Child Maltreatment Characteristics and Adult Physical Multimorbidity in Germany DOI Creative Commons
Daniëlle Otten, Inga Schalinski, Jörg M. Fegert

и другие.

JAMA Network Open, Год журнала: 2025, Номер 8(1), С. e2456050 - e2456050

Опубликована: Янв. 23, 2025

Importance Associations between child maltreatment (CM) and health have been studied broadly, but most studies focus on multiplicity (number of experienced subtypes CM). Studies assessing multiple CM characteristics are scarce, partly due to methodological challenges, were mostly conducted in patient samples. Objective To determine the importance association with physical multimorbidity adulthood for women men a German representative sample. Design, Setting, Participants This survey study used data from sample population July October 2021. Households randomly selected within regional areas by demographic consultation company, Kish-Grid method was applied ensure random participation. Reasons nonparticipation refusal household or target person participate failure contact after 4 visits. Analyses took place June 2023 2024. Exposure Characteristics CM, including multiplicity, age at time (timing), number years (duration), frequency, subjective severity (measured ISPCAN Child Abuse Screening Tools Retrospective version questionnaire). Main Outcomes Measures The main outcome multimorbidity, defined as sum score lifetime leading morbidity mortality causes Western countries (obesity, diabetes, cancer, hypertension, myocardial infarction, chronic obstructive pulmonary disease, incident stroke). Conditioned forest regression analyses (a machine learning technique) examine what importantly associated while considering all other variables model. Results Of 5908 individuals invited, included 2514 participants (response rate, 42.6%), 1297 (51.6%) (mean [SD] age, 50.6 [17.9] years) 1217 (48.4%) 49.5 [18.2] years). Duration important factor both (importance = 0.595; 95% CI, 0.599-0.601) 1.389; 1.386-1.394). timing more outcomes than men. For women, experiencing significantly adulthood. men, 11 Conclusions Relevance In this study, conditioned provide insights duration addition frequently multiplicity. These findings suggest that assessments should be considered diagnostics conditions may also inform strategies mitigate risk.

Язык: Английский

Gene–environment correlations and causal effects of childhood maltreatment on physical and mental health: a genetically informed approach DOI Creative Commons
Varun Warrier, Alex S. F. Kwong, Mannan Luo

и другие.

The Lancet Psychiatry, Год журнала: 2021, Номер 8(5), С. 373 - 386

Опубликована: Март 18, 2021

BackgroundChildhood maltreatment is associated with poor mental and physical health. However, the mechanisms of gene–environment correlations potential causal effects childhood on health are unknown. Using genetics, we aimed to delineate sources correlation for relationship between health.MethodsWe did a genome-wide association study meta-analysis using data from UK Biobank (n=143 473), Psychiatric Genomics Consortium (n=26 290), Avon Longitudinal Study Parents Children (n=8346), Adolescent Brain Cognitive Development (n=5400), Generation R (n=1905). We included individuals who had phenotypic genetic available. investigated single nucleotide polymorphism heritability among different subtypes, operationalisations, reports maltreatment. Family-based population-based polygenic score analyses were done elucidate mechanisms. used Mendelian randomisation identify shared genetics test relationships conditions.FindingsOur studies (N=185 414) identified 14 independent loci (13 novel). high overlap (genetic 0·24–1·00) reporting methods. Within-family provided some support active reactive but not show absence passive correlation. Robust suggested role in depression (unidirectional), as well both schizophrenia ADHD (bidirectional), conditions (coronary artery disease, type 2 diabetes) or inflammation (C-reactive protein concentration).InterpretationChildhood has heritable component, substantial retrospective prospective point correlation, equivocal supports (primarily bidirectional) health, conditions. Our identifies research avenues inform prevention its long-term effects.FundingWellcome Trust, Medical Research Council, Horizon 2020, National Institute Mental Health, Health Biomedical Centre.

Язык: Английский

Процитировано

159
The Prevalence and Consequences of Adverse Childhood Experiences in the German Population DOI
Andreas Witt, Cedric Sachser, Paul L. Plener

и другие.

Deutsches Ärzteblatt international, Год журнала: 2019, Номер unknown

Опубликована: Сен. 13, 2019

dverse childhood experiences (ACEs) include various that can have a persistent negative effect on health and wellbeing (1).The ACE Study investigated the correlation between adverse impacts those affected.The concept of includes household dysfunction in addition to child maltreatment; this is because, unless problems are included, long-term attributed only individual types abuse, cumulative multiple not examined (1).A number studies association combinations

Язык: Английский

Процитировано

105
Impact of COVID-19 on Child Maltreatment: Income Instability and Parenting Issues DOI Open Access
Janet Yuen Ha Wong, Abraham Ka Chung Wai, Man Ping Wang

и другие.

International Journal of Environmental Research and Public Health, Год журнала: 2021, Номер 18(4), С. 1501 - 1501

Опубликована: Фев. 5, 2021

: Children are widely recognized as a vulnerable population during disasters and emergencies. The COVID-19 pandemic, like natural disaster, brought uncertainties instability to the economic development of society social distancing, which might lead child maltreatment. This study aims investigate whether job loss, income reduction parenting affect

Язык: Английский

Процитировано

63
Childhood Maltreatment and Somatic Symptoms in Adulthood: Establishing a New Research Pathway DOI Creative Commons
Antonia M. Lüönd, Görkem Ayas, Rahel Bachem

и другие.

Neuropsychobiology, Год журнала: 2025, Номер unknown, С. 1 - 15

Опубликована: Янв. 14, 2025

Background: Somatic symptoms, such as chronic pain, fatigue, and gastrointestinal disturbances, are commonly reported in individuals with a history of childhood maltreatment (CM), which includes various forms abuse neglect experienced before age 18. Although CM is strongly associated somatic the specific relationships between subtypes these well mechanisms connecting them, remain insufficiently understood. This review examines complex interaction often coexist mental disorders significantly impact quality life healthcare systems. Summary: frequently mix "explained" "unexplained" conditions, personal distress pose diagnostic challenges. has been linked to symptoms through neurobiological mechanisms, HPA axis dysregulation allostatic load, while theoretical models emphasize roles hyperawareness, cultural factors, vulnerability symptom development. However, existing research fails account for subtypes, full range situational leading inconsistencies findings. Key Messages: Bridging gaps literature requires adopting World Health Organization’s subtype definitions ICD-11 codes (MA00-MH2Y) encompass broader spectrum symptoms. Employing rigorous methodologies, systematic reviews meta-analyses, essential advancing understanding. These approaches can enhance accuracy, support tailored interventions, promote biopsychosocial framework research, ultimately improving patient outcomes alleviating societal burdens.

Язык: Английский

Процитировано

1
A decennial review of psychotraumatology: what did we learn and where are we going? DOI Creative Commons
Miranda Olff, Ananda B. Amstadter, Chérie Armour

и другие.

European journal of psychotraumatology, Год журнала: 2019, Номер 10(1)

Опубликована: Ноя. 20, 2019

On 6 December 2019 we start the 10th year of European Journal Psychotraumatogy (EJPT), a full Open Access journal on psychotrauma. This editorial is part special issue celebrating 10 years anniversary and acknowledging some our most impactful articles past decade. In this editors present decennial review field addressing range topics that are core to both psychotraumatology as discipline. These include neurobiological developments (genomics, neuroimaging neuroendocrine research), forms trauma exposure impact across lifespan, mass early interventions, work-related trauma, in refugee populations, potential consequences such PTSD or Complex PTSD, but also resilience. We address innovations psychological, medication (enhanced) technology-assisted treatments, mediators moderators like social support finally how new research methods help us gain insights symptom structures better predict development treatment success. aimed answer three questions 1. Where did stand 2010? 2. What learn years? 3. knowledge gaps? conclude with number recommendations concerning top priorities for future direction correspondingly journal.

Язык: Английский

Процитировано

67
Inflammation and early life stress: An updated review of childhood trauma and inflammatory markers in adulthood DOI

Mollie Brown,

Courtney Worrell, Carmine M. Pariante

и другие.

Pharmacology Biochemistry and Behavior, Год журнала: 2021, Номер 211, С. 173291 - 173291

Опубликована: Окт. 22, 2021

Язык: Английский

Процитировано

54
Child maltreatment and hypothalamic-pituitary-adrenal axis functioning: A systematic review and meta-analysis DOI Creative Commons
Selina Schär, Ines Mürner‐Lavanchy, Stefanie J. Schmidt

и другие.

Frontiers in Neuroendocrinology, Год журнала: 2022, Номер 66, С. 100987 - 100987

Опубликована: Фев. 21, 2022

Alterations in hypothalamic-pituitary-adrenal (HPA) axis and its effector hormone cortisol have been proposed as one possible mechanism linking child maltreatment experiences to health disparities. In this series of meta-analyses, we aimed quantify the existing evidence on effect various measures HPA activity. The systematic literature search yielded 1,858 records, which 87 studies (k = 132) were included. Using random-effects models, found for blunted stress reactivity individuals exposed maltreatment. contrast, no overall differences any other activity (including daily activity, assessed context pharmacological challenges cumulative secretion). impact several moderators (e.g., sex, psychopathology, study quality), role methodological shortcomings studies, well potential directions future research are discussed.

Язык: Английский

Процитировано

35
Childhood maltreatment and DNA methylation: A systematic review DOI
Mackenzie Rubens, Dagmar Bruenig, Jessica Ann May Adams

и другие.

Neuroscience & Biobehavioral Reviews, Год журнала: 2023, Номер 147, С. 105079 - 105079

Опубликована: Фев. 9, 2023

Язык: Английский

Процитировано

19
Parental stress and physical violence against children during the second year of the COVID-19 pandemic: results of a population-based survey in Germany DOI Creative Commons

Alina Geprägs,

David Bürgin, Jörg M. Fegert

и другие.

Child and Adolescent Psychiatry and Mental Health, Год журнала: 2023, Номер 17(1)

Опубликована: Фев. 20, 2023

Abstract Background Parents and caregivers belonged to those with the highest burdens during COVID-pandemic. Considering close link between parental stress child maltreatment, identifying families high is of utmost importance prevent violence against children. Within this study, we thus aimed investigate interplay stress, changes in physical children second year COVID-pandemic on an exploratory level. Methods We conducted a cross-sectional, observational study Germany from July October 2021. By using different sampling steps, representative probability sample German population was generated. A subsample these participants under age 18 included for analysis within (N = 453, 60.3% females, M 40.08; SD 8.53). Results Higher levels were associated more children, higher own experiences mental health symptoms. An increase pandemic female sex, use experience maltreatment. who have ever used their been characterized by levels, stronger pandemic, symptoms sociodemographic characteristics. having pre-existing psychiatric disorders, maltreatment predicted increased pandemic. Conclusions Our results underscore risk so times overall due underline need low threshold support at crises.

Язык: Английский

Процитировано

19
Childhood Trauma and Adult Somatic Symptoms DOI Creative Commons

Hanna Eilers,

Marije aan het Rot, Bertus F. Jeronimus

и другие.

Psychosomatic Medicine, Год журнала: 2023, Номер 85(5), С. 408 - 416

Опубликована: Апрель 25, 2023

ABSTRACT Objective Childhood trauma is a key public health risk factor for developing physical illness. This study examined how childhood abuse and neglect predict adult somatic symptoms assessed retrospectively in real time. Methods Participants the HowNutsAreTheDutch project completed Trauma Questionnaire—Short Form and, to assess symptoms, cross-sectional Patient Health Questionnaire ( n = 406) or longitudinal ecological momentary assessment protocol that included responding an item on discomfort 3 times day 30 days 290). Results As hypothesized, was positively associated with using d 0.30) 0.31), also after adjustment age, sex, educational level, relationship status. Longitudinally, we explored whether interpersonal context moderated outcomes, observed social company dampened among people history of more 0.04). Conclusions trauma, especially emotional sexual abuse, predicts specific symptoms. Future work may examine symptom expression influenced by lives traumatized individuals.

Язык: Английский

Процитировано

17