Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
12(24)
Published: May 15, 2023
Abstract
Accurately
evaluating
tumor
responses
to
immunotherapy
is
clinically
relevant.
However,
non‐invasive,
real‐time
visualization
techniques
evaluate
are
still
lacking.
Herein,
a
smart
responsive
fluorescence‐MR
dual‐modal
nanoprobe,
QM(GP)‐MZF(CP),
reported
that
can
be
targeted
for
cleavage
by
the
cytotoxic
T
cell
activation
marker
granzyme
B
and
apoptosis‐related
cysteine‐aspartic
acid‐specific
protease
3
(Caspase‐3).
The
probe
uses
quinoline‐malononitrile
(QM),
an
aggregation‐induced
emission
luminogen,
Mn‐Zn
ferrite
magnetic
nanoparticles
(MZF‐MNPs),
T2‐weighted
imaging
(T2WI)
contrast
agent,
as
molecules
linked
with
substrate
peptides
specific
Caspase‐3.
Therefore,
both
Caspase‐3
target
cleave
in
QM(GP)‐MZF(CP).
Via
fluorescence
of
QM
T2WI‐enhanced
effect
MZF‐MNPs,
status
cells
after
subsequent
triggering
apoptosis
determined
identify
responsiveness
thereby
effectiveness
this
therapy
early
stages
treatment.
Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
123(11), P. 6891 - 6952
Published: May 3, 2023
All
forms
of
energy
follow
the
law
conservation
energy,
by
which
they
can
be
neither
created
nor
destroyed.
Light-to-heat
conversion
as
a
traditional
yet
constantly
evolving
means
converting
light
into
thermal
has
been
enduring
appeal
to
researchers
and
public.
With
continuous
development
advanced
nanotechnologies,
variety
photothermal
nanomaterials
have
endowed
with
excellent
harvesting
capabilities
for
exploring
fascinating
prospective
applications.
Herein
we
review
latest
progresses
on
nanomaterials,
focus
their
underlying
mechanisms
powerful
light-to-heat
converters.
We
present
an
extensive
catalogue
nanostructured
materials,
including
metallic/semiconductor
structures,
carbon
organic
polymers,
two-dimensional
materials.
The
proper
material
selection
rational
structural
design
improving
performance
are
then
discussed.
also
provide
representative
overview
techniques
probing
photothermally
generated
heat
at
nanoscale.
finally
recent
significant
developments
applications
give
brief
outlook
current
challenges
future
directions
nanomaterials.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(15), P. 14347 - 14405
Published: July 24, 2023
Light
has
profoundly
impacted
modern
medicine
and
healthcare,
with
numerous
luminescent
agents
imaging
techniques
currently
being
used
to
assess
health
treat
diseases.
As
an
emerging
concept
in
luminescence,
aggregation-induced
emission
(AIE)
shown
great
potential
biological
applications
due
its
advantages
terms
of
brightness,
biocompatibility,
photostability,
positive
correlation
concentration.
This
review
provides
a
comprehensive
summary
AIE
luminogens
applied
structure
dynamic
physiological
processes,
disease
diagnosis
treatment,
detection
monitoring
specific
analytes,
followed
by
representative
works.
Discussions
on
critical
issues
perspectives
future
directions
are
also
included.
aims
stimulate
the
interest
researchers
from
different
fields,
including
chemistry,
biology,
materials
science,
medicine,
etc.,
thus
promoting
development
fields
life
health.
Aggregate,
Journal Year:
2023,
Volume and Issue:
4(5)
Published: May 6, 2023
Abstract
Cancer
is
one
of
the
most
fatal
diseases
for
decades.
Aggregation‐induced
emission
luminogens
(AIEgens)
have
been
recently
used
as
molecular
imaging
or
therapeutic
agents
in
cancers,
due
to
advantages
large
Stokes
shift,
high
quantum
yield,
great
biocompatibility,
and
strong
photostability.
AIEgens
can
specifically
target
different
types
cancer
via
diverse
targeting
strategies.
AIEgen‐based
fluorescence
imaging,
especially
near‐infrared
demonstrated
deep
penetration
suitable
signal‐to‐noise
ratio,
which
allows
reliable
vivo
imaging.
Combined
with
other
modalities,
multimodal
could
provide
multidimensional
hallmarks
from
perspectives.
In
addition,
phototherapy
be
photodynamic
therapy
photothermal
therapy,
facilitate
ablation
cells
good
biosafety
effects
vivo.
nanoparticles
fabricated
some
specific
chemicals,
drugs,
siRNA,
display
synergistic
cancers.
This
paper
comprehensively
describes
current
status
future
perspectives
AIEgens,
showed
a
potential
preclinical
clinical
translation
on
theranostics
cancer.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 571 - 608
Published: Jan. 1, 2024
Abstract:
With
the
development
of
nanotechnology,
nanoparticles
(NPs)
have
shown
broad
prospects
as
drug
delivery
vehicles.
However,
they
exhibit
certain
limitations,
including
low
biocompatibility,
poor
physiological
stability,
rapid
clearance
from
body,
and
nonspecific
targeting,
which
hampered
their
clinical
application.
Therefore,
novel
systems
with
improved
biocompatibility
high
target
specificity
remains
a
major
challenge.
In
recent
years,
biofilm
mediated
biomimetic
nano-drug
system
(BNDDS)
has
become
research
hotspot
focus
in
field
life
sciences.
This
new
platform
uses
bio-nanotechnology
to
encapsulate
synthetic
NPswithin
membrane,
organically
integrating
immunogenicity,
toxicity,
tumor
good
adjustability
versatility
nanocarrier,
shows
promising
applications
precision
therapy.
this
review,
we
systematically
summarize
progress
BNDDS
used
for
optimizing
delivery,
providing
theoretical
reference
designing
safe
efficient
treatment
strategies
improve
outcomes.
Keywords:
nanoparticles,
cell
targeted
therapy
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(32)
Published: June 14, 2024
Abstract
Nanomedicine
on
the
basis
of
aggregated‐induced
emission
(AIE)
luminogens
with
exceptional
potency
is
growing
into
a
sparkling
frontier
in
fluorescence
imaging
and
phototheranostics.
Of
particular
interest
biomimetic
AIE
nanomedicine
comprised
by
biocarrier,
which
represents
win–win
integration
are
recently
developed
at
tremendous
pace,
mainly
benefiting
from
intrinsic
advantages
including
enhanced
biocompatibility,
prolonged
circulation
time,
specific
targeting
ability,
immune
activation,
supremely
extraordinary
phototheranostic
outputs.
In
view
inexhaustible
vigorous
vitality
field,
this
review
provides
an
integrated
picture
involving
basic
concepts,
significant
breakthroughs,
recent
trends.
addition,
based
current
achievements,
some
critical
challenges
perspectives
also
discussed.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(44)
Published: May 20, 2024
Abstract
Mild
photothermal
therapy
(PTT)
is
an
emerging
and
elegant
approach
with
minimal
adverse
effects,
demonstrating
itself
as
effective
treatment
for
cancer.
However,
potential
challenges
may
arise
from
the
overexpression
of
heat
shock
protein
90
(HSP90)
reliance
on
monotherapy.
Here,
a
near‐infrared
(NIR)
light‐triggered
MXene
nanocomposite
(FA@MXene/CuO
2
/GA)
developed
to
synergistically
combine
mild
PTT
chemodynamic
(CDT)
remarkably
tumor
eradication
without
any
notable
tissue
damage.
Under
irradiation
NIR
light,
effectively
enhances
by
suppressing
HSP90
expression
through
release
gambogic
acid
(GA)
due
excellent
performance
Ti
3
C
nanosheets
well
tumor‐targeting
ability
biocompatibility
surface‐modified
FA‐PEG‐SH.
The
copper‐based
catalyst
CuO
in
this
system
releases
Cu
2+
acid‐triggered
manner
within
microenvironment,
activating
Fenton‐like
reaction
generate
hydroxyl
radicals,
simultaneous
production
H
O
serves
alleviate
deficiency
endogenous
tumor.
Overall,
current
work
showcases
remarkable
synergistic
anticancer
effect
CDT,
also
proposes
new
avenues
research
utilizing
nanomaterials
treatment.
Aggregate,
Journal Year:
2024,
Volume and Issue:
5(3)
Published: Jan. 22, 2024
Abstract
The
induction
of
regulated
cell
death
(RCD)
through
photo/ultrasound
sensitization
therapeutic
agents
has
gained
significant
attention
as
a
vital
approach
to
combat
drug
resistance
in
tumors.
Aggregation‐induced
emission
(AIE)
generate
reactive
oxygen
species
activation,
which
can
synergize
with
RCD
inducers
or
directly
induce
RCD,
ultimately
resulting
the
tumor
cells.
presented
comprehensive
review
delves
into
recent
advancements
AIE
designed
trigger
inducers,
encompassing
apoptosis,
necroptosis,
pyroptosis,
immunogenic
death,
autophagy,
ferroptosis,
and
cuproptosis.
Additionally,
intricate
regulatory
mechanisms
activatory‐AIE
therapeutics
influence
distinct
pathways
are
examined.
A
forward‐looking
perspective
on
future
developments
pertinent
challenges
within
this
exciting
realm
is
presented,
anticipating
continued
evolution
activatable
transformative
enhance
therapy.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 23, 2025
Abstract
Engineered
modifications
of
nanomaterials
inspired
by
nature
hold
great
promise
for
disease‐specific
imaging
and
therapies.
However,
conventional
polyethylene
glycol
modification
is
limited
immune
system
rejection.
The
manipulation
gold
nanorods
(Au
NRs)
modified
endogenous
proteins
(eP@Au)
reported
as
an
engineered
biomodulator
enhanced
breast
tumor
therapy.
results
show
that
eP@Au
NRs
neither
activate
inflammatory
factors
in
vitro
nor
elicit
rejection
responses
vivo.
Tumor‐specific
exhibit
a
dual‐modal
capability
trigger
mild
photothermal
effect
under
near‐infrared
light
irradiation,
enabling
highly
efficient
therapy
tumors.
Transcriptome
sequencing
confirmatory
experiments
reveal
the
antitumor
mainly
attributed
to
repression
PI3K‐Akt/MAPK
signaling
pathways
at
molecular
level.
This
powerful
surprising
situ
eP‐regulated
biomodulation
demonstrates
advantages
convenient
fabrication,
inert
immunogenicity,
biocompatibility,
providing
alternative
strategy
biomedical
