Advances in Colloid and Interface Science,
Journal Year:
2024,
Volume and Issue:
330, P. 103207 - 103207
Published: June 3, 2024
To
overcome
the
challenges
of
poor
wound
diagnosis
and
limited
clinical
efficacy
current
management,
dressing
materials
with
aim
monitoring
various
biomarkers
vital
to
healing
process
such
as
temperature,
pH,
glucose
concentration,
reactive
oxygen
species
(ROS)
improving
therapeutic
outcomes
have
been
developed.
These
innovative
theranostic
dressings
are
smartly
engineered
using
stimuli-responsive
biomaterials
monitor
regulate
local
microenvironments
deliver
cargos
sites
in
a
timely
effective
manner.
This
review
provides
an
overview
recent
advances
novel
theranostics
for
therapy
well
giving
insights
into
future
treatment
wounds
via
smart
design
materials.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: May 13, 2024
Abstract
Excessive
production
of
reactive
oxygen
species
(ROS)
and
inflammation
are
the
key
problems
that
impede
diabetic
wound
healing.
In
particular,
dressings
with
ROS
scavenging
capacity
play
a
crucial
role
in
process
chronic
Herein,
Zr-based
large-pore
mesoporous
metal–organic
frameworks
(mesoMOFs)
were
successfully
developed
for
construction
spatially
organized
cascade
bioreactors.
Natural
superoxide
dismutase
(SOD)
an
artificial
enzyme
these
hierarchical
mesoMOFs,
forming
antioxidant
defense
system,
presenting
efficient
intracellular
extracellular
performance.
vivo
experiments
demonstrated
SOD@HMUiO-MnTCPP
nanoparticles
(S@M@H
NPs)
significantly
accelerated
Transcriptomic
western
blot
results
further
indicated
nanocomposite
could
inhibit
fibroblast
senescence
ferroptosis
as
well
stimulator
interferon
genes
(STING)
signaling
pathway
activation
macrophages
mediated
by
mitochondrial
oxidative
stress
through
elimination.
Thus,
biomimetic
multi-enzyme
catalytic
system
spatial
ordering
high
potential
healing,
where
senescence,
ferroptosis,
STING
pathways
may
be
targets.
Graphical
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 28, 2025
Abstract
Hyperglycemia
exacerbates
bacterial
infections,
disrupts
angiogenesis,
and
perpetuates
chronic
inflammation
in
the
wound.
Therefore,
effective
management
of
diabetic
wounds
necessitates
a
synergistic
approach
that
integrates
local
wound
microenvironment
remodeling
with
systemic
hyperglycemia
regulation.
Herein,
an
unprecedented
hierarchical
cobalt
pyrophosphate/DNA
(Co
2
PPi/DNA)
nanocomposite
is
reported
for
this
purpose.
Unlike
stereotypical
assembly
either
enzymatically
polymerized
ultralong
nucleic
acids
Mg
PPi
nanosheets
at
low
ratios
or
commercial
homo‐oligonucleotides
devoid
biofunctionalities
presence
metal
ions,
study
represents
first
demonstration
on
coordination‐driven
high‐efficiency
co‐assembly
biofunctional
hetero‐oligonucleotides
non‐Mg
nanosheets,
specifically
glucagon
receptor
(GCGR)
aptamer
Co
nanosheets.
To
improve
bioavailability
nanocomposites,
dissolvable
microneedle
patch
applied
their
delivery.
Thereafter,
nanocomposites
dissociate
sustained
release
2+
ions
GCGR
aptamer,
from
which
eliminate
colonized
bacteria
promote
angiogenesis
through
stabilizing
HIF‐1α,
meanwhile,
after
circulating
to
liver
reduces
blood
glucose
levels
by
binding
hepatocyte
GCGR.
Importantly,
hypoglycemic
effect
promotes
antibacterial
pro‐angiogenic
efficacy
alleviates
inflammatory
responses.
This
work
highlights
significant
advancements
coordination
into
versatile
architecture
remodel
pathological
facilitated
factor
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 10, 2025
Diabetic
wounds
are
refractory
and
recurrent
diseases
that
necessitate
the
development
of
multifunctional
dressings.
Inspired
by
structure
function
skin,
we
herein
delicately
design
a
novel
swollen
hydrophobic
hydrogel
(QL@MAB)
composed
methyl
acrylate
(MA)
(3-acrylamidophenyl)boronic
acid
(AAPBA)
network
co-loaded
with
antioxidant
quercetin
(Q)
antibiotic
levofloxacin
(L)
for
efficient
diabetic
wound
therapy.
The
MA
segments
undergo
phase
separation
to
form
dense
"epidermis",
ensuring
prolonged
drug
diffusion,
long-term
water
retention,
high
content.
Meanwhile,
AAPBA
generate
glucose-labile
"sweat
pores"
via
borate
ester
bonds
polyphenol
Q.
Upon
encountering
hyperglycemic
microenvironment,
dilated
due
cleavage
exposure
diffusion
channel,
facilitating
release
accelerated
healing.
In
infected
rats,
QL@MAB
achieves
rapid
debridement
re-epithelization
while
promoting
angiogenesis,
hair
follicle
regeneration,
extracellular
matrix
remodeling.
Taken
together,
this
study
not
only
represents
multipronged
dressing
effective
interventions
but
also
contributes
rational
smart
hydrogels
tailored
biomedical
applications.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 7, 2025
Abstract
Chronic
wounds
are
a
common
complication
of
diabetes,
causing
significant
inconvenience,
persistent
pain,
and
economic
burden
to
patients.
Real‐time
monitoring
wound
status
timely
treatment
with
intelligent
dressings
is
promising
way
treat
infection
accelerate
healing.
However,
the
traditional
make
it
difficult
simultaneously
maintain
true
state
meet
dynamic
needs
chronic
wounds.
Herein,
multifunctional
self‐powered
patch
(MSPP)
featured
antibacterial,
hypoglycemic,
electrical
stimulation
designed
promote
healing
real‐time
status,
in
which
laser‐induced
nanozyme
electrodes
prepared
situ
through
laser
scanning
technology
construct
highly
stable
nanozyme‐based
glucose
biofuel
cells
(GBFCs).
Enzymatic
cascade
reaction
GBFCs
can
use
local
hyperglycemia
produce
reactive
oxygen
species
effective
antibacterial
properties,
reduce
while
generating
microcurrent,
further
diabetes
In
just
10
days,
patch‐treated
group
achieves
100%
shrinkage.
Meanwhile,
pH
sensing
module
MSPP
also
monitor
fluctuations
correct
test
results,
improving
accuracy.
brief,
construction
provides
solutions
for
developing
closed‐loop
biomedical
systems
that
integrate
monitoring,
diagnosis,
treatment.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(23), P. 16714 - 16714
Published: Nov. 24, 2023
Numerous
innovative
advancements
in
dressing
technology
for
wound
healing
have
emerged.
Among
the
various
types
of
dressings
available,
hydrogel
dressings,
structured
with
a
three-dimensional
network
and
composed
predominantly
hydrophilic
components,
are
widely
used
care
due
to
their
remarkable
capacity
absorb
abundant
exudate,
maintain
moisture
environment,
provide
soothing
cooling
effects,
mimic
extracellular
matrix.
Composite
one
evolved
address
limitations
traditional
by
incorporating
additional
including
particles,
fibers,
fabrics,
or
foams,
within
hydrogels,
effectively
promoting
treatment
healing.
The
added
elements
enhance
features
add
specific
functionalities
such
as
sensitivity
external
factors,
adhesiveness,
mechanical
strength,
control
over
release
therapeutic
agents,
antioxidant
antimicrobial
properties,
tissue
regeneration
behavior.
They
can
be
categorized
natural
synthetic
based
on
origin
main
components
network.
This
review
focuses
recent
research
developing
polysaccharide-based
composite
dressings.
It
explores
preparation
composition,
reinforcement
materials
integrated
into
agents.
Furthermore,
it
discusses
wounds
where
applied.
Journal of Tissue Engineering,
Journal Year:
2024,
Volume and Issue:
15
Published: Jan. 1, 2024
The
rising
prevalence
of
diabetes
has
underscored
concerns
surrounding
diabetic
wounds
and
their
potential
to
induce
disability.
intricate
healing
mechanisms
are
multifaceted,
influenced
by
ambient
microenvironment,
including
prolonged
hyperglycemia,
severe
infection,
inflammation,
elevated
levels
reactive
oxygen
species
(ROS),
ischemia,
impaired
vascularization,
altered
wound
physicochemical
properties.
In
recent
years,
hydrogels
have
emerged
as
promising
candidates
for
treatment
owing
exceptional
biocompatibility
resemblance
the
extracellular
matrix
(ECM)
through
a
three-dimensional
(3D)
porous
network.
This
review
will
first
summarize
microenvironment
alterations
occurring
in
wounds,
aiming
provide
comprehensive
understanding
its
pathogenesis,
then
classification
recently
developed
be
presented,
encompassing
properties
such
hypoglycemic
effects,
anti-inflammatory
capabilities,
antibacterial
attributes,
ROS
scavenging
abilities,
promotion
angiogenesis,
pH
responsiveness,
more.
primary
objective
is
offer
valuable
reference
repairing
based
on
unique
microenvironment.
Moreover,
this
paper
outlines
avenues
future
advancements
hydrogel
dressings
facilitate
expedite
process
wounds.
