Frontiers in Chemistry,
Год журнала:
2024,
Номер
11
Опубликована: Янв. 10, 2024
Thyroid
carcinoma
(TC)
is
a
prevalent
malignancy
of
the
endocrine
system,
with
notable
rise
in
its
detection
rate
recent
decades.
The
primary
therapeutic
approaches
for
TC
now
encompass
thyroidectomy
and
radioactive
iodine
therapy,
yielding
favorable
prognoses
majority
patients.
survivors
may
necessitate
ongoing
surveillance,
remedial
treatment,
thyroid
hormone
supplementation,
while
also
enduring
adverse
consequences
fluctuations,
surgical
complications,
or
side
effects
linked
to
administration,
encountering
physical,
psychosocial,
economic
hardships.
In
vitro
vivo
studies
natural
products
against
are
demonstrating
potential
these
as
alternatives
treatment
cancer.
This
therapy
offer
greater
convenience,
affordability,
acceptability
than
traditional
therapies.
early
screening
products,
we
mainly
use
combination
database
prediction
literature
search.
pharmacological
on
selected
(quercetin,
genistein,
apigenin,
luteolin,
chrysin,
myricetin,
resveratrol,
curcumin
nobiletin),
which
hold
promise
applications
TC,
reviewed
detail
this
article
through
most
cell-level
evidence,
animal-level
small
amount
human-level
evidence.
addition,
explores
possible
issues,
such
bioavailability,
drug
safety.
Molecular Biomedicine,
Год журнала:
2023,
Номер
4(1)
Опубликована: Окт. 16, 2023
Abstract
Ferroptosis,
a
regulated
form
of
cellular
death
characterized
by
the
iron-mediated
accumulation
lipid
peroxides,
provides
novel
avenue
for
delving
into
intersection
metabolism,
oxidative
stress,
and
disease
pathology.
We
have
witnessed
mounting
fascination
with
ferroptosis,
attributed
to
its
pivotal
roles
across
diverse
physiological
pathological
conditions
including
developmental
processes,
metabolic
dynamics,
oncogenic
pathways,
neurodegenerative
cascades,
traumatic
tissue
injuries.
By
unraveling
intricate
underpinnings
molecular
machinery,
contributors,
signaling
conduits,
regulatory
networks
governing
researchers
aim
bridge
gap
between
intricacies
this
unique
mode
multifaceted
implications
health
disease.
In
light
rapidly
advancing
landscape
ferroptosis
research,
we
present
comprehensive
review
aiming
at
extensive
in
origins
progress
human
diseases.
This
concludes
careful
analysis
potential
treatment
approaches
carefully
designed
either
inhibit
or
promote
ferroptosis.
Additionally,
succinctly
summarized
therapeutic
targets
compounds
that
hold
promise
targeting
within
various
facet
underscores
burgeoning
possibilities
manipulating
as
strategy.
summary,
enriched
insights
both
investigators
practitioners,
while
fostering
an
elevated
comprehension
latent
translational
utilities.
revealing
basic
processes
investigating
possibilities,
crucial
resource
scientists
medical
aiding
deep
understanding
effects
situations.
Phytotherapy Research,
Год журнала:
2024,
Номер
38(8), С. 3954 - 3972
Опубликована: Июнь 4, 2024
Driven
by
iron-dependent
lipid
peroxidation,
ferroptosis
is
regulated
p53
and
solute
carrier
family
7
member
11
(SLC7A11)/glutathione/glutathione
peroxidase
4
(GPX4)
axis
in
colorectal
cancer
(CRC).
This
study
aimed
to
investigate
the
influence
of
curcumin
(CUR)
on
CRC.
The
efficacies
CUR
malignant
phenotype
CRC
cells
were
determined
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl
tetrazolium
bromide,
wound
healing,
clonogenic
assays.
effects
evaluated
transmission
electron
microscopy,
lactate
dehydrogenase
release
assay,
Fe
The Turkish Journal of Gastroenterology,
Год журнала:
2025,
Номер
35(8), С. 625 - 633
Опубликована: Апрель 8, 2025
As
a
very
common
malignancy
of
the
digestive
system,
incidence
and
mortality
rates
gastric
cancer
(GC)
are
increasing
year
by
year.
The
critical
role
ferroptosis
in
development
has
been
well-documented.
polyphenol
compound
curcumin
shows
prominent
anti-tumor
effects
multiple
types,
including
GC.
However,
whether
participates
GC
tumorigenesis
regulating
remains
unknown.
Gastric
cells
AGS
HGC-27
were
treated
with
(0,
10,
20
μM).
Cell
viability
death
evaluated
through
CCK-8
LDH
release
assays.
LC3B
expression
was
estimated
immunofluorescence
staining.
Intracellular
ferrous
iron
(Fe2+),
GSH,
MDA,
lipid
ROS
levels
assessed
corresponding
assay
kits.
cellular
autophagy
markers
(ATG5,
ATG7,
Beclin
1,
LC3B),
(ACSL4,
SLC7A11,
GPX4),
phosphorylated
(p)-PI3K,
p-AKT,
p-mTOR
determined
western
blotting.
Curcumin
attenuated
cell
but
stimulated
cells.
enhanced
cells,
as
demonstrated
increased
ATG5,
LC3B.
Besides,
upregulated
iron,
ACSL4
while
downregulated
ROS,
GPX4
levels,
suggesting
its
stimulation
on
decreased
p-PI3K,
Importantly,
inhibitor
ferrostatin-1
overturned
impacts
viability,
death,
ferroptosis.
suppresses
inducing
autophagy-mediated
inactivating
PI3K/AKT/mTOR
signaling.
Drug Design Development and Therapy,
Год журнала:
2024,
Номер
Volume 18, С. 2485 - 2529
Опубликована: Июнь 1, 2024
Abstract:
Ferroptosis,
a
unique
form
of
programmed
cell
death,
is
initiated
by
an
excess
iron
accumulation
and
lipid
peroxidation-induced
damage.
There
growing
body
evidence
indicating
that
ferroptosis
plays
critical
role
in
the
advancement
tumors.
The
increased
metabolic
activity
higher
levels
tumor
cells
make
them
particularly
vulnerable
to
ferroptosis.
As
result,
targeted
induction
becoming
increasingly
promising
approach
for
cancer
treatment.
This
review
offers
overview
regulatory
mechanisms
ferroptosis,
delves
into
mechanism
action
traditional
small
molecule
inducers
their
effects
on
various
In
addition,
latest
progress
inducing
using
new
means
such
as
proteolysis-targeting
chimeras
(PROTACs),
photodynamic
therapy
(PDT),
sonodynamic
(SDT)
nanomaterials
summarized.
Finally,
this
discusses
challenges
opportunities
development
ferroptosis-inducing
agents,
focusing
discovering
targets,
improving
selectivity,
reducing
toxic
side
effects.
Keywords:
inducers,
molecules,
PROTACs,
PDT,
SDT,
Phytotherapy Research,
Год журнала:
2024,
Номер
38(4), С. 2041 - 2076
Опубликована: Фев. 23, 2024
Abstract
In
recent
years,
heightened
interest
surrounds
the
exploration
of
natural
phenols
as
potential
agents
for
cancer
therapy,
specifically
by
inducing
ferroptosis,
a
unique
form
regulated
cell
death
characterized
iron‐dependent
lipid
peroxidation.
This
review
delves
into
roles
key
phenols,
flavonoids,
phenolic
acids,
curcumin,
and
stilbenes,
in
modulating
ferroptosis
their
underlying
mechanisms.
Emphasizing
significance
amino
acid,
lipid,
iron
metabolism,
study
elucidates
diverse
pathways
through
which
these
regulate
ferroptosis.
Notably,
well‐known
polyphenol,
exhibits
multifaceted
interactions
with
cellular
components
involved
regulation,
providing
distinctive
therapeutic
avenue.
Stilbenes,
another
class,
demonstrate
promising
influencing
metabolism
processes,
contributing
to
ferroptotic
death.
Understanding
intricate
interplay
between
not
only
illuminates
complex
regulatory
networks
but
also
unveils
avenues
novel
therapies.
Exploring
compounds
inducers
presents
strategy
targeted
treatment,
capitalizing
on
delicate
balance
article
synthesizes
current
knowledge,
aiming
stimulate
further
research
context
ferroptosis‐mediated
therapy.
Frontiers in Cellular Neuroscience,
Год журнала:
2023,
Номер
17
Опубликована: Авг. 9, 2023
Acute
central
nervous
system
injuries
(ACNSI),
encompassing
traumatic
brain
injury
(TBI),
non-traumatic
like
stroke
and
encephalomeningitis,
as
well
spinal
cord
injuries,
are
linked
to
significant
rates
of
disability
mortality
globally.
Nevertheless,
effective
feasible
treatment
plans
still
be
formulated.
There
primary
secondary
occurred
after
ACNSI.
Most
ACNSIs
exhibit
comparable
which
offer
numerous
potential
therapeutic
targets
for
enhancing
clinical
outcomes.
Ferroptosis,
a
newly
discovered
form
cell
death,
is
characterized
lipid
peroxidation
process
that
dependent
on
iron
oxidative
conditions,
also
indispensable
mitochondria.
Ferroptosis
play
vital
role
in
many
neuropathological
pathways,
may
induce
mitochondrial
dysfunction,
thereby
indicating
the
essentiality
connection
ferroptosis
ACNSIs.
there
remains
lack
clarity
regarding
involvement
mitochondria
occurrence
In
recent
studies,
anti-ferroptosis
agents
such
inhibitor
Ferrostain-1
chelation
therapy
have
shown
ameliorating
deleterious
effects
cases
The
importance
this
evidence
extremely
relation
research
control
Therefore,
our
review
aims
provide
researchers
focusing
outcomes
with
valuable
insights
by
summarizing
physiopathological
mechanisms
exploring
correlation
between
ferroptosis,
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Март 10, 2024
Abstract
Background
Despite
the
higher
sensitivity
of
melanoma
towards
ferroptosis
and
photodynamic
therapy
(PDT),
lack
efficient
inducers
poor
solubility
photosensitizers
restrict
their
synergistic
strategies.
With
unique
advantages,
carbon
dots
(CDs)
are
expected
to
serve
as
innovative
building
blocks
for
combination
cancers.
Results
Herein,
an
ferroptosis/PDT
integrated
nanoplatform
is
constructed
based
on
chlorin
e6-modified
Fe
ions-doped
(Fe-CDs@Ce6).
As
a
novel
type
iron-carbon
hybrid
nanoparticles,
as-prepared
Fe-CDs
can
selectively
activate
ferroptosis,
prevent
angiogenesis
inhibit
migration
mouse
skin
cells
(B16),
but
have
no
toxicity
normal
cells.
The
nano-conjugated
structures
facilitate
not
only
aqueous
dispersibility
Ce6,
also
self-accumulation
ability
Fe-CDs@Ce6
within
area
without
requiring
extra
targets.
Moreover,
therapeutic
effects
synergistically
enhanced
due
increased
GSH
depletion
by
PDT
elevated
singlet
oxygen
(
1
O
2
)
production
efficiency
Fe-CDs.
When
combined
with
laser
irradiation,
tumor
growth
be
significantly
suppressed
through
cyclic
administration.
T
-weighted
magnetic
resonance
imaging
(MRI)
capability
reveals
potentials
cancer
diagnosis
navigation
therapy.
Conclusions
Our
findings
indicate
multifunctionality
in
effectively
combining
therapy,
targeting
MRI
imaging,
which
enables
become
promising
biocompatible
treatment
melanoma.
Graphic
Antioxidants,
Год журнала:
2024,
Номер
13(3), С. 334 - 334
Опубликована: Март 10, 2024
Ferroptosis
is
a
recently
discovered
type
of
programmed
cell
death
that
mechanistically
different
from
other
types
such
as
apoptosis,
necroptosis,
and
autophagy.
It
characterized
by
the
accumulation
intracellular
iron,
overproduction
reactive
oxygen
species,
depletion
glutathione,
extensive
lipid
peroxidation
lipids
in
membrane.
was
ferroptosis
interconnected
with
many
diseases,
neurodegenerative
ischemia/reperfusion
injury,
cancer,
chronic
kidney
disease.
Polyphenols,
plant
secondary
metabolites
known
for
bioactivities,
are
being
extensively
researched
context
their
influence
on
which
resulted
great
number
publications
showing
need
systematic
review.
In
this
review,
an
literature
search
performed.
Databases
(Scopus,
Web
Science,
PubMed,
ScienceDirect,
Springer)
were
searched
time
span
2017
to
November
2023,
using
keyword
“ferroptosis”
alone
combination
“flavonoid”,
“phenolic
acid”,
“stilbene”,
“coumarin”,
“anthraquinone”,
“chalcone”;
after
selection
studies,
we
had
311
papers
143
phenolic
compounds.
total,
53
compounds
showed
ability
induce
ferroptosis,
110
able
inhibit
out
those
compounds,
20
both
abilities
depending
model
system.
The
most
shikonin,
curcumin,
quercetin,
resveratrol,
baicalin.
common
modes
action
modulation
Nrf2/GPX4
Nrf2/HO-1
axis
iron
metabolism.
Phytotherapy Research,
Год журнала:
2024,
Номер
38(7), С. 3307 - 3336
Опубликована: Апрель 15, 2024
Over
the
past
five
decades,
Curcumin
(Cur),
derived
from
turmeric
(Curcuma
longa),
has
gained
considerable
attention
for
its
potential
therapeutic
applications.
Synthesizing
insights
clinical
trials
conducted
over
last
25
years,
this
review
delves
into
diseases
where
Cur
demonstrated
promise,
offering
a
nuanced
understanding
of
pharmacokinetics,
safety,
and
effectiveness.
Focusing
on
specific
examples,
impact
various
human
is
explored.
Endocrine
glands
associated
signaling
pathways
are
highlighted,
elucidating
how
influences
cellular
signaling.
The
article
underscores
molecular
mechanisms
such
as
hormone
level
alteration,
receptor
interaction,
cytokine
adipokine
expression
inhibition,
antioxidant
enzyme
activity,
modulation
transcription
factors.
showcases
diverse
protective
against
inflammation
oxidative
damage
by
suppressing
antiapoptotic
genes
impeding
tumor
promotion.
This
comprehensive
overview
emphasizes
natural
agent
countering
aging
degenerative
diseases,
calling
further
dedicated
research
in
realm.