Cellular and Molecular Life Sciences, Год журнала: 2021, Номер 78(7), С. 3127 - 3140
Опубликована: Янв. 15, 2021
Язык: Английский
Cellular and Molecular Life Sciences, Год журнала: 2021, Номер 78(7), С. 3127 - 3140
Опубликована: Янв. 15, 2021
Язык: Английский
Cell, Год журнала: 2020, Номер 184(1), С. 33 - 63
Опубликована: Дек. 18, 2020
Язык: Английский
Процитировано
384Science, Год журнала: 2021, Номер 371(6530)
Опубликована: Фев. 11, 2021
Regulating multiple body clocks Circadian rhythms that affect tissues and organ systems are aligned with the dark-light cycle other external inputs such as feeding. But how is time keeping modulated throughout complex anatomical regions? Koronowski Sassone-Corsi reviewed central regulators in brain peripheral organs can behave cooperatively or independently to modulate circadian rhythms. This systemic view of rhythm modulation important understand behavior disease, because dysregulated associated metabolic syndrome cancer. Science , this issue p. eabd0951
Язык: Английский
Процитировано
234Опубликована: Янв. 13, 2022
Our highly seasonal world restricts insect activity to brief portions of the year. This feature necessitates a sophisticated interpretation changes and enactment mechanisms for bringing development halt then reinitiating it when inimical season is past. The dormant state diapause serves bridge unfavourable seasons, its timing provides powerful mechanism synchronizing development. book explores how signals are monitored used by insects enact specific molecular pathways that generate phenotype. broad perspective offered here scales from ecological thus comprehensive view this exciting vibrant research field, offering insights on topics ranging pest management, evolution, speciation, climate change disease transmission, human health, as well analogies with other forms invertebrate dormancy mammalian hibernation.
Язык: Английский
Процитировано
124The Innovation, Год журнала: 2023, Номер 4(1), С. 100380 - 100380
Опубликована: Янв. 1, 2023
•An atlas of age-, tissue-, and cell-type-specific benefits long-term exercise.•Exercise protects tissues from infectious injury, especially in younger ones.•Exercise promotes rejuvenation aged tissues, the nervous system.•Exercise exerts geroprotective effects, by resetting circadian programs via clock protein BMAL1. Exercise whole organism, yet, how across body orchestrally respond to exercise remains enigmatic. Here, young old mice, with or without exercise, exposed we characterized phenotypic molecular adaptations a 12-month 14 tissues/organs at single-cell resolution. Overall, although more effectively animals, individuals terms inflammaging suppression tissue rejuvenation, structural improvement central system systemic vasculature being most prominent. In vascular endothelial cells, found that readjusting rhythmic machinery core BMAL1 delayed senescence facilitated recovery damage, recapitulating beneficial effects exercise. Our study underscores effect reconstituting youthful network provides foundation for further investigating interplay between aging, immune challenges organism.
Язык: Английский
Процитировано
51Science, Год журнала: 2023, Номер 380(6648), С. 972 - 979
Опубликована: Июнь 1, 2023
The suprachiasmatic nucleus (SCN) drives circadian clock coherence through intercellular coupling, which is resistant to environmental perturbations. We report that primary cilia are required for coupling among SCN neurons maintain the robustness of internal in mice. Cilia neuromedin S-producing (NMS) exhibit pronounced rhythmicity abundance and length. Genetic ablation ciliogenesis NMS enabled a rapid phase shift under jet-lag conditions. rhythms individual cilia-deficient slices lost their after external Rhythmic changes drive oscillations Sonic Hedgehog (Shh) signaling gene expression. Inactivation Shh phenocopied effects ablation. Thus, cilia-Shh aids coupling.
Язык: Английский
Процитировано
49Nature Cancer, Год журнала: 2024, Номер 5(4), С. 546 - 556
Опубликована: Апрель 23, 2024
Язык: Английский
Процитировано
21Archives of Toxicology, Год журнала: 2021, Номер 95(6), С. 1943 - 1970
Опубликована: Май 18, 2021
Язык: Английский
Процитировано
100FEBS Letters, Год журнала: 2020, Номер 594(17), С. 2734 - 2769
Опубликована: Авг. 4, 2020
The circadian system is composed of coupled endogenous oscillators that allow living beings, including humans, to anticipate and adapt daily changes in their environment. In mammals, clocks form a hierarchically organized network with ‘master clock’ located the suprachiasmatic nucleus hypothalamus, which ensures entrainment subsidiary environmental cycles. Robust rhythmicity body indispensable for temporally coordinating organ functions, disruption or misalignment rhythms caused instance by modern lifestyle strongly associated various widespread diseases. This review aims provide comprehensive overview our current knowledge about molecular architecture system‐level organization mammalian oscillators. Furthermore, we discuss regulatory roles peripheral cell physiology implication temporal coordination metabolism human health disease. Finally, summarize methods assessing humans.
Язык: Английский
Процитировано
89Cellular and Molecular Life Sciences, Год журнала: 2021, Номер 78(10), С. 4563 - 4587
Опубликована: Март 8, 2021
Abstract The circadian clock exerts an important role in systemic homeostasis as it acts a keeper of time for the organism. synchrony between daily challenges imposed by environment needs to be aligned with biological processes and internal clock. In this review, is provided in-depth view molecular functioning clock, how system organized, central peripheral clocks communicate each other. sense, we provide overview neuro-hormonal factors controlled they affect tissues. We also evaluate signals released organs their effects other brain areas. Additionally, possible communication tissues novel layer organization reviewing recent studies literature. last section, analyze can modulate intracellular tissue-dependent metabolic organs. Taken altogether, goal review integrative function emphasis
Язык: Английский
Процитировано
68Nature Communications, Год журнала: 2021, Номер 12(1)
Опубликована: Янв. 15, 2021
Abstract Circadian clocks coordinate mammalian behavior and physiology enabling organisms to anticipate 24-hour cycles. Transcription-translation feedback loops are thought drive these in most of cells. However, red blood cells (RBCs), which do not contain a nucleus, cannot perform transcription or translation, nonetheless exhibit circadian redox rhythms. Here we show human RBCs display regulation glucose metabolism, is required sustain daily oscillations. We found rhythms metabolite levels flux through glycolysis the pentose phosphate pathway (PPP). that inhibition critical enzymes either abolished metabolic oscillations, determined oscillations necessary for rhythmicity. Furthermore, also occur nucleated cells, persist when core transcriptional clockwork absent Bmal1 knockouts. Thus, propose rhythmic metabolism an integral process
Язык: Английский
Процитировано
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