Bioinspired polydopamine hydrogels: Strategies and applications

Progress in Polymer Science, Journal Year: 2023, Volume and Issue: 146, P. 101740 - 101740

Published: Sept. 17, 2023

Language: Английский

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Smart‐Responsive Multifunctional Therapeutic System for Improved Regenerative Microenvironment and Accelerated Bone Regeneration via Mild Photothermal Therapy

Advanced Science, Journal Year: 2023, Volume and Issue: 11(2)

Published: Nov. 7, 2023

Abstract The treatment of bone defects remains a substantial clinical challenge due to the lack spatiotemporal management immune microenvironment, revascularization, and osteogenic differentiation. Herein, deferoxamine (DFO)‐loaded black phosphorus nanosheets decorated by polydopamine layer are prepared (BPPD) compounded into gelatin methacrylate/sodium alginate methacrylate (GA) hybrid hydrogel as smart‐responsive therapeutic system (GA/BPPD) for accelerated regeneration. BPPD nanocomposites served bioactive components near‐infrared (NIR) photothermal agents, which conferred with excellent NIR/pH dual‐responsive properties, realizing stimuli‐responsive release DFO PO 4 3 − during Under action NIR‐triggered mild therapy, GA/BPPD exhibited positive effect on promoting osteogenesis angiogenesis, eliminating excessive reactive oxygen species, inducing macrophage polarization M2 phenotype. More significantly, through polarization‐induced osteoimmune this platform could also drive functional cytokine secretion enhanced angiogenesis osteogenesis. In vivo experiments further demonstrated that facilitate healing attenuating local inflammatory response, increasing pro‐healing factors, stimulating endogenous cell recruitment, accelerating revascularization. Collectively, proposed intelligent provides promising strategy reshape damaged tissue microenvironment augmented

Language: Английский

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Mild Photothermal‐Stimulation Based on Injectable and Photocurable Hydrogels Orchestrates Immunomodulation and Osteogenesis for High‐Performance Bone Regeneration

Small, Journal Year: 2023, Volume and Issue: 19(28)

Published: May 16, 2023

Abstract A photoactivated bone scaffold integrated with minimally invasive implantation and mild thermal‐stimulation capability shows great promise in the repair regeneration of irregularly damaged tissues. Developing multifunctional photothermal biomaterials that can simultaneously serve as both controllable thermal stimulators biodegradable engineering scaffolds for immunomodulation, infection therapy, impaired remains an enormous challenge. Herein, injectable photocurable hydrogel therapeutic platform (AMAD/MP) based on alginate methacrylate, alginate‐graft‐dopamine, polydopamine (PDA)‐functionalized Ti3C2 MXene (MXene@PDA) nanosheets is rationally designed near‐infrared (NIR)‐mediated synergistic osteogenesis, bacterial elimination. The optimized AMAD/MP exhibits favorable biocompatibility, osteogenic activity, immunomodulatory functions vitro. proper immune microenvironment provided by could further modulate balance M1/M2 phenotypes macrophages, thereby suppressing reactive oxygen species‐induced inflammatory status. Significantly, this stimulation efficiently attenuates local reactions promotes new formation without addition exogenous cells, cytokines, or growth factors. This work highlights potential application advanced providing on‐demand cues tissue regenerative medicine.

Language: Английский

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3D Printing of Microenvironment‐Specific Bioinspired and Exosome‐Reinforced Hydrogel Scaffolds for Efficient Cartilage and Subchondral Bone Regeneration

Advanced Science, Journal Year: 2023, Volume and Issue: 10(26)

Published: July 9, 2023

Abstract In clinical practice, repairing osteochondral defects presents a challenge due to the varying biological properties of articular cartilages and subchondral bones. Thus, elucidating how spatial microenvironment‐specific biomimetic scaffolds can be used simultaneously regenerate tissue is an important research topic. Herein, novel bioinspired double‐network hydrogel scaffold produced via 3D printing with tissue‐specific decellularized extracellular matrix (dECM) human adipose mesenchymal stem cell (MSC)‐derived exosomes described. The bionic promote rat bone marrow MSC attachment, spread, migration, proliferation, chondrogenic osteogenic differentiation in vitro, as determined based on sustained release bioactive exosomes. Furthermore, 3D‐printed heterogeneous bilayer efficiently accelerate simultaneous regeneration cartilage tissues preclinical model. conclusion, dECM‐based biomimetics encapsulated serve cell‐free recipe for therapy when treating injured or degenerative joints. This strategy provides promising platform complex zonal whilst holding attractive translation potential.

Language: Английский

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Nanomedomics

ACS Nano, Journal Year: 2024, Volume and Issue: 18(17), P. 10979 - 11024

Published: April 18, 2024

Nanomaterials have attractive physicochemical properties. A variety of nanomaterials such as inorganic, lipid, polymers, and protein nanoparticles been widely developed for nanomedicine via chemical conjugation or physical encapsulation bioactive molecules. Superior to traditional drugs, nanomedicines offer high biocompatibility, good water solubility, long blood circulation times, tumor-targeting Capitalizing on this, several nanoformulations already clinically approved many others are currently being studied in clinical trials. Despite their undoubtful success, the molecular mechanism action vast majority remains poorly understood. To tackle this limitation, herein, review critically discusses strategy applying multiomics analysis study nanomedicines, named nanomedomics, including advantages, applications, future directions. comprehensive understanding could provide valuable insight therefore foster development translation nanomedicines.

Language: Английский

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Bioinspired soft-hard combined system with mild photothermal therapeutic activity promotes diabetic bone defect healing via synergetic effects of immune activation and angiogenesis

Theranostics, Journal Year: 2024, Volume and Issue: 14(10), P. 4014 - 4057

Published: Jan. 1, 2024

Background:The comprehensive management of diabetic bone defects remains a substantial clinical challenge due to the hostile regenerative microenvironment characterized by aggravated inflammation, excessive reactive oxygen species (ROS), bacterial infection, impaired angiogenesis, and unbalanced homeostasis.Thus, an advanced multifunctional therapeutic platform capable simultaneously achieving immune regulation, elimination, tissue regeneration is urgently designed for augmented under pathological milieu.Methods Results: Herein, photoactivated soft-hard combined scaffold system (PGCZ) was engineered introducing polydopamine-modified zeolitic imidazolate framework-8-loaded double-network hydrogel (soft matrix component) into 3D-printed poly(ε-caprolactone) (PCL) (hard component).The versatile PGCZ based on PCL thus prepared features highly extracellular matrix-mimicking microstructure, suitable biodegradability mechanical properties, excellent photothermal performance, allowing long-term structural stability support regeneration.Under periodic near-infrared (NIR) irradiation, localized effect triggers on-demand release Zn 2+ , which, together with repeated mild hyperthermia, collectively accelerates proliferation osteogenic differentiation preosteoblasts potently inhibits growth biofilm formation.Additionally, also presents outstanding immunomodulatory ROS scavenging capacities, which regulate M2 polarization macrophages drive functional cytokine secretion, leading pro-regenerative in situ enhanced vascularization.In vivo experiments further demonstrated that conjunction activity remarkably attenuated local inflammatory cascade, initiated endogenous stem cell recruitment neovascularization, orchestrated osteoblast/osteoclast balance, ultimately accelerating regeneration. Ivyspring

Language: Английский

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Sequential construction of vascularized and mineralized bone organoids using engineered ECM-DNA-CPO-based bionic matrix for efficient bone regeneration

Bioactive Materials, Journal Year: 2025, Volume and Issue: 49, P. 362 - 377

Published: March 14, 2025

Language: Английский

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Engineering Multifunctional Surface Topography to Regulate Multiple Biological Responses

Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123136 - 123136

Published: Jan. 1, 2025

Language: Английский

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Nanostructured 3D‐Printed Hybrid Scaffold Accelerates Bone Regeneration by Photointegrating Nanohydroxyapatite

Advanced Science, Journal Year: 2023, Volume and Issue: 10(13)

Published: March 11, 2023

Abstract Nanostructured biomaterials that replicate natural bone architecture are expected to facilitate regeneration. Here, nanohydroxyapatite (nHAp) with vinyl surface modification is acquired by silicon‐based coupling agent and photointegrated methacrylic anhydride‐modified gelatin manufacture a chemically integrated 3D‐printed hybrid scaffold (75.6 wt% solid content). This nanostructured procedure significantly increases its storage modulus 19.43‐fold (79.2 kPa) construct more stable mechanical structure. Furthermore, biofunctional hydrogel biomimetic extracellular matrix anchored onto the filament of (HGel‐ g ‐nHAp) polyphenol‐mediated multiple chemical reactions, which contributes initiate early osteogenesis angiogenesis recruiting endogenous stem cells in situ. Significant ectopic mineral deposition also observed subcutaneously implanted nude mice enhancement 25.3‐fold after 30 days. Meanwhile, HGel‐ ‐nHAp realizes substantial reconstruction rabbit cranial defect model, achieving 61.3% breaking load strength 73.1% volume fractions comparison cranium 15 weeks implantation. optical integration strategy modified nHAp provides prospective structural design for regenerative scaffold.

Language: Английский

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Photoactivated Hydrogel Therapeutic System with MXene‐Based Nanoarchitectonics Potentiates Endogenous Bone Repair Through Reshaping the Osteo‐Vascularization Network

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 8, 2024

Abstract The repair and reconstruction of large‐scale bone defects face enormous challenges because the failure to reconstruct osteo‐vascularization network. Herein, a near‐infrared (NIR) light‐responsive hydrogel system is reported achieve programmed tissue regeneration through synergetic effects on‐demand drug delivery mild heat stimulation. spatiotemporal (HG/MPa) composed polydopamine‐coated Ti 3 C 2 T x MXene (MP) nanosheets decorated with acidic fibroblast growth factor (aFGF, potent angiogenic drug) hydroxypropyl chitosan/gelatin (HG) developed orchestrate network boost regeneration. Upon exposure NIR light irradiation, engineered HG/MPa can initial complete release aFGF induce rapid angiogenesis provide sufficient blood supply, maximizing its biofunction in defect area. This integrated demonstrated good therapeutic efficacy promoting cell adhesion, proliferation, migration, angiogenesis, osteogenic differentiation periodic irradiation. In vivo, animal experiments further revealed that spatiotemporalized platform synergized photothermal treatment significantly accelerated critical‐sized healing by increasing density, recruiting endogenous stem cells, facilitating production osteogenesis/angiogenesis‐related factors. Overall, smart‐responsive could enhance

Language: Английский

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