International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(18), С. 10008 - 10008
Опубликована: Сен. 17, 2024
Tyrosine
kinase
inhibitors
(TKIs)
have
emerged
as
a
leading
targeted
cancer
therapy,
reducing
the
side
effects
often
seen
with
non-targeted
treatments,
especially
damage
to
healthy
cells.
To
tackle
resistance,
typically
caused
by
epidermal
growth
factor
receptor
(EGFR)
mutations,
four
generations
of
TKIs
been
developed.
Each
generation
has
shown
improved
effectiveness
and
fewer
effects,
resulting
in
better
patient
outcomes.
For
example,
patients
on
gefitinib,
first-generation
TKI,
experienced
progression-free
survival
(PFS)
10
months
compared
5
conventional
chemotherapy.
Second-generation
TKI
afatinib
outperformed
erlotinib
extended
PFS
11.1
6.9
cisplatin.
Third-generation
further
increased
38.6
months,
31.8
TKIs.
This
progress
demonstrates
ability
newer
overcome
particularly
T790M
mutation,
while
adverse
effects.
Ongoing
research
focuses
overcoming
resistance
from
mutations
like
C797S
improve
survival.
These
developments
highlight
significant
therapy
continued
effort
refine
treatment.
Recent
South
Korea
shows
that
third-generation
are
ineffective
against
non-small
cell
lung
(NSCLC)
mutation.
Several
trials
started
showing
promising
vitro
vivo
results,
but
more
needed
before
clinical
approval.
review
underscores
notable
advancements
field
EGFR
TKIs,
offering
comprehensive
analysis
their
mechanisms
action
progression
various
response
resistance.
Frontiers in Oncology,
Год журнала:
2022,
Номер
12
Опубликована: Март 24, 2022
Cancer
is
a
severe
public
health
issue
that
leading
cause
of
mortality
globally.
It
also
an
impediment
to
improving
life
expectancy
worldwide.
Furthermore,
the
global
burden
cancer
incidence
and
death
continuously
growing.
Current
therapeutic
options
are
insufficient
for
patients,
tumor
complexity
heterogeneity
necessitate
customized
medicine
or
targeted
therapy.
critical
identify
potential
targets.
Aberrant
activation
PI3K/AKT/mTOR
pathway
has
significant
role
in
carcinogenesis.
This
review
summarized
oncogenic
PI3K/Akt/mTOR
alterations
various
hallmarks
associated
with
pathway,
such
as
cell
proliferation,
autophagy,
apoptosis,
angiogenesis,
epithelial-to-mesenchymal
transition
(EMT),
chemoresistance.
Importantly,
this
provided
recent
advances
inhibitor
research.
Overall,
in-depth
understanding
association
between
tumorigenesis
development
therapies
targeting
will
help
make
clinical
decisions.
International Journal of Molecular Sciences,
Год журнала:
2021,
Номер
22(23), С. 13135 - 13135
Опубликована: Дек. 4, 2021
Liver
cancer
is
the
third
leading
cause
of
death
worldwide.
Representing
such
a
dramatic
impact
on
our
lives,
liver
significant
public
health
concern.
Sustainable
and
reliable
methods
for
preventing
treating
require
fundamental
research
its
molecular
mechanisms.
Cell
lines
are
treated
as
in
vitro
equivalents
tumor
tissues,
making
them
must-have
basic
nature
cancer.
According
to
recent
discoveries,
certified
cell
retain
most
genetic
properties
original
mimic
microenvironment.
On
other
hand,
modern
technologies
allowing
deepest
level
detail
omics
landscapes
have
shown
differences
even
between
samples
same
line
due
cross-
mycoplasma
infection.
This
observations
suggest
that,
some
cases,
cultures
not
suitable
models,
with
limited
predictive
value
effectiveness
new
treatments.
HepG2
popular
hepatic
line.
It
used
wide
range
studies,
from
oncogenesis
cytotoxicity
substances
liver.
In
this
regard,
we
set
out
collect
up-to-date
information
assess
whether
heterogeneity
allows
biomedical
studies
model
guaranteed
production
quality.
International Journal of Environmental Research and Public Health,
Год журнала:
2023,
Номер
20(4), С. 3640 - 3640
Опубликована: Фев. 18, 2023
The
overall
burden
of
cancer
is
rapidly
increasing
worldwide,
reflecting
not
only
population
growth
and
aging,
but
also
the
prevalence
spread
risk
factors.
Gastrointestinal
(GI)
cancers,
including
stomach,
liver,
esophageal,
pancreatic,
colorectal
represent
more
than
a
quarter
all
cancers.
While
smoking
alcohol
use
are
factors
most
commonly
associated
with
development,
growing
consensus
includes
dietary
habits
as
relevant
for
GI
Current
evidence
suggests
that
socioeconomic
development
results
in
several
lifestyle
modifications,
shifts
from
local
traditional
diets
to
less-healthy
Western
diets.
Moreover,
recent
data
indicate
increased
production
consumption
processed
foods
underlies
current
pandemics
obesity
related
metabolic
disorders,
which
directly
or
indirectly
emergence
various
chronic
noncommunicable
conditions
However,
environmental
changes
restricted
patterns,
unhealthy
behavioral
features
should
be
analyzed
holistic
view
lifestyle.
In
this
review,
we
discussed
epidemiological
aspects,
gut
dysbiosis,
cellular
molecular
characteristics
cancers
explored
impact
behaviors,
diet,
physical
activity
on
developing
context
progressive
societal
changes.
Molecular Biology Reports,
Год журнала:
2024,
Номер
51(1)
Опубликована: Янв. 22, 2024
Abstract
This
comprehensive
review
delves
into
cancer’s
complexity,
focusing
on
adhesion,
metastasis,
and
inhibition.
It
explores
the
pivotal
role
of
these
factors
in
disease
progression
therapeutic
strategies.
covers
cancer
cell
migration,
invasion,
colonization
distant
organs,
emphasizing
significance
adhesion
intricate
metastasis
process.
Inhibition
approaches
targeting
molecules,
such
as
integrins
cadherins,
are
discussed.
Overall,
this
contributes
significantly
to
advancing
research
developing
targeted
therapies,
holding
promise
for
improving
patient
outcomes
worldwide.
Exploring
different
inhibition
strategies
revealed
promising
targets
alleviate
cells.
The
effectiveness
integrin-blocking
antibodies,
small
molecule
inhibitors
Focal
kinase
(FAK)
Transforming
Growth
Factor
β
(TGF-β)
pathway,
combination
therapies
underscores
their
potential
disrupt
focal
adhesions
control
epithelial-mesenchymal
transition
processes.
identification
FAK,
Src,
β-catenin
SMAD4
offers
valuable
starting
points
further
development
therapies.
complex
interrelationships
between
metastatic
signaling
networks
will
be
relevant
new
treatment
approaches.
Cancers,
Год журнала:
2024,
Номер
16(8), С. 1554 - 1554
Опубликована: Апрель 18, 2024
Cancer
is
a
life-threatening
disease
and
one
of
the
leading
causes
death
worldwide.
Despite
significant
advancements
in
therapeutic
options,
most
available
anti-cancer
agents
have
limited
efficacy.
In
this
context,
natural
compounds
with
diverse
chemical
structures
been
investigated
for
their
multimodal
properties.
Curcumin
polyphenol
isolated
from
rhizomes
Curcuma
longa
has
widely
studied
its
anti-inflammatory,
anti-oxidant,
effects.
acts
on
regulation
different
aspects
cancer
development,
including
initiation,
metastasis,
angiogenesis,
progression.
The
phosphatidylinositol-3-kinase
(PI3K)/protein
kinase
B
(AKT)
pathway
key
target
therapy,
since
it
implicated
proliferation,
cell
survival.
found
to
inhibit
PI3K/Akt
tumor
cells,
primarily
via
mediators,
growth
factors,
protein
kinases,
cytokines.
This
review
presents
potential
curcumin
malignancies,
such
as
glioblastoma,
prostate
breast
cancer,
head
neck
cancers,
through
targeting
signaling
pathway.
Proteolysis-targeting
chimeras
(PROTACs)
represent
a
transformative
advancement
in
drug
discovery,
offering
method
to
degrade
specific
intracellular
proteins.
Unlike
traditional
inhibitors,
PROTACs
are
bifunctional
molecules
that
target
proteins
for
elimination,
enabling
the
potential
treatment
of
previously
"undruggable"
This
concept,
pioneered
by
Crews
and
his
team,
introduced
use
small
link
protein
an
E3
ubiquitin
ligase,
inducing
ubiquitination
subsequent
degradation
protein.
By
promoting
rather
than
merely
inhibiting
function,
present
novel
therapeutic
strategy
with
enhanced
specificity
effectiveness,
especially
areas
such
as
cancer
neurodegenerative
diseases.
Since
their
initial
field
PROTAC
research
has
rapidly
expanded
numerous
now
designed
wide
range
disease-relevant
The
substantial
research,
investment,
collaboration
across
academia
pharmaceutical
industry
reflect
growing
interest
PROTACs.
Review
discusses
journey
from
discovery
clinical
trials,
highlighting
advancements
challenges.
Additionally,
recent
developments
fluorescent
photogenic
PROTACs,
used
real-time
tracking
degradation,
presented,
showcasing
evolving
targeted
therapy.
Molecules,
Год журнала:
2023,
Номер
28(9), С. 3671 - 3671
Опубликована: Апрель 23, 2023
Magnolin
is
a
naturally
occurring,
multi-bioactive
lignan
molecule
with
inherent
anticancer
effects.
This
study
aims
to
summarize
the
botanical
origins
and
properties
of
magnolin.
For
this,
recent
(as
March
2023)
literature
review
was
conducted
using
various
academic
search
engines,
including
PubMed,
Springer
Link,
Wiley
Online,
Web
Science,
Science
Direct,
Google
Scholar.
All
currently
available
information
about
this
phytochemical
its
role
in
cancer
types
has
been
gathered
investigated.
compound
found
many
different
plants.
It
demonstrated
have
activity
numerous
experimental
models
by
inhibiting
cell
cycle
(G1
G2/M
phase);
inducing
apoptosis;
causing
antiinvasion,
antimetastasis,
antiproliferative
effects
via
modulation
several
pathways.
In
conclusion,
magnolin
showed
robust
against
lines
altering
signaling
pathways
non-
pre-clinical
models,
making
it
promising
plant-derived
chemotherapeutic
option
for
further
clinical
research.
