Cellular Signalling, Год журнала: 2022, Номер 94, С. 110323 - 110323
Опубликована: Март 29, 2022
Язык: Английский
Journal of Hematology & Oncology, Год журнала: 2022, Номер 15(1)
Опубликована: Июнь 28, 2022
Abstract Cancer is one of the leading causes death worldwide, and factors responsible for its progression need to be elucidated. Exosomes are structures with an average size 100 nm that can transport proteins, lipids, nucleic acids. This review focuses on role exosomes in cancer therapy. We discuss how able modulate components tumor microenvironment influence proliferation migration rates cells. also highlight that, depending their cargo, suppress or promote cell enhance reduce response radio- chemo-therapies. In addition, we describe trigger chronic inflammation lead immune evasion by focusing ability transfer non-coding RNAs between cells other molecular signaling pathways such as PTEN PI3K/Akt cancer. Subsequently, use carriers anti-tumor agents genetic tools control progression. then tumor-derived carcinogenesis. Finally, devote a section study diagnostic prognostic clinical courses important treatment patients. provides comprehensive understanding therapy, therapeutic value remodeling microenvironment. Graphical
Язык: Английский
Процитировано
362
Pharmacological Research, Год журнала: 2021, Номер 171, С. 105759 - 105759
Опубликована: Июль 8, 2021
Язык: Английский
Процитировано
136
Journal of Experimental & Clinical Cancer Research, Год журнала: 2022, Номер 41(1)
Опубликована: Июль 1, 2022
Abstract Background One of the most malignant tumors in men is prostate cancer that still incurable due to its heterogenous and progressive natures. Genetic epigenetic changes play significant roles development. The RNA molecules with more than 200 nucleotides length are known as lncRNAs these factors do not encode protein. They regulate gene expression at transcriptional, post-transcriptional levels. LncRNAs vital biological functions cells pathological events, hence their undergoes dysregulation. Aim review role alterations development emphasized here. Therefore, were chosen for this purpose level interaction other signaling networks progression examined. Key scientific concepts aberrant has been well-documented rate tumor regulated via affecting STAT3, NF-κB, Wnt, PI3K/Akt PTEN, among molecular pathways. Furthermore, radio-resistance chemo-resistance features cells. Overexpression tumor-promoting such HOXD-AS1 CCAT1 can result drug resistance. Besides, induce immune evasion upregulating PD-1. Pharmacological compounds quercetin curcumin have applied targeting lncRNAs. siRNA tool reduce thereby suppressing progression. Prognosis diagnosis clinical course be evaluated by exosomal lncRNA-p21 investigated serum patients a reliable biomarker.
Язык: Английский
Процитировано
125
Journal of Experimental & Clinical Cancer Research, Год журнала: 2022, Номер 41(1)
Опубликована: Март 22, 2022
Abstract Prostate cancer is a leading cause of death worldwide and new estimates revealed prostate as the in men 2021. Therefore, strategies are pertinent treatment this malignant disease. Macroautophagy/autophagy “self-degradation” mechanism capable facilitating turnover long-lived toxic macromolecules organelles. Recently, attention has been drawn towards role autophagy how its modulation provides effective therapy. In present review, we provide mechanistic discussion cancer. Autophagy can promote/inhibit proliferation survival cells. Besides, metastasis cells affected (via induction inhibition) by autophagy. affect response to therapy such chemotherapy radiotherapy, given close association between apoptosis. Increasing evidence demonstrated that upstream mediators AMPK, non-coding RNAs, KLF5, MTOR others regulate Anti-tumor compounds, for instance phytochemicals, dually inhibit or induce For improving therapy, nanotherapeutics chitosan nanoparticles have developed. With respect context-dependent cancer, genetic tools siRNA CRISPR-Cas9 be utilized targeting autophagic genes. Finally, these findings translated into preclinical clinical studies improve prognosis patients. Graphical abstract
Язык: Английский
Процитировано
110
Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 155, С. 113774 - 113774
Опубликована: Окт. 3, 2022
One of the malignant tumors in women that has involved both developed and developing countries is breast cancer. Similar to other types tumors, cancer cells demonstrate high metastatic nature. Besides, tumor have ability drug resistance. EMT related mechanism metastasis focus current manuscript highlighting function malignancy Breast increase their migration by induction During EMT, N-cadherin vimentin levels increase, E-cadherin decrease mediate EMT-induced invasion. Different kinds anti-cancer agents such as tamoxifen, cisplatin paclitaxel mediates chemoresistance feature cells. Furthermore, correlates with radio-resistance tumor. Clinical aspect reversing preventing chemotherapy or radiotherapy failure patients improving survival time. The anti-tumor suppress can be used for decreasing invasion increasing chemosensitivity lncRNAs, miRNAs factors modulate progression are discussed here.
Язык: Английский
Процитировано
95
Pharmacological Research, Год журнала: 2022, Номер 187, С. 106553 - 106553
Опубликована: Ноя. 16, 2022
Cancer progression results from activation of various signaling networks. Among these, PI3K/Akt contributes to proliferation, invasion, and inhibition apoptosis. Hepatocellular carcinoma (HCC) is a primary liver cancer with high incidence rate, especially in regions prevalence viral hepatitis infection. Autoimmune disorders, diabetes mellitus, obesity, alcohol consumption, inflammation can also lead initiation development HCC. The treatment HCC depends on the identification oncogenic factors that tumor cells develop resistance therapy. present review article focuses role progression. Activation promotes glucose uptake, favors glycolysis increases cell proliferation. It inhibits both apoptosis autophagy while promoting survival. stimulates epithelial-to-mesenchymal transition (EMT) matrix-metalloproteinase (MMP) expression during metastasis. In addition increasing colony formation capacity facilitating spread cells, angiogenesis. Therefore, silencing prevents aggressive behavior. confer drug resistance, particularly sorafenib, decreases radio-sensitivity cells. Anti-cancer agents, like phytochemicals small molecules suppress by limiting Being upregulated tissues clinical samples, be used as biomarker predict patients' response
Язык: Английский
Процитировано
83
Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 150, С. 112963 - 112963
Опубликована: Апрель 22, 2022
Among the different kinds of tumors threatening human life, lung cancer is one that commonly observed in both males and females. The aggressive behavior interactions occurring tumor microenvironment enhances malignancy this tumor. cells have demonstrated capacity developing chemo- radio-resistance. LncRNAs are a category non-coding RNAs do not encode proteins, but their aberrant expression responsible for development, especially cancer. In present review, we focus on lncRNAs exosomal cancer, ability regulating proliferation metastasis. Cell cycle progression molecular mechanisms related to metastasis such as EMT MMPs regulated by lncRNAs. interact with miRNAs, STAT, Wnt, EZH2, PTEN PI3K/Akt signaling pathways affect cells. demonstrate tumor-suppressor tumor-promoting functions They can be considered biomarkers body fluids potential tools minimally invasive diagnosis. Furthermore, discuss regulation anti-cancer drugs genetic well role these factors therapy response
Язык: Английский
Процитировано
80
Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 158, С. 114204 - 114204
Опубликована: Янв. 4, 2023
Glioblastoma (GBM) is one of the most malignant cancers central nervous system and due to its sensitive location, surgical resection has high risk therefore, chemotherapy radiotherapy are utilized for treatment. However, chemoresistance radio-resistance other problems in GBM Hence, new therapies based on genes recommended treatment GBM. PTEN a tumor-suppressor operator cancer that inhibits PI3K/Akt/mTOR axis diminishing growth, metastasis drug resistance. In current review, function PTEN/PI3K/Akt progression evaluated. Mutation or depletion leads increase progression. Low expression level mediates poor prognosis by increasing proliferation invasion, promotes malignancy tumor cells. Moreover, loss signaling can result therapy resistance Activation impairs metabolism via glycolysis inhibition. contrast PTEN, PI3K/Akt oncogenic during progression, enhances. shows positive association with pathways similar signaling, regulated non-coding RNAs. upregulation inhibition anti-cancer agents be beneficial interfering This review emphasizes networks related provides insights targeting this effective
Язык: Английский
Процитировано
74
Molecules, Год журнала: 2021, Номер 26(8), С. 2382 - 2382
Опубликована: Апрель 19, 2021
The failure of chemotherapy is a major challenge nowadays, and in order to ensure effective treatment cancer patients, it great importance reveal the molecular pathways mechanisms involved chemoresistance. Cisplatin (CP) platinum-containing drug with anti-tumor activity against different cancers both pre-clinical clinical studies. However, resistance has restricted its potential patients. CP can promote levels free radicals, particularly reactive oxygen species (ROS) induce cell death. Due double-edged sword role ROS as pro-survival or pro-death mechanism, result resistance. In present review, association sensitivity/resistance discussed, particular, how pathways, upstream downstream targets, affect response cells chemotherapy. Furthermore, compounds, such curcumin, emodin, chloroquine that regulate related increasing sensitivity are described. Nanoparticles provide co-delivery agents by mediating photodynamic therapy, overgeneration trigger sensitivity. Genetic tools, small interfering RNA (siRNA) down-regulate HIF-1α Nrf2 levels, leading Considering relationship between chemotherapy, translating these findings clinic pave way for
Язык: Английский
Процитировано
95
Bioengineering & Translational Medicine, Год журнала: 2022, Номер 8(1)
Опубликована: Сен. 13, 2022
Green chemistry has been a growing multidisciplinary field in recent years showing great promise biomedical applications, especially for cancer therapy. Chitosan (CS) is an abundant biopolymer derived from chitin and present insects fungi. This polysaccharide favorable characteristics, including biocompatibility, biodegradability, ease of modification by enzymes chemicals. CS-based nanoparticles (CS-NPs) have shown potential the treatment other diseases, affording targeted delivery overcoming drug resistance. The current review emphasizes on application CS-NPs chemotherapeutic agent, doxorubicin (DOX), therapy as they promote internalization DOX cells prevent activity P-glycoprotein (P-gp) to reverse These nanoarchitectures can provide co-delivery with antitumor agents such curcumin cisplatin induce synergistic Furthermore, co-loading siRNA, shRNA, miRNA suppress tumor progression chemosensitivity. Various nanostructures, lipid-, carbon-, polymeric- metal-based nanoparticles, are modifiable CS delivery, while functionalization ligands hyaluronic acid promotes selectivity toward prevents demonstrate high encapsulation efficiency due protonation amine groups CS, pH-sensitive release occur. redox- light-responsive prepared treatment. Leveraging these characteristics view biocompatibility CS-NPs, we expect soon see significant progress towards clinical translation.
Язык: Английский
Процитировано
62