Hallmarks of Health

Cell, Journal Year: 2020, Volume and Issue: 184(1), P. 33 - 63

Published: Dec. 18, 2020

Language: Английский

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Communicating clocks shape circadian homeostasis

Science, Journal Year: 2021, Volume and Issue: 371(6530)

Published: Feb. 11, 2021

Regulating multiple body clocks Circadian rhythms that affect tissues and organ systems are aligned with the dark-light cycle other external inputs such as feeding. But how is time keeping modulated throughout complex anatomical regions? Koronowski Sassone-Corsi reviewed central regulators in brain peripheral organs can behave cooperatively or independently to modulate circadian rhythms. This systemic view of rhythm modulation important understand behavior disease, because dysregulated associated metabolic syndrome cancer. Science , this issue p. eabd0951

Language: Английский

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Insect Diapause

Published: Jan. 13, 2022

Our highly seasonal world restricts insect activity to brief portions of the year. This feature necessitates a sophisticated interpretation changes and enactment mechanisms for bringing development halt then reinitiating it when inimical season is past. The dormant state diapause serves bridge unfavourable seasons, its timing provides powerful mechanism synchronizing development. book explores how signals are monitored used by insects enact specific molecular pathways that generate phenotype. broad perspective offered here scales from ecological thus comprehensive view this exciting vibrant research field, offering insights on topics ranging pest management, evolution, speciation, climate change disease transmission, human health, as well analogies with other forms invertebrate dormancy mammalian hibernation.

Language: Английский

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A single-cell transcriptomic atlas of exercise-induced anti-inflammatory and geroprotective effects across the body

The Innovation, Journal Year: 2023, Volume and Issue: 4(1), P. 100380 - 100380

Published: Jan. 1, 2023

•An atlas of age-, tissue-, and cell-type-specific benefits long-term exercise.•Exercise protects tissues from infectious injury, especially in younger ones.•Exercise promotes rejuvenation aged tissues, the nervous system.•Exercise exerts geroprotective effects, by resetting circadian programs via clock protein BMAL1. Exercise whole organism, yet, how across body orchestrally respond to exercise remains enigmatic. Here, young old mice, with or without exercise, exposed we characterized phenotypic molecular adaptations a 12-month 14 tissues/organs at single-cell resolution. Overall, although more effectively animals, individuals terms inflammaging suppression tissue rejuvenation, structural improvement central system systemic vasculature being most prominent. In vascular endothelial cells, found that readjusting rhythmic machinery core BMAL1 delayed senescence facilitated recovery damage, recapitulating beneficial effects exercise. Our study underscores effect reconstituting youthful network provides foundation for further investigating interplay between aging, immune challenges organism.

Language: Английский

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Rhythmic cilia changes support SCN neuron coherence in circadian clock

Science, Journal Year: 2023, Volume and Issue: 380(6648), P. 972 - 979

Published: June 1, 2023

The suprachiasmatic nucleus (SCN) drives circadian clock coherence through intercellular coupling, which is resistant to environmental perturbations. We report that primary cilia are required for coupling among SCN neurons maintain the robustness of internal in mice. Cilia neuromedin S-producing (NMS) exhibit pronounced rhythmicity abundance and length. Genetic ablation ciliogenesis NMS enabled a rapid phase shift under jet-lag conditions. rhythms individual cilia-deficient slices lost their after external Rhythmic changes drive oscillations Sonic Hedgehog (Shh) signaling gene expression. Inactivation Shh phenocopied effects ablation. Thus, cilia-Shh aids coupling.

Language: Английский

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Circadian regulation of cancer stem cells and the tumor microenvironment during metastasis

Nature Cancer, Journal Year: 2024, Volume and Issue: 5(4), P. 546 - 556

Published: April 23, 2024

Language: Английский

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The functions and regulation of heat shock proteins; key orchestrators of proteostasis and the heat shock response

Archives of Toxicology, Journal Year: 2021, Volume and Issue: 95(6), P. 1943 - 1970

Published: May 18, 2021

Language: Английский

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Coupled network of the circadian clocks: a driving force of rhythmic physiology

FEBS Letters, Journal Year: 2020, Volume and Issue: 594(17), P. 2734 - 2769

Published: Aug. 4, 2020

The circadian system is composed of coupled endogenous oscillators that allow living beings, including humans, to anticipate and adapt daily changes in their environment. In mammals, clocks form a hierarchically organized network with ‘master clock’ located the suprachiasmatic nucleus hypothalamus, which ensures entrainment subsidiary environmental cycles. Robust rhythmicity body indispensable for temporally coordinating organ functions, disruption or misalignment rhythms caused instance by modern lifestyle strongly associated various widespread diseases. This review aims provide comprehensive overview our current knowledge about molecular architecture system‐level organization mammalian oscillators. Furthermore, we discuss regulatory roles peripheral cell physiology implication temporal coordination metabolism human health disease. Finally, summarize methods assessing humans.

Language: Английский

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The circadian clock and metabolic homeostasis: entangled networks

Cellular and Molecular Life Sciences, Journal Year: 2021, Volume and Issue: 78(10), P. 4563 - 4587

Published: March 8, 2021

Abstract The circadian clock exerts an important role in systemic homeostasis as it acts a keeper of time for the organism. synchrony between daily challenges imposed by environment needs to be aligned with biological processes and internal clock. In this review, is provided in-depth view molecular functioning clock, how system organized, central peripheral clocks communicate each other. sense, we provide overview neuro-hormonal factors controlled they affect tissues. We also evaluate signals released organs their effects other brain areas. Additionally, possible communication tissues novel layer organization reviewing recent studies literature. last section, analyze can modulate intracellular tissue-dependent metabolic organs. Taken altogether, goal review integrative function emphasis

Language: Английский

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Rhythmic glucose metabolism regulates the redox circadian clockwork in human red blood cells

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: Jan. 15, 2021

Abstract Circadian clocks coordinate mammalian behavior and physiology enabling organisms to anticipate 24-hour cycles. Transcription-translation feedback loops are thought drive these in most of cells. However, red blood cells (RBCs), which do not contain a nucleus, cannot perform transcription or translation, nonetheless exhibit circadian redox rhythms. Here we show human RBCs display regulation glucose metabolism, is required sustain daily oscillations. We found rhythms metabolite levels flux through glycolysis the pentose phosphate pathway (PPP). that inhibition critical enzymes either abolished metabolic oscillations, determined oscillations necessary for rhythmicity. Furthermore, also occur nucleated cells, persist when core transcriptional clockwork absent Bmal1 knockouts. Thus, propose rhythmic metabolism an integral process

Language: Английский

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