Lab on a Chip, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Organoids-on-a-chip exhibit significant potential for advancing disease modeling, drug screening, and precision medicine, largely due to their capacity facilitate interactions among organoids.
Language: Английский
Nature Reviews Methods Primers, Journal Year: 2023, Volume and Issue: 3(1)
Published: Sept. 7, 2023
Language: Английский
Citations
46
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: March 12, 2024
Abstract Developing diagnostics and treatments for neurodegenerative diseases (NDs) is challenging due to multifactorial pathogenesis that progresses gradually. Advanced in vitro systems recapitulate patient-like pathophysiology are emerging as alternatives conventional animal-based models. In this review, we explore the interconnected pathogenic features of different types ND, discuss general strategy modelling NDs using a microfluidic chip, introduce organoid-on-a-chip next advanced relevant model. Lastly, overview how these models being applied academic industrial drug development. The integration chips, stem cells, biotechnological devices promises provide valuable insights biomedical research developing diagnostic therapeutic solutions NDs.
Language: Английский
Citations
30
Theranostics, Journal Year: 2024, Volume and Issue: 14(2), P. 788 - 818
Published: Jan. 1, 2024
Human organoids-on-chips (OrgOCs) are the synergism of human organoids (HOs) technology and microfluidic organs-on-chips (OOCs).OOCs can mimic extrinsic characteristics organs, such as environmental clues living tissue, while HOs more amenable to biological analysis genetic manipulation.By spatial cooperation, OrgOCs served 3D organotypic models allowing them recapitulate critical tissue-specific properties forecast responses outcomes.It represents a giant leap forward from regular 2D cell monolayers animal in improved ecological niche modeling.In recent years, have offered potential promises for clinical studies advanced preclinical-to-clinical translation medical industrial fields.In this review, we highlight cutting-edge achievements OrgOCs, introduce key features architectures, share revolutionary applications basic biology, disease modeling, preclinical assay precision medicine.Furthermore, discuss how combine wide range disciplines with accelerate translational applications, well challenges opportunities biomedical research applications.
Language: Английский
Citations
23
Materials Horizons, Journal Year: 2024, Volume and Issue: 11(12), P. 2820 - 2855
Published: Jan. 1, 2024
A systematic summary of fabrication technologies, a variety structures and biomedical applications polymeric microspheres.
Language: Английский
Citations
23
Cell stem cell, Journal Year: 2024, Volume and Issue: 31(5), P. 772 - 787.e11
Published: April 1, 2024
Language: Английский
Citations
19
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Jan. 2, 2025
Language: Английский
Citations
2
Biosensors, Journal Year: 2024, Volume and Issue: 14(5), P. 225 - 225
Published: May 1, 2024
Organ-on-a-chip (OOC) is an emerging technology that simulates artificial organ within a microfluidic cell culture chip. Current biology research focuses on in vitro cultures due to various limitations of vivo testing. Unfortunately, in-vitro culturing fails provide accurate microenvironment, and expensive has historically been source ethical controversy. OOC aims overcome these shortcomings the best both research. The critical component design utilizing microfluidics ensure stable concentration gradient, dynamic mechanical stress modeling, reconstruction cellular microenvironment. also advantage complete observation control system, which impossible recreate in-vivo Multiple throughputs, channels, membranes, chambers are constructed polydimethylsiloxane (PDMS) array simulate organs Various experiments can be performed technology, including drug delivery toxicology. technological expansions involve multiple microenvironments single chip, allowing for studying inter-tissue interactions. Other developments include finding more suitable material as replacement PDMS minimizing artefactual error non-translatable differences.
Language: Английский
Citations
15
Nanoscale Horizons, Journal Year: 2024, Volume and Issue: 9(3), P. 334 - 364
Published: Jan. 1, 2024
Integrating the advances of emerging hyperthermia techniques with 3D tumor models and non-invasive temperature control systems can contribute to identifying top-performing hyperthermic nanomedicines in preclinical evaluation stages.
Language: Английский
Citations
12
Tissue Engineering Part A, Journal Year: 2024, Volume and Issue: 30(11-12), P. 314 - 321
Published: Jan. 11, 2024
Organoids are three-dimensional (3D)
Language: Английский
Citations
11
ACS Sensors, Journal Year: 2024, Volume and Issue: 9(7), P. 3466 - 3488
Published: July 11, 2024
Organ-on-a-Chip (OOC) technology, which emulates the physiological environment and functionality of human organs on a microfluidic chip, is undergoing significant technological advancements. Despite its rapid evolution, this technology also facing notable challenges, such as lack vascularization, development multiorgan-on-a-chip systems, replication body single chip. The progress has played crucial role in steering OOC toward mimicking microenvironment, including microenvironment replication, multiorgan microphysiological systems. Additionally, advancements detection, analysis, organoid imaging technologies have enhanced efficiency Organs-on-Chips (OOCs). In particular, integration artificial intelligence revolutionized imaging, significantly enhancing high-throughput drug screening. Consequently, review covers research Human-on-a-chip, sensors OOCs, latest applications biomedical field.
Language: Английский
Citations
11