Advanced Dressings for Chronic Wound Management

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(5), P. 2660 - 2676

Published: May 9, 2024

Wound healing, particularly for chronic wounds, presents a considerable difficulty due to differences in biochemical and cellular processes that occur different types of wounds. Recent technological breakthroughs have notably advanced the understanding diagnostic therapeutic approaches wound healing. The evolution care has seen transition from traditional textile dressings variety alternatives, including self-healing hydrogels, hydrofibers, foams, hydrocolloids, environment responsive dressings, growth factor-based therapy, bioengineered skin substitutes, stem cell gene therapy. Technological advancements, such as 3D printing electronic (e-skin) contribute customization Despite these effectively managing wounds remains challenging. This necessitates development treatments consider performance, risk–benefit balance, cost-effectiveness. review discusses innovative strategies healing Incorporating biomarkers into coupled with corresponding biosensors drug delivery formulations, enables theranostic approach treatment Furthermore, integrating power sources user interfaces like near-field communication, radio frequency identification, Bluetooth enhances real-time monitoring on-demand delivery. It also provides thorough evaluation advantages, patient compliance, costs, durability emphasizing smart formulations their preparation methods.

Language: Английский

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Antibacterial and anti-inflammatory synergistic effects of double-layer hydrogel promoting bacterial wound healing

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 493, P. 152513 - 152513

Published: May 23, 2024

Language: Английский

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Flexible Triboelectric Nanogenerator Patch for Accelerated Wound Healing Through the Synergy of Electrostimulation and Photothermal Effect

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Physiological wound healing process can restore the functional and structural integrity of skin, but is often delayed due to external disturbance. The development methods for promoting repair skin wounds represents a highly desired challenging goal. Here, flexible, self‐powered, multifunctional triboelectric nanogenerator (TENG) patch (e‐patch) presented accelerating through synergy electrostimulation photothermal effect. To fabricate e‐patch, flexible conductive hydrogel with dual network polyacrylamide (PAM) polydopamine (PDA) synthesized doped multi‐walled carbon nanotubes (MCNTs). exhibits high conductivity, good stretchability, biocompatibility. e‐patch assembled from detect mechanical electrical signals human motions in real‐time manner. In rodent model full‐thickness dorsal wound, integrating self‐driven effect under near‐infrared light irradiation efficiently promotes hair follicle regeneration relieving inflammation, fastening collagen deposition, vascular regeneration, epithelialization. It offers promising way accelerate healing.

Language: Английский

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Expanding Our Horizons: AIE Materials in Bacterial Research

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 9, 2024

Abstract Bacteria share a longstanding and complex relationship with humans, playing role in protecting gut health sustaining the ecosystem to cause infectious diseases antibiotic resistance. Luminogenic materials that aggregation‐induced emission (AIE) characteristics have emerged as versatile toolbox for bacterial studies through fluorescence visualization. Numerous research efforts highlight superiority of AIE this field. Recent advances are categorized into four areas: understanding interactions, antibacterial strategies, diverse applications, synergistic applications bacteria. Initial focuses on visualizing unseen bacteria progresses developing strategies involving electrostatic amphiphilic luminogens (AIEgens), various enhance affinity. progress includes using photodynamic photothermal therapies, toxicity studies, combined therapies. Diverse from environmental disinfection disease treatment, utilizing coatings, sensors, wound healing materials, etc., also provided. Finally, combining achieve enhanced outcomes explored. This review summarizes developmental trend is expected provide future directions advancing methodologies.

Language: Английский

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Engineered Au@MOFs silk fibroin-based hydrogel phototherapy platform for enhanced wound healing performance

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 297, P. 139872 - 139872

Published: Jan. 14, 2025

Language: Английский

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Forsythin-Loaded PET Membrane with Variable Wettability to Construct a Double-Layer Dressing for Wound Healing

ACS Applied Polymer Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 9, 2025

Language: Английский

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Naphthalimide‐Conjugated Spiropyran: Dual‐State Emission and Photo‐Responsive Dynamic Fluorescence Color for Information Encryption Application

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Abstract Developing photo‐switch molecules that show fluorescence in both monomeric and aggregated states, with light‐controllable wavelength is far‐reaching a great challenge. Spiropyran (SP) has received considerable attention this field. Herein, by conjugating naphthalimide to the indole moiety of SP, new spiropyran derivative, named NMI‐SP obtained. shows dual‐state emission excellent its attributed intramolecular charge transfer character. Moreover, demonstrates obvious photochromic behavior, accompanied visible color change from yellow green THF solution, photo‐responsive orange red state. This work provides insights into design materials based on SP fluorophore highlights their potential applications digital coding information conversion.

Language: Английский

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Skin‐Inspired and Self‐Regulated Hydrophobic Hydrogel for Diabetic Wound Therapy

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Diabetic wounds are refractory and recurrent diseases that necessitate the development of multifunctional dressings. Inspired by structure function skin, we herein delicately design a novel swollen hydrophobic hydrogel (QL@MAB) composed methyl acrylate (MA) (3-acrylamidophenyl)boronic acid (AAPBA) network co-loaded with antioxidant quercetin (Q) antibiotic levofloxacin (L) for efficient diabetic wound therapy. The MA segments undergo phase separation to form dense "epidermis", ensuring prolonged drug diffusion, long-term water retention, high content. Meanwhile, AAPBA generate glucose-labile "sweat pores" via borate ester bonds polyphenol Q. Upon encountering hyperglycemic microenvironment, dilated due cleavage exposure diffusion channel, facilitating release accelerated healing. In infected rats, QL@MAB achieves rapid debridement re-epithelization while promoting angiogenesis, hair follicle regeneration, extracellular matrix remodeling. Taken together, this study not only represents multipronged dressing effective interventions but also contributes rational smart hydrogels tailored biomedical applications.

Language: Английский

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Plant-inspired visible-light-driven bioenergetic hydrogels for chronic wound healing

Bioactive Materials, Journal Year: 2024, Volume and Issue: 41, P. 523 - 536

Published: Aug. 10, 2024

Language: Английский

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Chitosan-based hydrogel dressings with antibacterial and antioxidant for wound healing

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 280, P. 135939 - 135939

Published: Sept. 23, 2024

Language: Английский

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