Science Signaling, Год журнала: 2022, Номер 15(728)
Опубликована: Апрель 5, 2022
The fungal pathogen
Язык: Английский
Oral Diseases, Год журнала: 2020, Номер 27(8), С. 1862 - 1880
Опубликована: Окт. 31, 2020
Oral potentially malignant disorders (OPMDs) are associated with an increased risk of occurrence cancers the lip or oral cavity. This paper presents updated report on nomenclature and classification OPMDs, based predominantly their clinical features, following discussions by expert group at a workshop held World Health Organization (WHO) Collaborating Centre for Cancer in UK. The first London 2005 considered wide spectrum under term "potentially mucosa" (PMD) (now referred to as disorders: OPMD) including leukoplakia, erythroplakia, proliferative verrucous lichen planus, submucous fibrosis, palatal lesions reverse smokers, lupus erythematosus, epidermolysis bullosa, dyskeratosis congenita. Any new evidence published intervening period was make essential changes 2007 classification. In current update, most entities were retained minor definition. There is sufficient cancer among patients diagnosed "oral lichenoid lesions" those manifestations 'chronic graft-versus-host disease'. These have now been added list OPMDs. is, date, insufficient concerning potential chronic hyperplastic candidosis exophytic hyperplasia consider these conditions Furthermore, due lack clear OPMD bullosa this moved category limited evidence. We recommend establishment global research consortium further study natural history OPMDs proposed here. will require multi-center longitudinal studies uniform diagnostic criteria improve identification stratification link them evidence-based interventions, goal facilitate prevention management cavity cancer.
Язык: Английский
Процитировано
765
Journal of Fungi, Год журнала: 2020, Номер 6(1), С. 27 - 27
Опубликована: Фев. 25, 2020
Candida albicans, along with other closely related species, are the primary causative agents of vulvovaginal candidiasis (VVC)—a multifactorial infectious disease lower female reproductive tract resulting in pathologic inflammation. Unlike forms candidiasis, VVC is a immunocompetent and otherwise healthy women, most predominant during their child-bearing years. While non-lethal, its high global incidence profound negative impact on quality-of-life necessitates further understanding host fungal factors that drive pathogenesis. In this review, we cover current state our epidemiology, response, pathogenicity mechanisms, microbiome, novel approaches to treatment prevalent human candidal infection. We also offer insight into latest advancements field identify important questions still remain.
Язык: Английский
Процитировано
258
Virulence, Год журнала: 2021, Номер 13(1), С. 89 - 121
Опубликована: Дек. 29, 2021
is a commensal yeast fungus of the human oral, gastrointestinal, and genital mucosal surfaces, skin. Antibiotic-induced dysbiosis, iatrogenic immunosuppression, and/or medical interventions that impair integrity mucocutaneous barrier perturb protective host defense mechanisms enable
Язык: Английский
Процитировано
258
FEMS Microbiology Reviews, Год журнала: 2020, Номер 45(3)
Опубликована: Ноя. 18, 2020
Candida albicans is a major fungal pathogen of humans. It exists as commensal in the oral cavity, gut or genital tract most individuals, constrained by local microbiota, epithelial barriers and immune defences. Their perturbation can lead to outgrowth development mucosal infections such oropharyngeal vulvovaginal candidiasis, patients with compromised immunity are susceptible life-threatening systemic infections. The importance interplay between fungus, host microbiota driving transition from C. commensalism pathogenicity widely appreciated. However, complexity these interactions, significant impact fungal, variability upon disease severity outcome, less well understood. Therefore, we summarise features fungus that promote infection, how genetic variation clinical isolates influences pathogenicity. We discuss antifungal immunity, this differs mucosae, individual person's susceptibility infection. Also, describe factors influence composition gut, vaginal microbiotas, affect colonisation immunity. argue detailed understanding variables, which underlie fungal-host-microbiota will present opportunities for directed therapies benefit vulnerable patients.
Язык: Английский
Процитировано
236
Current Opinion in Microbiology, Год журнала: 2019, Номер 52, С. 100 - 109
Опубликована: Июль 6, 2019
Candidalysin is a cytolytic peptide toxin secreted by the invasive form of human pathogenic fungus, Candida albicans. critical for mucosal and systemic infections key driver host cell activation, neutrophil recruitment Type 17 immunity. regarded as first true classical virulence factor C. albicans but also triggers protective immune responses. This review will discuss how candidalysin was discovered, mechanisms which this contributes to infections, its discovery has advanced our understanding fungal pathogenesis disease.
Язык: Английский
Процитировано
181
Nature Communications, Год журнала: 2022, Номер 13(1)
Опубликована: Ноя. 14, 2022
Epidermal growth factor is an excellent drug for promoting wound healing; however, its conventional administration strategies are associated with pharmacodynamic challenges, such as low transdermal permeability, reduction, and receptor desensitization. Here, we develop a microneedle-based self-powered transcutaneous electrical stimulation system (mn-STESS) by integrating sliding free-standing triboelectric nanogenerator microneedle patch to achieve improved epidermal pharmacodynamics. We show that the mn-STESS facilitates penetration utilization using microneedles pierce stratum corneum. More importantly, find it converts mechanical energy of finger into electricity mediates through microneedles. demonstrate applied acts "adjuvant" suppresses reduction glutathione upregulates expression in keratinocyte cells, successfully compensating Collectively, this work highlights promise adjuvants improving pharmacodynamics, creating combinatorial therapeutic traditional drugs.
Язык: Английский
Процитировано
116
Microbiome, Год журнала: 2021, Номер 9(1)
Опубликована: Март 14, 2021
Abstract Bacteria, viruses, protozoa, and fungi establish a complex ecosystem in the gut. Like other microbiota, gut mycobiota plays an indispensable role modulating intestinal physiology. Notably, most striking characteristics of are their extraintestinal functions. Here, we provide comprehensive review importance regulation intestinal, pulmonary, hepatic, renal, pancreatic, brain functions, present possible opportunities for application to alleviate/treat human diseases.
Язык: Английский
Процитировано
111
Microbiology and Molecular Biology Reviews, Год журнала: 2024, Номер 88(2)
Опубликована: Июнь 4, 2024
SUMMARYA significant increase in the incidence of
Язык: Английский
Процитировано
32
Nature Reviews Microbiology, Год журнала: 2024, Номер 22(11), С. 687 - 704
Опубликована: Июнь 25, 2024
Язык: Английский
Процитировано
28
Seminars in Cancer Biology, Год журнала: 2025, Номер 109, С. 67 - 82
Опубликована: Янв. 7, 2025
Язык: Английский
Процитировано
4