Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 158748 - 158748
Published: Dec. 1, 2024
Language: Английский
Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(18), P. 6447 - 6496
Published: Jan. 1, 2023
This review highlights the use of nanoprobes to stratify various therapeutic modalities and provides an outlook on challenges future directions for patient stratification.
Language: Английский
Citations
50
Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: 30(17)
Published: Jan. 6, 2024
Platinum supramolecular complexes based on photosensitizers have garnered great interest in photodynamic therapy (PDT) due to Pt (II) centers as chemotherapeutic agents eliminate tumor cells completely, which greatly improve the antitumor efficacy of PDT. However, comparison precursor photosensitizer ligand, formed platinum typically exhibit inferior outcomes terms reactive oxygen species (ROS) generation. How boost ROS generation for enhanced PDT is an enticing yet highly challenging task. Here we report a Pt-coordination-based dimeric complex (Cz-BTZ-Py)
Language: Английский
Citations
6
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(37)
Published: March 5, 2024
Abstract Based on the properties of photodynamic therapy (PDT) and magnetic resonance imaging (MRI), combining them to construct multifunctional nanotheranostics can leverage strengths avoid weaknesses for tumor diagnosis treatment. However, certain problems remain unsolved, notably short observation window caused by insufficient retention time. In this study, a GSH‐responsive shape‐transformable Gd‐Ce6‐FFVLGGGC‐SS‐PEG are designed (abbreviated as GdCFS) single metal Gd with Ce6, peptide (Phe‐Phe‐Val‐Leu‐Gly‐Gly‐Gly‐Cys) disulfide‐conjugated polyethylene glycol (PEG) perform dual‐modal T 1 /T 2 MRI specifically at site. Due its amphiphilic features, GdCFS self‐assemble spherical nanoparticles, while transforming nanofibers (NFs) in presence intracellular overexpressed GSH stimuli. After NFs formation, hydrophobic core is exposed, resulting positive contrast enhancement, whereas simultaneously achieve negative enhancement. Furthermore, depletion cause imbalance redox state, ultimately improving PDT efficacy. benefits from shape‐transformation terms sufficient time, thus positively minimizing toxicity risk. On model nasopharyngeal carcinoma, vivo vitro outcomes confirm that be promising candidate early diagnosis, real‐time monitoring, precise treatment tumors great biocompatibility.
Language: Английский
Citations
6
ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(15), P. 19571 - 19584
Published: April 2, 2024
Bioinspired photoactive composites, in terms of photodynamic inactivation, cost-effectiveness, and biosafety, are promising alternatives to antibiotics for combating bacterial infections while avoiding antibacterial resistance. However, the weak membrane affinity substrate lack synergistic effect remain crucial shortcomings their applications. Herein, we developed a hydrophobic film from food antioxidant lauryl gallate covalently functionalized chitosan (LG-g-CS conjugates) through green radical-induced grafting reaction that utilizes bacteria capture, contact-killing, inactivation activities achieve enhanced bactericidal biofilm elimination capabilities. Besides, mechanism between LG CS ascorbic acid (AA)/H2O2 redox system was further proposed. The LG-g-CS films feature side chains phenolic hydroxyl groups, facilitating dual capture contact-killing via strong electrostatic interactions with membranes as well blue light (BL)-driven eradication generation reactive oxygen species. As result, efficiently immobilize exhibit excellent activity against model (Escherichia coli Staphylococcus aureus) biofilms under BL irradiation. Moreover, could significantly promote healing process S. aureus-infected wounds. This research demonstrates new strategy designing fabricating sustainable biofilm-removing materials high activity.
Language: Английский
Citations
4
Matter, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 1, 2024
Language: Английский
Citations
4
Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(12), P. 5106 - 5131
Published: Nov. 2, 2024
Reactive oxygen species (ROS)-responsive drug delivery systems (DDSs) have garnered significant attention in cancer research because of their potential for precise spatiotemporal release tailored to high ROS levels within tumors. Despite the challenges posed by distribution heterogeneity and endogenous supply constraints, this review highlights strategic alliance ROS-responsive DDSs with photodynamic therapy (PDT), enabling selective leveraging PDT-induced enhanced therapeutic efficacy. This delves into biological importance progression treatment. We elucidate detail operational mechanisms linkers, including thioether, thioketal, selenide, diselencide, telluride aryl boronic acids/esters, as well latest developments nanomedicines that integrate PDT strategies. These insights are intended inspire design innovative nanocarriers PDT.
Language: Английский
Citations
4
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 163263 - 163263
Published: April 1, 2025
Language: Английский
Citations
0
Biomaterials, Journal Year: 2024, Volume and Issue: 313, P. 122765 - 122765
Published: Aug. 24, 2024
Language: Английский
Citations
3
Dyes and Pigments, Journal Year: 2024, Volume and Issue: 224, P. 112026 - 112026
Published: Feb. 16, 2024
Language: Английский
Citations
1
Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
This review discusses phototherapeutic nanosystems for oral cancer, emphasizing diverse drug delivery systems, advanced photodynamic therapy approaches, and combination therapies.
Language: Английский
Citations
0