International Journal of Molecular Sciences,
Год журнала:
2021,
Номер
22(11), С. 6112 - 6112
Опубликована: Июнь 6, 2021
Skin
cancers
are
growing
in
incidence
worldwide
and
primarily
caused
by
exposures
to
ultraviolet
(UV)
wavelengths
of
sunlight.
UV
radiation
induces
the
formation
photoproducts
other
lesions
DNA
that
if
not
removed
repair
may
lead
mutagenesis
carcinogenesis.
Though
factors
cause
skin
carcinogenesis
reasonably
well
understood,
studies
over
past
10-15
years
have
linked
timing
exposure
implicate
a
role
for
body's
circadian
clock
response
disease
risk.
Here
we
review
what
is
known
about
clock,
how
it
affects
various
aspects
physiology,
affect
rhythms
skin.
Furthermore,
molecular
understanding
has
led
development
small
molecules
target
proteins;
thus,
discuss
potential
use
such
compounds
manipulating
clock-controlled
processes
modulate
responses
mitigate
cancer
Regulating
multiple
body
clocks
Circadian
rhythms
that
affect
tissues
and
organ
systems
are
aligned
with
the
dark-light
cycle
other
external
inputs
such
as
feeding.
But
how
is
time
keeping
modulated
throughout
complex
anatomical
regions?
Koronowski
Sassone-Corsi
reviewed
central
regulators
in
brain
peripheral
organs
can
behave
cooperatively
or
independently
to
modulate
circadian
rhythms.
This
systemic
view
of
rhythm
modulation
important
understand
behavior
disease,
because
dysregulated
associated
metabolic
syndrome
cancer.
Science
,
this
issue
p.
eabd0951
Our
highly
seasonal
world
restricts
insect
activity
to
brief
portions
of
the
year.
This
feature
necessitates
a
sophisticated
interpretation
changes
and
enactment
mechanisms
for
bringing
development
halt
then
reinitiating
it
when
inimical
season
is
past.
The
dormant
state
diapause
serves
bridge
unfavourable
seasons,
its
timing
provides
powerful
mechanism
synchronizing
development.
book
explores
how
signals
are
monitored
used
by
insects
enact
specific
molecular
pathways
that
generate
phenotype.
broad
perspective
offered
here
scales
from
ecological
thus
comprehensive
view
this
exciting
vibrant
research
field,
offering
insights
on
topics
ranging
pest
management,
evolution,
speciation,
climate
change
disease
transmission,
human
health,
as
well
analogies
with
other
forms
invertebrate
dormancy
mammalian
hibernation.
The Innovation,
Год журнала:
2023,
Номер
4(1), С. 100380 - 100380
Опубликована: Янв. 1, 2023
•An
atlas
of
age-,
tissue-,
and
cell-type-specific
benefits
long-term
exercise.•Exercise
protects
tissues
from
infectious
injury,
especially
in
younger
ones.•Exercise
promotes
rejuvenation
aged
tissues,
the
nervous
system.•Exercise
exerts
geroprotective
effects,
by
resetting
circadian
programs
via
clock
protein
BMAL1.
Exercise
whole
organism,
yet,
how
across
body
orchestrally
respond
to
exercise
remains
enigmatic.
Here,
young
old
mice,
with
or
without
exercise,
exposed
we
characterized
phenotypic
molecular
adaptations
a
12-month
14
tissues/organs
at
single-cell
resolution.
Overall,
although
more
effectively
animals,
individuals
terms
inflammaging
suppression
tissue
rejuvenation,
structural
improvement
central
system
systemic
vasculature
being
most
prominent.
In
vascular
endothelial
cells,
found
that
readjusting
rhythmic
machinery
core
BMAL1
delayed
senescence
facilitated
recovery
damage,
recapitulating
beneficial
effects
exercise.
Our
study
underscores
effect
reconstituting
youthful
network
provides
foundation
for
further
investigating
interplay
between
aging,
immune
challenges
organism.
Science,
Год журнала:
2023,
Номер
380(6648), С. 972 - 979
Опубликована: Июнь 1, 2023
The
suprachiasmatic
nucleus
(SCN)
drives
circadian
clock
coherence
through
intercellular
coupling,
which
is
resistant
to
environmental
perturbations.
We
report
that
primary
cilia
are
required
for
coupling
among
SCN
neurons
maintain
the
robustness
of
internal
in
mice.
Cilia
neuromedin
S-producing
(NMS)
exhibit
pronounced
rhythmicity
abundance
and
length.
Genetic
ablation
ciliogenesis
NMS
enabled
a
rapid
phase
shift
under
jet-lag
conditions.
rhythms
individual
cilia-deficient
slices
lost
their
after
external
Rhythmic
changes
drive
oscillations
Sonic
Hedgehog
(Shh)
signaling
gene
expression.
Inactivation
Shh
phenocopied
effects
ablation.
Thus,
cilia-Shh
aids
coupling.
FEBS Letters,
Год журнала:
2020,
Номер
594(17), С. 2734 - 2769
Опубликована: Авг. 4, 2020
The
circadian
system
is
composed
of
coupled
endogenous
oscillators
that
allow
living
beings,
including
humans,
to
anticipate
and
adapt
daily
changes
in
their
environment.
In
mammals,
clocks
form
a
hierarchically
organized
network
with
‘master
clock’
located
the
suprachiasmatic
nucleus
hypothalamus,
which
ensures
entrainment
subsidiary
environmental
cycles.
Robust
rhythmicity
body
indispensable
for
temporally
coordinating
organ
functions,
disruption
or
misalignment
rhythms
caused
instance
by
modern
lifestyle
strongly
associated
various
widespread
diseases.
This
review
aims
provide
comprehensive
overview
our
current
knowledge
about
molecular
architecture
system‐level
organization
mammalian
oscillators.
Furthermore,
we
discuss
regulatory
roles
peripheral
cell
physiology
implication
temporal
coordination
metabolism
human
health
disease.
Finally,
summarize
methods
assessing
humans.
Cellular and Molecular Life Sciences,
Год журнала:
2021,
Номер
78(10), С. 4563 - 4587
Опубликована: Март 8, 2021
Abstract
The
circadian
clock
exerts
an
important
role
in
systemic
homeostasis
as
it
acts
a
keeper
of
time
for
the
organism.
synchrony
between
daily
challenges
imposed
by
environment
needs
to
be
aligned
with
biological
processes
and
internal
clock.
In
this
review,
is
provided
in-depth
view
molecular
functioning
clock,
how
system
organized,
central
peripheral
clocks
communicate
each
other.
sense,
we
provide
overview
neuro-hormonal
factors
controlled
they
affect
tissues.
We
also
evaluate
signals
released
organs
their
effects
other
brain
areas.
Additionally,
possible
communication
tissues
novel
layer
organization
reviewing
recent
studies
literature.
last
section,
analyze
can
modulate
intracellular
tissue-dependent
metabolic
organs.
Taken
altogether,
goal
review
integrative
function
emphasis
Nature Communications,
Год журнала:
2021,
Номер
12(1)
Опубликована: Янв. 15, 2021
Abstract
Circadian
clocks
coordinate
mammalian
behavior
and
physiology
enabling
organisms
to
anticipate
24-hour
cycles.
Transcription-translation
feedback
loops
are
thought
drive
these
in
most
of
cells.
However,
red
blood
cells
(RBCs),
which
do
not
contain
a
nucleus,
cannot
perform
transcription
or
translation,
nonetheless
exhibit
circadian
redox
rhythms.
Here
we
show
human
RBCs
display
regulation
glucose
metabolism,
is
required
sustain
daily
oscillations.
We
found
rhythms
metabolite
levels
flux
through
glycolysis
the
pentose
phosphate
pathway
(PPP).
that
inhibition
critical
enzymes
either
abolished
metabolic
oscillations,
determined
oscillations
necessary
for
rhythmicity.
Furthermore,
also
occur
nucleated
cells,
persist
when
core
transcriptional
clockwork
absent
Bmal1
knockouts.
Thus,
propose
rhythmic
metabolism
an
integral
process
