ACS Applied Materials & Interfaces,
Journal Year:
2022,
Volume and Issue:
14(23), P. 26455 - 26468
Published: June 1, 2022
Nanozymes
are
promising
new-generation
antibacterial
agents
owing
to
their
low
cost,
high
stability,
broad-spectrum
activity,
and
minimal
antimicrobial
resistance.
However,
the
inherent
catalytic
activity
of
nanozymes
tends
limit
efficacy.
Herein,
a
heterostructure
zinc
oxide
nanorod@graphdiyne
nanosheets
(ZnO@GDY
NR)
with
unparallel
piezocatalytic
enzyme
mimic
is
reported,
which
concurrently
possesses
intrinsic
peroxidase-like
strong
piezoelectric
responses
effectively
promotes
decomposition
hydrogen
peroxide
(H2O2)
generation
reactive
oxygen
species
under
ultrasound
irradiation.
Moreover,
this
nanozyme
exhibits
almost
100%
efficacy
against
multidrug-resistant
pathogens
involving
methicillin-resistant
Staphylococcus
aureus
Pseudomonas
aeruginosa
in
vitro
vivo.
In
addition,
activatable
nanozyme-based
skin
patch
developed
for
rapid
wound
disinfections
satisfactory
hemocompatibility
cytocompatibility.
This
work
not
only
sheds
light
on
development
an
innovative
disinfection
but
also
provides
new
insights
engineering
therapy.
Nano-Micro Letters,
Journal Year:
2022,
Volume and Issue:
14(1)
Published: April 6, 2022
Abstract
Natural
enzymes
usually
suffer
from
high
production
cost,
ease
of
denaturation
and
inactivation,
low
yield,
making
them
difficult
to
be
broadly
applicable.
As
an
emerging
type
artificial
enzyme,
nanozymes
that
combine
the
characteristics
nanomaterials
are
promising
alternatives.
On
one
hand,
have
enzyme-like
catalytic
activities
regulate
biochemical
reactions.
other
also
inherit
properties
nanomaterials,
which
can
ameliorate
shortcomings
natural
serve
as
versatile
platforms
for
diverse
applications.
In
this
review,
various
mimic
activity
different
introduced.
The
achievements
in
cancer
diagnosis
treatment
technologies
summarized
by
highlighting
advantages
these
Finally,
future
research
directions
rapidly
developing
field
outlooked."Image
missing"
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(10)
Published: Feb. 11, 2023
Nanozymes,
a
class
of
nanomaterials
mimicking
the
function
enzymes,
have
aroused
much
attention
as
candidate
in
diverse
fields
with
arbitrarily
tunable
features
owing
to
diversity
crystalline
nanostructures,
composition,
and
surface
configurations.
However,
uncertainty
their
active
sites
lower
intrinsic
deficiencies
nanomaterial-initiated
catalysis
compared
natural
enzymes
promote
pursuing
alternatives
by
imitating
biological
centers.
Single-atom
nanozymes
(SAzymes)
maximize
atom
utilization
well-defined
structure,
providing
an
important
bridge
investigate
mechanism
relationship
between
structure
catalytic
activity.
They
risen
new
burgeoning
alternative
enzyme
from
vitro
bioanalytical
tool
vivo
therapy
flexible
atomic
engineering
structure.
Here,
focus
is
mainly
on
three
parts.
First,
detailed
overview
single-atom
catalyst
synthesis
strategies
including
bottom-up
top-down
approaches
given.
Then,
according
structural
feature
nanocatalysts,
influence
factors
such
central
metal
atom,
coordination
number,
heteroatom
doping,
metal-support
interaction
are
discussed
representative
applications
(including
antibacterial/antiviral
performance,
cancer
therapy,
biosensing)
highlighted.
In
end,
future
perspective
challenge
facing
demonstrated.
ACS Nano,
Journal Year:
2022,
Volume and Issue:
16(11), P. 18849 - 18862
Published: Oct. 24, 2022
Single-atom
nanozymes
(SAzymes),
with
individually
isolated
metal
atom
as
active
sites,
have
shown
tremendous
potential
enzyme-based
drugs
for
enzymatic
therapy.
However,
using
SAzymes
in
tumor
theranostics
remains
challenging
because
of
deficient
activity
and
insufficient
endogenous
H2O2.
We
develop
an
external-field-enhanced
catalysis
by
atom-level
engineered
FeN4-centered
nanozyme
(FeN4-SAzyme)
radio-enzymatic
This
FeN4-SAzyme
exhibits
peroxidase-like
capable
catalyzing
H2O2
into
hydroxyl
radicals
converting
single-site
FeII
species
to
FeIII
subsequent
glutathione
oxidase-like
activity.
Density
functional
theory
calculations
are
used
rationalize
the
origin
self-cascade
Importantly,
X-rays
can
improve
overall
cascade
reaction
process
via
promoting
conversion
frequency
FeII/FeIII.
As
a
producer,
natural
glucose
oxidase
is
further
decorated
onto
surface
yield
final
construct
GOD@FeN4-SAzyme.
The
resulting
GOD@FeN4-SAzyme
not
only
supplies
situ
continuously
produce
highly
toxic
but
also
induces
localized
deposition
radiation
dose,
subsequently
inducing
intensive
apoptosis
ferroptosis
vitro.
Such
synergistic
effect
radiotherapy
therapy
allows
improved
growth
inhibition
minimal
side
effects
vivo.
Collectively,
this
work
demonstrates
introduction
external
fields
enhance
enzyme-like
performance
without
changing
their
properties
highlights
robust
therapeutic
self-supplying
amplifying
reactions
address
limitations
treatment.
Small Methods,
Journal Year:
2022,
Volume and Issue:
6(11)
Published: Oct. 6, 2022
Abstract
Nanozymes
refer
to
nanomaterials
that
catalyze
enzyme
substrates
into
products
under
relevant
physiological
conditions
following
kinetics.
Compared
natural
enzymes,
nanozymes
possess
the
characteristics
of
higher
stability,
easier
preparation,
and
lower
cost.
Importantly,
magnetic,
fluorescent,
electrical
properties
nanomaterials,
making
them
promising
replacements
for
enzymes
in
industrial,
biological,
medical
fields.
On
account
rapid
development
recently,
their
application
potentials
regeneration
medicine
are
gradually
being
explored.
To
highlight
achievements
field,
this
review
summarizes
catalytic
mechanism
four
types
representative
nanozymes.
Then,
strategies
improve
biocompatibility
discussed.
covers
recent
advances
tissue
including
wound
healing,
nerve
defect
repair,
bone
regeneration,
cardiovascular
disease
treatment.
In
addition,
challenges
prospects
nanozyme
researches
summarized.
Advanced Functional Materials,
Journal Year:
2022,
Volume and Issue:
32(47)
Published: Sept. 18, 2022
Abstract
Single‐atom
nanozymes
(SAzymes)
can
effectively
mimic
the
metal
active
centers
of
natural
enzymes
at
atomic
level
owing
to
their
atomically
dispersed
sites,
thereby
maximizing
atom
utilization
efficiency
and
density
sites.
Hence,
SAzymes
be
considered
most
promising
candidates
replace
enzymes.
Herein,
a
PEGylated
mesoporous
Mn‐based
single‐atom
nanozyme
(PmMn/SAE)
employing
coordination‐assisted
polymerization
pyrolysis
strategy
that
uses
polydopamine
for
photothermal‐augmented
nanocatalytic
therapy
is
designed.
PmMn/SAE
exhibits
excellent
multiple
enzymatic
performance,
including
catalase‐like,
oxidase‐like,
peroxidase
(POD)‐like
due
Mn
species.
As
result,
not
only
catalyzes
decomposition
endogenous
H
2
O
generate
relieving
hypoxia
inside
tumor
but
also
transfers
electrons
produce
superoxide
radicals
kill
cells.
Meanwhile,
able
trigger
Fenton‐like
reactions
highly
toxic
hydroxyl
induce
cancer
cell
apoptosis.
The
POD‐like
catalytic
mechanism
mMn/SAE
revealed
using
experimental
results
functional
theory.
Furthermor,
shows
good
photothermal
conversion
(η
=
22.1%)
in
second
near‐infrared
region
(1064
nm).
Both
vitro
vivo
indicate
cells
through
photothermal‐enhanced
therapy.
