Chemical Reviews,
Год журнала:
2021,
Номер
121(22), С. 14281 - 14347
Опубликована: Май 4, 2021
Self-assembly
is
promising
for
construction
of
a
wide
variety
supramolecular
assemblies,
whose
1D/2D/3D
structures
are
typically
relevant
to
their
functions.
In-depth
understanding
structure–function
relationships
essential
rational
design
and
development
functional
molecular
assemblies.
Microscopic
imaging
has
been
used
as
powerful
tool
elucidate
individual
assemblies
with
subnanometer
millimeter
resolution,
which
complementary
conventional
spectroscopic
techniques
that
provide
the
ensemble
structural
information.
In
this
review,
we
highlight
representative
examples
visualization
by
use
electron
microscopy,
atomic
force
confocal
super-resolution
microscopy.
This
review
comprehensively
describes
nanofibers/gels,
micelles/vesicles,
coacervate
droplets,
polymer
protein/DNA
Advanced
can
address
key
challenges,
like
evaluation
dynamics
multicomponent
self-assembly,
self-assembly/disassembly
in
complex
cellular
milieu,
also
discussed.
We
believe
would
guidelines
deeper
analyses
develop
next-generation
materials.
Journal of the American Chemical Society,
Год журнала:
2019,
Номер
141(9), С. 4073 - 4079
Опубликована: Фев. 11, 2019
Therapeutic
enzymes
hold
great
promise
for
cancer
therapy;
however,
in
vivo
remote
control
of
enzymatic
activity
to
improve
their
therapeutic
specificity
remains
challenging.
This
study
reports
the
development
an
organic
semiconducting
pro-nanoenzyme
(OSPE)
with
a
photoactivatable
feature
metastasis-inhibited
therapy.
Upon
near-infrared
(NIR)
light
irradiation,
this
not
only
generates
cytotoxic
singlet
oxygen
(1O2)
photodynamic
therapy
(PDT),
but
also
triggers
spontaneous
cascade
reaction
induce
degradation
ribonucleic
acid
(RNA)
specifically
tumor
microenvironment.
More
importantly,
OSPE-mediated
RNA
is
found
downregulate
expression
metastasis-related
proteins,
contributing
inhibition
metastasis
after
treatment.
Such
photoactivated
and
cancer-specific
synergistic
action
OSPE
enables
complete
growth
lung
mouse
xenograft
model,
which
possible
counterpart
PDT
nanoagent.
Thus,
our
proposes
phototherapeutic-proenzyme
approach
toward
complete-remission
ACS Applied Materials & Interfaces,
Год журнала:
2021,
Номер
13(17), С. 19543 - 19571
Опубликована: Апрель 26, 2021
Subcellular
organelles
are
the
cornerstones
of
cells,
and
destroying
them
will
cause
cell
dysfunction
even
death.
Therefore,
realizing
precise
organelle
targeting
photosensitizers
(PSs)
can
help
reduce
PS
dosage,
minimize
side
effects,
avoid
drug
resistance,
enhance
therapeutic
efficacy
in
photodynamic
therapy
(PDT).
Organelle-targeted
PSs
provide
a
new
paradigm
for
construction
next
generation
may
implementable
strategies
future
precision
medicine.
In
this
Review,
recent
different
corresponding
design
principles
molecular
nanostructured
summarized
discussed.
The
current
challenges
opportunities
organelle-targeted
PDT
also
presented.
Chemical Reviews,
Год журнала:
2020,
Номер
120(18), С. 9994 - 10078
Опубликована: Авг. 19, 2020
Enzymatic
reactions
and
noncovalent
(i.e.,
supramolecular)
interactions
are
two
fundamental
nongenetic
attributes
of
life.
synthesis
(ENS)
refers
to
a
process
where
enzymatic
control
intermolecular
for
spatial
organization
higher-order
molecular
assemblies
that
exhibit
emergent
properties
functions.
Like
covalent
(ECS),
in
which
an
enzyme
catalyzes
the
formation
bonds
generate
individual
molecules,
ENS
is
unifying
theme
understanding
functions,
morphologies,
locations
ensembles
cellular
environments.
This
review
intends
provide
summary
works
within
past
decade
emphasize
After
comparing
ECS
ENS,
we
describe
few
representative
examples
nature
uses
as
rule
life,
create
biomacromolecules
properties/functions
myriad
processes.
Then,
focus
on
man-made
(synthetic)
molecules
cell-free
conditions,
classified
by
types
enzymes.
that,
introduce
exploration
context
cells
discussing
intercellular,
peri/intracellular,
subcellular
cell
morphogenesis,
imaging,
cancer
therapy,
other
applications.
Finally,
perspective
promises
developing
assemblies/processes
aims
be
updated
introduction
researchers
who
interested
exploring
science
technologies
address
societal
needs.
Chemical Society Reviews,
Год журнала:
2021,
Номер
50(13), С. 7436 - 7495
Опубликована: Янв. 1, 2021
Compounds
with
a
nitrobenzoxadiazole
(NBD)
skeleton
exhibit
high
reactivity
toward
biological
nucleophilies
accompanied
by
distinct
colorimetric
and
fluorescent
changes,
environmental
sensitivity,
small
size,
all
of
which
facilitate
biomolecular
sensing
self-assembly.
Journal of the American Chemical Society,
Год журнала:
2022,
Номер
144(10), С. 4667 - 4677
Опубликована: Март 7, 2022
Constructing
artificial
dynamic
architectures
inside
cells
to
rationally
interfere
with
organelles
is
emerging
as
an
efficient
strategy
regulate
the
behaviors
and
fate
of
cells,
thus
providing
new
routes
for
therapeutics.
Herein,
we
develop
intracellular
K+-mediating
assembly
DNA
tetrahedrons
which
realizes
mitochondrial
interference
consequent
regulation
on
energy
metabolism
living
cells.
In
designer
tetrahedron,
one
vertex
was
modified
triphenylphosphine
(TPP)
targeting,
other
three
vertexes
were
tethered
guanine-rich
sequences
that
could
realize
formation
intermolecular
G-quadruplexes,
consequently
led
form
aggregates
in
cytoplasm.
The
specially
targeted
mitochondria
served
a
polyanionic
barrier
substance
communication,
generating
significant
inhibition
effect
aerobic
respiration
function
associated
glycolysis
process,
reduced
production
adenosine
triphosphate
(ATP).
lack
ATP
impeded
lamellipodium
essential
movement
resulting
inhibitory
cell
migration.
Remarkably,
migration
capacity
suppressed
by
high
50%
cancer
This
work
provides
manipulation
via
endogenous
molecule-mediating
exogenous
envisioned
have
great
potential
precise
biomedicine.
Chemical Reviews,
Год журнала:
2023,
Номер
123(18), С. 10920 - 10989
Опубликована: Сен. 15, 2023
Anticancer
nanomedicines
have
been
proven
effective
in
mitigating
the
side
effects
of
chemotherapeutic
drugs.
However,
challenges
remain
augmenting
their
therapeutic
efficacy.
Nanomedicines
responsive
to
pathological
abnormalities
tumor
microenvironment
(TME)
are
expected
overcome
biological
limitations
conventional
nanomedicines,
enhance
efficacies,
and
further
reduce
effects.
This
Review
aims
quantitate
various
TME,
which
may
serve
as
unique
endogenous
stimuli
for
design
stimuli-responsive
provide
a
broad
objective
perspective
on
current
understanding
cancer
treatment.
We
dissect
typical
transport
process
barriers
drug
delivery,
highlight
key
principles
designed
tackle
series
delivery
process,
discuss
"all-into-one"
"one-for-all"
strategies
integrating
needed
properties
nanomedicines.
Ultimately,
we
insight
into
future
perspectives
toward
clinical
translation
Advanced Therapeutics,
Год журнала:
2022,
Номер
5(2)
Опубликована: Янв. 10, 2022
Abstract
Since
the
1960s
membrane‐bound
enzyme
alkaline
phosphatase
(ALP)
has
been
utilized
in
drug
delivery.
As
it
cleaves
phosphate
substructures
from
drugs,
auxiliary
agents,
and
even
surface
of
nanocarriers,
this
enables
design
delivery
systems
that
can
alter
their
properties
body
on
demand.
Anionic
nanocarriers
exhibiting
bioinert
to
interactive
once
having
reached
target
site
as
due
an
ALP‐triggered
cleavage
anionic
groups
charge
converts
cationic
improving
for
instance
cellular
uptake.
Moreover,
features
such
accumulation
at
or
a
targeted
release
triggered
by
ALP
be
introduced.
In
addition,
is
improve
potential
numerous
diagnostic
systems.
Within
review,
one
provides
overview
about
activity,
selectivity,
distribution
enzyme,
well
great
variety
applications
diagnostics
making
use
it.
Abstract
Dynamic‐responsive
self‐assembly
is
the
process
of
ordered
supramolecular
structure
formation
or
reversible
decomposition
from
building
blocks.
This
driven
by
non‐covalent
interactions
based
on
complex
stimulus‐responsive
systems
comprising
different
components
within
a
microenvironment.
Furthermore,
stimuli‐responsive
assembly‐disassembly
an
intrinsic
interaction
in
organisms,
indispensable
maintaining
life
activities
and
functions.
However,
dynamic
between
dynamically
responsive
nano‐drug
(DRNSs)
biological
remain
unpredictable,
which
are
challenge
for
precisely
targeted
therapy
controlled
drug
release
DRNSs
vivo.
review
highlights
novel
self‐assembling
peptide‐based
their
interactions.
By
controlling
shape
size
self‐assembled
peptide
nanomaterials,
biologically
simulated
with
diverse
functions
precise
transport
at
subcellular
level
can
be
achieved.
We
have
also
summarized
limitations
challenges
nanomaterials
clinical
translation.
Additionally,
we
discussed
future
perspectives
therapeutics
using
signaling
molecule
gradient
concentrations
efficiencies
highlighted
direction
developing
clinically
translatable
smart
nanomedicines.
