Journal of Affective Disorders, Год журнала: 2023, Номер 327, С. 425 - 438
Опубликована: Фев. 3, 2023
Язык: Английский
Applied Microbiology and Biotechnology, Год журнала: 2021, Номер 105(14-15), С. 5785 - 5794
Опубликована: Июль 27, 2021
Язык: Английский
Процитировано
130
Nutrients, Год журнала: 2022, Номер 14(3), С. 453 - 453
Опубликована: Янв. 20, 2022
The effect of diet on the composition gut microbiota and consequent impact disease risk have been expanding interest. present review focuses current insights changes associated with dietary protein-induced microbial populations examines their potential roles in metabolism, health, animals. Preferred Reporting Items for Systematic Reviews Meta-Analysis (PRISMA) protocol was used, 29 highly relevant articles were obtained, which included 6 mouse studies, 7 pig 15 rat 1 vitro study. Analysis these studies indicated that several factors, such as protein source, content, (such carbohydrate content), glycation protein, processing oxidation, affect digestibility bioavailability proteins. These factors can influence fermentation, absorption, functional properties and, consequently, human health. While release metabolites host physiology either positively or negatively, selection quality suitable food conditions are important to a positive
Язык: Английский
Процитировано
123
Microbiology Spectrum, Год журнала: 2021, Номер 9(2)
Опубликована: Сен. 22, 2021
Akkermansia muciniphila, as a member of the gut microbiota, has been proposed next-generation probiotic. Liver fibrosis is main determinant liver dysfunction and mortality in patients with chronic disease. In this study, we aimed to determine beneficial effects live pasteurized A. muciniphila its extracellular vesicles (EVs) on prevention fibrosis. The response hepatic stellate cells (HSCs) EVs was examined quiescent, lipopolysaccharide (LPS)-activated LX-2 cells. induced 8-week-old C57BL/6 mice, using high-fat diet (HFD) carbon tetrachloride (CCl4) administration for 4 weeks. mice were concomitantly treated via oral gavage three forms bacteria. relative expression different inflammatory markers assessed tissues. Histological markers, serum biochemical parameters, cytokine production also analyzed, their correlations abundance targeted fecal bacteria examined. All preparations exhibited protective against HSC activation; however, showed greatest activity regression. Oral ameliorated cytokines improved colon histopathological damages. biomarkers substantially attenuated tissues all mice. composition stool group clearly from that group. This study indicated derivatives could successfully protect HFD/CCl4-induced injury. However, further studies are needed prove liver. IMPORTANCE results present normalize composition, improve intestinal permeability, modulate responses, subsequently prevent injury HFD/CCl4-administered Following improvement histopathology, kidney damage adipose tissue inflammation by treatments.
Язык: Английский
Процитировано
112
CNS Neuroscience & Therapeutics, Год журнала: 2022, Номер 29(1), С. 140 - 157
Опубликована: Окт. 25, 2022
Abstract Introduction Recent advances have highlighted the relationships between gut dysbiosis and Parkinson's disease (PD). Microbiota transplantation from PD patients to mice can induce increased alpha‐synuclein‐mediated motor deficits. Human studies identified differences in microbiota of compared healthy controls. We undertook a systematic review evaluate available evidence for involvement bacteria etiology PD. Methods The PubMed databank, China National Knowledge Infrastructure Wanfang Data were searched inception until June 2021 identify human case–control that investigated quantified feces. evaluated resulting focusing on bacterial taxa different Results Twenty‐six found which 53 microbial families 98 genera exhibited with by more than two as Bifidobacterium , Alistipes Christensenella Enterococcus Oscillospira Bilophila Desulfovibrio Escherichia/Shigella Akkermansia while Prevotella Blautia Faecalibacterium Fusicatenibacter Haemophilus had three or reports being lower patients. More one report demonstrated Bacteroides Odoribacter Parabacteroides Butyricicoccus Butyrivibrio Clostridium Coprococcus Lachnospira Lactobacillus Megasphaera Phascolarctobacterium Roseburia Ruminococcus Streptococcus Klebsiella altered both directions. Conclusion Our shows microbiome may involve alterations short‐chain fatty acids (SCFAs)‐producing an increase putative pathobionts. SCFAs‐producing vary above below “optimal range,” causing imbalances. Considering are beneficial health, be associated medications, especially COMT inhibitors, high level aging.
Язык: Английский
Процитировано
106
International Journal of Nanomedicine, Год журнала: 2021, Номер Volume 16, С. 2949 - 2963
Опубликована: Апрель 1, 2021
Purpose: Prostate cancer (PCa) is one of the most common malignancies in males. Despite success immunotherapy many malignant cancers, strategies are still needed to improve therapeutic efficacy PCa. This study aimed investigate effects Akkermansia muciniphila -derived extracellular vesicles ( Akk -EVs) on PCa and elucidate underlying immune-related mechanism. Methods: -EVs were isolated by ultracentrifugation intravenously injected treat syngeneic PCa-bearing immune-competent mice. Immunophenotypic changes immune cells, such as cytotoxic T lymphocytes macrophages, measured via flow cytometry analysis. Histological examination was used detect morphological major organs after treatments. In vitro, performed confirm activation CD8 + cells. Quantitative PCR immunofluorescence staining carried out test impact macrophage polarization. Cell counting kit-8 (CCK-8) analysis, colony formation assays, scratch wound healing assays conducted assess -EVs-treated macrophages proliferation invasion CCK-8 also confirmed viability normal Results: Intravenous injection mice reduced tumor burden without inducing obvious toxicity tissues. treatment elevated proportion granzyme B-positive (GZMB ) interferon γ-positive (IFN-γ cells caused recruitment, with increased tumor-killing M1 decreased immunosuppressive M2 macrophages. number GZMB IFN-γ M1-like addition, conditioned medium from suppressed prostate Furthermore, effective dose well-tolerated Conclusion: Our revealed promising prospects an efficient biocompatible immunotherapeutic agent for treatment. Keywords: , vesicles, immunotherapy, cancer, lymphocytes,
Язык: Английский
Процитировано
104
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(4), С. 3900 - 3900
Опубликована: Фев. 15, 2023
Appreciation of the importance Akkermansia muciniphila is growing, and it becoming increasingly relevant to identify preventive and/or therapeutic solutions targeting gut–liver–brain axes for multiple diseases via muciniphila. In recent years, its components such as outer membrane proteins extracellular vesicles have been known ameliorate host metabolic health intestinal homeostasis. However, impacts on disease are complex, both potentially beneficial adverse effects mediated by derivatives, in some cases, these dependent upon physiology microenvironment forms, genotypes, strain sources Therefore, this review aims summarize current knowledge how interacts with influences homeostasis progression. Details will be discussed including biological genetic characteristics; functions anti-obesity, anti-diabetes, anti-metabolic-syndrome, anti-inflammation, anti-aging, anti-neurodegenerative disease, anti-cancer therapy functions; strategies elevate abundance. Key events referred specific states, should facilitate identification muciniphila-based probiotic axes.
Язык: Английский
Процитировано
84
Gut Microbes, Год журнала: 2022, Номер 14(1)
Опубликована: Фев. 15, 2022
Gut microbiota and its association with cancer development/treatment has been intensively studied during the past several years. Currently, there is a growing interest toward next-generation probiotics (NGPs) as therapeutic agents that alter gut impact on development. In present review we focus three emerging NGPs, namely Faecalibacterium prausnitzii, Akkermansia muciniphila, Bacteroides fragilis their presence in digestive tract can have an incidence. These NGPs enhance gastrointestinal immunity, maintain intestinal barrier integrity, produce beneficial metabolites, act against pathogens, improve immunotherapy efficacy, reduce complications associated chemotherapy radiotherapy. Notably, use of patients does not long history and, although safety remains relatively undefined, recently published data shown they are non-toxigenic. Notwithstanding, A. muciniphila may promote colitis whereas enterotoxigenic B. stimulates chronic inflammation participates colorectal carcinogenesis. Nevertheless, majority strains provide effect to host, non-toxigenic considered best current NGP candidate. Overall, studies indicate role these prevention carcinogenesis open new promising options for patients.
Язык: Английский
Процитировано
80
Journal of the Neurological Sciences, Год журнала: 2022, Номер 434, С. 120166 - 120166
Опубликована: Янв. 26, 2022
Alzheimer's disease (AD) and Parkinson's (PD) are the two most prevalent neurodegenerative diseases, both without prevention or cure. The Mediterranean diet (MeDi) may be neuroprotective by modulating gut microbiota. We aimed to assess effects of adherence MeDi on microbiota in relation AD PD risk. A search from inception November 2020 was conducted PubMed, CINAHL, EMBASE, Web Science, Global Health, Biological Abstracts, Grey Literature Report databases. Two searches were conducted: 1) (MeDi Microbiota) (PD AD) 2) Inclusion criteria for papers specified prior review. Of 4672 studies identified, 64 eligible inclusion. These divided into five groups: risk (n = 4), 2), microbial composition metabolomics 21), 7), 30). Adherence associated with a lower development. Eight genera species bacteria had an inverse relationship AD, one family, eight three PD. More needed investigate if MeDi, microbiota, neurodegeneration causally related.
Язык: Английский
Процитировано
78
Microorganisms, Год журнала: 2022, Номер 10(12), С. 2382 - 2382
Опубликована: Ноя. 30, 2022
Probiotics and synbiotics are used to treat chronic illnesses due their roles in immune system modulation anti-inflammatory response. They have been shown reduce inflammation a number of immune-related disorders, including systemic lupus erythematosus (SLE), human immunodeficiency virus (HIV), inflammatory skin conditions such as psoriasis atopic dermatitis (AD). Akkermansia muciniphila (A. muciniphila) Faecalibacterium prausnitzii (F. prausnitzii) two different types bacteria that play significant part this function. It has established abundant normal populations protective benefits on digestive health while also enhancing the system, metabolism, gut barrier host. potential be therapeutic target diseases connected microbiota, immunological disorders cancer immunotherapy. There not review effects Faecalibacterium, particularly diseases. In review, we highlight most recent scientific findings regarding A. F. microbiota for microbiome alterations seek provide cutting-edge insight terms microbiome-targeted therapies promising preventive tools
Язык: Английский
Процитировано
76
Microbiome, Год журнала: 2022, Номер 10(1)
Опубликована: Авг. 25, 2022
Abstract Background Succinate is produced by both human cells and gut bacteria couples metabolism to inflammation as an extracellular signaling transducer. Circulating succinate elevated in patients with obesity type 2 diabetes linked numerous complications, yet no studies have specifically addressed the contribution of microbiota systemic or explored consequences reducing intestinal levels this setting. Results Using germ-free microbiota-depleted mouse models, we show that a significant source circulating succinate, which obesity. We also vivo therapeutic treatments selected diminish obese mice. Specifically, demonstrate Odoribacter laneus promising probiotic based on its ability deplete improve glucose tolerance inflammatory profile two independent models ( db/db mice diet-induced mice). Mechanistically, partly mediated receptor 1. Supporting these preclinical findings, inverse correlation between plasma fecal cohort severe associated several components metabolic syndrome including waist circumference, triglycerides, uric acid, among others, primary determinant insulin sensitivity evaluated euglycemic-hyperinsulinemic clamp. Conclusions Overall, our work uncovers O. next-generation obesity-related inflammation.
Язык: Английский
Процитировано
75