JAMA Network Open, Journal Year: 2024, Volume and Issue: 7(8), P. e2427063 - e2427063
Published: Aug. 9, 2024
Adverse childhood experiences (ACEs), potentially traumatic occurring before the age of 18 years, are associated with epigenetic aging later in life and may be transmitted across generations.
Language: Английский
Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(3), P. 721 - 721
Published: Jan. 26, 2024
Many factors have contributed to rendering frailty an emerging, relevant, and very popular concept. First, many pandemics that affected humanity in history, including COVID-19, most recently, had more severe effects on frail people compared non-frail ones. Second, the increase human life expectancy observed developed countries, Italy has led a rise percentage of older population is likely be frail, which why much common concern among geriatricians other various health-care professionals. Third, stratification according occurrence degree allows healthcare decision makers adequately plan for allocation available professional economic resources. Since considered fully preventable, there are relevant consequences terms potential benefits both clinical outcome costs. Frailty becoming popular, pervasive, almost omnipresent concept different contexts, medicine, physical health, lifestyle behavior, mental health policy, socio-economic planning sciences. The emergence new “science frailty” been recently acknowledged. However, still debate exact definition frailty, pathogenic mechanisms involved, appropriate method assess consequently, who should frail. This narrative review aims analyze from aspects points view, with special focus proposed mechanisms, assessment emerging role biomarkers early recognition particularly mitochondria. According extensive literature this topic, it clear complex syndrome, involving domains affecting multiple physiological systems. Therefore, its management directed towards comprehensive multifaceted holistic approach personalized intervention strategy slow down progression or even completely reverse course condition.
Language: Английский
Citations
16
Environment International, Journal Year: 2024, Volume and Issue: 188, P. 108773 - 108773
Published: May 25, 2024
Long-term air pollution exposure is a major health concern, yet its associations with thyroid dysfunction (hyperthyroidism and hypothyroidism) biological aging remain unclear. We aimed to determine the association of long-term investigate potential roles aging. A prospective cohort study was conducted on 432,340 participants available data pollutants including particulate matter (PM2.5, PM10, PM2.5-10), nitrogen dioxide (NO2), nitric oxide (NO) from UK Biobank. An score calculated using principal component analysis reflect joint these pollutants. Biological assessed Klemera-Doubal method age phenotypic algorithms. The individual were estimated Cox proportional hazards regression model. explored interaction mediation analyses. During median follow-up 12.41 years, 1,721 (0.40 %) 9,296 (2.15 developed hyperthyroidism hypothyroidism, respectively. All observed be significantly associated an increased risk incident while PM2.5, NO2 hyperthyroidism. hazard ratios (HRs) for hypothyroidism 1.15 (95 % confidence interval: 1.00–1.32) (1.08–1.22) individuals in highest quartile compared those lowest score, Additionally, we noticed that higher pollutant levels biologically older generally had dysfunction. Moreover, accelerated partially mediated 1.9 %–9.4 pollution-associated Despite possible underestimation dysfunction, may increase particularly participants, potentially involved mechanisms.
Language: Английский
Citations
15
Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 354, P. 181 - 190
Published: March 12, 2024
The long-lasting influence of childhood adversity on mental health is well documented; however empirical research examining how this association extends into older adults limited. This study defines using cumulative risk and latent class analysis (LCA) models to assess exposure typologies may predict anxiety depression in adults. Data came from the Personality Total Health (PATH) Through Life Project (N = 2551, age 60–66). Participants retrospectively reported their experiences domestic a 17-item scale. Mental was measured four validated questionnaires anxiety. Linear generalised additive (GAM) indicated dose-response relationship, where greater number adversities were associated with poorer scores all measures. LCA identified four-class solution; high parental dysfunction being poorest outcomes while moderate low groups scored at healthy levels. Women higher overall than men, but no notable interactions between ACEs gender observed. Patterns revealed by similar patterns shown model. There large time gap assessment, making our susceptible recall bias. Also, findings based cross-sectional data, limiting causal inferences. Childhood had independent contributions adulthood, both person-centred approaches captured relationship.
Language: Английский
Citations
10
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Jan. 2, 2025
Unhealthy lifestyles risk factors, such as smoking, alcohol consumption, physical inactivity, poor diet, and obesity, have been associated with a higher of all-cause cause-specific mortality. However, composite score these unhealthy behaviours has not considered, particularly in Latin American populations. Herein, we examined the association lifestyle factors mortality Mexican adults. A total 159,517 adults from Mexico City Prospective Study (MCPS) were included. Data on sociodemographic, medical histories was collected through self-reported baseline questionnaire census-style door-to-door interviews. Lifestyle assessment based five modifiable their respective cut-off points according to current health recommendations, including tobacco, consumption fruits vegetables intake. Multivariable Cox regression models used estimate associations factor (ranging 0 5) (cardiovascular disease, renal or hepatobiliary diseases, diabetes, respiratory cancer mortality). We excluded first 2, 5, 10, 15 years follow-up account for reverse causation bias. found high prevalence (77%) adults, two more factors. Hazard ratio diseases 1.86 (95%CI: 1.45–2.39) 2.00 1.60–2.52) comparing participants 4–5 vs. those none. For mortality, had 49% (HR: 1.49; 95%CI: 1.03–2.16) compared The magnitude increased exclusion time after 10 years. There positive between number showing highest rate respiratory, among After accounting causation, stronger.
Language: Английский
Citations
1
Brain Behavior and Immunity, Journal Year: 2025, Volume and Issue: 126, P. 30 - 37
Published: Feb. 4, 2025
Language: Английский
Citations
1
The American Journal of Medicine, Journal Year: 2023, Volume and Issue: 136(8), P. 773 - 779.e4
Published: April 17, 2023
Language: Английский
Citations
22
Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 92, P. 102121 - 102121
Published: Nov. 8, 2023
Aging is widespread worldwide and a significant risk factor for cardiovascular disease (CVD). Mechanisms underlying aging have attracted considerable attention in recent years. Remarkably, CVD overlap numerous ways, with deregulated nutrient sensing as common mechanism lifestyle communal modifier. Interestingly, triggers or suppresses multiple nutrient-related signaling pathways. In this review, we first present the composition of nutrient-sensing network (NSN) its metabolic impact on CVD. Secondly, review how factors closely associated CVD, including adverse life states such sedentary behavior, sleep disorders, high-fat diet, psychosocial stress, contribute to focus bridging role NSN. Finally, positive effects beneficial dietary interventions, specifically restriction Mediterranean regulation metabolism delayed that depend balance summary, expound interaction between lifestyle, NSN, aging,
Language: Английский
Citations
19
Advanced Science, Journal Year: 2024, Volume and Issue: 11(26)
Published: May 5, 2024
Abstract Is childhood adversity associated with biological aging, and if so, does sex modify the association, do lifestyle mental health mediate association? A lifespan analysis is conducted using data on 142 872 participants from UK Biobank to address these questions. Childhood assessed through online questionnaire (2016), including physical neglect, abuse, emotional sexual a cumulative score. Biological aging indicated by telomere length (TL) measured leukocyte DNA qPCR, shorter TL indicates accelerated aging; score constructed body mass index, activity, drinking, smoking, diet; disorder depression, anxiety, insomnia at baseline survey. The results reveal sex‐specific association such that in women after adjusting for covariates polygenic risk TL, but not men. Unhealthy partially women. proportions of indirect effects are largest abuse. These findings highlight importance behavioral psychological interventions promoting healthy among who experienced adversity, particularly
Language: Английский
Citations
6
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: June 10, 2024
Abstract Complicated associations between multiplexed environmental factors and aging are poorly understood. We manipulated using multidimensional metrics such as phenotypic age, brain volumes in the UK Biobank. Weighted quantile sum regression was used to examine relative individual contributions of aging, self-organizing maps (SOMs) were joint effects. Air pollution presented a relatively large contribution most cases. also found fair heterogeneities which same factor contributed inconsistently different metrics. Particulate matter variance while noise green space showed considerable volumes. SOM identified five subpopulations with distinct exposure patterns air subpopulation had worst status. This study reveals heterogeneous serves proof concept when analyzing multifactors multiple outcomes.
Language: Английский
Citations
6
Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)
Published: Oct. 18, 2023
Abstract The retina is an important target organ of diabetes mellitus, with increasing evidence from patients and animal models suggesting that retinal pigment epithelium (RPE) may serve as early marker for diabetes-related damages. However, their longitudinal relationship the biological underpinnings remain less well understood. Here, we demonstrate reduced in vivo measurements RPE thickness (RPET) represents a significant risk factor future type 2 mellitus (T2DM) its microvascular phenotypes. After performing systematic analyses circulating plasma metabolites using two complementary approaches, identify wide range RPET metabolic fingerprints are independently associated RPET. These hold potential to improve predictability clinical utility stratifying T2DM related phenotypes beyond traditional indicators, providing insights into promising role retinas window systemic health.
Language: Английский
Citations
11