The effects of aging in the hippocampus and cognitive decline

Neuroscience & Biobehavioral Reviews, Год журнала: 2017, Номер 79, С. 66 - 86

Опубликована: Май 2, 2017

Язык: Английский

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d-Galactose-induced accelerated aging model: an overview

Biogerontology, Год журнала: 2019, Номер 20(6), С. 763 - 782

Опубликована: Сен. 20, 2019

Язык: Английский

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Role of D-galactose-induced brain aging and its potential used for therapeutic interventions

Experimental Gerontology, Год журнала: 2017, Номер 101, С. 13 - 36

Опубликована: Ноя. 10, 2017

Язык: Английский

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Fecal Microbiota Transplantation (FMT) Alleviates Experimental Colitis in Mice by Gut Microbiota Regulation

Journal of Microbiology and Biotechnology, Год журнала: 2020, Номер 30(8), С. 1132 - 1141

Опубликована: Июль 2, 2020

Язык: Английский

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Caffeine prevents d-galactose-induced cognitive deficits, oxidative stress, neuroinflammation and neurodegeneration in the adult rat brain

Neurochemistry International, Год журнала: 2015, Номер 90, С. 114 - 124

Опубликована: Июль 21, 2015

Язык: Английский

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Anti-senescence compounds: A potential nutraceutical approach to healthy aging

Ageing Research Reviews, Год журнала: 2018, Номер 46, С. 14 - 31

Опубликована: Май 6, 2018

Язык: Английский

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Chinese herbal medicine for Alzheimer’s disease: Clinical evidence and possible mechanism of neurogenesis

Biochemical Pharmacology, Год журнала: 2017, Номер 141, С. 143 - 155

Опубликована: Июль 8, 2017

Язык: Английский

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Polydatin attenuatesd-galactose-induced liver and brain damage through its anti-oxidative, anti-inflammatory and anti-apoptotic effects in mice

Food & Function, Год журнала: 2016, Номер 7(11), С. 4545 - 4555

Опубликована: Янв. 1, 2016

Accumulating evidence has shown that chronic injection of d-galactose (d-gal) can mimic natural aging, with accompanying liver and brain injury. Oxidative stress apoptosis play a vital role in the aging process. In this study, antioxidant ability polydatin (PD) was investigated using four established vitro systems. An vivo study also conducted to investigate possible protective effect PD on d-gal-induced damage. The results showed had remarkable free radical scavenging activity 2,2-diphenyl-1-picryl-hydrazyl (DPPH˙), 2,2'-azino-bis(3-ethylbenzo-thiazoline-6-sulfonic acid) (ABTS+˙) ions, hydroxyl superoxide anions. Results indicated that, group treated d-gal plus PD, remarkably decreased depression body weight organ indexes, reduced levels serum alanine aminotransferase (ALT) aspartate (AST), alleviated alterations histopathology. significantly level MDA elevated SOD, GSH-Px, CAT T-AOC brain. addition, inflammatory mediators, such as TNF-α, IL-1β IL-6 were markedly after treatment. Western blotting revealed treatment noticeably attenuated elevation Bcl-2/Bax ratio caspase-3 protein expression Overall, our findings indicate could effectively attenuate damage, mechanism might be associated decreasing oxidative stress, inflammation caused by d-gal. holds good potential for further development into promising pharmaceutical candidate age-associated diseases.

Язык: Английский

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Salidroside suppresses inflammation in a D-galactose-induced rat model of Alzheimer’s disease via SIRT1/NF-κB pathway

Metabolic Brain Disease, Год журнала: 2016, Номер 31(4), С. 771 - 778

Опубликована: Фев. 24, 2016

Язык: Английский

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The effects of ginsenoside Rg1 on chronic stress induced depression-like behaviors, BDNF expression and the phosphorylation of PKA and CREB in rats

Neuroscience, Год журнала: 2016, Номер 322, С. 358 - 369

Опубликована: Фев. 28, 2016

Язык: Английский

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