Harnessing genomics to fast-track genetic improvement in aquaculture

Nature Reviews Genetics, Год журнала: 2020, Номер 21(7), С. 389 - 409

Опубликована: Апрель 16, 2020

Язык: Английский

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Nutrigenomics and immune function in fish: new insights from omics technologies

Developmental & Comparative Immunology, Год журнала: 2017, Номер 75, С. 86 - 98

Опубликована: Март 1, 2017

The interplay between nutrition and immune system is well recognised, however the true integration of research nutrition, animal energy status function still far from clear. In fish especially for species maintained in aquaculture, formulated feeds are significantly different natural diet with recent changes nutrient sources, protein oil sources now being predominated by terrestrial derived ingredients. Additionally, many incorporated to health management termed functional feeds, which believed improve health, reduce disease outbreaks and/or post-infection recovery. Using new omics technologies, including transcriptomics (microarray RNA-seq) proteomics, impacts on becoming clearer. By using molecular pathway enrichment analysis, modules genes can indicate how both local (intestinal) systemic altered. Although great progress has been made define host function, understanding intestinal microbiome only just beginning emerge.

Язык: Английский

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Genomic Selection in Aquaculture: Application, Limitations and Opportunities With Special Reference to Marine Shrimp and Pearl Oysters

Frontiers in Genetics, Год журнала: 2019, Номер 9

Опубликована: Янв. 23, 2019

Within aquaculture industries, selection based on genomic information (genomic selection) has the profound potential to change genetic improvement programs and production systems. Genomic exploits use of realized relationships among individuals, from genome-wide markers in close linkage disequilibrium with genes biological economic importance. We discuss technical advances, practical requirements commercial applications that have made feasible a range particular focus molluscs (pearl oysters, Pinctada maxima) marine shrimp (Litopeneaus vannamei Penaeus monodon). The low-cost genome sequencing enabled cost-effective genotyping large-scale is value for species without reference or access arrays. highlight pitfalls offer solutions by approach, building appropriate resources undertake first-hand experience. describe capture phenotypes image analysis artificial intelligence through machine learning, as inputs calculation breeding values. application over traditional aquatic offers significant advantages being able accurately predict complex polygenic traits including disease resistance; increasing rates gain; minimizing inbreeding; negating limiting effects genotype environment interactions. Further selection, communal mating rearing systems are highlighted, well presenting rate-limiting steps which impact attaining maximum benefits adopting selection. now at tipping point where can be readily adopted short long-term sustainable profitable industries.

Язык: Английский

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An overview of disruptive technologies for aquaculture

Aquaculture and Fisheries, Год журнала: 2021, Номер 7(2), С. 111 - 120

Опубликована: Июнь 11, 2021

The world wild fish stocks are being depleted in an ever-increasing speed. Aquaculture is the only way to ensure sufficient seafood for world. Conventional aquaculture can be traced back 4000 years China and has been very successful past three decades. However, faced serious challenges, including a few improved species, labour-intensiveness, environmental pollution, diseases lack of traceability products. needs disruptive technologies increase production. Novel technologies, genome editing, artificial intelligence, offshore farming, recirculating systems, alternative proteins oils replace meals oils, oral vaccination, blockchain marketing internet things, may provide solutions sustainable profitable aquaculture. This review briefly introduces these emerging open up forum in-depth discussion on how integrate into improve its sustainability profitability.

Язык: Английский

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Advancing genetic improvement in the omics era: status and priorities for United States aquaculture

BMC Genomics, Год журнала: 2025, Номер 26(1)

Опубликована: Фев. 17, 2025

The innovations of the "Omics Era" have ushered in significant advancements genetic improvement agriculturally important animal species through transforming genetics, genomics and breeding strategies. These were often coordinated, part, by support provided over 30 years 1993-2023 National Research Support Project 8 (NRSP8, Animal Genome Program, NAGRP) affiliate projects focused on enabling genomic discoveries livestock, poultry, aquaculture species. parallel advances demand strategic planning future research priorities. This paper, as an output from May 2023 Aquaculture Genomics, Genetics, Breeding Workshop, provides updated status resources for United States species, highlighting major achievements emerging Finfish shellfish genome omics enhance our understanding architecture heritability performance production traits. Workshop identified present aims genomics/omics to build this progress: (1) advancing reference assembly quality; (2) integrating multi-omics data analysis traits; (3) developing collection integration phenomics data; (4) creating pathways applying information across industries; (5) providing training, extension, outreach application phenome. focuses should emphasize collection, artificial intelligence, identifying causative relationships between genotypes phenotypes, establishing apply tools industries, expansion training programs next-generation workforce facilitate sciences into operations productivity, competitiveness, sustainability. collective vision with focus highlighted priorities is intended continued advancement genomics, genetics community industries. Critical challenges ahead include practical analytical frameworks beyond academic communities that require collaborative partnerships academia, government, industry. scope review encompasses use applications study aquatic animals cultivated human consumption settings throughout their life-cycle.

Язык: Английский

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Generation of Myostatin Gene-Edited Channel Catfish (Ictalurus punctatus) via Zygote Injection of CRISPR/Cas9 System

Scientific Reports, Год журнала: 2017, Номер 7(1)

Опубликована: Июль 31, 2017

Abstract The myostatin (MSTN) gene is important because of its role in regulation skeletal muscle growth all vertebrates. In this study, CRISPR/Cas9 was utilized to successfully target the channel catfish, Ictalurus punctatus , suppressor MSTN. induced high rates (88–100%) mutagenesis protein-encoding sites MSTN-edited fry had more cells ( p < 0.001) than controls, and mean body weight gene-edited increased by 29.7%. nucleic acid alignment mutated sequences against wild-type sequence revealed multiple insertions deletions. These results demonstrate that a highly efficient tool for editing catfish genome, opens ways facilitating genetic enhancement functional genomics. This approach may produce growth-enhanced increase productivity.

Язык: Английский

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Research advances in the genomics and applications for molecular breeding of aquaculture animals

Aquaculture, Год журнала: 2020, Номер 526, С. 735357 - 735357

Опубликована: Апрель 10, 2020

Язык: Английский

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Transcriptomics in aquaculture: current status and applications

Reviews in Aquaculture, Год журнала: 2018, Номер 11(4), С. 1379 - 1397

Опубликована: Окт. 12, 2018

Abstract Transcriptomics is the analysis of total RNA transcript in a cell, which gives broad idea cellular processes that are active and dormant. Recent advancement next‐generation sequencing technologies like high‐throughput mRNA ( ‐seq) facilitates deciphering functional complexity whole transcriptome an organism. In recent past, profiling has been widely used aquaculture for effective identification expression candidate genes involved growth, reproduction, development, immunity, disease, stress toxicology. On paucity comprehensive genome sequence, transcriptomics enables detection molecular markers such as simple sequence repeats single‐nucleotide polymorphism associated with trait interest. This review summarizes process current state related to diseases reproduction growth nutrition, toxicology stress. Further, this highlights application transcriptomics, including generation genetic resources, differential gene expression, pathways development markers.

Язык: Английский

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Rethinking fish biology and biotechnologies in the challenge era for burgeoning genome resources and strengthening food security

Water Biology and Security, Год журнала: 2021, Номер 1(1), С. 100002 - 100002

Опубликована: Ноя. 22, 2021

Fish biology has been developed for more than 100 years, but some important breakthroughs have made in the last decade. Early studies commonly concentrated on morphology, phylogenetics, development, growth, reproduction manipulation, and disease control. Recent mostly focused genetics, molecular biology, genomics, genome biotechnologies, which provided a solid foundation enhancing aquaculture to ensure food security improving aquatic environments sustain ecosystem health. Here, we review research advances five major areas: (1) biological innovations genomic evolution of four significant fish lineages including non-teleost ray-finned fishes, northern hemisphere sticklebacks, East African cichlid Asian cyprinid fishes; (2) evolutionary fates consequences natural polyploid (3) domestication selection; (4) development innovation breeding biotechnologies; (5) applicable approaches potential genetic biotechnologies. Moreover, precision biotechniques are examined discussed detail gene editing introgression or removal beneficial detrimental alleles, use sex-specific markers production mono-sex populations, controllable primordial germ cell on-off strategy producing sterile offspring, surrogate broodstock-based strategies accelerate breeding, incorporation sexual regain-based approach create synthetic polyploids. Based these scientific technological advances, propose blueprint improvement new breed creation species analyze seed industry strengthening security.

Язык: Английский

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Kelp aquaculture in China: a retrospective and future prospects

Reviews in Aquaculture, Год журнала: 2021, Номер 13(3), С. 1324 - 1351

Опубликована: Фев. 12, 2021

Abstract Globally, China has the largest scale of kelp cultivation and production operations. However, its aquaculture industry is suffering from declining germplasm diversity, degradation agronomic traits, presence polluted environments, changing ocean conditions increasing anthropological interference. This review covers two most commercially important species in China, viz. Saccharina japonica Undaria pinnatifida . It summarizes history their cultivation, production, economic ecological benefits, breeding programmes (e.g. inter‐ intra‐specific hybridization marker‐assisted selection) efforts towards population genetic diversity conservation. The article focuses on three significant challenges, for example cross‐contamination between wild farmed populations, warming acidification. Accordingly, we outline steps required to provide several intervention measures, (i) collection preservation cultivated germplasm; (ii) selection suitable sites under environmental conditions; (iii) developing stress‐resistant cultivars; finally, (iv) adoption innovative models. concludes with genome‐based, designs molecular calls establishment an East Asian Kelp Consortium (EAKC). Collectively, Chinese could beneficial goods services, bioenergy fine chemicals such as carbon capture, pH amelioration provision habitat many other marine commercial value. strategies proposed this thus have potential not only improve but also reinvigorate nearby Japan Korea, context both health benefits.

Язык: Английский

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