The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(22), С. 16809 - 16827
Опубликована: Ноя. 1, 2024
A
photocatalytic
three-component
cascade
reaction
of
readily
available
enaminones,
hydrazines,
and
CBr4
for
the
synthesis
bromo-substituted
pyrazoles
in
one
pot
has
been
demonstrated.
This
strategy
involves
intermolecular
C-N/C-Br
bond
formation
represents
an
efficient
approach
to
construction
4-bromo-substituted
with
high
regioselectivity,
broad
substrate
scope,
good
functional
group
tolerance,
convenient
operation,
mild
conditions.
Mechanistic
investigations
show
that
this
proceeds
via
cyclization
enaminones
followed
by
a
regioselective
bromination
using
as
"Br"
source.
Chemical Communications,
Год журнала:
2023,
Номер
60(4), С. 432 - 435
Опубликована: Дек. 5, 2023
Highly
functionalized
benzodiazepine
skeletons
were
efficiently
synthesized
via
a
Rh(
iii
)-catalyzed
selective
mono-
and
dual-C–H
bond
functionalization/cyclization
reaction
between
readily
available
1-aryl-5-aminopyrazoles
iodonium
ylides
under.
By
means
of
simple
Rh
catalysis,
the
direct
activation
ortho-C-H
bond
in
aryl
enaminones
has
been
realized
with
enaminone
structure
as
a
traceless
directing
fragment.
The
products
resulting
from
C-H
alkenylation
and
further
annulation
via
intramolecular
addition
could
be
accessed
depending
upon
alkenes.
annulated
used
for
easy
synthesis
valuable
2-aza-fluorenones
one-pot
operation
by
employing
NH4OAc.
The Journal of Organic Chemistry,
Год журнала:
2023,
Номер
88(16), С. 11627 - 11636
Опубликована: Авг. 9, 2023
Syntheses
of
highly
functionalized
4-alkylated
1,4-dihydropyridines
(1,4-DHPs)
from
cyclic
ethers
and
enaminones
via
iron(II)-mediated
oxidative
free
radical
cascade
C(sp3)-H
bond
functionalization/C(sp3)-O
cleavage/cyclization
reaction
have
been
first
developed.
This
novel
synthetic
strategy
offers
an
alternative
method
for
the
construction
1,4-DHPs
by
using
esters
as
C4
sources,
well
expands
application
in
heterocycle
synthesis.
Green Synthesis and Catalysis,
Год журнала:
2023,
Номер
unknown
Опубликована: Окт. 1, 2023
The
synthesis
of
4-halo-functionalized
pyrazoles
by
electrochemical
cascade
reactions
between
N,N-dimethyl
enaminones
and
proper
hydrazine
reagents
in
the
presence
a
halogen
source
is
realized
at
room
temperature.
work
provides
tunable
efficient
accesses
to
4-chloro-
4-bromopyrazoles
aqueous
THF
(tetrahydrofuran)
without
using
any
transition
metal
reagent.
Synthetic Communications,
Год журнала:
2024,
Номер
54(6), С. 491 - 503
Опубликована: Фев. 10, 2024
By
using
easily
accessible
heterocyclic
enamines,
acetaldehyde
(or
formaldehyde)
and
primary
amines
as
suitable
precursors,
a
water-assisted
three-component
synthesis
of
new
3-oxothiazolo[3,2-c]pyridimines
has
been
efficiently
achieved
in
mild
semi-aqueous
medium.
All
the
cyclization
reactions
under
optimized
catalyst-free
conditions
furnish
target
compounds
40–100%
yields.
Although
cyclizations
with
arylamines
presence
formaldehyde
yield
moderate
to
good
yields,
certain
involving
aryl
do
not
result
any
product
formation.
Structural
characterization
all
products
were
performed
by
means
FT-IR,1H
13C
NMR
HRMS
analyses.
Besides,
some
demonstrated
bacteriostatic
effects
antibacterial
study
conducted
against
S.
aureus
epidermidis
bacteria.
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
β-Enaminone
transformation
strategies
are
widely
employed
in
the
synthesis
of
numerous
biologically
active
drugs
and
natural
products,
highlighting
their
significance
medicinal
chemistry.
Applied Organometallic Chemistry,
Год журнала:
2024,
Номер
38(9)
Опубликована: Июль 5, 2024
A
novel
Rh‐catalyzed
three‐component
synthesis
of
N
‐(
o
‐alkylaryl)
pyrazoles
via
cascade
pyrazole
annulation
and
aryl
C‐H
conjugate
addition
to
alkenes
has
been
developed
with
enaminones,
hydrazines,
functionalized
as
starting
materials.
The
raw
materials
used
in
this
reaction
are
simple,
cheap,
readily
available,
the
reactions
feature
excellent
step
economy
by
furnishing
products
formation
a
ring
key
activation
one‐step
operation.
Moreover,
proceeds
smoothly
under
air
atmosphere,
making
it
easy
operate.
