Frontiers in Bioengineering and Biotechnology,
Год журнала:
2023,
Номер
11
Опубликована: Март 13, 2023
The
rapid
healing
and
repair
of
skin
wounds
has
been
receiving
much
clinical
attention.
Covering
the
wound
with
dressing
to
promote
is
currently
main
treatment
for
repair.
However,
performance
prepared
by
a
single
material
limited
cannot
meet
requirements
complex
conditions
healing.
MXene
new
two-dimensional
electrical
conductivity,
antibacterial
photothermal
properties
other
physical
biological
properties,
which
wide
range
applications
in
field
biomedicine.
Based
on
pathophysiological
process
ideal
dressing,
this
review
will
introduce
preparation
modification
methods
MXene,
systematically
summarize
application
status
mechanism
healing,
provide
guidance
subsequent
researchers
further
apply
design
dressing.
Pharmaceutics,
Год журнала:
2023,
Номер
15(7), С. 1829 - 1829
Опубликована: Июнь 26, 2023
Nanofiber
scaffolds
have
emerged
as
a
revolutionary
drug
delivery
platform
for
promoting
wound
healing,
due
to
their
unique
properties,
including
high
surface
area,
interconnected
porosity,
excellent
breathability,
and
moisture
absorption,
well
spatial
structure
which
mimics
the
extracellular
matrix.
However,
use
of
nanofibers
achieve
controlled
loading
release
still
presents
many
challenges,
with
ongoing
research
exploring
how
load
drugs
onto
nanofiber
without
loss
activity
control
in
specific
spatiotemporal
manner.
This
comprehensive
study
systematically
reviews
applications
recent
advances
related
drug-laden
skin-wound
management.
First,
we
introduce
commonly
used
methods
preparation,
electrostatic
spinning,
sol-gel,
molecular
self-assembly,
thermally
induced
phase
separation,
3D-printing
techniques.
Next,
summarize
polymers
preparation
utilizing
scaffolds.
We
then
review
application
drug-loaded
considering
different
stages
healing
acts.
Finally,
briefly
describe
stimulus-responsive
schemes
scaffolds,
other
exciting
systems.
Journal of Nanobiotechnology,
Год журнала:
2023,
Номер
21(1)
Опубликована: Июль 24, 2023
Abstract
The
stimuli-responsive
nanofibers
prepared
by
electrospinning
have
become
an
ideal
material
due
to
their
large
specific
surface
area
and
porosity,
which
can
respond
extremely
quickly
external
environmental
incitement.
As
intelligent
drug
delivery
platform,
efficiently
load
drugs
then
be
stimulated
conditions
(light,
temperature,
magnetic
field,
ultrasound,
pH
or
ROS,
etc.)
achieve
slow,
on-demand
targeted
release,
showing
great
potential
in
areas
such
as
delivery,
tumor
therapy,
wound
dressing,
tissue
engineering.
Therefore,
this
paper
reviews
the
recent
trends
of
electrospun
platforms
field
biomedicine.
Biomolecules,
Год журнала:
2024,
Номер
14(7), С. 789 - 789
Опубликована: Июль 3, 2024
Alginate
is
a
natural
polymer
with
good
biocompatible
properties
and
potential
polymeric
material
for
the
sustainable
development
replacement
of
petroleum
derivatives.
However,
non-spinnability
pure
alginate
solutions
has
hindered
expansion
applications.
With
continuous
electrospinning
technology,
synthetic
polymers,
such
as
PEO
PVA,
are
used
co-spinning
agents
to
increase
spinnability
alginate.
Moreover,
coaxial,
parallel
Janus,
tertiary
other
diverse
novel
electrospun
fiber
structures
prepared
by
multi-fluid
have
found
new
breakthrough
problem
poor
spinning
polymers.
Meanwhile,
effectively
achieve
multiple
release
modes
drugs.
The
powerful
combination
electrostatic
widely
in
many
biomedical
fields,
tissue
engineering,
regenerative
bioscaffolds,
drug
delivery,
research
fever
continues
climb.
This
particularly
true
controlled
delivery
aspect
review
provides
brief
overview
alginate,
introduces
advances
spinning,
highlights
progress
alginate-based
nanofibers
achieving
various
modes,
pulsed
release,
sustained
biphasic
responsive
targeted
release.
International Journal of Pharmaceutics X,
Год журнала:
2024,
Номер
8, С. 100265 - 100265
Опубликована: Июнь 26, 2024
Cancer
remains
a
major
global
health
challenge,
and
despite
available
treatments,
its
prognosis
poor.
Recently,
researchers
have
turned
their
attention
to
intelligent
nanofibers
for
cancer
drug
delivery.
These
exhibit
remarkable
capabilities
in
targeted
controlled
release.
Their
inherent
characteristics,
such
as
high
surface
area-to-volume
ratio,
make
them
attractive
candidates
delivery
applications.
Smart
can
release
drugs
response
specific
stimuli,
including
pH,
temperature,
magnetic
fields,
light.
This
unique
feature
not
only
reduces
side
effects
but
also
enhances
the
overall
efficiency
of
systems.
Electrospinning,
widely
used
method,
allows
precision
fabrication
smart
nanofibers.
Its
advantages
include
efficiency,
user-friendliness,
ability
control
various
manufacturing
parameters.
In
this
review,
we
explore
latest
developments
producing
electrospun
treatment.
Additionally,
discuss
materials
these
critical
parameters
involved
electrospinning
process.
Biomedicine & Pharmacotherapy,
Год журнала:
2022,
Номер
157, С. 113996 - 113996
Опубликована: Ноя. 15, 2022
A
Non-healing
infected
wound
is
an
ever-growing
global
epidemic,
with
increasing
burden
of
mortality
rates
and
management
costs.
The
problems
chronic
infections
their
outcomes
will
continue
as
long
underlying
causes
like
diabetic
wounds
grow
spread.
Commercial
therapies
employed
have
limited
potential
that
inhibits
pivotal
functions
tissue
re-epithelialization
properties
resulting
in
infections.
Nanomaterial
based
drug
delivery
formulations
involving
biological
macromolecules
are
developing
areas
interest
healing
applications
which
utilized
the
skin
cost-effective
preparations.
Research
conducted
on
nanofibers
has
shown
enhanced
establishment
improved
cell
proliferation
growth
bioactive
organic
molecules
at
site.
However,
targeted
anti-scarring
regeneration
aspects
not
been
updated
discussed
case
macromolecule
impregnated
nanofibrous
mats.
Hence,
this
review
focuses
brief
concepts
management,
therapeutic
commercialized
dressings
currently
available
field
care,
effective
electrospun
different
advancement
nanomaterials
for
engineering
discussed.
These
new
findings
pave
way
producing
high
scaffolds
delivery.
Biomolecules,
Год журнала:
2022,
Номер
12(12), С. 1727 - 1727
Опубликована: Ноя. 22, 2022
Chronic
diabetic
wounds
are
one
of
the
main
complications
diabetes,
manifested
by
persistent
inflammation,
decreased
epithelialization
motility,
and
impaired
wound
healing.
This
will
not
only
lead
to
repeated
hospitalization
patients,
but
also
bear
expensive
costs.
In
severe
cases,
it
can
amputation,
sepsis
or
death.
Electrospun
nanofibers
membranes
have
characteristics
high
porosity,
specific
surface
area,
easy
functionalization
structure,
so
they
be
used
as
a
safe
effective
platform
in
treatment
great
application
potential.
article
briefly
reviewed
pathogenesis
chronic
types
dressings
commonly
used,
then
development
electrospinning
technology
recent
years
advantages
electrospun
wounds.
Finally,
reports
different
nanofiber
on
summarized,
method
using
multi-drug
combination
therapy
is
emphasized,
which
provides
new
ideas
for
Macromolecular Bioscience,
Год журнала:
2022,
Номер
23(2)
Опубликована: Ноя. 21, 2022
The
development
of
tissue
engineering
scaffolds
is
great
significance
for
the
repair
and
regeneration
damaged
tissues
organs.
Silk
fibroin
(SF)
a
natural
protein
polymer
with
good
biocompatibility,
biodegradability,
excellent
physical
mechanical
properties
processability,
making
it
an
ideal
universal
scaffold
material.
Nanofibers
prepared
by
electrospinning
have
attracted
extensive
attention
in
field
due
to
their
properties,
high
specific
surface
area,
similar
morphology
as
extracellular
matrix
(ECM).
combination
silk
promising
strategy
preparation
scaffolds.
In
this
review,
research
progress
electrospun
nanofibers
skin,
vascular,
bone,
neural,
tendons,
cardiac,
periodontal,
ocular
other
discussed
detail.
