25 Years of Reticular Chemistry

Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 60(45), P. 23946 - 23974

Published: March 30, 2021

At its core, reticular chemistry has translated the precision and expertise of organic inorganic synthesis to solid state. While initial excitement over metal-organic frameworks (MOFs) covalent (COFs) was undoubtedly fueled by their unprecedented porosity surface areas, most profound scientific innovation field been elaboration design strategies for extended crystalline solids through strong directional bonds. In this contribution we highlight different classes materials that have developed, how these can be functionalized, complexity introduced into backbones. Finally, show structural control is being from molecular scale crystal morphology shape on nanoscale, all way shaping bulk scale.

Language: Английский

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Toxicity of metal–organic framework nanoparticles: from essential analyses to potential applications

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(2), P. 464 - 484

Published: Jan. 1, 2022

This tutorial review highlights the key aspects of nanotoxicity and importance its systematic assessment for metal–organic framework (MOF) nanoparticles to pave way towards their potential applications in a safe sustainable manner.

Language: Английский

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Extremely stable amidoxime functionalized covalent organic frameworks for uranium extraction from seawater with high efficiency and selectivity

Science Bulletin, Journal Year: 2021, Volume and Issue: 66(19), P. 1994 - 2001

Published: May 16, 2021

Language: Английский

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Stimuli-responsive metal–organic framework nanoparticles for controlled drug delivery and medical applications

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(7), P. 4541 - 4563

Published: Jan. 1, 2021

Different chemical, physical, and biomarker triggers to unlock the metal–organic framework nanoparticles release drugs loaded in particles will be addressed.

Language: Английский

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Applications of Metal‐Organic Frameworks in Water Treatment: A Review

Small, Journal Year: 2021, Volume and Issue: 18(11)

Published: Dec. 8, 2021

Abstract The ever‐expanding scale of industry and agriculture has led to the gradual increase pollutants (e.g., heavy metal ions, synthetic dyes, antibiotics) in water resources, ecology wastewater are grave problems that need be solved urgently attracted widespread attention from research community recent years. Metal‐organic frameworks (MOFs) a type organic–inorganic hybrid material with distinctive 3D network crystal structure. Lately, MOFs have made striking progress fields adsorption, catalytic degradation, biomedicine on account their large specific surface well‐developed pore This review summarizes latest achievements preparation pristine MOFs, MOF composites, derivatives for various applications including removal organic other harmful substances sewage. Furthermore, working mechanisms utilizing photocatalytic membrane separation technologies also briefly described It is expected this will provide inspiration references synthesis as well composites excellent treatment performance.

Language: Английский

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Metal organic framework-based antibacterial agents and their underlying mechanisms

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(16), P. 7138 - 7169

Published: Jan. 1, 2022

MOFs can kill the bacteria efficiently by multiple mechanisms, such as releasing metal ions and/or antibacterial micro-molecules; performing catalytically active site; acting photosensitizers; mimicking enzymes; based on gas therapy and so on.

Language: Английский

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Upconverted Metal–Organic Framework Janus Architecture for Near-Infrared and Ultrasound Co-Enhanced High Performance Tumor Therapy

ACS Nano, Journal Year: 2021, Volume and Issue: 15(7), P. 12342 - 12357

Published: June 23, 2021

Strict conditions such as hypoxia, overexpression of glutathione (GSH), and high concentration hydrogen peroxide (H2O2) in the tumor microenvironment (TME) limit therapeutic effects reactive oxygen species (ROS) for photodynamic therapy (PDT), chemodynamic (CDT), sonodynamic (SDT). Here we fabricated a biocatalytic Janus nanocomposite (denoted UPFB) ultrasound (US) driven SDT 808 nm near-infrared (NIR) light mediated PDT by combining core-shell-shell upconversion nanoparticles (UCNPs, NaYF4:20%Yb,1%Tm@NaYF4:10%Yb@NaNdF4) ferric zirconium porphyrin metal organic framework [PCN-224(Fe)]. Our design not only substantially overcomes inefficient effect arising from inadequate Förster resonance energy transfer (FRET) process UCNPs (donor) to MOFs (acceptor) with NIR laser irradiation, but also promotes ROS generation via GSH depletion supply contributed Fe3+ ions coordinated UPFB catalase-like nanozyme. Additionally, converted Fe2+ foregoing can achieve CDT performance under acidic conditions, lysosomes. Meanwhile, linked biotin exhibits good targeting ability rapidly accumulate region, verified fluorescence imaging T2-weighted magnetic (MRI). In word, it is believed that synthesis antitumor detection heterostructures render them suitable application cancer therapeutics.

Language: Английский

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The chemistry and applications of hafnium and cerium(iv) metal–organic frameworks

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(7), P. 4629 - 4683

Published: Jan. 1, 2021

This review offers a holistic perspective on Hf and Ce(iv) based metal–organic frameworks (MOFs), with focus Hf/Ce(iv)-clusters, topologies, ligand structures, synthetic strategies, practical applications of these promising MOFs.

Language: Английский

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Antitumor Agents Based on Metal–Organic Frameworks

Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 60(31), P. 16763 - 16776

Published: March 9, 2021

Abstract Metal–organic frameworks (MOFs) hold great promise for biomedical applications owing to their unique properties. The porous structures make MOFs excellent candidates the delivery of different drugs; flexibility in choosing metal ions and organic ligands makes it feasible prepare with intrinsic antitumor activities further devise MOF–drug synergistic systems; many other types agents could also be developed using as precursors/templates. Thus, past two decades have witnessed development MOF‐based drugs, especially field. This Minireview mainly focuses on design agents. Four aspects covering whole field are introduced: carriers, agents, systems, MOF‐derived challenges opportunities clinical discussed.

Language: Английский

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Metallodrugs in cancer nanomedicine

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(7), P. 2544 - 2582

Published: Jan. 1, 2022

Metal complexes are extensively used for cancer therapy. The multiple variables available tuning (metal, ligand, and metal-ligand interaction) offer unique opportunities drug design, have led to a vast portfolio of metallodrugs that can display higher diversity functions mechanisms action with respect pure organic structures. Clinically approved metallodrugs, such as cisplatin, carboplatin oxaliplatin, treat many types play prominent roles in combination regimens, including immunotherapy. However, generally suffer from poor pharmacokinetics, low levels target site accumulation, metal-mediated off-target reactivity development resistance, which all limit their efficacy clinical translation. Nanomedicine has arisen powerful tool help overcome these shortcomings. Several nanoformulations already significantly improved the reduced toxicity (chemo-)therapeutic drugs, some promising metallodrug-containing nanomedicines currently trials. In this critical review, we analyse challenges assess advantages limitations metallodrug delivery, both nanocarrier metal-nano interaction perspective. We describe latest most relevant nanomedicine formulations developed metal complexes, discuss how rational coordination chemistry technology assist promoting translation metallodrugs.

Language: Английский

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