Coordination Chemistry Reviews, Год журнала: 2024, Номер 516, С. 215986 - 215986
Опубликована: Июнь 2, 2024
Язык: Английский
Coordination Chemistry Reviews, Год журнала: 2024, Номер 516, С. 215986 - 215986
Опубликована: Июнь 2, 2024
Язык: Английский
Small Methods, Год журнала: 2021, Номер 5(3)
Опубликована: Янв. 18, 2021
Near-infrared (NIR) fluorescence imaging is an emerging noninvasive modality, with unique advantages in guiding tumor resection surgery, thanks to its high sensitivity and instantaneity. In the past decade, studies on conventional NIR window (NIR-I, 750-900 nm) have gradually focused second (NIR-II, 1000-1700 nm). With reduced light scattering, photon absorption, auto-fluorescence qualities, NIR-II significantly improves penetration depths signal-to-noise ratios bio-imaging. Recently, several applied navigating cancer including localizing cancers, assessing surgical margins, tracing lymph nodes, mapping important anatomical structures. These exemplified significant prospects of this new approach. review, agents some complex applications for surgeries are summarized. Future challenges clinical translation also discussed.
Язык: Английский
Процитировано
109Advanced Materials, Год журнала: 2023, Номер 35(20)
Опубликована: Март 3, 2023
Molecular fluorophores with the second near-infrared (NIR-II) emission hold great potential for deep-tissue bioimaging owing to their excellent biocompatibility and high resolution. Recently, J-aggregates are used construct long-wavelength NIR-II emitters as optical bands show remarkable red shifts upon forming water-dispersible nano-aggregates. However, wide applications in fluorescence imaging impeded by limited varieties of J-type backbone serious quenching. Herein, a bright benzo[c]thiophene (BT) J-aggregate fluorophore (BT6) anti-quenching effect is reported highly efficient phototheranostics. The BT manipulated have Stokes shift over 400 nm aggregation-induced (AIE) property conquering self-quenching issue fluorophores. Upon BT6 assemblies an aqueous environment, absorption 800 1000 boosted more than 41 26 folds, respectively. In vivo visualization whole-body blood vessel imaging-guided phototherapy results verify that NPs agent cancer This work develops strategy precisely properties biomedical applications.
Язык: Английский
Процитировано
109Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 203, С. 115115 - 115115
Опубликована: Окт. 14, 2023
Silica nanoparticles (SNP) have gained tremendous attention in the recent decades. They been used many different biomedical fields including diagnosis, biosensing and drug delivery. Medical uses of SNP for anti-cancer, anti-microbial theranostic applications are especially prominent due to their exceptional performance deliver small molecules recently biologics (mRNA, siRNA, antigens, antibodies, proteins, peptides) at targeted sites. The physical chemical properties such as large specific surface area, tuneable particle size porosity, excellent biodegradability biocompatibility make them an ideal delivery diagnostic platform. Based on available data pre-clinical SNP, interest has driven these innovative materials towards clinical application with formulations already Phase I II trials. Herein, progress field is reviewed, safety aspects analysed. Importantly, we critically evaluate key structural characteristics overcome biological barriers blood-brain barrier (BBB), skin, tumour mucosal barrier. Future directions, potential pathways, target areas rapid translation also recommended.
Язык: Английский
Процитировано
96Coordination Chemistry Reviews, Год журнала: 2022, Номер 468, С. 214609 - 214609
Опубликована: Май 31, 2022
Язык: Английский
Процитировано
95Chemical Society Reviews, Год журнала: 2022, Номер 51(18), С. 7692 - 7714
Опубликована: Янв. 1, 2022
This paper reviews organic and inorganic species as building blocks various design strategies of NIR-II nanohybrids for intensity-based lifetime-based bioimaging biosensing.
Язык: Английский
Процитировано
87Science Advances, Год журнала: 2022, Номер 8(48)
Опубликована: Дек. 2, 2022
Organic dyes with absorption maxima in the second near-infrared window (NIR-II; 1000 to 1700 nm) are of great interest biophotonics. However, because lack appropriate molecular scaffolds, current research this field is limited cyanine dyes, and developing NIR-II-absorbing organic for biophotonics remains an immense challenge. Here, we rationally designed ethenylene-bridged BODIPY scaffold featuring excellent J-aggregation capabilities revealed that bridging ethylene unit crucial intermolecular J-coupling regulation. By integrating electron-donating groups into scaffold, obtained a dye, BisBDP2, J-aggregate maximum around 1300 nm. BisBDP2 J-aggregates show photothermal performance, including intense photoacoustic response, high conversion efficiency value 63%. In vivo results demonstrate potential imaging ablation deep-seated tumors. This study will speed up exploration future biophotonic applications.
Язык: Английский
Процитировано
82Chemical Science, Год журнала: 2022, Номер 13(38), С. 11280 - 11293
Опубликована: Янв. 1, 2022
Polymethine cyanine dyes, as the most important class of organic near-infrared-II (NIR-II) fluorophores, recently received increasing attention due to their high molar extinction coefficients, intensive fluorescence brightness, and flexible wavelength tunability for fluorescent bioimaging applications. Very recently, remarkable advances have been made in development NIR-II polymethine fluorophores with improved optical performance, mainly including tunable fluorescence, water solubility stability. In this review, we summarize recent research molecular tailoring design strategies then emphasize representative biosensing The potential challenges perspectives emerging field are also discussed. This review may provide guidance reference further high-performance boost clinical translation future.
Язык: Английский
Процитировано
81Nature Reviews Methods Primers, Год журнала: 2024, Номер 4(1)
Опубликована: Апрель 4, 2024
Язык: Английский
Процитировано
80Chemical Reviews, Год журнала: 2023, Номер 124(2), С. 554 - 628
Опубликована: Ноя. 22, 2023
In vivo imaging technologies have emerged as a powerful tool for both fundamental research and clinical practice. particular, luminescence in the tissue-transparent near-infrared (NIR, 700–1700 nm) region offers tremendous potential visualizing biological architectures pathophysiological events living subjects with deep tissue penetration high contrast owing to reduced light–tissue interactions of absorption, scattering, autofluorescence. The distinctive quantum effects nanocrystals been harnessed achieve exceptional photophysical properties, establishing them promising category luminescent probes. this comprehensive review, between light tissues, well advantages NIR imaging, are initially elaborated. Subsequently, we focus on achieving improved by optimizing performance nanocrystal fluorophores. ingenious design strategies probes discussed, along their respective biomedical applications versatile modalities. Finally, thought-provoking reflections challenges prospects future translation nanocrystal-based wisely provided.
Язык: Английский
Процитировано
74Advanced Materials, Год журнала: 2023, Номер 36(1)
Опубликована: Авг. 1, 2023
Molecular fluorophores emitting in the second near-infrared (NIR-II, 1000-1700 nm) window with strong optical harvesting and high quantum yields hold great potential for vivo deep-tissue bioimaging high-resolution biosensing. Recently, J-aggregates are harnessed to engineer long-wavelength NIR-II emitters show unique superiority tumor detection, vessel mapping, surgical navigation, phototheranostics due their bathochromic-shifted bands required slip-stacked arrangement aggregation state. However, despite preliminary progress of theoretical study structure-property relationships, further paradigms remain scarce lack on aggregated fashion. In this effort, how utilize specific molecular structure form packing motifs J-type exciton coupling is emphatically elucidated. First, several regulating strategies achieve containing intermolecular interactions external conditions positively summarized deeply analyzed. Then, recent reports theranostics systematically provide a clear reference direction promoting development organic fluorophores. Eventually, prospective efforts ameliorating clinical practices outlined.
Язык: Английский
Процитировано
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