Biological Trace Element Research, Год журнала: 2022, Номер 201(8), С. 3903 - 3918
Опубликована: Ноя. 8, 2022
Язык: Английский
Antioxidants, Год журнала: 2022, Номер 11(11), С. 2237 - 2237
Опубликована: Ноя. 13, 2022
Inflammation of the human lung is mediated in response to different stimuli (e.g., physical, radioactive, infective, pro-allergenic or toxic) such as cigarette smoke and environmental pollutants. They often promote an increase inflammatory activities airways that manifest themselves chronic diseases allergic airway diseases, asthma, bronchitis/chronic obstructive pulmonary disease (COPD) even cancer). Increased levels oxidative stress (OS) reduce antioxidant defenses, affect autophagy/mitophagy processes, regulatory mechanisms cell survival, promoting inflammation lung. In fact, OS potentiate lung, favoring progression diseases. increases production reactive oxygen species (ROS), including superoxide anions (O2-), hydroxyl radicals (OH) hydrogen peroxide (H2O2), by transformation through enzymatic non-enzymatic reactions. this manner, reduces endogenous defenses both nucleated non-nucleated cells. The ROS can derive from exogenous insults (cigarette pollution) sources injury and/or activated structural review, we describe most relevant knowledge concerning functional interrelation between
Язык: Английский
Процитировано
105
Archives of Toxicology, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 20, 2024
Abstract Heavy metals are naturally occurring components of the Earth’s crust and persistent environmental pollutants. Human exposure to heavy occurs via various pathways, including inhalation air/dust particles, ingesting contaminated water or soil, through food chain. Their bioaccumulation may lead diverse toxic effects affecting different body tissues organ systems. The toxicity depends on properties given metal, dose, route, duration (acute chronic), extent bioaccumulation. detrimental impacts human health largely linked their capacity interfere with antioxidant defense mechanisms, primarily interaction intracellular glutathione (GSH) sulfhydryl groups (R-SH) enzymes such as superoxide dismutase (SOD), catalase, peroxidase (GPx), reductase (GR), other enzyme Although arsenic (As) is believed bind directly critical thiols, alternative hydrogen peroxide production processes have also been postulated. known signaling pathways affect a variety cellular processes, cell growth, proliferation, survival, metabolism, apoptosis. For example, cadmium can BLC-2 family proteins involved in mitochondrial death overexpression antiapoptotic Bcl-2 suppression proapoptotic (BAX, BAK) thus increasing resistance cells undergo malignant transformation. Nuclear factor erythroid 2-related 2 (Nrf2) an important regulator enzymes, level oxidative stress, oxidants has shown act double-edged sword response arsenic-induced stress. Another mechanism significant threats metal (e.g., Pb) involves substitution essential calcium (Ca), copper (Cu), iron (Fe)) structurally similar (Cd) (Pb)) metal-binding sites proteins. Displaced redox (copper, iron, manganese) from natural catalyze decomposition Fenton reaction generate damaging ROS hydroxyl radicals, causing damage lipids, proteins, DNA. Conversely, some metals, cadmium, suppress synthesis nitric oxide radical (NO · ), manifested by altered vasorelaxation and, consequently, blood pressure regulation. Pb-induced stress be indirectly responsible for depletion due its (O ·− resulting formation potent biological oxidant, peroxynitrite (ONOO − ). This review comprehensively discusses mechanisms effects. Aluminum (Al), (Cd), (As), mercury (Hg), (Pb), chromium (Cr) roles development gastrointestinal, pulmonary, kidney, reproductive, neurodegenerative (Alzheimer’s Parkinson’s diseases), cardiovascular, cancer (e.g. renal, lung, skin, stomach) diseases discussed. A short account devoted detoxification chelation use ethylenediaminetetraacetic acid ( EDTA), dimercaprol (BAL), 2,3-dimercaptosuccinic (DMSA), 2,3-dimercapto-1-propane sulfonic (DMPS), penicillamine chelators.
Язык: Английский
Процитировано
27
The Science of The Total Environment, Год журнала: 2022, Номер 836, С. 155716 - 155716
Опубликована: Май 5, 2022
Язык: Английский
Процитировано
49
Food and Chemical Toxicology, Год журнала: 2022, Номер 164, С. 113001 - 113001
Опубликована: Апрель 18, 2022
Язык: Английский
Процитировано
38
Environmental Science and Pollution Research, Год журнала: 2024, Номер 31(9), С. 12841 - 12855
Опубликована: Янв. 26, 2024
Abstract Mercury (Hg) is a widely distributed and bioavailable metal of public health concern, with many known human toxicities, but data regarding mercury's influence on thyroid cancer (TC) scarce. to impact several molecular pathways implicated in carcinogenesis, its proclivity for bioaccumulation the suggests potential modulatory effect. We conducted literature/systematic review studies between 1995–2022 intending define better establish relationships these two entities, congregate evidence role identify populations interest further study. Insufficient precludes definitive conclusions dietary mercury as TC risk factor; however, common mechanisms affected by are crucial development, including biochemical, endocrine, reactive oxygen species effects. Quantitative analysis revealed associations exposure. In three studies, average urine levels were higher patients, mean difference 1.86 µg/g creatinine (95% CI = 0.32–3.41). investigating exposure elevated levels, exposed group exhibited developing TC, relative 1.90 1.76–2.06). tissue (ppm) averaging 0.14 (0.06–0.22) cancerous cases (N 178) 0.08 (0.04–0.11) normal thyroids 257). Our findings suggest an association risk, implying possible predisposing factor. Further research necessary reveal clinical relevance environmental exposures pathogenesis.
Язык: Английский
Процитировано
8
Antioxidants and Redox Signaling, Год журнала: 2023, Номер 40(10-12), С. 636 - 662
Опубликована: Июль 20, 2023
The nuclear factor erythroid 2-related 2 (NRF2)-Kelch-like ECH-associated protein 1 (KEAP1) system is a master regulator of redox homeostasis and cell adaptation to variety exogenous endogenous stressors. Accumulating evidence from the last decade indicates that impairment balance leads oxidative stress (OS), common alteration occurring in many human acute chronic inflammatory diseases, such as cancer, diabetes, neurodegeneration, metabolic disorders, aging.
Язык: Английский
Процитировано
16
Heliyon, Год журнала: 2024, Номер unknown, С. e37545 - e37545
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
7
Antioxidants, Год журнала: 2024, Номер 13(5), С. 597 - 597
Опубликована: Май 13, 2024
Oxidative stress occurs when there is an imbalance between the production of reactive oxygen species (ROS) and body’s antioxidant defenses. It poses a significant threat to physiological function reproductive cells. Factors such as xenobiotics heat can worsen this stress, leading cellular damage apoptosis, ultimately decreasing efficiency. The nuclear factor erythroid 2–related 2 (Nrf2) signaling pathway plays crucial role in defending against oxidative protecting cells via enhancing responses. Dysregulation Nrf2 has been associated with infertility suboptimal performance mammals. Recent advancements therapeutic interventions have underscored critical mitigating restoring functional integrity In narrative review, we delineate harmful effects xenobiotic-induced on explain how provides protection these challenges. studies shown that activating using various bioactive compounds ameliorate distress apoptosis mammalian By comprehensively analyzing existing literature, propose key target for caused by exposure xenobiotic stress. Additionally, based synthesis findings, discuss potential therapies focused improve
Язык: Английский
Процитировано
6
Toxics, Год журнала: 2023, Номер 11(3), С. 223 - 223
Опубликована: Фев. 26, 2023
Cadmium has been well recognized as a critical toxic agent in acute and chronic poisoning cases occupational nonoccupational settings environmental exposure situations. is released into the environment after natural anthropogenic activities, particularly contaminated industrial areas, causing food pollution. In body, cadmium no biological activity, but it accumulates primarily liver kidney, which are considered main targets of its toxicity, through oxidative stress inflammation. However, last few years, this metal linked to metabolic diseases. The pancreas-liver-adipose axis largely affected by accumulation. Therefore, review aims collect bibliographic information that establishes basis for understanding molecular cellular mechanisms with carbohydrate, lipids, endocrine impairments contribute developing insulin resistance, syndrome, prediabetes, diabetes.
Язык: Английский
Процитировано
15
Frontiers in Molecular Biosciences, Год журнала: 2024, Номер 11
Опубликована: Фев. 26, 2024
Introduction: Cadmium (Cd) is a harmful heavy metal that results in many toxic issues. Urtica pilulifera showed potential pharmaceutical applications. This study investigated the possible ameliorative mechanism of leaves extract (UPLE) against hepatotoxicity induced by cadmium chloride (CdCl 2 ) mice. Methods: In vitro phytochemical screening and metal-chelating activity UPLE were ascertained. Four groups forty male mice used ( n = 10) as follows; Group 1 (G1) was negative control. G2 injected i.p., with (100 mg/kg b. wt) daily. G3 Cd (5 G4 G2. On day 11, body weight changes evaluated, blood, serum samples collected for hematological biochemical assessments. Liver tissues biochemical, molecular, histopathological investigations. Results: The contains promising secondary metabolites considerably lessen effects on liver. Furthermore, inhibited oxidative stress inflammation; restored antioxidant molecules; promoted nuclear-related factor-2 (Nrf-2) expression. Also, improved alterations Cd. Discussion: explored beneficial role treatment Cd-induced liver injury through enhancing Nrf-2 signaling enzyme gene expression Therefore, could have valuable implications environmental exposure. Which can be chelating agent
Язык: Английский
Процитировано
5