An NIR-propelled janus nanomotor with enhanced ROS-scavenging, immunomodulating and biofilm-eradicating capacity for periodontitis treatment

Bioactive Materials, Journal Year: 2024, Volume and Issue: 41, P. 271 - 292

Published: July 24, 2024

Periodontitis is an inflammatory disease caused by bacterial biofilms, which leads to the destruction of periodontal tissue. Current treatments, such as mechanical cleaning and antibiotics, struggle effectively address persistent inflammation, tissue damage. A new approach involves developing a Janus nanomotor (J-CeM@Au) coating cerium dioxide-doped mesoporous silica (CeM) with gold nanoparticles (AuNPs). This exhibits thermophoretic motion when exposed near-infrared (NIR) laser light due temperature gradient produced photothermal effects asymmetrically distributed AuNPs. The NIR provides energy for propulsion activates nanomotor's antibacterial properties, allowing it penetrate biofilms kill bacteria. Additionally, ability scavenge reactive oxygen species (ROS) can modulate immune response create regenerative environment, promoting healing Overall, this multifunctional offers promising treating periodontitis simultaneously addressing biofilm management modulation autonomous movement.

Language: Английский

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Multicomponent Synergistic Antibacterial Hydrogel Based on Gelatin-Oxidized Carboxymethyl Cellulose for Wound Healing of Drug-Resistant Chronic Infection

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(5), P. 3469 - 3482

Published: April 23, 2024

Bacterial invasion hinders the healing process of wound, leading to formation chronic infected wound; meanwhile, misuse antibiotics has resulted in emergence numerous drug-resistant bacteria. The application conventional antimicrobial methods and wound treatment techniques is not appropriate for dressings. In this paper, quaternized poly(vinyl alcohol) (QPVA) pomegranate-like copper uniformly doped polydopamine nanoparticles (PDA@Cu) were introduced into a gelatin-oxidized carboxymethyl cellulose system form multicomponent synergistic antibacterial hydrogel (GOQ

Language: Английский

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An Intramolecular Rotor-Bridged Dimeric Cyanine Photothermal Transducer for Efficient Near-Infrared II Fluorescence Imaging-Guided Mitochondria-Targeted Phototherapy

ACS Sensors, Journal Year: 2024, Volume and Issue: 9(7), P. 3581 - 3593

Published: July 3, 2024

Near-infrared (NIR) heptamethine cyanine (HCy) dyes are promising photothermal transducers for image-guided cancer treatment owing to their prominent photophysical properties and high conversion ability. However, HCy usually have poor photostability due degradation induced by the self-generated reactive oxygen species. Herein, a novel mitochondria-targeting dimeric dye, named oBHCy, is rationally designed, exhibiting strong near-infrared II (NIR-II) fluorescence emission, efficiency (PCE), excellent photostability. The large π-conjugation drastic intramolecular motion of diphenol rotor in oBHCy enhance nonradiative energy dissipation suppress intersystem crossing process, thereby achieving PCE (49.2%) improved Impressively, can precisely target mitochondria induce mitochondrial damage upon NIR light irradiation. Under guidance vivo NIR-II imaging, efficient light-activated therapy 4T1 breast tumors accomplished with tumor inhibitory rate 96% following single injection oBHCy. This work offers an innovative strategy designing integrated theranostics.

Language: Английский

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Shining Light on Multidrug‐Resistant Bacterial Infections: Rational Design of Multifunctional Organosilver‐Based AIEgen Probes as Light‐Activated Theranostics for Combating Biofilms and Liver Abscesses

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(45)

Published: Aug. 2, 2023

Abstract The intricate environment of biofilms provides a heaven for bacteria to escape antibiotic eradication, leading persistent chronic infections. Therefore, it is urgently needed develop effective therapies combat biofilm‐associated To address this problem, series antimicrobial agents are designed and synthesized utilizing triphenylamine imidazole silver complexes ( TPIMS ). Due the photoactivated release Ag + coupled with aggregation‐induced emission (AIE) properties efficient 1 O 2 generation, exhibits excellent visual diagnostic capabilities potent broad‐spectrum activity, showing efficacy against both Gram (+) (−) bacteria. Additionally, shows extraordinary antibacterial performance biofilm resistance methicillin‐resistant Staphylococcus aureus MRSA ), reduced potential thanks synergistic effect phototoxicity dark toxicity. Notably, among variants tested, TPIMS‐8 has demonstrated exceptional curative ability resistant bacterial infections in vivo minimal side effects. Furthermore, applied clinical samples from infected patients results indicated that able achieve bacterial‐specific detection superior killing drug‐resistant even complex systems, demonstrating its great applications. This study presents promising foundation development advanced therapeutics targeting multidrug‐resistant

Language: Английский

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Biomimetic Metal–Organic Framework Combats Biofilm‐Associated Infections via Hyperthermia‐Enhanced Bacterial Metabolic Interference and Autophagy‐Promoted Adaptive Immunity

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(8)

Published: Nov. 12, 2023

Abstract Robust bacterial metabolism and the immunosuppression on peripheral immune cells cause biofilm‐associated infections (BAIs) extremely refractory to be eradicated via antibiotics alone. Herein, hierarchical mesoporous UiO‐66 metal–organic framework is decorated with selenite, polypyrrole, macrophage membrane (MM) develop a biomimetic nanosphere (USPM). Following recruitment of USPM biofilm microenvironment (BME) pathogen‐targeting ability derived from MM. The BME‐responsive can precisely release selenite penetrate loosened in synergy near‐infrared‐induced mild photothermal therapy (mPTT). Selenite quickly react reducing substances generate hydrogen selenide (H 2 Se) inside biofilm. H Se competitively inhibit metabolic processes disrupt homeostasis by cascade amplification effects. Furthermore, further sensitizes photothermia exert precise local effect. Outside biofilm, simultaneously promote phagocytosis autophagy macrophages kill decompose phagocytosed bacteria. Finally, well‐decomposed antigens presented antigen‐presenting arouse adaptive responses enhance anti‐biofilm effectiveness further. Such powerful mPTT‐enhanced disruption macrophagic autophagy‐promoted activation suggest an alternative therapeutic strategy cure BAIs.

Language: Английский

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Tunable Fluorescence, Morphology, and Antibacterial Behaviors of Conjugated Oligomers via Host–Guest Supramolecular Self-Assembly

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(4), P. 2533 - 2543

Published: March 25, 2024

Host–guest supramolecular self-assembly has become one facile but efficient way to regulate the optical properties of conjugated oligomers and construct promising photofunctional materials. Herein, we design two linear terminated with or four pyridinium moieties, which show different 1:1 'head-to-tail' binding patterns cucurbit[8]uril (CB[8]) form host–guest supramolecules. After being encapsulated in hydrophobic cavity CB[8] host, fluorescence emission undergoes significant changes, resulting tunable color enhanced quantum yields. Triggered by aggregation supramolecules, regular rigid modes lead formation cuboids spheroids nanoscale, respectively. Due macrocyclic-confinement effect, light-driven reactive oxygen species (ROS) production complex is increased significantly, thereby improving photodynamic antibacterial performance toward Staphylococcus aureus (S. aureus).

Language: Английский

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Microenvironment with NIR-Controlled ROS and Mechanical Tensions for Manipulating Cell Activities in Wound Healing

Nano Letters, Journal Year: 2024, Volume and Issue: 24(10), P. 3257 - 3266

Published: March 1, 2024

The extracellular matrix (ECM) orchestrates cell behavior and tissue regeneration by modulating biochemical mechanical signals. Manipulating cell-material interactions is crucial for leveraging biomaterials to regulate functions. Yet, integrating multiple cues in a single material remains challenge. Here, near-infrared (NIR)-controlled multifunctional hydrogel platforms, named PIC/CM@NPs, are introduced dictate fibroblast during wound healing tuning the oxidative stress tensions. PIC/CM@NPs prepared through adhesion-medicated assembly of collagen-like polyisocyanide (PIC) polymers cell-membrane-coated conjugated polymer nanoparticles (CM@NPs), which closely mimic fibrous structure nonlinear mechanics ECM. Upon NIR stimulation, composites enhance proliferation, migration, cytokine production, myofibroblast activation, closure. Moreover, they exhibit effective toxin removal antibacterial properties, reducing inflammation. This approach accelerates 95%, highlighting importance biophysical biomaterial design advanced regeneration.

Language: Английский

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Emerging Trends in Dissolving-Microneedle Technology for Antimicrobial Skin-Infection Therapies

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(9), P. 1188 - 1188

Published: Sept. 8, 2024

Skin and soft-tissue infections require significant consideration because of their prolonged treatment duration propensity to rapidly progress, resulting in severe complications. The primary challenge stems from the involvement drug-resistant microorganisms that can form impermeable biofilms, as well possibility infection extending deep into tissues, thereby complicating drug delivery. Dissolving microneedle patches are an innovative transdermal drug-delivery system effectively enhances penetration through stratum corneum barrier, increasing concentration at site infection. They offer highly efficient, safe, patient-friendly alternatives conventional topical formulations. This comprehensive review focuses on recent advances emerging trends dissolving-microneedle technology for antimicrobial skin-infection therapy. Conventional antibiotic microneedles compared with those based agents, such quorum-sensing inhibitors, peptides, antimicrobial-matrix materials. also highlights potential incorporating chemodynamic, nanoenzyme antimicrobial, photodynamic, photothermal antibacterial therapies. explores advantages various therapies emphasizes combined application improve efficacy microneedles. Finally, this analyzes druggability different discusses possible future developments.

Language: Английский

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Photo-Controlled extracellular electron transfer in Non-Extracellular respiratory bacteria by constructing a nanoscale interface material for energy transformation

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159553 - 159553

Published: Jan. 1, 2025

Language: Английский

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Non‐Fused Conjugated Oligomer with Manipulated Intermolecular Charge Transfer for Highly Efficient Near‐Infrared Phototheranostics of Cancer

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Abstract Near‐infrared (NIR) phototheranostics, combining photoacoustic imaging (PAI) and photothermal therapy (PTT), show great promise for cancer diagnosis treatment. Organic molecules are excellent agents (PTAs) due to their strong NIR absorption biodegradability. Typically, achieving good response involves using fused‐ring backbones, which require complex synthesis yield lower production. In this work, 2F nanoparticles (NPs) reported as an organic phototheranostic agent with high responses, synthesized in just two simple steps 87% production efficient PAI‐guided PTT of cancer. Unlike traditional structures, is formed by joining donor acceptor moieties carbon–carbon bonds, simplifying increasing yield. Although isolated have absorption, forming NPs shifts the peak from 708 808 nm, comparable state‐of‐the‐art phototheranostics. This shift significant charge transfer between dimers, a single‐component charge‐transfer improved shown spectra theoretical studies. Finally, demonstrate successful under excitation anti‐tumor performance. work provides valuable insight into both photophysical performance PTAs, advancing development PTT.

Language: Английский

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