Pharmaceutics,
Год журнала:
2023,
Номер
15(2), С. 652 - 652
Опубликована: Фев. 15, 2023
Lung
cancer
is
one
of
the
deadliest
pulmonary
diseases
in
world.
Although
docetaxel
(DTX)
has
exhibited
superior
efficacy
lung
treatment,
it
demonstrated
numerous
adverse
effects
and
poor
bioavailability.
The
natural
product
extract,
curcumin
(CCM),
reportedly
reduced
toxicity
synergistically
improved
DTX
Nonetheless,
hydrophobic
nature
CCM
limits
their
clinical
use.
Nanoemulsion
delivery
potential
as
a
drug
carrier
to
alleviate
these
drawbacks.
controlled
preparation
inhalable
DTX-
CCM-loaded
nanoemulsions
within
100
200
nm
range
was
explored
this
study.
A
response
surface
methodology
(RSM)
based
on
central
composite
design
(CCD)
utilized
fabricate
desired
size
nanoemulsion
under
optimized
conditions.
Different
process
parameters
were
employed
control
procured
through
high-energy
emulsification
technique.
resultant
decreased
with
increasing
energy
input.
actual
according
targeted
sizes
for
models
excellent
agreement
predicted
value
at
below
5%
residual
standard
error
particle
better
membrane
permeability
than
larger
counterparts.
Moreover,
formulations
documented
favorable
physicochemical
aerodynamic
properties
human
fibroblast
(MRC-5)
cells.
Hence,
tunable
could
be
suitable
alternative
increased
local
concentration.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Май 20, 2024
Abstract
SARS-CoV-2
infection
causes
severe
pulmonary
manifestations,
with
poorly
understood
mechanisms
and
limited
treatment
options.
Hyperferritinemia
disrupted
lung
iron
homeostasis
in
COVID-19
patients
imply
that
ferroptosis,
an
iron-dependent
cell
death,
may
occur.
Immunostaining
lipidomic
analysis
autopsies
reveal
increases
ferroptosis
markers,
including
transferrin
receptor
1
malondialdehyde
accumulation
fatal
cases.
lungs
display
dysregulation
of
lipids
involved
metabolism
ferroptosis.
We
find
increased
ferritin
light
chain
associated
pathology.
Iron
overload
promotes
both
primary
cells
cancerous
epithelial
cells.
In
addition,
markers
strongly
correlate
injury
severity
a
disease
model
using
male
Syrian
hamsters.
These
results
role
for
disease;
pharmacological
inhibition
serve
as
adjuvant
therapy
to
prevent
damage
during
infection.
Bioactive Materials,
Год журнала:
2022,
Номер
20, С. 548 - 560
Опубликована: Июнь 29, 2022
Bacterial
outer
membrane
vesicles
(OMVs)
are
potent
immuno-stimulating
agents
and
have
the
potentials
to
be
bioengineered
as
platforms
for
antitumor
nanomedicine.
In
this
study,
OMVs
demonstrated
promising
therapeutics.
can
lead
beneficial
M2-to-M1
polarization
of
macrophages
induce
pyroptosis
enhance
immunity,
but
therapeutic
window
is
narrow
its
toxicity.
We
propose
a
bioengineering
strategy
tumor-targeting
ability
by
macrophage-mediated
delivery
improve
efficacy
co-loading
photosensitizer
chlorin
e6
(Ce6)
chemotherapeutic
drug
doxorubicin
(DOX)
into
platform.
demonstrate
that
systemic
injection
DOX/Ce6-OMVs@M
platform,
providing
combinational
photodynamic/chemo-/immunotherapy,
eradicates
triple-negative
breast
tumors
in
mice
without
side
effects.
Importantly,
also
effectively
prevents
tumor
metastasis
lung.
This
OMVs-based
with
may
serve
powerful
platform
synergic
therapy.
Biomaterials Research,
Год журнала:
2023,
Номер
27(1)
Опубликована: Фев. 9, 2023
With
the
great
success
of
coronavirus
disease
(COVID-19)
messenger
ribonucleic
acid
(mRNA)
vaccines,
mRNA
therapeutics
have
gained
significant
momentum
for
prevention
and
treatment
various
refractory
diseases.
To
function
efficiently
in
vivo
overcome
clinical
limitations,
demands
safe
stable
vectors
a
reasonable
administration
route,
bypassing
multiple
biological
barriers
achieving
organ-specific
targeted
delivery
mRNA.
Nanoparticle
(NP)-based
systems
representing
leading
vector
approaches
ensure
successful
intracellular
to
target
organ.
In
this
review,
chemical
modifications
types
advanced
NPs,
including
lipid
NPs
polymers
are
summarized.
The
importance
passive
targeting,
especially
endogenous
active
targeting
nano-delivery
is
emphasized,
different
cellular
endocytic
mechanisms
discussed.
Most
importantly,
based
on
above
content
physiological
structure
characteristics
organs
vivo,
design
strategies
cells
classified
Furthermore,
influence
routes
highlighted.
Finally,
an
outlook
remaining
challenges
future
development
toward
therapies
precision
medicine
provided.
Pharmaceuticals,
Год журнала:
2023,
Номер
16(10), С. 1360 - 1360
Опубликована: Сен. 26, 2023
The
World
Health
Organization
identifies
tuberculosis
(TB),
caused
by
Mycobacterium
tuberculosis,
as
a
leading
infectious
killer.
Although
conventional
treatments
for
TB
exist,
they
come
with
challenges
such
heavy
pill
regimen,
prolonged
treatment
duration,
and
strict
schedule,
to
multidrug-resistant
(MDR)
extensively
drug-resistant
(XDR)
strains.
rise
of
MDR
strains
endangers
future
control.
Despite
these
concerns,
the
hunt
an
efficient
continues.
One
breakthrough
has
been
use
nanotechnology
in
medicines,
presenting
novel
approach
treatment.
Nanocarriers,
lipid
nanoparticles,
nanosuspensions,
liposomes,
polymeric
micelles,
facilitate
targeted
delivery
anti-TB
drugs.
benefits
nanocarriers
include
reduced
drug
doses,
fewer
side
effects,
improved
solubility,
better
bioavailability,
patient
compliance,
speeding
up
recovery.
Additionally,
can
be
made
even
more
linking
them
ligands
mannose
or
hyaluronic
acid.
This
review
explores
innovative
treatments,
including
studies
on
containing
drugs
related
patents.
Frontiers in Pharmacology,
Год журнала:
2023,
Номер
14
Опубликована: Март 6, 2023
Prolonged
exposure
to
environmental
respirable
toxicants
can
lead
the
development
and
worsening
of
severe
respiratory
diseases
such
as
asthma,
chronic
obstructive
pulmonary
disease
(COPD)
fibrosis.
The
limited
number
FDA-approved
inhaled
drugs
for
these
serious
lung
conditions
has
led
a
shift
from
in
vivo
towards
use
alternative
vitro
human-relevant
models
better
predict
toxicity
particles
preclinical
research.
While
there
are
several
inhalation
upper
airways,
fragile
dynamic
nature
alveolar
microenvironment
reproducible
distal
lung.
Here,
we
present
mechanistic
approach
using
new
generation
systems,
Cloud
α
AX12.
This
novel
tool
consists
cloud-based
chamber
(VITROCELL)
that
integrates
breathing
AX
Lung-on-chip
system
(AlveoliX).
ultrathin
porous
membrane
AX12
plate
was
used
create
complex
multicellular
model
enables
key
physiological
culture
conditions:
air-liquid
interface
(ALI)
three-dimensional
cyclic
stretch
(CS).
Human-relevant
cellular
were
established
a)
alveolar-capillary
primary
cell-derived
immortalized
epithelial
cells
(
iAECs),
macrophages
(THP-1)
endothelial
(HLMVEC)
cells,
b)
upper-airways
Calu3
cells.
Primary
human
hAEpCs)
validate
results
obtained
cell
lines.
To
mimic
relevant
aerosol
exposures
with
AX12,
three
different
using:
titanium
dioxide
(TiO2)
zinc
oxide
nanoparticles
polyhexamethylene
guanidine
toxic
chemical
c)
an
anti-inflammatory
corticosteroid,
fluticasone
propionate
(FL).
Our
suggest
important
synergistic
effect
on
air-blood
barrier
sensitivity,
cytotoxicity
inflammation,
when
combined.
best
our
knowledge,
this
is
first
time
been
described
lung-on-chip
technology.
thus
represents
state-of-the-art
pre-clinical
study
risks,
drug
safety
efficacy.
Polymers,
Год журнала:
2023,
Номер
15(18), С. 3849 - 3849
Опубликована: Сен. 21, 2023
The
evolution
of
respiratory
diseases
represents
a
considerable
public
health
challenge,
as
they
are
among
the
leading
causes
death
worldwide.
In
this
sense,
in
addition
to
high
prevalence
such
asthma,
chronic
obstructive
pulmonary
disease,
pneumonia,
cystic
fibrosis,
and
lung
cancer,
emerging
diseases,
particularly
those
caused
by
members
coronavirus
family,
have
contributed
significant
number
deaths
on
global
scale
over
last
two
decades.
Therefore,
several
studies
been
conducted
optimize
efficacy
treatments
against
these
focusing
drug
delivery
using
nanomedicine.
Thus,
development
nanocarriers
has
emerged
promising
alternative
overcome
limitations
conventional
therapy,
increasing
bioavailability
at
target
site
reducing
unwanted
side
effects.
context,
nanoparticles
composed
chitosan
(CS)
show
advantages
other
because
possesses
intrinsic
biological
properties,
anti-inflammatory,
antimicrobial,
mucoadhesive
capacity.
Moreover,
CS
potential
enhance
stability,
prolong
duration
action,
improve
targeting,
control
release,
dissolution
poorly
soluble
drugs,
increase
cell
membrane
permeability
hydrophobic
drugs.
These
properties
could
performance
after
its
administration.
review
aims
discuss
for
delivery,
highlighting
how
their
can
treatment
including
synergistic
action
with
encapsulated
drug.
Drug Delivery and Translational Research,
Год журнала:
2024,
Номер
14(11), С. 3032 - 3054
Опубликована: Апрель 13, 2024
Cell-mediated
nanoparticle
delivery
systems
(CMNDDs)
utilize
cells
as
carriers
to
deliver
the
drug-loaded
nanoparticles.
Unlike
traditional
drug
approaches,
CMNDDs
take
advantages
of
cell
characteristics,
such
homing
capabilities
stem
cells,
inflammatory
chemotaxis
neutrophils,
prolonged
blood
circulation
red
and
internalization
macrophages.
Subsequently,
can
easily
prolong
circulation,
cross
biological
barriers,
blood-brain
barrier
bone
marrow-blood
barrier,
rapidly
arrive
at
diseased
areas.
Such
advantageous
properties
make
promising
candidates
for
precision
targeting.
In
this
review,
we
summarize
recent
advances
in
fabrication
biomedical
applications.
Specifically,
ligand-receptor
interactions,
non-covalent
covalent
are
commonly
applied
constructing
vitro.
By
hitchhiking
macrophages,
monocytes,
platelets,
nanoparticles
be
internalized
or
attached
construct
vivo.
Then
highlight
application
treating
different
diseases,
cancer,
central
nervous
system
disorders,
lung
cardiovascular
with
a
brief
discussion
about
challenges
future
perspectives
end.
