Targeting drugs to tumours using cell membrane-coated nanoparticles

Nature Reviews Clinical Oncology, Journal Year: 2022, Volume and Issue: 20(1), P. 33 - 48

Published: Oct. 28, 2022

Language: Английский

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Conquering the Hypoxia Limitation for Photodynamic Therapy

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(48)

Published: Sept. 27, 2021

Photodynamic therapy (PDT) has aroused great research interest in recent years owing to its high spatiotemporal selectivity, minimal invasiveness, and low systemic toxicity. However, due the hypoxic nature characteristic of many solid tumors, PDT is frequently limited therapeutic effect. Moreover, consumption O2 during may further aggravate tumor condition, which promotes proliferation, metastasis, invasion resulting poor prognosis treatment. Therefore, numerous efforts have been made increase content with goal enhancing efficacy. Herein, these strategies developed past decade are comprehensively reviewed alleviate hypoxia, including 1) delivering exogenous directly, 2) generating situ, 3) reducing cellular by inhibiting respiration, 4) regulating TME, (e.g., normalizing vasculature or disrupting extracellular matrix), 5) hypoxia-inducible factor 1 (HIF-1) signaling pathway relieve hypoxia. Additionally, -independent Type-I also discussed as an alternative strategy. By reviewing progress, it hoped that this review will provide innovative perspectives new nanomaterials designed combat hypoxia avoid associated limitation PDT.

Language: Английский

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Recent advances in nanomedicines for photodynamic therapy (PDT)-driven cancer immunotherapy

Theranostics, Journal Year: 2021, Volume and Issue: 12(1), P. 434 - 458

Published: Dec. 15, 2021

Cancer immunotherapy has made tremendous clinical progress in advanced-stage malignancies. However, patients with various tumors exhibit a low response rate to because of powerful immunosuppressive tumor microenvironment (TME) and insufficient immunogenicity tumors. Photodynamic therapy (PDT) can not only directly kill cells, but also elicit immunogenic cell death (ICD), providing antitumor immunity. Unfortunately, limitations from the inherent nature complex TME significantly reduce efficiency PDT. Recently, smart nanomedicine-based strategies could subtly modulate pharmacokinetics therapeutic compounds optimize both PDT immunotherapy, resulting an improved effect. Here, emerging nanomedicines for PDT-driven cancer are reviewed, including hypoxia-reversed nanomedicines, nanosized metal-organic frameworks, subcellular targeted nanoparticles (NPs). Moreover, we highlight synergistic nanotherapeutics used amplify immune responses combined against Lastly, challenges future expectations field discussed.

Language: Английский

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Regulatory mechanisms of PD-1/PD-L1 in cancers

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: May 18, 2024

Abstract Immune evasion contributes to cancer growth and progression. Cancer cells have the ability activate different immune checkpoint pathways that harbor immunosuppressive functions. The programmed death protein 1 (PD-1) cell ligands (PD-Ls) are considered be major molecules. interaction of PD-1 PD-L1 negatively regulates adaptive response mainly by inhibiting activity effector T while enhancing function regulatory (Tregs), largely contributing maintenance homeostasis prevents dysregulated immunity harmful responses. However, exploit PD-1/PD-L1 axis cause escape in development Blockade neutralizing antibodies restores enhances anti-tumor immunity, achieving remarkable success therapy. Therefore, mechanisms cancers attracted an increasing attention. This article aims provide a comprehensive review roles signaling human autoimmune diseases cancers. We summarize all aspects underlying expression cancers, including genetic, epigenetic, post-transcriptional post-translational mechanisms. In addition, we further progress clinical research on antitumor effects targeting alone combination with other therapeutic approaches, providing new strategies for finding tumor markers developing combined approaches.

Language: Английский

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Nanomaterials in tumor immunotherapy: new strategies and challenges

Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)

Published: June 13, 2023

Abstract Tumor immunotherapy exerts its anti-tumor effects by stimulating and enhancing immune responses of the body. It has become another important modality therapy with significant clinical efficacy advantages compared to chemotherapy, radiotherapy targeted therapy. Although various kinds tumor immunotherapeutic drugs have emerged, challenges faced in delivery these drugs, such as poor permeability low cell uptake rate, had prevented their widespread application. Recently, nanomaterials emerged a means for treatment different diseases due targeting properties, biocompatibility functionalities. Moreover, possess characteristics that overcome defects traditional immunotherapy, large drug loading capacity, precise easy modification, thus leading wide application immunotherapy. There are two main classes novel nanoparticles mentioned this review: organic (polymeric nanomaterials, liposomes lipid nanoparticles) inorganic (non-metallic metallic nanomaterials). Besides, fabrication method nanoparticles, Nanoemulsions, was also introduced. In summary, review article mainly discussed research progress based on past few years offers theoretical basis exploring strategies future.

Language: Английский

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Engineered nanomaterials for synergistic photo-immunotherapy

Biomaterials, Journal Year: 2022, Volume and Issue: 282, P. 121425 - 121425

Published: Feb. 19, 2022

Language: Английский

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Intracellular Self‐Assembly Driven Nucleus‐Targeted Photo‐Immune Stimulator with Chromatin Decompaction Function for Robust Innate and Adaptive Antitumor Immunity

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(17)

Published: March 4, 2022

Abstract Efficient nuclear DNA damage and release is highly recommended to improve the photodynamic immunotherapy by eliciting innate immune response yet remains challenging. Herein, an intracellular self‐assembly driven nucleus‐targeted photo‐immune stimulator (PIS) with chromatin decompaction function reported for adaptive antitumor immunity co‐activation. The PIS consists of vorinostat (SAHA)‐loaded manganese‐porphyrin metal‐organic framework (Mn (III)‐TCPP MOF) further modification AS1411 aptamer. can be efficiently internalized tumor cells disassembled under overexpressed glutathione (GSH). Notably, released able self‐assembled photosensitizer TCPP in situ within cells, driving delivery TCPP; meanwhile, loaded SAHA induce decompaction, cooperatively promoting TCPP‐mediated cytosolic laser irradiation. In addition, manganese ions 2+ ) enhance DNA/cyclic GMP‐AMP synthase (cGAS)‐stimulator interferon gene (STING) pathway mediated immunity, which synergizes PDT‐induced immunogenic cell death achieve co‐activation immunity. Compared traditional PDT, PDT system show significantly enhanced efficacy inhibiting primary growth distant metastasis several xenograft models, mechanistically maturation dendritic infiltration natural killer cell, cytotoxic T lymphocytes.

Language: Английский

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Hypoxia signaling in cancer: Implications for therapeutic interventions

MedComm, Journal Year: 2023, Volume and Issue: 4(1)

Published: Jan. 23, 2023

Abstract Hypoxia is a persistent physiological feature of many different solid tumors and key driver malignancy, in recent years, it has been recognized as an important target for cancer therapy. occurs the majority due to poor vascular oxygen supply that not sufficient meet needs rapidly proliferating cells. A hypoxic tumor microenvironment (TME) can reduce effectiveness other therapies, such radiotherapy, chemotherapy, immunotherapy. In this review, we discuss critical role hypoxia development, including metabolism, immunity, angiogenesis. The treatment methods TME are summarized, hypoxia‐targeted therapy improving oxygenation by alleviating itself. Hyperoxia be used improve tissue partial pressure relieve hypoxia. We focus on underlying mechanisms hyperoxia their impact current therapies prospects treatment.

Language: Английский

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Photodynamic therapy combined with immunotherapy: Recent advances and future research directions

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 495, P. 215350 - 215350

Published: Aug. 19, 2023

Innovative anticancer therapies based on the activation of immune system offer promise in battle against cancers resistant to traditional treatments. Examples such therapeutic approaches include, along with various types immunotherapies, photodynamic therapy (PDT). PDT is a photochemistry-based strategy that results not only from its direct effects cancer cells but also disruption tumor vasculature and host system. However, achieve success manifested eradication primary distant metastases, it necessary design suitable photosensitizers (PSs) desired optical photophysical properties enable efficient generation ROS under microenvironmental (TME) conditions, especially hypoxia. Thus, this review particular attention paid photochemical PSs, notably sufficiently long-lived triplet states mechanisms energy/electron transfer reactions. Photogenerated initiate inflammatory reaction, expression heat-shock proteins, infiltration long-term memory. These unique features give new possibilities combine agents stimulating response as well immunotherapy, PD-1/PD-L1 blockade. Most systems explored aspect so far are either derivatives naturally occurring metal complexes (Heme, Chlorophyll a, Bacteiochorophyll - inspired PSs), synthetic (metallo)porphyrins, (metallo)phthalocyanines or hybrid materials containing nanoparticles. This work summarizes recent reports synthesis antibody-PS conjugates spectroscopic enhanced selectivity biological activity. Finally, most notable drawbacks presented, scenario outlined for development alone, combined immunotherapy overcome these challenges future.

Language: Английский

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Biomimetic Nano-Drug Delivery System: An Emerging Platform for Promoting Tumor Treatment

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 571 - 608

Published: Jan. 1, 2024

Abstract: With the development of nanotechnology, nanoparticles (NPs) have shown broad prospects as drug delivery vehicles. However, they exhibit certain limitations, including low biocompatibility, poor physiological stability, rapid clearance from body, and nonspecific targeting, which hampered their clinical application. Therefore, novel systems with improved biocompatibility high target specificity remains a major challenge. In recent years, biofilm mediated biomimetic nano-drug system (BNDDS) has become research hotspot focus in field life sciences. This new platform uses bio-nanotechnology to encapsulate synthetic NPswithin membrane, organically integrating immunogenicity, toxicity, tumor good adjustability versatility nanocarrier, shows promising applications precision therapy. this review, we systematically summarize progress BNDDS used for optimizing delivery, providing theoretical reference designing safe efficient treatment strategies improve outcomes. Keywords: nanoparticles, cell targeted therapy

Language: Английский

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