Rational Design Strategies for Nanozymes

ACS Nano, Journal Year: 2023, Volume and Issue: 17(14), P. 13062 - 13080

Published: July 3, 2023

Nanozymes constitute an emerging class of nanomaterials with enzyme-like characteristics. Over the past 15 years, more than 1200 nanozymes have been developed, and they demonstrated promising potentials in broad applications. With diversification complexity its applications, traditional empirical trial-and-error design strategies no longer meet requirements for efficient nanozyme design. Thanks to rapid development computational chemistry artificial intelligence technologies, first-principles methods machine-learning algorithms are gradually being adopted as a easier means assist This review focuses on potential elementary reaction mechanisms rational nanozymes, including peroxidase (POD)-, oxidase (OXD)-, catalase (CAT)-, superoxide dismutase (SOD)-, hydrolase (HYL)-like nanozymes. The activity descriptors introduced, aim providing further guidelines active material screening. computing- data-driven approaches thoroughly reviewed give proposal how proceed next-generation paradigm At end this review, personal perspectives prospects challenges put forward, hoping promote toward superior application performance future.

Language: Английский

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Current Advances on the Single‐Atom Nanozyme and Its Bioapplications

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(10)

Published: Feb. 11, 2023

Nanozymes, a class of nanomaterials mimicking the function enzymes, have aroused much attention as candidate in diverse fields with arbitrarily tunable features owing to diversity crystalline nanostructures, composition, and surface configurations. However, uncertainty their active sites lower intrinsic deficiencies nanomaterial-initiated catalysis compared natural enzymes promote pursuing alternatives by imitating biological centers. Single-atom nanozymes (SAzymes) maximize atom utilization well-defined structure, providing an important bridge investigate mechanism relationship between structure catalytic activity. They risen new burgeoning alternative enzyme from vitro bioanalytical tool vivo therapy flexible atomic engineering structure. Here, focus is mainly on three parts. First, detailed overview single-atom catalyst synthesis strategies including bottom-up top-down approaches given. Then, according structural feature nanocatalysts, influence factors such central metal atom, coordination number, heteroatom doping, metal-support interaction are discussed representative applications (including antibacterial/antiviral performance, cancer therapy, biosensing) highlighted. In end, future perspective challenge facing demonstrated.

Language: Английский

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A Molybdenum Disulfide Nanozyme with Charge‐Enhanced Activity for Ultrasound‐Mediated Cascade‐Catalytic Tumor Ferroptosis

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 62(11)

Published: Dec. 31, 2022

Abstract The deficient catalytic activity of nanozymes and insufficient endogenous H 2 O in the tumor microenvironment (TME) are major obstacles for nanozyme‐mediated therapy. Since electron transfer is basic essence catalysis‐mediated redox reactions, we explored contributing factors enzymatic based on positive negative charges, which experimentally theoretically demonstrated to enhance peroxidase (POD)‐like a MoS nanozyme. Hence, an acidic microenvironment‐responsive ultrasound‐mediated cascade nanocatalyst (BTO/MoS @CA) presented that made from few‐layer nanosheets grown surface piezoelectric tetragonal barium titanate (T‐BTO) modified with pH‐responsive cinnamaldehyde (CA). integration CA‐mediated self‐supply, charge‐enhanced activity, glutathione (GSH) depletion enables out‐of‐balance homeostasis, leading effective ferroptosis minimal side effects.

Language: Английский

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Biomedicine meets nanozyme catalytic chemistry

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 491, P. 215245 - 215245

Published: May 22, 2023

Language: Английский

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Enhancing Catalytic Activity of a Nickel Single Atom Enzyme by Polynary Heteroatom Doping for Ferroptosis-Based Tumor Therapy

ACS Nano, Journal Year: 2023, Volume and Issue: 17(3), P. 3064 - 3076

Published: Jan. 16, 2023

As a rising generation of nanozymes, single atom enzymes show significant promise for cancer therapy, due to their maximum utilization efficiency and well-defined electronic structures. However, it remains tremendous challenge precisely produce heteroatom-doped enzyme with an expected coordination environment. Herein, we develop anion exchange strategy controlled production edge-rich sulfur (S)- nitrogen (N)-decorated nickel (S-N/Ni PSAE). In particular, sulfurized S-N/Ni PSAE exhibits stronger peroxidase-like glutathione oxidase-like activities than the nitrogen-monodoped enzyme, which is attributed vacancies defective sites atoms. Moreover, both in vitro vivo results demonstrate that, compared N/Ni PSAE, more effectively triggers ferroptosis tumor cells via inactivating peroxidase 4 inducing lipid peroxidation. This study highlights enhanced catalytic efficacy polynary ferroptosis-based therapy.

Language: Английский

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Machine‐Learning‐Assisted Nanozyme Design: Lessons from Materials and Engineered Enzymes

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(10)

Published: Jan. 26, 2023

Abstract Nanozymes are nanomaterials that exhibit enzyme‐like biomimicry. In combination with intrinsic characteristics of nanomaterials, nanozymes have broad applicability in materials science, chemical engineering, bioengineering, biochemistry, and disease theranostics. Recently, the heterogeneity published results has highlighted complexity diversity terms consistency catalytic capacity. Machine learning (ML) shows promising potential for discovering new materials, yet it remains challenging design based on ML approaches. Alternatively, is employed to promote optimization intelligent application engineered enzymes. Incorporation successful algorithms used enzymes can concomitantly facilitate guided development next‐generation desirable properties. Here, recent progress ML, its utilization enzymes, how emergent applications serve as strategies circumvent challenges associated time‐expensive laborious testing nanozyme research summarized. The examples ML‐aided also highlighted, special focus unified aims enhancing recapitulation substrate selectivity activity.

Language: Английский

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Specific detection of fungicide thiophanate-methyl: A smartphone colorimetric sensor based on target-regulated oxidase-like activity of copper-doped carbon nanozyme

Biosensors and Bioelectronics, Journal Year: 2023, Volume and Issue: 237, P. 115554 - 115554

Published: July 26, 2023

Language: Английский

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Single‐Atom Nanozymes for Catalytic Therapy: Recent Advances and Challenges

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(16)

Published: Jan. 4, 2024

Abstract As a powerful tool, nanozyme catalysts broaden the avenues to implement bio‐inspired solutions for addressing many important concerns, covering energy, healthcare, environment, and more. Recent endeavors, characterized by atomic precision, have enabled extensive exploration of single‐atom nanozymes (SAzymes) with high catalytic activity, superior substrate selectivity, integrated multifunctionalities, thus becoming an emerging field that bridges nanotechnology biology. This review provides brief outline progress summarizes latest research advances regarding SAzymes in biomedical therapeutics, mainly including tumor therapy, wound antibacterial tissue anti‐inflammatory focus on their prototypical synthesis therapeutic mechanisms. Finally, current challenges future perspectives engineering advanced are also discussed outlooked. It is anticipated this area shall provide useful guidance therapy.

Language: Английский

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Atomic Engineering of Single‐Atom Nanozymes for Biomedical Applications

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(21)

Published: Feb. 7, 2024

Single-atom nanozymes (SAzymes) showcase not only uniformly dispersed active sites but also meticulously engineered coordination structures. These intricate architectures bestow upon them an exceptional catalytic prowess, thereby captivating numerous minds and heralding a new era of possibilities in the biomedical landscape. Tuning microstructure SAzymes on atomic scale is key factor designing targeted with desirable functions. This review first discusses summarizes three strategies for their impact reactivity biocatalysis. The effects choices carrier, different synthesis methods, modulation first/second shell, type number metal centers enzyme-like activity are unraveled. Next, attempt made to summarize biological applications tumor therapy, biosensing, antimicrobial, anti-inflammatory, other from mechanisms. Finally, how designed regulated further realization diverse reviewed prospected. It envisaged that comprehensive presented within this exegesis will furnish novel perspectives profound revelations regarding SAzymes.

Language: Английский

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Oxygen-Independent Radiodynamic Therapy: Radiation-Boosted Chemodynamics for Reprogramming the Tumor Immune Environment and Enhancing Antitumor Immune Response

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(17), P. 21546 - 21556

Published: April 16, 2024

Radiodynamic therapy (RDT) has emerged as a promising modality for cancer treatment, offering notable advantages such deep tissue penetration and radiocatalytic generation of oxygen free radicals. However, the oxygen-dependent nature RDT imposes limitations on its efficacy in hypoxic conditions, particularly modulating eliminating radioresistant immune suppression cells. A novel approach involving creation "super" tetrahedron polyoxometalate (POM) cluster, Fe12-POM, been developed radiation boosted chemodynamic catalysis to enable oxygen-independent conditions. This nanoscale cluster comprises four P2W15 units functioning energy antennas, while Fe3 core serves an electron receptor catalytic center. Under X-ray radiation, metal-to-metal charge transfer phenomenon occurs between core, resulting valence transition Fe3+ Fe2+ remarkable 139-fold increase hydroxyl radical compared Fe12-POM alone. The rapid radicals, combination with PD-1 therapy, induces reprogramming environment within tumors. is characterized by upregulation CD80/86, downregulation CD163 FAP, well release interferon-γ tumor necrosis factor-α. Consequently, occurrence abscopal effects facilitated, leading significant regression both local distant tumors mice. development represents address recurrence improve treatment outcomes.

Language: Английский

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