Ferroptosis and Triple-Negative Breast Cancer: A Systematic Overview of Prognostic Insights and Therapeutic Potential DOI Open Access
Mohsin Khan, Vyshnavidevi Sunkara, Mansi Yadav

и другие.

Cureus, Год журнала: 2024, Номер unknown

Опубликована: Янв. 5, 2024

In the realm of oncology, prognosis and treatment triple-negative breast cancer (TNBC) have long been challenges for researchers clinicians. Characterized by its aggressive nature limited therapeutic options, TNBC demands innovative approaches to understanding underlying mechanisms improving patient outcomes. One such avenue exploration that has emerged in recent years is study ferroptosis, a form regulated cell death driven iron-dependent lipid peroxidation. Ferroptosis garnered increasing attention due potential relevance context TNBC. This systematic review aims shed light on intricate interplay between ferroptosis The article delves into comprehensive examination existing literature provide holistic subject. By investigating as both an intervention prognostic factor TNBC, this seeks unravel target marker. emerging evidence heterogeneity underscore need approach assess impact will serve valuable resource researchers, clinicians, healthcare professionals striving enhance our knowledge explore novel avenues treatment.

Язык: Английский

Comprehensive insights into mechanism of nanotoxicity, assessment methods and regulatory challenges of nanomedicines DOI Creative Commons
Ujwal Havelikar,

Kabirdas B. Ghorpade,

Amit Kumar

и другие.

Discover Nano, Год журнала: 2024, Номер 19(1)

Опубликована: Окт. 4, 2024

Nanomedicine has the potential to transform healthcare by offering targeted therapies, precise diagnostics, and enhanced drug delivery systems. The National Institutes of Health coined term "nanomedicine" describe use nanotechnology in biological system monitoring, control, diagnosis, treatment. continues receive increasing interest for rationalized therapeutics pharmaceutical agents achieve required response while reducing its side effects. However, as advance, concerns about toxicological effects have also grown. This review explores current state nanomedicine, focusing on types nanoparticles used their associated properties that contribute nanotoxicity. It examines mechanisms through which exert toxicity, encompassing various cellular molecular interactions. Furthermore, it discusses assessment methods employed evaluate nanotoxicity, in-vitro in-vivo models, well emerging techniques. addresses regulatory issues surrounding nanotoxicology, highlighting challenges developing standardized guidelines ensuring secure translation nanomedicine into clinical settings. ethical with understanding safety profile is essential effective therapeutic applications.

Язык: Английский

Процитировано

18
Rosmarinic acid promotes mitochondrial fission and induces ferroptosis in triple-negative breast cancer cells DOI

Chufei Xie,

Liujia Chan,

Yuheng Pang

и другие.

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 25, 2025

Язык: Английский

Процитировано

6
Molecular mechanism of ZC3H13 -mediated ferroptosis in doxorubicin resistance of triple negative breast cancer DOI Creative Commons
Li‐Shan Huang, Lei Han, Shuai Liang

и другие.

Cell Biology and Toxicology, Год журнала: 2025, Номер 41(1)

Опубликована: Фев. 26, 2025

Triple negative breast cancer (TNBC) continues to be the most aggressive subtype of that frequently develops resistance chemotherapy. Doxorubicin (DOX) belongs anthracycline chemical class drug and is one widely used anticancer drugs. This study investigates mechanism m6A methyltransferase ZC3H13 in DOX TNBC. ZC3H13, KCNQ1OT1, TRABD expressions TNBC tissues or cells were detected by RT-qPCR Western blot. The effect on was evaluated CCK-8, clone formation, EdU staining. RIP performed analyze enrichment YTHDF2 KCNQ1OT1. RNA pull-down verified binding between KCNQ1OT1 MLL4. MLL H3K9me1/2/3 promoter analyzed ChIP. A nude mouse xenograft tumor model established verify vivo. poorly expressed TNBC, its expression further decreased drug-resistant cells. Overexpression IC50 DOX, repressed proliferation, induced ferroptosis. Mechanistically, ZC3H13-mediated modification reduced transcriptional stability inhibited a YTHDF2-dependent manner. enhanced H3K4me1/2/3 recruiting MLL4, thus increasing expression. ferroptosis inhibiting KCNQ1OT1/TRABD, thereby restraining growth DOX-treated tumors reduces promoting via KCNQ1OT1/TRABD axis.

Язык: Английский

Процитировано

2
Ferroptosis as a promising targeted therapy for triple negative breast cancer DOI

Kasra Mokhtarpour,

Sepideh Razi,

Nima Rezaei

и другие.

Breast Cancer Research and Treatment, Год журнала: 2024, Номер 207(3), С. 497 - 513

Опубликована: Июнь 14, 2024

Язык: Английский

Процитировано

9
Ferroptosis in Cancer Therapy: Mechanisms, Small Molecule Inducers, and Novel Approaches DOI Creative Commons

YiLin Luo,

Xin Yue Bai,

L.J. Zhang

и другие.

Drug Design Development and Therapy, Год журнала: 2024, Номер Volume 18, С. 2485 - 2529

Опубликована: Июнь 1, 2024

Abstract: Ferroptosis, a unique form of programmed cell death, is initiated by an excess iron accumulation and lipid peroxidation-induced damage. There growing body evidence indicating that ferroptosis plays critical role in the advancement tumors. The increased metabolic activity higher levels tumor cells make them particularly vulnerable to ferroptosis. As result, targeted induction becoming increasingly promising approach for cancer treatment. This review offers overview regulatory mechanisms ferroptosis, delves into mechanism action traditional small molecule inducers their effects on various In addition, latest progress inducing using new means such as proteolysis-targeting chimeras (PROTACs), photodynamic therapy (PDT), sonodynamic (SDT) nanomaterials summarized. Finally, this discusses challenges opportunities development ferroptosis-inducing agents, focusing discovering targets, improving selectivity, reducing toxic side effects. Keywords: inducers, molecules, PROTACs, PDT, SDT,

Язык: Английский

Процитировано

9
Apatinib combined with paclitaxel suppresses synergistically TNBC progression through enhancing ferroptosis susceptibility regulated SLC7A11/GPX4/ACSL4 axis DOI
Xiaoxia Ma, Di Cao, Yan Zhang

и другие.

Cellular Signalling, Год журнала: 2025, Номер unknown, С. 111760 - 111760

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

1
Exploring beyond Common Cell Death Pathways in Oral Cancer: A Systematic Review DOI Creative Commons
Leonardo de Oliveira Siquara da Rocha, Éverton Freitas de Morais, Lilianny Querino Rocha de Oliveira

и другие.

Biology, Год журнала: 2024, Номер 13(2), С. 103 - 103

Опубликована: Фев. 6, 2024

Oral squamous cell carcinoma (OSCC) is the most common and lethal type of head neck cancer in world. Variable response acquisition resistance to traditional therapies show that it essential develop novel strategies can provide better outcomes for patient. Understanding cellular molecular mechanisms death control has increased rapidly recent years. Activation pathways, such as emerging forms non-apoptotic programmed death, including ferroptosis, pyroptosis, necroptosis, NETosis, parthanatos, mitoptosis paraptosis, may represent clinically relevant therapeutic opportunities. This systematic review summarizes recently described OSCC, highlighting their potential informing diagnosis, prognosis treatment. Original studies explored any selected deaths OSCC were included. Electronic search, study selection, data collection risk bias assessment tools realized. The literature search was carried out four databases, extracted from 79 articles categorized grouped by death. Ferroptosis, necroptosis represented main studies, with links immunity inflammatory responses, progression OSCC. Harnessing these pathways be useful patient-specific individualized therapy. We perspectives on how different types integrated decision prognosis, treatment

Язык: Английский

Процитировано

8
Metal‐(Acyclic Diaminocarbene) Complexes Demonstrate Nanomolar Antiproliferative Activity against Triple‐Negative Breast Cancer DOI
Svetlana A. Katkova, Alexander S. Bunev, Rovshan Е. Gasanov

и другие.

Chemistry - A European Journal, Год журнала: 2024, Номер 30(28)

Опубликована: Фев. 16, 2024

Abstract Hydrolytically stable Pd II and Pt complexes supported by acyclic diaminocarbene ligands represent a novel class of structural organometallic anticancer agents exhibiting nanomolar antiproliferative activity in panel cancer cell lines (IC 50 0.07–0.81 μ M) up to 300‐fold selectivity for cells over normal primary fibroblasts. The lead drug candidate was 300 times more potent than cisplatin vitro showed higher efficacy reducing the growth aggressive MDA‐MB‐231 xenograft tumors mice.

Язык: Английский

Процитировано

5
Osteopontin promotes tumor growth and metastasis and GPX4-mediated anti-lipid peroxidation in triple-negative breast cancer by activating the PI3k/Akt/mTOR pathway DOI Creative Commons
Man Guo, Mengyue Liu, Weihan Li

и другие.

Journal of Cancer Research and Clinical Oncology, Год журнала: 2024, Номер 150(3)

Опубликована: Март 25, 2024

Abstract Purpose Triple-negative breast cancer (TNBC) features high aggressiveness, metastasis rate, drug resistance as well poor prognosis. Osteopontin (OPN) is a key protein in the process of osteogenesis and has emerged new tumor marker recent years. Methods Cell viability was tested with CCK-8 kit. Transwell wound healing were adopted to test cell invasive migratory abilities. Tumor sphere formation detected by assay. Human umbilical vein endothelial (HUVEC) tube assay used measure angiogenesis cells. Western blot applied for estimation expression stem markers, angiogenesis-, signaling pathway-related proteins OPN. Bioinformatics tools predicted OPN tissues. The levels oxidative stress-related markers assessed ELISA. Following overexpression MD-MB-436 cells addition PI3K/AKT/mTOR pathway inhibitor LY294002, aforementioned functional experiments implemented again investigate mechanism. Finally, vivo tumor-bearing mice performed further verification. Results proliferative, invasive, capabilities TNBC conspicuously increased contrast non-TNBC lines. tissues dramatically enhanced. upregulation significantly elevated angiogenesis. mechanism might be achieved activating regulate glutathione peroxidase 4 (GPX4)-mediated anti-lipid peroxidation. Conclusion promoted GPX4-mediated peroxidation levels.

Язык: Английский

Процитировано

4
Ferroptosis: emerging roles in lung cancer and potential implications in biological compounds DOI Creative Commons

Qiuran Liang,

Yuehui Wang,

Yili Li

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Май 9, 2024

Lung cancer has high metastasis and drug resistance. The prognosis of lung patients is poor the patients’ survival chances are easily neglected. Ferroptosis a programmed cell death proposed in 2012, which differs from apoptosis, necrosis autophagy. novel type regulated driven by iron-dependent lipid peroxidation subsequent plasma membrane ruptures. It broad prospects field tumor disease treatment. At present, multiple studies have shown that biological compounds can induce ferroptosis cells, exhibits significant anti-cancer effects, they advantages safety, minimal side less possibility to In this review, we summarize used for treatment focusing on its mechanism. addition, systematically review current research status combining nanotechnology with treatment, shed new light targeting pathways applying compounds-based therapies.

Язык: Английский

Процитировано

4