Nanoscale,
Journal Year:
2024,
Volume and Issue:
16(18), P. 9029 - 9035
Published: Jan. 1, 2024
Precise
monitoring
and
quantification
of
H2O2
is
highly
urgent
great
significance
for
biomedicine,
food
safety,
environmental
monitoring,
etc.
Herein,
we
proposed
a
facile
near-infrared
(NIR)
excited
fluorescent
probe
composed
upconversion
nanoparticles
(UCNPs)
non-metallic
plasmonic
WO3-x
ultrasensitive
quantitative
detection.
Plasmonic
with
oxygen
vacancy-induced
LSPR
achieved
over
680-fold
enhancement
fluorescence
at
520
nm,
also
acts
as
the
sensitive
recognition
site
H2O2.
quenched
band
WO3-x,
further
significantly
influencing
adjacent
signals
depending
on
its
concentration.
The
exhibits
good
linear
response
to
low
detection
limit
(10-9
M)
wide
concentration
range
(0-50
μM),
shows
satisfactory
application
in
determination
blood
milk.
This
work
may
provide
new
ideas
development
non-invasive
nanoprobes
plasmon-assisted
biochemical
methods.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(5), P. 1168 - 1168
Published: March 6, 2024
Many
important
biological
species
have
been
identified
as
cancer
biomarkers
and
are
gradually
becoming
reliable
targets
for
early
diagnosis
late
therapeutic
evaluation
of
cancer.
However,
accurate
quantitative
detection
remains
challenging
due
to
the
complexity
systems
diversity
development.
Fluorescent
probes
extensively
utilized
identifying
substances
their
notable
benefits
being
non-invasive,
quickly
responsive,
highly
sensitive
selective,
allowing
real-time
visualization,
easily
modifiable.
This
review
critiques
fluorescent
used
detecting
imaging
over
last
five
years.
Focuses
made
on
design
strategies
small-molecule
nano-sized
probes,
construction
methods
fluorescence
sensing
platforms,
further
applications
in
multiple
biomarkers,
including
enzymes,
reactive
oxygen
species,
sulfur
microenvironments.
aims
guide
development
excellent
diagnostic
promote
broad
application
analysis
diagnosis.
Small Methods,
Journal Year:
2024,
Volume and Issue:
unknown
Published: March 12, 2024
Abstract
Intravital
fluorescence
imaging
in
the
second
near‐infrared
window
(NIR‐II,
900–1700
nm)
has
emerged
as
a
promising
method
for
non‐invasive
diagnostics
complex
biological
systems
due
to
its
advantages
of
less
background
interference,
high
tissue
penetration
depth,
contrast,
and
sensitivity.
However,
traditional
NIR‐II
imaging,
which
is
characterized
by
“always
on”
or
“turn
mode,
lacks
ability
quantitative
detection,
leading
low
reproducibility
reliability
during
bio‐detection.
In
ratiometric
can
realize
reliable
analysis
detection
vivo
providing
reference
signals
correction,
generating
new
opportunities
prospects
bioimaging
biosensing.
this
review,
current
design
strategies
sensing
mechanisms
probes
biosensing
applications
are
systematically
summarized.
Further,
challenges,
future
perspectives
designing
also
discussed.
It
hoped
that
review
provide
effective
guidance
promote
adoption
vivo.
Accounts of Chemical Research,
Journal Year:
2023,
Volume and Issue:
56(13), P. 1766 - 1779
Published: June 14, 2023
ConspectusDevelopment
of
multifunctional
nanoparticles
(NPs)
with
desired
properties
is
a
significant
topic
in
the
field
nanotechnology
and
has
been
anticipated
to
revolutionize
cancer
diagnosis
treatment
modalities.
The
surface
character
one
most
important
parameters
NPs
that
can
directly
affect
their
vivo
fate,
bioavailability,
final
theranostic
outcomes
thus
should
be
carefully
tuned
maximize
effects
while
minimizing
unwanted
side
effects.
Surface
engineered
have
utilized
various
functionality
types
approaches
meet
requirements
therapy
imaging.
Despite
strategies,
these
modifications
generally
serve
similar
purposes,
namely,
introducing
therapeutic/imaging
modules,
improving
stability
circulation,
enhancing
targeting
ability,
achieving
controlled
functions.
These
hence
could
applied
scenarios
continuously
contribute
clinical
translation
next-generation
NP-based
platforms
toward
theranostics.In
this
Account,
we
present
recent
advances
research
efforts
on
development
NP
engineering
theranostics.
First,
summarize
general
strategies
for
engineering.
Various
functionalities
including
inorganic
material-based
functionality,
organic
like
small
molecules,
polymers,
nucleic
acids,
peptides,
proteins,
carbohydrates,
antibodies,
etc.,
biomembrane-based
functionality.
realized
by
prefabrication
or
postfabrication
functionalization,
driven
covalent
conjugations
noncovalent
interactions.
Second,
highlight
aims
different
functionalities.
Different
therapeutic
diagnostic
such
as
nanozymes,
imaging
contrast
agents,
modified
achieve
function.
modification
also
improve
circulation
protecting
from
immune
recognition
clearance.
In
addition,
targeted
imaging,
moieties
attached
enhance
active
ability
tissues
cells
interest.
Furthermore,
surfaces
tailored
functions
which
only
respond
specific
internal
(e.g.,
pH,
thermal,
redox,
enzyme,
hypoxia)
external
light,
ultrasound)
triggers
at
precise
action
sites.
Finally,
our
perspective
remaining
challenges
future
developments
rapidly
evolving
field.
We
hope
Account
offer
an
insightful
overlook
progress
illuminating
prospect
advanced
promoting
more
attention
area
adoption
scientists
fields,
accelerating
solid
foundation
broad
theranostics
applications.
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
53(12), P. 6068 - 6099
Published: Jan. 1, 2024
Combining
optoacoustics
with
other
imaging
techniques
helps
bring
its
powerful
label-free
functional
readings
and
molecular
sensitivity
into
precise
anatomical
context
while
providing
an
essential
cross-validation
against
established
methods.
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
33(29)
Published: April 18, 2023
Abstract
Rheumatoid
arthritis
(RA)
is
a
chronic
autoimmune
disease
characterized
by
joint
inflammation.
Macrophages
accelerate
the
pathological
process
of
RA
through
continuous
cell
accumulation
and
secretion
cytokines.
Therefore,
multiscale
visualization
macrophages
great
significance
for
early
diagnosis
RA.
In
this
work,
folate
receptor‐targeted
Cptnc‐4F
nanoprobes,
named
FA‐CF‐NPs,
are
developed
dual‐model
molecular
imaging
in
mouse
models.
FA‐CF‐NPs
exhibit
complementary
advantages
with
high
fluorescence
sensitivity
resolution
second
near‐infrared
window
(NIR‐II)
promising
photoacoustic
(PA)
contrast
deep
tissue
penetration.
The
affinity
ligand
on
surface
to
overexpressed
receptors
ensures
specific
targeting
function
nanoprobes
vivo.
employed
achieve
NIR‐II
accurately
localize
joint,
obtaining
signal‐to‐background
ratio
(SBR)
15.5.
Meanwhile,
PA
also
performed
observe
macrophage
distribution
longitudinal
section
whole
joint.
Moreover,
infiltration
detected
mice
absence
pathologies
such
as
synovitis
cartilage
loss.
results
provide
an
opportunity
vivo
tracking
Small,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 15, 2024
Abstract
The
recruitment
of
T
lymphocytes
holds
great
potential
for
suppressing
the
most
aggressive
glioblastoma
(GBM)
recurrence
with
immunotherapy.
However,
phenomenon
immune
privilege
and
generally
low
immunogenicity
vaccines
often
reduce
presence
within
brain
tumors,
especially
in
tumor
clusters.
In
this
study,
an
implantable
self‐cascading
catalytic
therapy
antigen
capture
scaffold
(CAS)
that
can
boost
efficiency
at
post‐surgery
antigens
via
urethane‐polyethylene
glycol‐polypropylene
glycol
(PU‐EO‐PO)
segments
are
developed
postoperative
CAS
consists
3D‐printed
elastomers
modified
iron
(Fe
2+
)
metal‐organic
frameworks
(MOFs,
MIL88)
acts
as
a
programmed
peroxide
mimic
cancer
cells
to
initiate
Fenton
reaction
sustain
ROS
production.
With
assistance
chloroquine
(CQ),
autophagy
is
inhibited
through
lysosome
deacidification,
which
interrupts
self‐defense
mechanism,
further
enhances
cytotoxicity,
releases
antigens.
Then,
containing
PU‐EO‐PO
groups
depot
detain
autologous
tumor‐associated
dendritic
maturation
cell
augments
sustained
stimulation.
enhanced
response
tumors
improved
survival
Advanced Science,
Journal Year:
2023,
Volume and Issue:
11(11)
Published: Dec. 31, 2023
Abstract
Tumor
metastasis
remains
a
leading
factor
in
the
failure
of
cancer
treatments
and
patient
mortality.
To
address
this,
silver‐induced
absorption
red‐shifted
core‐shell
nano‐particle
is
developed,
surface‐modified
with
triphenylphosphonium
bromide
(TPP)
hyaluronic
acid
(HA)
to
obtain
novel
nanodiagnosis‐treatment
agent
(Ag@CuS‐TPP@HA).
This
diagnosis‐treatment
can
dual‐targets
cells
mitochondria,
exhibits
maximal
light
at
1064
nm,
thereby
enhancing
nesr‐infrared
II
(NIR‐II)
photoacoustic
(PA)
signal
photothermal
effects
under
nm
laser
irradiation.
Additionally,
silver
Ag@CuS‐TPP@HA
catalyze
Fenton‐like
reactions
H
2
O
tumor
tissue,
yielding
reactive
oxygen
species
(ROS).
The
ROS
production,
coupled
enhanced
effects,
instigates
immunogenic
cell
death
(ICD),
substantial
release
tumor‐associated
antigens
(TAAs)
damage‐associated
molecular
patterns,
which
have
improved
immune
suppression
microenvironment
boosting
checkpoint
blockade
therapy,
thus
stimulating
systemic
antitumor
response.
Hence,
Ag@CuS‐TPP@HA,
as
diagnostic‐treatment
agent,
not
only
accomplishes
targeted
NIR‐II
PA
imaging
tissue
addresses
challenge
accurate
diagnosis
deep
vivo,
but
it
also
leverages
ROS/photothermal
therapy
enhance
blockade,
eliminating
primary
tumors
effectively
inhibiting
distant
growth.
