Reevaluating the Concept of Aging: Long-Term Stress Adaptation as a Key Factor in Yeast Aging DOI Open Access
Yanzhuo Kong, Damola O. Adejoro, Christopher Winefield

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Ноя. 5, 2023

Abstract It has been demonstrated that short-term stress can enhance cellular responses and promote longevity, whereas long-term shortens lifespan. Understanding the relationship between could offer new insights into comprehending modulating age-related diseases. In this study, we investigate using transcriptomic metabolomic analyses in yeast model system ( Saccharomyces cerevisiae ). We employed three metabolic treatments: firstly, treating cells with threshold levels of benzoic acid for 24 hours (Short-term [ST] Stressed Cells); secondly, 500 hours, sub-culturing every (Long-term [LT] thirdly, allowing stressed to grow 16 without any (Recovered Cells). Here, propose aging is an evolutionarily conserved adaptation mechanism response exposure. Under conditions, prominent lifespan-extending metabolites such as trehalose linked tumor suppression humans, 5’-methylthioadenosine, were overexpressed. contrast, LT Cells activated genes those responsible epigenetic regulatory enzymes govern process, secondary genes, heat shock proteins (HSPs) which are associated cell damage but also often aged cells. Chronological lifespan experiments showed lived a shorter compared ST Cells. This suggests markers (eg. HSPs, certain regulators) expressed enable survival have effect reducing support hypothesis, show exclusively solely eukaryotes, while significantly (aging related) exhibit high conservation across all domains life, majority having originated from bacteria hinting at potential evolutionary benefit aging.

Язык: Английский

Glycine and aging: Evidence and mechanisms DOI Creative Commons
Adiv A. Johnson, Trinna Cuellar

Ageing Research Reviews, Год журнала: 2023, Номер 87, С. 101922 - 101922

Опубликована: Март 31, 2023

The restriction of calories, branched-chain amino acids, and methionine have all been shown to extend lifespan in model organisms. Recently, glycine was found boost longevity genetically heterogenous mice. This simple acid similarly extends rats improves health mammalian models age-related disease. While compelling data indicate that is a pro-longevity molecule, divergent mechanisms may underlie its effects on aging. Glycine abundant collagen, building block for glutathione, precursor creatine, an acceptor the enzyme N-methyltransferase (GNMT). A review literature strongly implicates GNMT, which clears from body by taking methyl group S-adenosyl-L-methionine methylating form sarcosine. In flies, Gnmt required reduced insulin/insulin-like growth factor 1 signaling dietary fully lifespan. geroprotector spermidine requires upregulate autophagy genes longevity. Moreover, overexpression sufficient reduce levels. Sarcosine, or methylglycine, declines with age multiple species capable inducing both vitro vivo. Taken together, existing evidence suggests prolongs life mimicking activating autophagy.

Язык: Английский

Процитировано

23
Methionine restriction diets: Unravelling biological mechanisms and enhancing brain health DOI
Yi Liu,

Jingjing Guo,

Hao Cheng

и другие.

Trends in Food Science & Technology, Год журнала: 2024, Номер 149, С. 104532 - 104532

Опубликована: Май 14, 2024

Язык: Английский

Процитировано

5
S‐adenosyl‐L‐homocysteine extends lifespan through methionine restriction effects DOI
Takafumi Ogawa,

Koji Masumura,

Yuki Kohara

и другие.

Aging Cell, Год журнала: 2022, Номер 21(5)

Опубликована: Апрель 7, 2022

Abstract Methionine restriction (MetR) can extend lifespan and delay the onset of aging‐associated pathologies in most model organisms. Previously, we showed that supplementation with metabolite S ‐adenosyl‐L‐homocysteine (SAH) extends activates energy sensor AMP‐activated protein kinase (AMPK) budding yeast Saccharomyces cerevisiae . However, mechanism involved whether SAH metazoan have remained unknown. Here, show reduces Met levels recapitulates many physiological molecular effects MetR. In yeast, leads to inhibition target rapamycin complex 1 (TORC1) activation autophagy. Furthermore, Caenorhabditis elegans treatment by activating AMPK providing benefits Therefore, propose be used as an intervention lower intracellular confer

Язык: Английский

Процитировано

20
Glibenclamide targets MDH2 to relieve aging phenotypes through metabolism-regulated epigenetic modification DOI Creative Commons
Zhifan Mao, Wénwén Liú, R. Zou

и другие.

Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)

Опубликована: Фев. 17, 2025

Язык: Английский

Процитировано

0
Systemic aging and aging‐related diseases DOI Open Access
Qiao Li,

Nanyin Xiao,

Heng Zhang

и другие.

The FASEB Journal, Год журнала: 2025, Номер 39(5)

Опубликована: Март 1, 2025

Abstract Aging is a biological process along with systemic and multiple organ dysfunction. It more recognized that aging disease instead of single‐organ functional disorder. Systemic plays profound role in diseases including neurodegenerative diseases, cardiovascular malignant diseases. Aged organs communicate other accelerate aging. Skeletal muscle, heart, bone marrow, skin, liver each through organ–organ crosstalk. The crosstalk can be mediated by metabolites lipids, glucose, short‐chain fatty acids (SCFA), inflammatory cytokines, exosomes. Metabolic disorders hyperglycemia, hyperinsulinemia, hypercholesterolemia caused chronic hallmarks leads to the destruction hemostasis, causes release senescence‐associated secretory phenotype (SASP), imbalance microbiota composition. Released factors further aggregate senescence, which promotes solid organs. Targeting senescence or delaying emerging as critical health strategy for solving age‐related especially old population. In current review, we will delineate mechanisms provide therapeutic targets

Язык: Английский

Процитировано

0
Modulation of DNA methylation by one-carbon metabolism: a milestone for healthy aging DOI Open Access
Sang‐Woon Choi, Simonetta Friso

Nutrition Research and Practice, Год журнала: 2023, Номер 17(4), С. 597 - 597

Опубликована: Янв. 1, 2023

Healthy aging can be defined as an extended lifespan and health span. Nutrition has been regarded important factor in healthy aging, because nutrients, bioactive food components, diets have demonstrated beneficial effects on hallmarks such oxidative stress, mitochondrial function, apoptosis autophagy, genomic stability, immune function. also plays a role epigenetic regulation of gene expression, DNA methylation is the most extensively investigated phenomenon aging. Interestingly, age-associated modulated by one-carbon metabolism or inhibition methyltransferases. One-carbon ultimately controls balance between universal methyl donor S-adenosylmethionine methyltransferase inhibitor S-adenosylhomocysteine. Water-soluble B-vitamins folate, vitamin B6, B12 serve coenzymes for multiple steps metabolism, whereas methionine, choline, betaine, serine act donors. Thus, these nutrients modify subsequently alter physiologic pathologic processes. We cannot elude per se but we may at least change methylation, which could mitigate diseases disorders.

Язык: Английский

Процитировано

9
Dietary restriction and ageing: Recent evolutionary perspectives DOI
Mark T. Mc Auley

Mechanisms of Ageing and Development, Год журнала: 2022, Номер 208, С. 111741 - 111741

Опубликована: Сен. 24, 2022

Язык: Английский

Процитировано

11
Transcriptome and metabolome analysis reveals stage-specific metabolite accumulation during maturity of Chinese black truffle Tuber indicum DOI
Yang Li,

Yong-Mei Xing,

Claude Murat

и другие.

Plant Physiology and Biochemistry, Год журнала: 2023, Номер 205, С. 108158 - 108158

Опубликована: Ноя. 2, 2023

Язык: Английский

Процитировано

5
A novel mechanism of major ginsenosides from Panax ginseng against multiple organ aging in middle-aged mice: phosphatidylcholine-myo-inositol metabolism based on metabolomic analysis DOI Creative Commons

E Mingyao,

Zepeng Zhang, Peng Ji

и другие.

Biochemical and Biophysical Research Communications, Год журнала: 2024, Номер 719, С. 150027 - 150027

Опубликована: Май 9, 2024

Aging is a complex, degenerative process associated with various metabolic abnormalities. Ginsenosides (GS) the main active components of Panax ginseng, which has anti-aging effects and improves metabolism. However, effect mechanism GS in middle-aged mice not been elucidated. In this study, after 3-month treatment significantly improved grip strength, fatigue resistance, cognitive indices, cardiac function 15-month-old mice. Meanwhile, reduced fat content obviously inhibited histone H2AX phosphorylation at Ser 139 (γ-H2AX), marker DNA damage major organs, especially heart liver. Further, correlation analysis serum metabolomics combined aging phenotype suggested that myo-inositol (MI) upregulated by was positively correlated left ventricular ejection fraction (LVEF) fractional shortening (LVFS), indicators function. More importantly, liver tissue metabolomic showed increased MI promoting synthesis pathway from phosphatidylcholine (PC) to for inhibition aging. Finally, we proved percentage senescence-associated β-galactosidase staining, γ-H2AX immunofluorescence p21 expression, production reactive oxygen species H

Язык: Английский

Процитировано

1
A set of common buccal CpGs that predict epigenetic age and associate with lifespan-regulating genes DOI Creative Commons
Adiv A. Johnson, Nicole S. Torosin, Maxim N. Shokhirev

и другие.

iScience, Год журнала: 2022, Номер 25(11), С. 105304 - 105304

Опубликована: Окт. 7, 2022

Epigenetic aging clocks are computational models that use DNA methylation sites to predict age. Since cheek swabs non-invasive and painless, collecting from buccal tissue is highly desirable. Here, we review 11 existing have been applied tissue. Two of these were exclusively trained on adults and, while moderately accurate, not used capture health-relevant differences in epigenetic Using 130 common CpGs utilized by two or more clocks, generate a proof-of-concept predictor an adult methylomic dataset. In addition accurately estimating age (r = 0.95 mean absolute error 3.88 years), this clock predicted Down syndrome subjects significantly older relative controls. A literature database CpG-associated genes identified numerous (e.g., CLOCK, ELOVL2, VGF) molecules alpha-linolenic acid, glycine, spermidine) reported influence lifespan and/or age-related disease model organisms.

Язык: Английский

Процитировано

6