Stimuli-responsive ferroptosis for cancer therapy

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(12), P. 3955 - 3972

Published: Jan. 1, 2023

This review highlights recent advances in the utilization of various endogenous and exogenous stimuli to activate nanocarrier-based ferroptosis cancer therapy that can be effective treating conventional drug-resistant tumors.

Language: Английский

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Magnetic nanoparticles for ferroptosis cancer therapy with diagnostic imaging

Bioactive Materials, Journal Year: 2023, Volume and Issue: 32, P. 66 - 97

Published: Sept. 29, 2023

Ferroptosis offers a novel method for overcoming therapeutic resistance of cancers to conventional cancer treatment regimens. Its effective use as therapy requires precisely targeted approach, which can be facilitated by using nanoparticles and nanomedicine, their enhance ferroptosis is indeed growing area research. While few review papers have been published on iron-dependent mechanism inducers that partly covers nanoparticles, there need comprehensive focusing the design magnetic typically supply iron ions promote simultaneously enable nanomedicine. Furthermore, locally induce combinational with diagnostic resonance imaging (MRI). The remotely controllable nanocarriers offer highly localized image-guided Here, recent developments in magnetically manipulable nanomedicine medical are summarized. This also highlights advantages current state-of-the-art Finally, image guided apoptosis-based enables synergistic tumor discussed clinical translations.

Language: Английский

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Remote Control of Energy Transformation‐Based Cancer Imaging and Therapy

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(27)

Published: March 29, 2024

Cancer treatment requires precise tumor-specific targeting at specific sites that allows for high-resolution diagnostic imaging and long-term patient-tailorable cancer therapy; while, minimizing side effects largely arising from non-targetability. This can be realized by harnessing exogenous remote stimuli, such as tissue-penetrative ultrasound, magnetic field, light, radiation, enable local activation therapy in deep tumors. A myriad of nanomedicines efficiently activated when the energy stimuli transformed into another type energy. review discusses control transformation targetable, efficient, therapy. Such ultrasonic, magnetic, photonic, radiative, radioactive mechanical, thermal, chemical, radiative to a variety modalities. The current article describes multimodal where serial cascade or multiple types occur. includes not only hyperthermia, radiation but also emerging thermoelectric, pyroelectric, piezoelectric therapies treatment. It illustrates resonance, fluorescence, computed tomography, photoluminescence, photoacoustic imaging-guided therapies. highlights afterglow eliminate autofluorescence sustained signal emission after excitation.

Language: Английский

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A Novel Superparamagnetic Multifunctional Nerve Scaffold: A Remote Actuation Strategy to Boost In Situ Extracellular Vesicles Production for Enhanced Peripheral Nerve Repair

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(3)

Published: Sept. 1, 2023

Abstract Extracellular vesicles (EVs) have inherent advantages over cell‐based therapies in regenerative medicine because of their cargos abundant bioactive cues. Several strategies are proposed to tune EVs production vitro. However, it remains a challenge for manipulation vivo, which poses significant difficulties EVs‐based that aim promote tissue regeneration, particularly long‐term treatment diseases like peripheral neuropathy. Herein, superparamagnetic nanocomposite scaffold capable controlling on‐demand is constructed by incorporating polyethyleneglycol/polyethyleneimine modified nanoparticles into polyacrylamide/hyaluronic acid double‐network hydrogel (Mag‐gel). The Mag‐gel highly sensitive rotating magnetic field (RMF), and can act as mechano‐stimulative platform exert micro/nanoscale forces on encapsulated Schwann cells (SCs), an essential glial cell supporting nerve regeneration. By switching the ON/OFF state RMF, scale up local SCs‐derived (SCs‐EVs) both vitro vivo. Further transcriptome sequencing indicates enrichment transcripts favorable axon growth, angiogenesis, inflammatory regulation SCs‐EVs with ultimately results optimized repair Overall, this research provides noninvasive remotely time‐scheduled method fine‐tuning accelerate including nerves.

Language: Английский

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Skin-interfaced electronics: A promising and intelligent paradigm for personalized healthcare

Biomaterials, Journal Year: 2023, Volume and Issue: 296, P. 122075 - 122075

Published: March 7, 2023

Language: Английский

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Photonic control of image-guided ferroptosis cancer nanomedicine

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 500, P. 215532 - 215532

Published: Nov. 10, 2023

Language: Английский

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κ-Carrageenan-essential oil loaded composite biomaterial film facilitates mechanosensing and tissue regenerative wound healing

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 241, P. 124490 - 124490

Published: April 18, 2023

Language: Английский

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Multimodal biomedical utility of polyaniline-based supramolecular nanomaterials

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 493, P. 152530 - 152530

Published: May 24, 2024

Language: Английский

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Self‐Assembled Aza‐Boron‐Dipyrromethene‐Based H₂S Prodrug for Synergistic Ferroptosis‐Enabled Gas and Sonodynamic Tumor Therapies

Advanced Science, Journal Year: 2024, Volume and Issue: 11(30)

Published: June 13, 2024

Glioblastoma multiforme (GBM) is the most aggressive and lethal subtype of gliomas central nervous system. The efficacy sonodynamic therapy (SDT) against GBM significantly reduced by expression apoptosis-inhibitory proteins in cells. In this study, an intelligent nanoplatform (denoted as Aza-BD@PC NPs) based on aza-boron-dipyrromethene dye phenyl chlorothionocarbonate-modified DSPE-PEG molecules developed for synergistic ferroptosis-enabled gas (GT) SDT GBM. Once internalized cells, NPs showed effective cysteine (Cys) consumption Cys-triggered hydrogen sulfide (H

Language: Английский

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Injectable Hydrogels Including Magnetic Nanosheets for Multidisciplinary Treatment of Hepatocellular Carcinoma via Magnetic Hyperthermia

Small, Journal Year: 2023, Volume and Issue: 20(3)

Published: July 14, 2023

Abstract Relapse and unresectability have become the main obstacle for further improving hepatocellular carcinoma (HCC) treatment effect. Currently, single therapy HCC in clinical practice is limited by postoperative recurrence, intraoperative blood loss poor patient outcomes. Multidisciplinary has been recognized as key to long‐term survival rate HCC. However, application of synthetic restricted functional biomaterials. In this study, a magnetic nanocomposite hydrogel (CG‐IM) with iron oxide nanoparticle‐loaded mica nanosheets (Iron nanoparticles@Mica, IM) reported. This biocompatible integrated high injectability, magnetocaloric property, mechanical robustness, wet adhesion, hemostasis, leading efficient multidisciplinary therapies including tumor margin percutaneous locoregional ablation. After minimally invasive hepatectomy HCC, CG‐IM can facilely seal bleeding hepatic margin, followed hyperthermia ablation effectively prevent recurrence. addition, inhibit unresectable through intervention under ultrasound guidance.

Language: Английский

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