Microbial Biotechnology,
Год журнала:
2025,
Номер
18(1)
Опубликована: Янв. 1, 2025
Using
synthetic
biology
techniques,
bacteria
have
been
engineered
to
serve
as
microrobots
for
diagnosing
diseases
and
delivering
treatments.
These
can
be
used
individually
or
in
combination
microbial
consortia.
The
components
within
these
consortia
complement
each
other,
enhancing
diagnostic
accuracy
providing
synergistic
effects
that
improve
treatment
efficacy.
application
of
therapies
cancer,
intestinal
diseases,
metabolic
disorders
underscores
their
significant
potential.
impact
on
the
host's
native
microbiota
is
crucial,
microbes
modulate
interact
with
environment,
influencing
outcomes
overall
health.
Despite
numerous
advancements,
challenges
remain.
include
ensuring
long-term
survival
safety
bacteria,
developing
new
chassis
gene
editing
techniques
non-model
strains,
minimising
potential
toxicity,
understanding
bacterial
interactions
host
microbiota.
This
mini-review
examines
current
state
disease
diagnosis
treatment,
highlighting
challenges,
future
directions
this
promising
field.
ACS Nano,
Год журнала:
2023,
Номер
17(4), С. 3225 - 3258
Опубликована: Фев. 6, 2023
The
immune
checkpoint
blockade
(ICB)
therapy
has
revolutionized
the
field
of
cancer
treatment,
while
low
response
rates
and
systemic
toxicity
limit
its
clinical
outcomes.
With
rapid
advances
in
nanotechnology
materials
science,
various
types
biomaterials
have
been
developed
to
maximize
therapeutic
efficacy
minimizing
side
effects
by
increasing
tumor
antigenicity,
reversing
immunosuppressive
microenvironment,
amplifying
antitumor
response,
reducing
extratumoral
distribution
inhibitors
as
well
enhancing
their
retention
within
target
sites.
In
this
review,
we
reviewed
current
design
strategies
for
different
augment
ICB
effectively
then
discussed
present
representative
biomaterial-assisted
modulation
targeted
delivery
boost
therapy.
Current
challenges
future
development
prospects
expanding
with
were
also
summarized.
We
anticipate
review
will
be
helpful
developing
emerging
promoting
application
Advanced Materials,
Год журнала:
2023,
Номер
unknown
Опубликована: Июль 12, 2023
Abstract
Natural
living
materials
serving
as
biotherapeutics
exhibit
great
potential
for
treating
various
diseases
owing
to
their
immunoactivity,
tissue
targeting,
and
other
biological
activities.
In
this
review,
the
recent
developments
in
engineered
materials,
including
mammalian
cells,
bacteria,
viruses,
fungi,
microalgae,
plants,
active
derivatives
that
are
used
summarized.
Further,
future
perspectives
challenges
of
such
material‐based
discussed
provide
considerations
advances
biomedical
applications.
Nanomaterials,
Год журнала:
2023,
Номер
13(15), С. 2185 - 2185
Опубликована: Июль 27, 2023
Probiotics
have
garnered
significant
attention
in
recent
years
due
to
their
potential
advantages
diverse
biomedical
applications,
such
as
acting
antimicrobial
agents,
aiding
tissue
repair,
and
treating
diseases.
These
live
bacteria
must
exist
appropriate
quantities
precise
locations
exert
beneficial
effects.
However,
viability
activity
can
be
significantly
impacted
by
the
surrounding
tissue,
posing
a
challenge
maintain
stability
target
location
for
an
extended
duration.
To
counter
this,
researchers
formulated
various
strategies
that
enhance
of
probiotics
encapsulating
them
within
biomaterials.
This
approach
enables
site-specific
release,
overcoming
technical
impediments
encountered
during
processing
application
probiotics.
A
range
materials
utilized
probiotics,
several
methods
employed
this
encapsulation
process.
article
reviews
advancements
encapsulated
biomaterials,
examining
materials,
methods,
effects
encapsulation.
It
also
provides
overview
hurdles
faced
currently
available
biomaterial-based
probiotic
capsules
suggests
future
research
directions
field.
Despite
progress
achieved
date,
numerous
challenges
persist,
necessity
developing
efficient,
reproducible
Furthermore,
there
is
need
design
more
robust
targeted
delivery
vehicles.
Nano-Micro Letters,
Год журнала:
2023,
Номер
15(1)
Опубликована: Янв. 11, 2023
We
conceptualize
bioresource
upgrade
for
sustainable
energy,
environment,
and
biomedicine
with
a
focus
on
circular
economy,
sustainability,
carbon
neutrality
using
high
availability
low
utilization
biomass
(HALUB).
acme
energy-efficient
technologies
energy
material
recovery
applications.
The
of
thermochemical
conversion
(TC),
biochemical
(BC),
electrochemical
(EC),
photochemical
(PTC)
are
summarized
HALUB.
Microalgal
could
contribute
to
biofuel
HHV
35.72
MJ
Kg
The
ability
to
physically
manipulate
specific
cells
is
critical
for
the
fields
of
biomedicine,
synthetic
biology,
and
living
materials.
Ultrasound
has
with
high
spatiotemporal
precision
via
acoustic
radiation
force
(ARF).
However,
because
most
have
similar
properties,
this
capability
disconnected
from
cellular
genetic
programs.
Here,
we
show
that
gas
vesicles
(GVs)-a
unique
class
gas-filled
protein
nanostructures-can
serve
as
genetically
encodable
actuators
selective
manipulation.
Because
their
lower
density
higher
compressibility
relative
water,
GVs
experience
strong
ARF
opposite
polarity
other
When
expressed
inside
cells,
invert
cells'
contrast
amplify
magnitude
ARF,
allowing
be
selectively
manipulated
sound
waves
based
on
genotype.
provide
a
direct
link
between
gene
expression
acoustomechanical
actuation,
opening
paradigm
control
in
broad
range
contexts.
Materials Today Bio,
Год журнала:
2023,
Номер
19, С. 100560 - 100560
Опубликована: Янв. 21, 2023
Filamentous
fungi
drive
carbon
and
nutrient
cycling
across
our
global
ecosystems,
through
its
interactions
with
growing
decaying
flora
their
constituent
microbiomes.
The
remarkable
metabolic
diversity,
secretion
ability,
fiber-like
mycelial
structure
that
have
evolved
in
filamentous
been
increasingly
exploited
commercial
operations.
industrial
potential
of
fermentation
ranges
from
the
discovery
bioproduction
enzymes
bioactive
compounds,
decarbonization
food
material
production,
to
environmental
remediation
enhanced
agricultural
production.
Despite
fundamental
impact
ecology
biotechnology,
molds
mushrooms
not,
to-date,
significantly
intersected
synthetic
biology
ways
comparable
other
cell
factories
(e.g.
Escherichia
coli,Saccharomyces
cerevisiae,
Komagataella
phaffii).
In
this
review,
we
summarize
a
suite
computational
tools
for
mining,
engineering
optimization
as
chassis.
A
combination
methods
genetic
engineering,
mutagenesis,
experimental
evolution,
modeling
can
be
used
address
strain
development
bottlenecks
established
emerging
industries.
These
include
slow
mycelium
growth
rate,
low
production
yields,
non-optimal
alternative
feedstocks,
difficulties
downstream
purification.
scope
biomanufacturing,
then
detail
previous
efforts
improving
key
by
targeting
protein
processing
pathways,
hyphae
morphogenesis,
transcriptional
control.
Bringing
practices
into
hidden
world
will
serve
expand
limited
panel
host
organisms
allow
commercially-feasible
environmentally-sustainable
enzymes,
chemicals,
therapeutics,
foods,
materials
future.
Nature Communications,
Год журнала:
2023,
Номер
14(1)
Опубликована: Янв. 19, 2023
Abstract
Living
materials
bring
together
material
science
and
biology
to
allow
the
engineering
augmenting
of
living
systems
with
novel
functionalities.
Bioprinting
promises
accurate
control
over
formation
such
complex
through
programmable
deposition
cells
in
soft
materials,
but
current
approaches
had
limited
success
fine-tuning
cell
microenvironments
while
generating
robust
macroscopic
morphologies.
Here,
we
address
this
challenge
use
core-shell
microgel
ink
decouple
from
structural
shell
for
further
processing.
Cells
are
microfluidically
immobilized
viscous
core
that
can
promote
both
microbial
populations
mammalian
cellular
spheroids,
followed
by
interparticle
annealing
give
covalently
stabilized
functional
scaffolds
controlled
microporosity.
The
results
show
strategy
mitigates
leakage
affording
a
favorable
environment
culture.
Furthermore,
demonstrate
different
consortia
be
printed
into
range
applications.
By
compartmentalizing
separate
microgels,
collective
bioprocessing
capability
scaffold
is
significantly
enhanced,
shedding
light
on
strategies
augment
capabilities.
Science,
Год журнала:
2024,
Номер
384(6699), С. 1023 - 1030
Опубликована: Май 30, 2024
Seamless
interfaces
between
electronic
devices
and
biological
tissues
stand
to
revolutionize
disease
diagnosis
treatment.
However,
biomechanical
disparities
synthetic
materials
living
present
challenges
at
bioelectrical
signal
transduction
interfaces.
We
introduce
the
active
biointegrated
electronics
(ABLE)
platform,
encompassing
capabilities
across
biogenic,
biomechanical,
properties
simultaneously.
The
biointerface,
comprising
a
bioelectronics
layout
