Composites Communications, Год журнала: 2025, Номер unknown, С. 102362 - 102362
Опубликована: Март 1, 2025
Язык: Английский
Biomaterials, Год журнала: 2024, Номер 309, С. 122608 - 122608
Опубликована: Май 9, 2024
Язык: Английский
Процитировано
11
Journal of Applied Polymer Science, Год журнала: 2025, Номер unknown
Опубликована: Янв. 23, 2025
ABSTRACT Chitosan (CS)‐based drug delivery systems often face challenges in obtaining clinical approval. Enhancing the binding affinity of CS‐based carriers to target cells, such as tumor is crucial for their translation from bench bedside. Strategies like crosslinking (NHS‐disulfide‐NHS) and utilizing materials albumin have proven effective strengthening interactions between nanoparticles thereby enhancing cellular uptake (cellular avidity). This study presents a novel approach using crosslinked CS loaded with doxorubicin, featuring reduction‐responsive release coating. The albumin‐coated chitosan (ACCC) was assembled via reaction amino CS/albumin NHS‐disulfide‐NHS. resulting ACCC nanoparticle micelles demonstrate enhanced stability micelles. hybrid network ensures while providing ample space loading achieves through disulfide bond crosslinking. Moreover, proposed system possesses excellent biocompatibility. Compared uncoated micelles, exhibit potent cytotoxicity against particularly reducing environment. Fluorescence imaging flow cytometry analyses confirm conferred by These findings underscore potential improving cell adhesion anti‐tumor efficacy, thus offering promising prospects translational medicine delivery.
Язык: Английский
Процитировано
1
Pharmaceuticals, Год журнала: 2023, Номер 16(10), С. 1360 - 1360
Опубликована: Сен. 26, 2023
The World Health Organization identifies tuberculosis (TB), caused by Mycobacterium tuberculosis, as a leading infectious killer. Although conventional treatments for TB exist, they come with challenges such heavy pill regimen, prolonged treatment duration, and strict schedule, to multidrug-resistant (MDR) extensively drug-resistant (XDR) strains. rise of MDR strains endangers future control. Despite these concerns, the hunt an efficient continues. One breakthrough has been use nanotechnology in medicines, presenting novel approach treatment. Nanocarriers, lipid nanoparticles, nanosuspensions, liposomes, polymeric micelles, facilitate targeted delivery anti-TB drugs. benefits nanocarriers include reduced drug doses, fewer side effects, improved solubility, better bioavailability, patient compliance, speeding up recovery. Additionally, can be made even more linking them ligands mannose or hyaluronic acid. This review explores innovative treatments, including studies on containing drugs related patents.
Язык: Английский
Процитировано
22
Pharmaceuticals, Год журнала: 2023, Номер 16(8), С. 1108 - 1108
Опубликована: Авг. 4, 2023
Resistance to isoniazid (INH) is common and increases the possibility of acquiring multidrug-resistant tuberculosis. For this study, isoniazid-loaded nanostructured lipid carriers (INH-NLCs) were developed effectively functionalized with mannose (Man) enhance residence time drug within lungs via specific delivery increase therapeutic efficacy formulation. The mannose-functionalized carrier (Man-INH-NLC) formulation was evaluated respect various parameters, namely, encapsulation efficiency (EE), loading (DL), average particle size (PS), zeta potential (ZP), polydispersity index (PDI), in vitro release (DR), kinetics. inhalation behavior after nebulization investigated using an Andersen cascade impactor estimation mass median aerosolized diameter (MMAD) geometric aerodynamic (GAD) subsequently found be suitable for effective lung delivery. An vivo pharmacokinetic study carried out a guinea pig animal model, it demonstrated that Man-INH-NLC has longer improved pharmacokinetics when compared unfunctionalized INH-NLC, indicating enhanced Histopathological analysis led us determine extent tissue damage more severe case pure solution nebulization. Thus, safe, forming sound basis enhancing management treatment pulmonary
Язык: Английский
Процитировано
18
Processes, Год журнала: 2023, Номер 11(9), С. 2698 - 2698
Опубликована: Сен. 9, 2023
This research presents a straightforward, effective, and eco-friendly method for the production of silver nanoparticles (AgNPs) copper oxide (CuONPs) using dried fruit Amomum subulatum as reducing, stabilizing, capping agent. The formation AgNPs CuONPs is supported by presence surface plasmon resonance band (SPR) at 440 nm 245 CuONPs. Additionally, identification specific biomolecules responsible synthesis was confirmed through FTIR spectra analysis. Transmission electron microscope (TEM) images demonstrated that had spherical shapes, with mean particle diameters 20.6 24.7 nm, respectively. X-ray diffraction selected area (SAED) analyses provided evidence crystalline nature synthesized elements observed energy-dispersive spectroscopy (EDS) Furthermore, antibacterial activity found to be superior against human pathogens such Escherichia coli, Staphylococcus aureus, Bacillus subtilis. cytotoxic biosynthesized (NPs) evaluated in vitro cervical cells (HeLa) breast (MCF-7). In MCF-7 cells, IC50 value estimated 39.79 µg/mL, while 83.89 µg/mL. HeLa 45.5 CuONPs, it 97.07 For first time, an from extract has been discussed along their comparative evaluation study. These results highlight promising applications effective agents microbial infections potential candidates cancer therapy.
Язык: Английский
Процитировано
16
Carbohydrate Polymer Technologies and Applications, Год журнала: 2024, Номер 8, С. 100537 - 100537
Опубликована: Июнь 21, 2024
Chitosan is a natural polysaccharide that has earned much credit in the pharmaceutical field due to its broad implementation drugs, antigens, and vaccine delivery. Owing unique characteristics of biocompatibility, biodegradability, mucoadhesiveness, less toxicity, chitosan holds promise as adjuvant or delivery system. Furthermore, exhibits antiviral properties making it an ideal carrier for vaccine. The presence ridiculous functional groups parent structure enables creation modified derivatives having improved physiochemical which provide enhanced chitosan. This review summarizes potential agent along with patents related application carrier.
Язык: Английский
Процитировано
7
Cellular Signalling, Год журнала: 2024, Номер 122, С. 111329 - 111329
Опубликована: Авг. 5, 2024
Язык: Английский
Процитировано
7
Pharmaceutics, Год журнала: 2024, Номер 16(8), С. 1043 - 1043
Опубликована: Авг. 6, 2024
Chitosan nanoparticles (CSNPs) are promising vehicles for targeted and controlled drug release. Recognized their biodegradability, biocompatibility, low toxicity, ease of production, CSNPs represent an effective approach to delivery. Encapsulating drugs within (NPs) provides numerous benefits compared free drugs, such as increased bioavailability, minimized toxic side effects, improved delivery, the incorporation additional features like release, imaging agents, combination therapies with multiple drugs. Keys parameters in nanomedicines loading content efficiency. Most current NP systems struggle loading, presenting a significant challenge field. This review summarizes recent research on developing high capacity, focusing various synthesis strategies. It examines CSNP using different materials providing details methods, loadings, encapsulation efficiencies, release profiles, stability, applications Additionally, discusses factors affecting valuable guidelines future CSNPs’ development.
Язык: Английский
Процитировано
5
Cancers, Год журнала: 2024, Номер 16(24), С. 4234 - 4234
Опубликована: Дек. 19, 2024
Cancer remains a predominant global health concern, necessitating effective treatment options. Conventional cancer therapies, particularly chemotherapy, often face constraints such as low selectivity, insufficient solubility, and multidrug resistance (MDR), which diminish effectiveness exacerbate negative effects. Metal oxide nanoparticles (MONPs), iron oxide, zinc copper offer promising solution by enhancing targeted drug delivery, reducing systemic toxicity, mitigating chemotherapy-induced disabilities like neurotoxicity cardiotoxicity. Nanocarriers conjugated with drugs can improve delivery within the body enhance their circulation in bloodstream. Recent advancements MONP synthesis functionalization have further improved stability drug-loading capacity, making them valuable tool treatment. MONPs distinctive physicochemical characteristics, enabling better imaging, encapsulation, medication to cancerous cells. These nanocarriers through focused controlled release, off-target effects addressing resistance. This review aims explore potential of efficient for anticancer drugs, limitations traditional chemotherapy poor specificity, Additionally, discusses recent functionalization, stability, compatibility.
Язык: Английский
Процитировано
5
Current Pharmaceutical Design, Год журнала: 2023, Номер 29(38), С. 3018 - 3039
Опубликована: Окт. 1, 2023
Background: Colorectal cancer (CRC) is a highly widespread malignancy and ranks as the second most common cause of cancer-related mortality. Objective: Cancer patients, including those with CRC, who undergo chemotherapy, are often treated platinum- based anticancer drugs such oxaliplatin (OXA). Nevertheless, administration OXA associated range gastrointestinal problems, neuropathy, respiratory tract infections. Hence, it necessary to devise potential strategy that can effectively tackle these aforementioned challenges. The use nanocarriers has shown great in treatment due their ability minimize side effects, target directly cells, improve drug efficacy. Furthermore, numerous studies have been published regarding therapeutic efficacy nanoparticles management colorectal cancer. Methods: In this review, we present relevant nanostructures used for encapsulation recent years, solid lipid nanoparticles, liposomes, polysaccharides, proteins, silica metal synthetic polymer-carriers. Additionally, paper provides summary disadvantages limits nanoparticles. Results: different carriers delivery increased efficiency reduced effects drug. It observed majority research investigations focused on liposomes polysaccharides. Conclusion: This potentially auspicious method enhance results quality life patients undergoing chemotherapy. However, additional investigation required ascertain suitable medium transportation assess its through clinical trials.
Язык: Английский
Процитировано
11