Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 484, P. 149641 - 149641
Published: Feb. 15, 2024
Language: Английский
Exploration, Journal Year: 2022, Volume and Issue: 2(3)
Published: March 15, 2022
Immunotherapy strategies that use cell-based delivery systems have sparked much interest in the treatment of malignancies, owing to their high biocompatibility, excellent tumor targeting capability, and unique biofunctionalities growth process. A variety design principles for immunotherapy, including cell surface decoration, membrane coating, encapsulation, genetically engineered cell, cell-derived exosomes, give cancer immunotherapy great potential improve therapeutic efficacy reduce adverse effects. However, methods is still limited, practical uses are hampered due complex physiological immunological obstacles, such as physical barriers immune infiltration, immunosuppressive microenvironment, upregulation pathways, metabolic restriction. In this review, we present an overview maximize impact, along with anatomical, metabolic, impediments using treat cancer. Following that, a summary novel been created overcome these obstacles immunotherapeutic provided. Also, prospects next-step development concluded end.
Language: Английский
Citations
153
Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 190, P. 114536 - 114536
Published: Sept. 13, 2022
Language: Английский
Citations
108
Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)
Published: Nov. 11, 2022
Abstract Glioblastoma multiforme (GBM) is one of the most fatal malignancies due to existence blood-brain barrier (BBB) and difficulty maintain an effective drug accumulation in deep GBM lesions. Here we present a biomimetic nanogel system that can be precisely activated by near infrared (NIR) irradiation achieve BBB crossing tumor penetration drugs. Synthesized crosslinking pullulan poly(deca-4,6-diynedioic acid) (PDDA) loaded with temozolomide indocyanine green (ICG), nanogels are inert endogenous oxidative conditions but selectively disintegrated ICG-generated reactive oxygen species upon NIR irradiation. Camouflaging apolipoprotein E peptide-decorated erythrocyte membrane further allows prolonged blood circulation active targeting. The controlled on lesions excites ICG deforms cumulated trigger burst release for facilitated permeation infiltration into distal cells. These NIR-activatable suppress growth orthotopic stem cells-bearing mouse models significantly extended survival.
Language: Английский
Citations
78
Cancer Nanotechnology, Journal Year: 2023, Volume and Issue: 14(1)
Published: April 25, 2023
Abstract Bone metastasis is the main cause of death in patients with prostate cancer (PCa), but there lacks effective treatment method. Immunotherapy shows new hopes for bone metastatic PCa patients, while efficacy still unsatisfactory and limited by unique immunosuppressive microenvironment site. Here, we developed a bone-targeted nano-delivery system as nano-regulator to enhance immunotherapy PCa. The nanosystem was assembled via coordination between phytic acid (PA) Fe 3+ form nano-sized metal–organic framework (MOF), through which mitoxantrone (MTO) encapsulated. At cellular level, showed selective cytotoxicity towards RM-1 cells over immune cells, could induce tumor immunogenic cell (ICD) improve immunogenicity tumor. Moreover, able ubiquitination TGFβ receptor (TβR) on promote its degradation, thus serving block functions TGF-β, an abundant cytokine that has systematically effect microenvironment. Upon intravenous injection, nanoparticle pro-longed blood circulation targeting accumulation into site, imposed robust anti-tumor combination αCTLA-4. In addition, destruction significantly alleviated after reduce skeletal-related events. Overall, this work provides biocompatible nanomedicine restore sensitivity enhanced blocking TGF-β signaling pathway.
Language: Английский
Citations
62
Deleted Journal, Journal Year: 2023, Volume and Issue: 1(2)
Published: Feb. 21, 2023
Abstract Phototherapy, mainly including photothermal therapy (PTT) and photodynamic (PDT), can kill cancer cells by generating heat or reactive oxygen species, which has the advantages of being minimally invasive, high efficiency, low toxicity. However, traditional phototherapeutic agents face challenges such as poor tumor targeting, susceptibility to passive immune clearance, suboptimal biocompatibility, limit their clinical application. Recently, cell membrane biomimetic technology endows with unique biological functions, promoted escape, prolonged in vivo circulation time, improved enhanced anti‐tumor efficacy. In addition, phototherapy mediated (CCM) membrane‐modified promote broad immunity. this review, we deeply analyze mechanisms PTT PDT, systematically discuss synthesis strategies functions nanomaterials, focus on progress based nanomaterials synergistic therapies chemotherapy, radiotherapy, immunotherapy, sonodynamic therapy. Finally, address opportunities future prospects field phototherapy. This comprehensive review is expected provide insights into promoting translation agents.
Language: Английский
Citations
61
ACS Nano, Journal Year: 2023, Volume and Issue: 17(4), P. 3225 - 3258
Published: Feb. 6, 2023
The immune checkpoint blockade (ICB) therapy has revolutionized the field of cancer treatment, while low response rates and systemic toxicity limit its clinical outcomes. With rapid advances in nanotechnology materials science, various types biomaterials have been developed to maximize therapeutic efficacy minimizing side effects by increasing tumor antigenicity, reversing immunosuppressive microenvironment, amplifying antitumor response, reducing extratumoral distribution inhibitors as well enhancing their retention within target sites. In this review, we reviewed current design strategies for different augment ICB effectively then discussed present representative biomaterial-assisted modulation targeted delivery boost therapy. Current challenges future development prospects expanding with were also summarized. We anticipate review will be helpful developing emerging promoting application
Language: Английский
Citations
59
Exploration, Journal Year: 2023, Volume and Issue: 3(6)
Published: July 27, 2023
Carbon monoxide (CO) gas therapy demonstrates great potential to induce cancer cell apoptosis and antitumor immune responses, which exhibits tremendous in treatment. However, the therapeutic efficacy of CO is inhibited by immunosuppressive tumor microenvironment (TME). Herein, a facile strategy proposed construct hollow-structured rough nanoplatforms boost immunity simultaneously reverse immunosuppression exploring intrinsic immunomodulatory properties morphological optimization nanomaterials. The TME-responsive delivery nanosystems (M-RMH) are developed encapsulating prodrug within hollow MnO
Language: Английский
Citations
56
ACS Nano, Journal Year: 2023, Volume and Issue: 17(6), P. 5503 - 5516
Published: March 14, 2023
Incomplete microwave ablation (iMWA) caused by uncontrollable heat diffusion enhances the immunosuppressive tumor microenvironment (ITM), consequently disabling prevalent immune checkpoint blockade-combined immunotherapy against recurrence. Herein, we successfully constructed an intratumorally synthesized Au bioreactor to disperse in thermally sensitive hydrogel-filled tumors and improve energy utilization efficiency, which magnified effective zone (EAZ), counteracted iMWA, simultaneously established enhanced multiple biological process-regulated microwavegenetics. More significantly, identified extracellular matrix (ECM) viscosity as a general escape "target". After remodeling ECM, including ECM ingredients cell adhesion molecules, this physical target was blocked reprogramming, furnishing tool regulate target. Thereby, such situ bioreactor-enlarged EAZ microwavegenetics reversed immune-desert microenvironment, mitigated ITM, secreted cell-attracting chemokines, recruited polarized various cells, activated or reactivated them like dendritic natural killing M1-type macrophages, effector CD8+ CAR-T cells. Contributed these actions, oncolytic bioreactors evoked acquire considerably increased inhibition effect progression recurrence after thus providing method enhance iMWA immunotherapy.
Language: Английский
Citations
46
Bioactive Materials, Journal Year: 2023, Volume and Issue: 32, P. 124 - 146
Published: Oct. 4, 2023
Due to its multiple features, including the ability orchestrate remote communication between different tissues, exosomes are extracellular vesicles arousing highest interest in scientific community. Their size, established as an average of 30-150 nm, allows them be easily uptaken by most cells. According type cells-derived exosomes, they may carry specific biomolecular cargoes used reprogram cells interacting with. In certain circumstances, stimulate immune response facilitating or amplifying release foreign antigens-killing cells, inflammatory factors, antibodies (immune activation). Meanwhile, other cases, efficiently malignant elements such cancer mislead recognition mechanism, carrying and transferring their cancerous distant healthy thus contributing antigenic invasion suppression). Exosome dichotomic patterns upon system regulation present broad advantages immunotherapy. Its perfect comprehension, from early biogenesis interaction with recipient will promote a significant enhancement immunotherapy employing molecular biology, nanomedicine, nanotechnology.
Language: Английский
Citations
43
Science Advances, Journal Year: 2024, Volume and Issue: 10(15)
Published: April 10, 2024
Disruptions in metal balance can trigger a synergistic interplay of cuproptosis and ferroptosis, offering promising solutions to enduring challenges oncology. Here, we have engineered Cellular Trojan Horse, named MetaCell, which uses live neutrophils stably internalize thermosensitive liposomal bimetallic Fe-Cu MOFs (Lip@Fe-Cu-MOFs). MetaCell instigate thereby enhancing treatment efficacy. Mirroring the characteristics neutrophils, evade immune system not only infiltrate tumors but also respond inflammation by releasing therapeutic components, surmounting traditional barriers. Notably, Lip@Fe-Cu-MOFs demonstrate notable photothermal effects, inciting targeted release Fe-Cu-MOFs within cancer cells amplifying action ferroptosis. has demonstrated outcomes tumor-bearing mice, effectively eliminating solid forestalling recurrence, leading extended survival. This research provides great insights into complex between copper iron homeostasis malignancies, potentially paving way for innovative approaches treatment.
Language: Английский
Citations
29