Cell death regulation: A new way for natural products to treat osteoporosis

Pharmacological Research, Год журнала: 2022, Номер 187, С. 106635 - 106635

Опубликована: Дек. 26, 2022

Osteoporosis is a common metabolic bone disease that results from the imbalance of homeostasis within bone. Intra-bone dependent on precise dynamic balance between resorption by osteoclasts and formation mesenchymal lineage osteoblasts, which comprises series complex highly standardized steps. Programmed cell death (PCD) (e.g., apoptosis, autophagy, ferroptosis, pyroptosis, necroptosis) process involves cascade gene expression events with tight structures. These play certain role in regulating metabolism determining fate cells. Moreover, existing research has suggested natural products derived wide variety dietary components medicinal plants modulate PCDs based different mechanisms, show great potential for prevention treatment osteoporosis, thus revealing emergence more acceptable complementary alternative drugs lower costs, fewer side effects long-term application. Accordingly, this review summarizes types field osteoporosis. perspective targeting PCDs, also discussed roles currently reported osteoporosis involved mechanisms. Based this, provides insights into new molecular mechanisms reference developing anti-osteoporosis future.

Язык: Английский

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Topography-mediated immunomodulation in osseointegration; Ally or Enemy

Biomaterials, Год журнала: 2022, Номер 291, С. 121903 - 121903

Опубликована: Ноя. 9, 2022

Язык: Английский

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Host-microbiome interactions regarding peri-implantitis and dental implant loss

Journal of Translational Medicine, Год журнала: 2022, Номер 20(1)

Опубликована: Сен. 22, 2022

In the last decades, ortho-aesthetic-functional rehabilitation had significant advances with advent of implantology. Despite success in implantology surgeries, there is a percentage failures mainly due to loco infections, through bacterial proliferation, presence fungi and biofilm formation, originating peri-implantitis. this sense, several studies have been conducted since then, seeking answers numerous questions that remain unknown. Thus, present work aims discuss interaction between host-oral microbiome development Peri-implantitis was associated diversity species, being Porphiromonas gingivalis, Treponema denticola Tannerella forsythia described higher proportion peri-implantitis samples. parallel role, injury peri-implant tissue causes an inflammatory response mediated by activation innate immune cells such as macrophages, dendritic cells, mast neutrophils. summary, host system may lead imbalance oral microbiota, and, turn, microbiota dysbiosis reported leading cytokines, chemokines, prostaglandins, proteolytic enzymes production. These biological processes be responsible for implant loss.

Язык: Английский

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Effects of Mechanical Stress Stimulation on Function and Expression Mechanism of Osteoblasts

Frontiers in Bioengineering and Biotechnology, Год журнала: 2022, Номер 10

Опубликована: Фев. 17, 2022

Osteoclasts and osteoblasts play a major role in bone tissue homeostasis. The homeostasis integrity of are maintained by ensuring balance between osteoclastic osteogenic activities. remodeling is continuous ongoing process. mainly resorption, whereas involved processes, such as cell formation, mineralization, secretion. These types restrict each other to maintain metabolism. Bone very sensitive mechanical stress stimulation. Unloading loading closely related the differentiation formation osteoclasts resorption function well function. Consequently, exerts an important influence on microenvironment This review focuses effects different forms stimulation (including gravity, continuously compressive pressure, tensile strain, fluid shear stress) osteoclast osteoblast expression mechanism. article highlights involvement activating transduction pathways reports changings their differentiation, functional mechanism induced application tissue. could provide new ideas for further microscopic studies health, disease, damage reconstruction.

Язык: Английский

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Osteoimmune regulation underlies oral implant osseointegration and its perturbation

Frontiers in Immunology, Год журнала: 2023, Номер 13

Опубликована: Янв. 24, 2023

In the field of biomaterials, an endosseous implant is now recognized as osteoimmunomodulatory but not bioinert biomaterial. Scientific advances in bone cell biology and immunology have revealed a close relationship between immune systems resulting science called osteoimmunology. These discoveries allowed for novel interpretation osseointegration representing osteoimmune reaction rather than classic healing response, which activation state macrophages ((M1-M2 polarization) appears to play critical role. Through this viewpoint, system responsible isolating biomaterial foreign body by forming around oral effectively shielding off from host system, i.e. becomes continuous dynamic defense reaction. At same time, has led proposal new model osseointegration, equilibrium (FBE). addition, wound, soft tissues are involved with all their innate characteristics. When integration viewed reaction, implications how marginal regulated. For example, while bacteria constitutive components tissue sulcus, if inflammatory front at some distance bone, established. If however, inflammation approaches osteoclastic occurs removed. A number clinical scenarios can be envisioned whereby disturbed loss occurs, such complications aseptic nature synergistic pro-inflammatory pathways (implant/wear debris, DAMPs, PAMPs). Understanding that reacts osteoimmunologically shield allows distinction drawn osteoimmunological conditions peri-implant loss. This review will examine dental placement its

Язык: Английский

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Recent Clinical Treatment and Basic Research on the Alveolar Bone

Biomedicines, Год журнала: 2023, Номер 11(3), С. 843 - 843

Опубликована: Март 10, 2023

The periodontal ligament is located between the bone (alveolar bone) and cementum of tooth, it connected by tough fibers called Sharpey's fibers. To maintain healthy teeth, foundation supporting teeth must be healthy. Periodontal diseases, also known as tooth loss, cause alveolar to dissolve. bone, similar bones in other body parts, repeatedly resorbed osteoclasts renewed osteogenic cells. This means that an old constantly being replaced a new bone. In around absorbed, disease progresses, shrinks gradually. most cases, does not return its original form even after cured. Gum covers surface so matches shape exposing more than before, making look longer, leaving gaps some cases causing sting. Previously, only treatment for diseases was stop from progressing further before fell out, restoration condition almost impossible. However, method can help regeneration tissues destroyed their state much possible introduced. Recently, with improvements implant material properties, therapy has become indispensable dentistry important prosthetic option. Treatment methods techniques, which are mainly based on experience, have gradually accumulated scientific evidence, number indications increased. development augmentation contributed remarkably expansion indications, this been made various advances materials science. induced pluripotent stem cell (iPS) technology regenerating tissues, including expected applied such loss periodontitis. review focuses describes clinical practice, latest basic research.

Язык: Английский

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Current Knowledge on the Healing of the Extraction Socket: A Narrative Review

Bioengineering, Год журнала: 2023, Номер 10(10), С. 1145 - 1145

Опубликована: Сен. 29, 2023

The concept of extraction socket healing has been severally researched and reported over the years, since tooth remains one most common procedures performed in dental clinic. Understanding this process is utmost importance because outcome a direct bearing on future prosthetic rehabilitation and, by extension, patients’ esthetics masticatory function, among others. This mini review, therefore, summarized current knowledge different stages healing, including biologic clinical events that occur following up until complete closure socket. Additionally, modeling alveolar bone/process post extraction, resultant dimensional changes that, altogether, shape bone, were reviewed documented. effects various preservation interventions to mitigate these changes, therefore preserve condition suitable for rehabilitation, highlighted. Finally, review some factors influence entire was also carried out.

Язык: Английский

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Multifunctionalized and Dual‐Crosslinked Hydrogel Promotes Inflammation Resolution and Bone Regeneration via NLRP3 Inhibition in Periodontitis

Small Structures, Год журнала: 2024, Номер 5(3)

Опубликована: Фев. 5, 2024

Alveolar bone resorption caused by bacteria‐induced periodontitis remains challenging due to sustained inflammation. Periodontal pathogens like Porphyromonas gingivalis launch the primed signal of NOD‐like receptor family pyrin domain‐containing 3 (NLRP3) inflammasome in macrophages; consequent overproduction proinflammatory cytokines and reactive oxygen species (ROS) leads tissue destruction. This provides potential targets for a new therapeutic strategy. Herein, multifunctionalized dual‐crosslinked hydrogel pGM/cPL@NI with NLRP3 inhibitor MCC950 loaded is prepared. Driven strategic functionalization gelatin methacryloyl ε ‐poly‐lysine phenylboronic acid catechol, respectively, containing dynamic photo‐crosslinking networks demonstrates superior mechanical strength stimuli‐responsive behavior, as well overwhelmed performance bacteria killing ROS scavenging. Crucially, restores compromised osteogenesis specifically suppressing cytokine cascade triggered activation promoting anti‐inflammatory polarization macrophages. Collectively, presents robust an effective “cocktail therapy” combining antibacterial, antioxidant, inflammation resolution, regenerative functions. The present study reveals underlying mechanism bacterial‐immune‐regeneration extended approach periodontal engineering.

Язык: Английский

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Correlation between Inflammasomes and Microbiota in Peri-Implantitis

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(2), С. 961 - 961

Опубликована: Янв. 12, 2024

The activation of inflammasomes is thought to induce the inflammatory process around dental implants. No information available on correlation between microbiota and in clinical samples from patients suffering peri-implantitis. For this cross-sectional study, 30 biofilm were obtained 19 undergoing surgical treatment for peri-implantitis because presence bleeding probing, probing depth higher than 6 mm, radiographic bone loss 3 mm. Then, soft tissue implant also collected. relative abundance bacteria alpha-diversity indexes calculated after analyzing 16S rRNA gene using next-generation sequencing. soft-tissue processed evaluation NLRP3 AIM2 as well caspase-1 IL-1β. (mean (SD)) specific species indicated that most abundant Porphyromonas gingivalis (10.95 (14.17)%), Fusobacterium vincentii (10.93 (13.18)%), endodontalis (5.89 (7.23)%), Prevotella oris (3.88 (4.94)%), Treponema denticola (2.91 (3.19)%), Tannerella forsythia (2.84 (4.15)%). Several correlations found immunohistochemical detection IL-1β, both epithelium lamina propria. A network analysis an important cluster variables formed by propria AIM2, caspase-1, IL-1β with dentalis, tannerae, forsythia, or Selenomonas timonae. Thus, it could be concluded their downstream effectors interleukin-1β can significantly associated bacteria.

Язык: Английский

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The immune landscape in apical periodontitis: From mechanism to therapy

International Endodontic Journal, Год журнала: 2024, Номер 57(11), С. 1526 - 1545

Опубликована: Авг. 1, 2024

Apical periodontitis (AP) is featured by a persistent inflammatory response and alveolar bone resorption initiated microorganisms, posing risks to both dental systemic health. Nonsurgical endodontic treatment the recommended plan for AP with high success rate, but in some cases, periapical lesions may persist despite standard treatment. Better comprehension of microenvironment can help develop adjunct therapies improve outcome This review presents an overview immune landscape AP, elucidating how microbial invasion triggers host activation shapes microenvironment, ultimately impacting homeostasis. The destructive effect excessive on tissues emphasized. aimed systematically discuss immunological basis cell network thereby providing insights into potential immunotherapeutic strategies such as targeted therapy, antioxidant adoptive therapy cytokine mitigate AP-associated tissue destruction.

Язык: Английский

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