Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 479, P. 147804 - 147804
Published: Dec. 5, 2023
Language: Английский
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(34)
Published: March 10, 2024
Abstract Native bone inherently requires a balanced ionic microenvironment to maintain homeostasis. Hence, scaffolds designed for the sustained release of therapeutic ions into defects hold great promise regeneration. Magnesium (Mg) and silicon (Si) are essential elements, which play crucial roles in process regeneration, impacting immunomodulation, angiogenesis, osteogenesis. Herein, porous cryogel‐type organic–inorganic composite microspheres developed as injectable microscaffolds (denoted GMN). GMN enables Mg/Si at an optimized ratio, achieving most significant synergistic effect on vascularized Various conditioned media obtained explore angiogenesis‐osteogenesis coupling, well crosstalk between marrow mesenchymal stromal cells (BMSCs) macrophages. Meanwhile, autocrine paracrine effects simultaneously modulating functions determining cell fates under guidance biofactors secreted by cells. Overall, ion‐engineering create conducive efficiently augment regeneration tissue vivo, offering versatile platform engineering.
Language: Английский
Citations
17
Materials & Design, Journal Year: 2023, Volume and Issue: 234, P. 112313 - 112313
Published: Sept. 9, 2023
Language: Английский
Citations
39
Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 16(1)
Published: July 15, 2024
Macrophage immunotherapy represents an emerging therapeutic approach aimed at modulating the immune response to alleviate disease symptoms. Nanomaterials (NMs) have been engineered monitor macrophage metabolism, enabling evaluation of progression and replication intricate physiological signal patterns. They achieve this either directly or by delivering regulatory signals, thereby mapping phenotype effector functions through metabolic repurposing customize fate for therapy. However, a comprehensive summary regarding NM-mediated visualization coordinated rewiring maintain phenotypic equilibrium is currently lacking. This review aims address gap outlining recent advancements in NM-based immunotherapy. We initially explore relationship between polarization, disease, before delving into NM innovations that visualize activity elucidate onset fine-tune its remodeling macrophage-centered Finally, we discuss prospects challenges immunotherapy, aiming accelerate clinical translation. anticipate will serve as valuable reference researchers seeking leverage novel intervention-matched immunomodulators macrophages other fields engineering.
Language: Английский
Citations
10
Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown
Published: March 24, 2025
Abstract Replicating the complex mechanical forces of muscle movement and fluid flow in vitro cell culture systems is crucial for understanding differentiation development. However, previous research focused on static micro/nanotextures without a force field or flat 2‐dimensional substrates under continuous in‐plane force. In this study, reported using spatial geometric platform that can periodically modulate through custom‐made soft pneumatic device (SPD) to mimic interfaces between periosteum interstitial fluid. To elucidate fluidic dynamics fates relevant bone physiology, exhibited distinct functional responses based levels: low mechanotransduction induced mesenchymal stem/progenitor cells into osteoprogenitor (≈1.5‐fold increase osteo‐differentiation), while high resulted structural disruptions resembling detachment protein degradation (≈2‐fold effective detachment). Numerical simulations SPD elucidated principal components programmable by deconvoluting out‐of‐plane mode. This study offers comprehensive novel insights correlation differentiation, recovery, injury organisms.
Language: Английский
Citations
0
Composites Part B Engineering, Journal Year: 2025, Volume and Issue: unknown, P. 112503 - 112503
Published: April 1, 2025
Language: Английский
Citations
0
Journal of Materials Science, Journal Year: 2024, Volume and Issue: 59(24), P. 10650 - 10676
Published: June 1, 2024
Language: Английский
Citations
3
Ceramics International, Journal Year: 2024, Volume and Issue: 50(20), P. 39608 - 39626
Published: July 24, 2024
Language: Английский
Citations
3
Trends in biotechnology, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 1, 2024
Language: Английский
Citations
2
Nano Letters, Journal Year: 2024, Volume and Issue: 24(46), P. 14574 - 14583
Published: Nov. 8, 2024
The creation of complex multilayer periosteal graft structures is challenging. This study introduced a novel bottom-up approach to assemble cell-laden nanofiber mats into three-dimensional (3D) periosteum mimic, successfully replicating the hierarchical complexity natural periosteum. These mats, which were fabricated by electrospinning, surface modification, and stimulated body fluid (SBF) immersion, are composed nanoscale polycaprolactone (PCL) fibers coated with mineralized collagen layer along fiber orientation. They closely resembled matrix, thereby promoting osteogenic differentiation rat bone marrow mesenchymal stem cells (rBMSCs) in vitro. biomimetic periosteum, constructed via layer-by-layer assembly, offered advantages such as nanofibrous structure, controlled cell distribution, reservoir for osteoprogenitors, enhanced pro-osteogenic potential. calvarial defect model confirmed its potent repair capacity. presents an efficient construct tissue-engineered mimics, holding promise serving grafts orthopedic applications.
Language: Английский
Citations
2
Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 479, P. 147804 - 147804
Published: Dec. 5, 2023
Language: Английский
Citations
2