Surgical Navigation for Malignancies Guided by Near‐Infrared‐II Fluorescence Imaging

Small Methods, Journal Year: 2021, Volume and Issue: 5(3)

Published: Jan. 18, 2021

Near-infrared (NIR) fluorescence imaging is an emerging noninvasive modality, with unique advantages in guiding tumor resection surgery, thanks to its high sensitivity and instantaneity. In the past decade, studies on conventional NIR window (NIR-I, 750-900 nm) have gradually focused second (NIR-II, 1000-1700 nm). With reduced light scattering, photon absorption, auto-fluorescence qualities, NIR-II significantly improves penetration depths signal-to-noise ratios bio-imaging. Recently, several applied navigating cancer including localizing cancers, assessing surgical margins, tracing lymph nodes, mapping important anatomical structures. These exemplified significant prospects of this new approach. review, agents some complex applications for surgeries are summarized. Future challenges clinical translation also discussed.

Language: Английский

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Anti‐Quenching NIR‐II J‐Aggregates of Benzo[c]thiophene Fluorophore for Highly Efficient Bioimaging and Phototheranostics

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(20)

Published: March 3, 2023

Molecular fluorophores with the second near-infrared (NIR-II) emission hold great potential for deep-tissue bioimaging owing to their excellent biocompatibility and high resolution. Recently, J-aggregates are used construct long-wavelength NIR-II emitters as optical bands show remarkable red shifts upon forming water-dispersible nano-aggregates. However, wide applications in fluorescence imaging impeded by limited varieties of J-type backbone serious quenching. Herein, a bright benzo[c]thiophene (BT) J-aggregate fluorophore (BT6) anti-quenching effect is reported highly efficient phototheranostics. The BT manipulated have Stokes shift over 400 nm aggregation-induced (AIE) property conquering self-quenching issue fluorophores. Upon BT6 assemblies an aqueous environment, absorption 800 1000 boosted more than 41 26 folds, respectively. In vivo visualization whole-body blood vessel imaging-guided phototherapy results verify that NPs agent cancer This work develops strategy precisely properties biomedical applications.

Language: Английский

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Design of NIR-II high performance organic small molecule fluorescent probes and summary of their biomedical applications

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 468, P. 214609 - 214609

Published: May 31, 2022

Language: Английский

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Management of fluorescent organic/inorganic nanohybrids for biomedical applications in the NIR-II region

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(18), P. 7692 - 7714

Published: Jan. 1, 2022

This paper reviews organic and inorganic species as building blocks various design strategies of NIR-II nanohybrids for intensity-based lifetime-based bioimaging biosensing.

Language: Английский

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Silica nanoparticles: A review of their safety and current strategies to overcome biological barriers

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 203, P. 115115 - 115115

Published: Oct. 14, 2023

Silica nanoparticles (SNP) have gained tremendous attention in the recent decades. They been used many different biomedical fields including diagnosis, biosensing and drug delivery. Medical uses of SNP for anti-cancer, anti-microbial theranostic applications are especially prominent due to their exceptional performance deliver small molecules recently biologics (mRNA, siRNA, antigens, antibodies, proteins, peptides) at targeted sites. The physical chemical properties such as large specific surface area, tuneable particle size porosity, excellent biodegradability biocompatibility make them an ideal delivery diagnostic platform. Based on available data pre-clinical SNP, interest has driven these innovative materials towards clinical application with formulations already Phase I II trials. Herein, progress field is reviewed, safety aspects analysed. Importantly, we critically evaluate key structural characteristics overcome biological barriers blood-brain barrier (BBB), skin, tumour mucosal barrier. Future directions, potential pathways, target areas rapid translation also recommended.

Language: Английский

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The pursuit of polymethine fluorophores with NIR-II emission and high brightness forin vivoapplications

Chemical Science, Journal Year: 2022, Volume and Issue: 13(38), P. 11280 - 11293

Published: Jan. 1, 2022

Polymethine cyanine dyes, as the most important class of organic near-infrared-II (NIR-II) fluorophores, recently received increasing attention due to their high molar extinction coefficients, intensive fluorescence brightness, and flexible wavelength tunability for fluorescent bioimaging applications. Very recently, remarkable advances have been made in development NIR-II polymethine fluorophores with improved optical performance, mainly including tunable fluorescence, water solubility stability. In this review, we summarize recent research molecular tailoring design strategies then emphasize representative biosensing The potential challenges perspectives emerging field are also discussed. This review may provide guidance reference further high-performance boost clinical translation future.

Language: Английский

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Discovery of BODIPY J-aggregates with absorption maxima beyond 1200 nm for biophotonics

Science Advances, Journal Year: 2022, Volume and Issue: 8(48)

Published: Dec. 2, 2022

Organic dyes with absorption maxima in the second near-infrared window (NIR-II; 1000 to 1700 nm) are of great interest biophotonics. However, because lack appropriate molecular scaffolds, current research this field is limited cyanine dyes, and developing NIR-II-absorbing organic for biophotonics remains an immense challenge. Here, we rationally designed ethenylene-bridged BODIPY scaffold featuring excellent J-aggregation capabilities revealed that bridging ethylene unit crucial intermolecular J-coupling regulation. By integrating electron-donating groups into scaffold, obtained a dye, BisBDP2, J-aggregate maximum around 1300 nm. BisBDP2 J-aggregates show photothermal performance, including intense photoacoustic response, high conversion efficiency value 63%. In vivo results demonstrate potential imaging ablation deep-seated tumors. This study will speed up exploration future biophotonic applications.

Language: Английский

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Near-infrared II fluorescence imaging

Nature Reviews Methods Primers, Journal Year: 2024, Volume and Issue: 4(1)

Published: April 4, 2024

Language: Английский

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J‐Aggregation Strategy toward Potentiated NIR‐II Fluorescence Bioimaging of Molecular Fluorophores

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(1)

Published: Aug. 1, 2023

Molecular fluorophores emitting in the second near-infrared (NIR-II, 1000-1700 nm) window with strong optical harvesting and high quantum yields hold great potential for vivo deep-tissue bioimaging high-resolution biosensing. Recently, J-aggregates are harnessed to engineer long-wavelength NIR-II emitters show unique superiority tumor detection, vessel mapping, surgical navigation, phototheranostics due their bathochromic-shifted bands required slip-stacked arrangement aggregation state. However, despite preliminary progress of theoretical study structure-property relationships, further paradigms remain scarce lack on aggregated fashion. In this effort, how utilize specific molecular structure form packing motifs J-type exciton coupling is emphatically elucidated. First, several regulating strategies achieve containing intermolecular interactions external conditions positively summarized deeply analyzed. Then, recent reports theranostics systematically provide a clear reference direction promoting development organic fluorophores. Eventually, prospective efforts ameliorating clinical practices outlined.

Language: Английский

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Nanocrystals for Deep-Tissue In Vivo Luminescence Imaging in the Near-Infrared Region

Chemical Reviews, Journal Year: 2023, Volume and Issue: 124(2), P. 554 - 628

Published: Nov. 22, 2023

In vivo imaging technologies have emerged as a powerful tool for both fundamental research and clinical practice. particular, luminescence in the tissue-transparent near-infrared (NIR, 700–1700 nm) region offers tremendous potential visualizing biological architectures pathophysiological events living subjects with deep tissue penetration high contrast owing to reduced light–tissue interactions of absorption, scattering, autofluorescence. The distinctive quantum effects nanocrystals been harnessed achieve exceptional photophysical properties, establishing them promising category luminescent probes. this comprehensive review, between light tissues, well advantages NIR imaging, are initially elaborated. Subsequently, we focus on achieving improved by optimizing performance nanocrystal fluorophores. ingenious design strategies probes discussed, along their respective biomedical applications versatile modalities. Finally, thought-provoking reflections challenges prospects future translation nanocrystal-based wisely provided.

Language: Английский

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