Abstract
Rheumatoid
arthritis
and
osteoarthritis,
the
most
common
forms
of
arthritis,
are
chronic,
painful,
disabling
conditions.
Although
both
diseases
differ
in
etiology,
they
manifest
progressive
joint
destruction
characterized
by
pathological
changes
articular
cartilage,
bone,
synovium.
While
potent
anti-inflammatory
properties
therapeutic
(i.e.,
exogenous)
glucocorticoids
have
been
heavily
researched
widely
used
clinical
practice,
role
endogenous
susceptibility
disease
progression
remains
poorly
understood.
Current
evidence
from
mouse
models
suggests
that
local
glucocorticoid
signaling
is
upregulated
pro-inflammatory
microenvironment
rheumatoid
aging-related
mechanisms
osteoarthritis.
Furthermore,
these
indicate
macrophages,
mast
cells,
chondrocytes
has
effects,
while
fibroblast-like
synoviocytes,
myocytes,
osteoblasts,
osteocytes
actions
arthritis.
Conversely,
osteoblasts
destructive
actions.
Together
studies
provide
insights
into
pathogenesis
inflammatory
degenerative
disease.
Cells,
Год журнала:
2022,
Номер
11(6), С. 1017 - 1017
Опубликована: Март 17, 2022
Aging
is
the
greatest
risk
factor
for
nearly
all
major
chronic
diseases,
including
cardiovascular
cancer,
Alzheimer’s
and
other
neurodegenerative
diseases
of
aging.
Age-related
impairment
immune
function
(immunosenescence)
one
important
cause
age-related
morbidity
mortality,
which
may
extend
beyond
its
role
in
infectious
disease.
One
aspect
immunosenescence
that
has
received
less
attention
natural
killer
(NK)
cell
dysfunction,
characterized
by
reduced
cytokine
secretion
decreased
target
cytotoxicity,
accompanied
despite
an
increase
NK
numbers
with
age.
Moreover,
recent
studies
have
revealed
cells
are
central
actors
immunosurveillance
senescent
cells,
whose
accumulation
itself
a
probable
contributor
to
sterile
low-grade
inflammation
developed
aging
(“inflammaging”).
dysfunction
therefore
implicated
increasing
burden
infection,
malignancy,
inflammatory
disorders,
This
review
will
focus
on
advances
open
questions
understanding
interplay
between
systemic
inflammation,
senescence
burden,
context
Understanding
factors
driving
enforcing
potentially
lead
therapies
countering
underlying
drivers
biological
process
itself.
Frontiers in Endocrinology,
Год журнала:
2023,
Номер
14
Опубликована: Март 6, 2023
Stress
is
viewed
as
a
state
of
real
or
perceived
threat
to
homeostasis,
the
management
which
involves
endocrine,
nervous,
and
immune
systems.
These
systems
work
independently
interactively
part
stress
response.
The
scientific
literature,
spans
both
animal
human
studies,
contains
heterogeneous
findings
about
effects
on
brain
body.
This
review
seeks
summarise
integrate
literature
relationships
between
these
systems,
examining
particularly
roles
physiological
psychosocial
stress,
hormone
cortisol,
controlled
by
hypothalamic-pituitary-adrenal
(HPA)
axis,
cognitive
functioning.
Health
conditions
related
impaired
HPA
axis
functioning
their
associated
neuropsychiatric
symptoms
will
also
be
considered.
Lastly,
this
provide
suggestions
clinical
applicability
for
endocrinologists
who
are
uniquely
placed
measure
outcomes
nervous
system
identify
areas
intervention.
Animals,
Год журнала:
2023,
Номер
13(2), С. 317 - 317
Опубликована: Янв. 16, 2023
Compared
to
other
animal
species,
production
has
dramatically
increased
in
the
poultry
sector.
However,
intensive
systems,
are
subjected
stress
conditions
that
may
compromise
their
well-being.
Much
like
living
organisms,
respond
various
stressors
by
synthesising
a
group
of
evolutionarily
conserved
polypeptides
named
heat
shock
proteins
(HSPs)
maintain
homeostasis.
These
proteins,
as
chaperones,
play
pivotal
role
protecting
animals
against
re-establishing
normal
protein
conformation
and,
thus,
cellular
In
last
few
decades,
many
advances
have
been
made
ascertaining
HSP
response
thermal
and
non-thermal
poultry.
The
present
review
focuses
on
what
is
currently
known
about
discusses
factors
modulate
its
induction
regulatory
mechanisms.
development
practical
strategies
alleviate
detrimental
effects
environmental
stresses
will
benefit
from
detailed
studies
describe
mechanisms
resilience
enhance
our
understanding
nature
signalling
gene
expression.
Aging,
Год журнала:
2020,
Номер
12(6), С. 5551 - 5565
Опубликована: Март 27, 2020
Chronologically-aged
skin
displays
multiple
functional
changes
in
both
the
dermis
and
epidermis.
It
appears
that
epidermal
dysfunction,
compromised
permeability
homeostasis,
reduced
stratum
corneum
hydration
elevated
surface
pH
predispose
to
development
of
aging-associated
cutaneous
extracutaneous
disorders.
Improvements
function
have
been
shown
be
an
effective
alternative
therapy
prevention
treatment
some
disorders,
including
eczematous
dermatitis,
pruritus,
xerosis.
Recent
studies
demonstrated
dysfunction
leads
chronic,
low-grade
systemic
inflammation,
termed
'inflammaging,'
which
is
linked
Thus,
correction
could
comprise
a
novel
strategy
disorders
as
well.
In
this
review,
we
summarize
alterations
function,
their
underlying
mechanisms,
clinical
significance.
Regimens
improve
elderly
are
also
discussed.
Scientific Reports,
Год журнала:
2021,
Номер
11(1)
Опубликована: Сен. 29, 2021
Abstract
Anxiety
is
recognized
as
a
major
health
issue
and
quite
prevalent
among
older
adults.
An
efficient
way
to
manage
anxiety
abdominal
breathing.
Breathing
exercises
seem
reduce
increase
parasympathetic
activity
assessed
by
HRV
indexes.
Yet,
the
effect
of
breathing
on
physiological
stress
(HRV)
in
adults
remains
poorly
understood.
Therefore,
aim
this
study
test
effects
deep
slow
(DSB,
low
inhale/exhale
ratio)
(n
=
22)
comparison
with
younger
ones
25).
DSB
increased
significantly
HFpower
reduced
state
both
Interestingly,
HF
power
was
higher
than
ones.
As
expected,
ratio
being
not
equal,
RMSSD
did
following
DSB.
Thus,
we
provide
evidence
suggesting
that
more
beneficial
restore
vagal
outflow.
Despite
future
work
required,
those
results
relevant
clinical
application
leads
promote
successfull
aging.
Aging,
Год журнала:
2020,
Номер
12(23), С. 24371 - 24393
Опубликована: Дек. 9, 2020
There
is
ample
scientific
and
clinical
evidence
of
the
effects
gut
microbiota
on
brain
but
no
definitive
that
can
affect
changes
in
under
bi-directional
gut-brain
axis
concept.
As
there
pharmacotherapeutic
intervention
for
early
stages
cognitive
decline,
research
has
focused
stimulation
reversing
or
slowing
impairment.
Elderly
patients
diagnosed
with
mild
impairment
underwent
a
randomized-control
trial
mindful
awareness
practice.
Neuropsychological
assessments,
inflammatory
markers,
profiles
were
tested.
Here,
we
report
their
was
improved
associated
bacterial
profile.
A
cognition-score-dependent-abundance
observed
Ruminococcus
vs
Recognition
Trials
(RT),
Digit
Span
Backward
(DSB),
Semantic
Fluency
(SFS)
Memory
Domain
(MD);
Coprococcus
DSB,
Color
Trails
Test
2
(CTT2)
Block
Design
(BD);
Parabacteroides
DSB
SFS;
Fusobacterium
CTT2;
Enterobacteriaceae
BD
Ruminococcaceae
DSB;
Phascolarctobacterium
MD.
The
study
showed
first-time,
alteration
capacity
leading
to
corresponding
profiles.
This
strongly
suggests
signals
from
different
segments
could
dictate
directly
indirectly
abundances
specific
microbes.
Journal of Pineal Research,
Год журнала:
2021,
Номер
71(1)
Опубликована: Июнь 4, 2021
Melatonin
is
the
primary
circadian
output
signal
from
brain
and
mainly
synthesized
in
pinealocytes.
The
rhythm
secretion
of
melatonin
are
under
control
an
endogenous
oscillator
located
SCN
or
master
biological
clock.
Disruptions
rhythms
by
shift
work,
aging,
light
at
night
associated
with
bone
loss
increased
fracture
risk.
Restoration
nocturnal
peaks
to
normal
levels
therapeutic
through
timed
supplementation
has
been
demonstrated
provide
bone-protective
actions
various
models.
a
unique
molecule
diverse
molecular
targeting
receptors
on
plasma
membrane
mitochondria
acting
independently
its
as
antioxidant
free
radical
scavenger
stimulate
osteoblastogenesis,
inhibit
osteoclastogenesis,
improve
density.
Its
additional
entraining
improving
quality
life
aging
population
coupled
safety
profile
make
it
ideal
candidate
for
protecting
against
susceptible
populations.
intent
this
review
focused
discussion
disorders
relates
conditions
that
modify
hope
future
therapies
include
those
correct
factors
like
disruption.
