Apolipoproteins have a major role in cellular tumor dormancy in triple negative breast cancer: In-silico study DOI Creative Commons
Zaynab El-Gammal,

Usama Bakry,

Ahmed F. El‐Sayed

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 4, 2024

Abstract Triple-negative breast cancer (TNBC) lacks estrogen, progesterone, and human epidermal growth factor receptors has a poor prognosis as it is resistant to chemotherapy. A new treatment option for this type of may be by putting these malignant cells into dormancy. The oocyte’s embryonic milieu presents unique tumor reversion microenvironment inducing arrest changing cells’ phenotypes. We conducted an in-silico study determine the most likely oocyte extract (OE) proteins involved in dormancy using HDock, CluPro, molecular dynamic (MD) simulation. Results showed low energy scores complexes between OE four surface markers: K1C14, CLD3, CLD4, ITA6. Apolipoprotein A1 (APOA1) C3 (APOC3) highest stability affinity with These are key tumor-related pathways such angiogenesis, proliferation, apoptosis, migration. This will pave way exploring novel therapeutic options induce TNBC cells.

Language: Английский

Rosmarinic acid promotes mitochondrial fission and induces ferroptosis in triple-negative breast cancer cells DOI

Chufei Xie,

Liujia Chan,

Yuheng Pang

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Language: Английский

Citations

6
Comprehensive insights into mechanism of nanotoxicity, assessment methods and regulatory challenges of nanomedicines DOI Creative Commons
Ujwal Havelikar,

Kabirdas B. Ghorpade,

Amit Kumar

et al.

Discover Nano, Journal Year: 2024, Volume and Issue: 19(1)

Published: Oct. 4, 2024

Nanomedicine has the potential to transform healthcare by offering targeted therapies, precise diagnostics, and enhanced drug delivery systems. The National Institutes of Health coined term "nanomedicine" describe use nanotechnology in biological system monitoring, control, diagnosis, treatment. continues receive increasing interest for rationalized therapeutics pharmaceutical agents achieve required response while reducing its side effects. However, as advance, concerns about toxicological effects have also grown. This review explores current state nanomedicine, focusing on types nanoparticles used their associated properties that contribute nanotoxicity. It examines mechanisms through which exert toxicity, encompassing various cellular molecular interactions. Furthermore, it discusses assessment methods employed evaluate nanotoxicity, in-vitro in-vivo models, well emerging techniques. addresses regulatory issues surrounding nanotoxicology, highlighting challenges developing standardized guidelines ensuring secure translation nanomedicine into clinical settings. ethical with understanding safety profile is essential effective therapeutic applications.

Language: Английский

Citations

14
Ferroptosis in Cancer Therapy: Mechanisms, Small Molecule Inducers, and Novel Approaches DOI Creative Commons

YiLin Luo,

Xin Yue Bai,

L.J. Zhang

et al.

Drug Design Development and Therapy, Journal Year: 2024, Volume and Issue: Volume 18, P. 2485 - 2529

Published: June 1, 2024

Abstract: Ferroptosis, a unique form of programmed cell death, is initiated by an excess iron accumulation and lipid peroxidation-induced damage. There growing body evidence indicating that ferroptosis plays critical role in the advancement tumors. The increased metabolic activity higher levels tumor cells make them particularly vulnerable to ferroptosis. As result, targeted induction becoming increasingly promising approach for cancer treatment. This review offers overview regulatory mechanisms ferroptosis, delves into mechanism action traditional small molecule inducers their effects on various In addition, latest progress inducing using new means such as proteolysis-targeting chimeras (PROTACs), photodynamic therapy (PDT), sonodynamic (SDT) nanomaterials summarized. Finally, this discusses challenges opportunities development ferroptosis-inducing agents, focusing discovering targets, improving selectivity, reducing toxic side effects. Keywords: inducers, molecules, PROTACs, PDT, SDT,

Language: Английский

Citations

9
Molecular mechanism of ZC3H13 -mediated ferroptosis in doxorubicin resistance of triple negative breast cancer DOI Creative Commons
Li‐Shan Huang, Lei Han, Shuai Liang

et al.

Cell Biology and Toxicology, Journal Year: 2025, Volume and Issue: 41(1)

Published: Feb. 26, 2025

Triple negative breast cancer (TNBC) continues to be the most aggressive subtype of that frequently develops resistance chemotherapy. Doxorubicin (DOX) belongs anthracycline chemical class drug and is one widely used anticancer drugs. This study investigates mechanism m6A methyltransferase ZC3H13 in DOX TNBC. ZC3H13, KCNQ1OT1, TRABD expressions TNBC tissues or cells were detected by RT-qPCR Western blot. The effect on was evaluated CCK-8, clone formation, EdU staining. RIP performed analyze enrichment YTHDF2 KCNQ1OT1. RNA pull-down verified binding between KCNQ1OT1 MLL4. MLL H3K9me1/2/3 promoter analyzed ChIP. A nude mouse xenograft tumor model established verify vivo. poorly expressed TNBC, its expression further decreased drug-resistant cells. Overexpression IC50 DOX, repressed proliferation, induced ferroptosis. Mechanistically, ZC3H13-mediated modification reduced transcriptional stability inhibited a YTHDF2-dependent manner. enhanced H3K4me1/2/3 recruiting MLL4, thus increasing expression. ferroptosis inhibiting KCNQ1OT1/TRABD, thereby restraining growth DOX-treated tumors reduces promoting via KCNQ1OT1/TRABD axis.

Language: Английский

Citations

1
Exploring beyond Common Cell Death Pathways in Oral Cancer: A Systematic Review DOI Creative Commons
Leonardo de Oliveira Siquara da Rocha, Éverton Freitas de Morais, Lilianny Querino Rocha de Oliveira

et al.

Biology, Journal Year: 2024, Volume and Issue: 13(2), P. 103 - 103

Published: Feb. 6, 2024

Oral squamous cell carcinoma (OSCC) is the most common and lethal type of head neck cancer in world. Variable response acquisition resistance to traditional therapies show that it essential develop novel strategies can provide better outcomes for patient. Understanding cellular molecular mechanisms death control has increased rapidly recent years. Activation pathways, such as emerging forms non-apoptotic programmed death, including ferroptosis, pyroptosis, necroptosis, NETosis, parthanatos, mitoptosis paraptosis, may represent clinically relevant therapeutic opportunities. This systematic review summarizes recently described OSCC, highlighting their potential informing diagnosis, prognosis treatment. Original studies explored any selected deaths OSCC were included. Electronic search, study selection, data collection risk bias assessment tools realized. The literature search was carried out four databases, extracted from 79 articles categorized grouped by death. Ferroptosis, necroptosis represented main studies, with links immunity inflammatory responses, progression OSCC. Harnessing these pathways be useful patient-specific individualized therapy. We perspectives on how different types integrated decision prognosis, treatment

Language: Английский

Citations

8
Ferroptosis as a promising targeted therapy for triple negative breast cancer DOI

Kasra Mokhtarpour,

Sepideh Razi,

Nima Rezaei

et al.

Breast Cancer Research and Treatment, Journal Year: 2024, Volume and Issue: 207(3), P. 497 - 513

Published: June 14, 2024

Language: Английский

Citations

8
Metal‐(Acyclic Diaminocarbene) Complexes Demonstrate Nanomolar Antiproliferative Activity against Triple‐Negative Breast Cancer DOI
Svetlana A. Katkova, Alexander S. Bunev, Rovshan Е. Gasanov

et al.

Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: 30(28)

Published: Feb. 16, 2024

Abstract Hydrolytically stable Pd II and Pt complexes supported by acyclic diaminocarbene ligands represent a novel class of structural organometallic anticancer agents exhibiting nanomolar antiproliferative activity in panel cancer cell lines (IC 50 0.07–0.81 μ M) up to 300‐fold selectivity for cells over normal primary fibroblasts. The lead drug candidate was 300 times more potent than cisplatin vitro showed higher efficacy reducing the growth aggressive MDA‐MB‐231 xenograft tumors mice.

Language: Английский

Citations

5
A snapshot into the transcriptomic landscape of apoptosis and ferroptosis in cancer DOI Creative Commons
Yaron Vinik, Sima Lev

Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(5)

Published: May 29, 2024

Apoptosis and ferroptosis are two regulated cell death (RCD) pathways implicated in different human diseases considered as promising strategies to eliminate cancer cells. These characterized by distinct morphological biochemical properties, induce through mechanisms, but share common regulators types. Although apoptosis have been extensively studied over the last few years, their transcriptomic responses not yet systematically compared due remarkable variability data. Here we provide a brief snapshot of landscapes cancer, discuss divergent convergent implications therapy.

Language: Английский

Citations

4
Treating incurable non-communicable diseases by targeting iron metabolism and ferroptosis DOI

Ruoxuan Ni,

Jianwei Jiang, Fudi Wang

et al.

Science China Life Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

Language: Английский

Citations

0
Kinsenoside Suppresses DGAT1-Mediated Lipid Droplet Formation to Trigger Ferroptosis in Triple-Negative Breast Cancer DOI Open Access

Yaqin Yang,

Dandan Chen,

Yimin Zhu

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2322 - 2322

Published: March 5, 2025

Triple-negative breast cancer (TNBC) presents limited therapeutic options and is characterized by a poor prognosis. Although Kinsenoside (KIN) possesses wide range of pharmacological activities, its effect mechanism in TNBC remain unclear. The objective this research was to explore the effectiveness molecular mechanisms KIN on TNBC. Xenograft experiment carried out assess impact vivo. vitro evaluated through analysis cell cytotoxicity colony formation assays. Oil Red O staining BODIPY 493/503 fluorescence were employed detect lipid droplet (LD) formation. Transcriptomics inhibitor-rescue experiments conducted investigate role Mechanistic experiments, including quantitative real-time polymerase chain reaction (RT-qPCR), Western blotting, diacylglycerol acyltransferase 1 (DGAT1) overexpression assay, flow cytometric uncover regulatory inhibited tumor growth without causing obvious toxicity liver kidneys. In demonstrated that significantly viability proliferation cells, accompanied decreased LD content. Polyunsaturated fatty acids (PUFAs) levels increased KIN. Furthermore, transcriptomics revealed induced ferroptosis cells. could regulate ferroptosis-related proteins. Lipid peroxidation, iron accumulation, GSH depletion also confirmed this. inducer mitigated KIN-induced DGAT1 attenuated effects proliferation. trigger Our findings suppressing DGAT1-mediated formation, thereby demonstrating promising

Language: Английский

Citations

0