, it is easily found that populations lesions animals after fall sharply, well‐developed nanosystem decrease inflammatory reaction promote hard or soft tissue repair. Together, high Fenton‐like activity, strong affinity, excellent overall safety nanoplatform promise its great therapeutic potential disinfection.

Язык: Английский

---

Programmed Transformation of Osteogenesis Microenvironment by a Multifunctional Hydrogel to Enhance Repair of Infectious Bone Defects

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 22, 2025

Abstract Repair of infectious bone defects remains a serious problem in clinical practice owing to the high risk infection and excessive reactive oxygen species (ROS) during early stage, residual bacteria delayed Osseo integrated interface later which jointly creates complex dynamic microenvironment leads non‐union. The melatonin carbon dots (MCDs) possess antibacterial osteogenesis abilities, greatly simplifying composition multifunctional material. Therefore, hydrogel containing MCDs (GH‐MCD) is developed meet multi‐stage repair needs injury this study. GH‐MCD can intelligently release responding acidic scavenge intracellular ROS exhibit good activity by inducing production inhibiting expression secA2 . Moreover, it has long‐lasting antimicrobial repair. RNA‐seq results reveal that hydrogels promote infected healing enhancing cellular resistance bacteria, balancing osteoclastogenesis, regulating immune microenvironment. In conclusion, through programmed transformation microenvironment, providing novel strategy for defects.

Язык: Английский

---