Ultrasensitive NIR‐II Surface‐Enhanced Resonance Raman Scattering Nanoprobes with Nonlinear Photothermal Effect for Optimized Phototheranostics DOI

Laicui Song,

Jin Li

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 28, 2024

Abstract Surface‐enhanced resonance Raman scattering (SERRS) in the second near‐infrared (NIR‐II) window has great potential for improved phototheranostics, but lacks nonfluorescent, resonant and high‐affinity dyes. Herein, it is designed synthesize a multi‐sulfur reporter, NF1064, whose maximum absorption of 1064 nm rigidly resonates with NIR‐II excitation laser while possessing absolutely nonfluorescent backgrounds. Ultrafast spectroscopy suggests that fluorescence quenching mechanism NF1064 originates from twisted intramolecular charge transfer (TICT) excited state. Gold nanorods (AuNRs) decorated such (AuNR@NF1064) show remarkable SERRS performances, including zero‐fluorescence background, femtomolar‐level sensitivity as well superb photostability without photobleaching. More importantly, AuNR@NF1064 exhibits nonlinear photothermal effect upon plasmonic fields AuNRs by amplifying non‐radiative decay thus achieving high conversion 68.5% further augmentation. With properties, nanoprobes allow high‐precision intraoperative guided tumor resection within 8 min, high‐efficient hyperthermia combating drug‐resistant bacterial infection living mouse body. This work not only unlocks dyes imaging, also opens up new method boosting efficiency nanomaterials.

Language: Английский

NIR-II Light-Driven Genetically Engineered Exosome Nanocatalysts for Efficient Phototherapy against Glioblastoma DOI

Xueyang Fang,

Rui Gong,

Decai Yang

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(22), P. 15251 - 15263

Published: May 23, 2024

Glioblastoma (GBM) poses a significant therapeutic challenge due to its invasive nature and limited drug penetration through the blood–brain barrier (BBB). In response, here we present an innovative biomimetic approach involving development of genetically engineered exosome nanocatalysts (Mn@Bi2Se3@RGE-Exos) for efficient GBM therapy via improving BBB enzyme-like catalytic activities. Interestingly, photothermally activatable multiple reactivity is observed in such nanosystem. Upon NIR-II light irradiation, Mn@Bi2Se3@RGE-Exos are capable converting hydrogen peroxide into hydroxyl radicals, oxygen, superoxide providing peroxidase (POD), oxidase (OXD), catalase (CAT)-like nanocatalytic cascade. This consequently leads strong oxidative stresses damage cells. vitro, vivo, proteomic analysis further reveal potential disruption cellular homeostasis, enhancement immunological induction cancer cell ferroptosis, showcasing great promise anticancer efficacy against with favorable biosafety profile. Overall, success this study provides feasible strategy future design clinical stimuli-responsive medicine, especially context challenging brain cancers like GBM.

Language: Английский

Citations

24
Surface-Enhanced Raman Spectroscopy for Biomedical Applications: Recent Advances and Future Challenges DOI Creative Commons
Li Lin, Ramón A. Álvarez‐Puebla, Luis M. Liz‐Marzán

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

The year 2024 marks the 50th anniversary of discovery surface-enhanced Raman spectroscopy (SERS). Over recent years, SERS has experienced rapid development and became a critical tool in biomedicine with its unparalleled sensitivity molecular specificity. This review summarizes advancements challenges substrates, nanotags, instrumentation, spectral analysis for biomedical applications. We highlight key developments colloidal solid an emphasis on surface chemistry, hotspot design, 3D hydrogel plasmonic architectures. Additionally, we introduce innovations including those interior gaps, orthogonal reporters, near-infrared-II-responsive properties, along biomimetic coatings. Emerging technologies such as optical tweezers, nanopores, wearable sensors have expanded capabilities single-cell single-molecule analysis. Advances analysis, signal digitalization, denoising, deep learning algorithms, improved quantification complex biological data. Finally, this discusses applications nucleic acid detection, protein characterization, metabolite monitoring, vivo spectroscopy, emphasizing potential liquid biopsy, metabolic phenotyping, extracellular vesicle diagnostics. concludes perspective clinical translation SERS, addressing commercialization potentials tissue sensing imaging.

Language: Английский

Citations

7
Tumor-Homing Biomimetic Near-Infrared II SERS Probes for Targeted Intraoperative Resection Guidance of Orthotopic Glioblastoma DOI

Yaxuan Lu,

Beibei Shan,

Linhu Li

et al.

Nano Letters, Journal Year: 2025, Volume and Issue: 25(6), P. 2325 - 2333

Published: Jan. 30, 2025

In vivo optical imaging holds great potential for surgical guidance with the ability to intraoperatively identify tumor lesions in a bed and navigate their excision real time. Nevertheless, its full remains underexploited, mainly due dearth of high-performance probes. Herein, hybrid cell membrane-biomimetic near-infrared II surface-enhanced Raman spectroscopy (NIR-II SERS) probes are reported intraoperative resection orthotopic glioblastoma. A novel class plasmonic Au nanorod (AuNR)@Au-Ag frames is developed remarkable properties tunable beyond 1700 nm. We demonstrate exceptional NIR-II SERS performance both vitro biomimetic created AuNR@Au-Ag membranes. The successfully applied an glioblastoma mouse model complete removal improved outcomes. This study presents promising strategy precise navigation.

Language: Английский

Citations

1
Multifunctional Ultra‐Bright Plasmonic Gold@Fluorescence Nanoprobe for Biomedical Applications DOI Creative Commons

Caiping Ding,

Wenjing Li, Xiaolin Huang

et al.

Aggregate, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

ABSTRACT Metal‐enhanced fluorescence (MEF) represents a captivating phenomenon that transpires when fluorophores are situated in close vicinity to the surface of metallic nanostructures, leading nuanced augmentation their fluorescent characteristics. Given its efficacy enhancing excitation rates, quantum yield, and photostability, MEF has firmly established itself as highly valuable tool for augmenting biosensor sensitivity, bioimaging clarity, intensifying therapeutic responses. Notably, plasmonic gold inherently advantageous MEF, have been widely utilized signal amplification, labeling, theranostics. In this endeavor, we undertake comprehensive examination MEF‐enabled meticulously analyzing fundamental enhancement mechanisms, crucial influencing factors, diverse modes enhancement. Furthermore, spotlight exemplary applications these nanostructures biosensing, bioimaging, theranostics, underscoring revolutionary potential. Ultimately, offer glimpse into future prospects improvement challenges beset gold‐based MEF. Our attention is steadfastly directed toward essential scientific questions technical hurdles remain be surmounted, inviting readers partake an exciting exploration dynamic promising field.

Language: Английский

Citations

1
NIR‐II Surface‐Enhanced Raman Scattering Nanoprobes in Biomedicine: Current Impact and Future Directions DOI
Binge Deng, Yuqing Zhang, Guangyu Qiu

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: June 7, 2024

Abstract The field of second near‐infrared (NIR‐II) surface‐enhanced Raman scattering (SERS) nanoprobes has made commendable progress in biomedicine. This article reviews recent advances and future development NIR‐II SERS nanoprobes. It introduces the fundamental principles highlights key window, including reduced tissue attenuation, deep penetration, maximized allowable exposure, improved photostability. discussion directions includes refinement nanoprobe substrates, emphasizing tailoring optical properties metallic SERS‐active nanoprobes, exploring non‐metallic alternatives. intricacies designing reporters for resonance potential these to advance are also discussed. integration artificial intelligence (AI) into design represents a cutting‐edge approach overcome current challenges. examines emergence techniques through‐tissue detection, toward tomography. acknowledges instrumental advancements like charge‐coupled device sensitivity accelerated imaging speeds. concludes by addressing critical aspects biosafety, ease functionalization, compatibility, path clinical translation. With comprehensive overview achievements prospects, this review aims illuminate innovate diagnostic therapeutic approaches

Language: Английский

Citations

6
Synchronously Manipulating the D−A Interaction and Planarity in Semiconducting Polymers to Achieve 84.7% Photothermal Conversion Efficiency for NIR‐II Imaging‐Guided Tumor Therapy DOI

Xiankun Hu,

Qian Jia, Qiyu Fang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(44)

Published: July 18, 2024

Abstract Exploiting photothermal agents with second‐near‐infrared (NIR‐II, 1000−1700 nm) emission and a high conversion efficiency (PCE) is an appealing challenging task. Herein, by simultaneously tailoring the D−A interaction planarity in fluorophores, two donor‐acceptor (D−A) −type semiconducting polymers (SPs), T‐BTP B‐BTP, are constructed. Compared T‐BTP, B‐BTP shows increased intramolecular interactions improved molecular planarity, leading to bathochromic‐shift absorption, NIR‐II emission, PCE. Notably, NPs achieve remarkable PCE of 84.7%, which among highest PCEs SPs fluorescence imaging‐guided therapy (PTT). Because these promising features, successfully used vascular imaging cancer therapy. This study provides valuable guidelines for development high‐performance SPs.

Language: Английский

Citations

4
Innovative Applications of SERS in Precision Medicine: In Situ and Real-Time Live Imaging DOI

Biqing Chen,

Jiayin Gao,

Haizhu Sun

et al.

Talanta, Journal Year: 2025, Volume and Issue: 294, P. 128225 - 128225

Published: April 28, 2025

Language: Английский

Citations

0
Near‐Infrared Excitation/Emission Metal‐Free Probe with Frequency Up‐Conversion for Dual‐Modality Imaging DOI

Yong Guo,

Hao Li, Luwei Wang

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 5, 2025

Abstract A multimodal fluorescent probe with near‐infrared excitation/emission, exceptional photostability, and superior biocompatibility is essential for exploring complex life science challenges significant diseases. Carbon dots (CDs), due to their rich optical properties favorable biocompatibility, have garnered growing interest in the field of bioimaging. Here, it demonstrated first time that nitrogen‐doped CDs (N‐CDs) exhibit frequency up‐conversion luminescence (FUCL) excitation (λ = 740–820 nm) emission 723 S(NIR) region. These N‐CDs also possess outstanding ability target biomolecules, such as nucleic acids. Utilizing a self‐developed imaging microscope, probes enable multifunctional imaging, including visualization mitosis process corresponding changes chromosome diameter onion root tip cells; dual‐modality (fluorescence intensity lifetime) multicolor mouse kidney tissue structure; monitoring cortical vascular distribution blood flow dynamics mice.

Language: Английский

Citations

0
Recent Progress on High-Precision Construction of Nanoarchitectured SERS Substrates for Ultrasensitive Bio-Medical Sensors DOI Creative Commons

Heguang Liu,

Ben Mou,

Jinxin Li

et al.

Advanced Powder Materials, Journal Year: 2025, Volume and Issue: unknown, P. 100300 - 100300

Published: May 1, 2025

Language: Английский

Citations

0
Dramatically Enhancing Multiphoton Harvesting Metal–Organic Frameworks for NIR-II Photocatalysis through Functional Regulation of Octupolar Molecules DOI

L. Y. Zhang,

Bo Li,

Wenyao Duan

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(36), P. 47348 - 47356

Published: Sept. 2, 2024

The development of effective multiphoton absorption (MPA) materials for near-infrared (NIR) light-driven photocatalysis holds great significance. In this study, we incorporated two multibranched cyclometallated iridium(III) modules with varying degrees conjugation onto MPA-inert metal–organic frameworks (MOFs) to active MPA performance. Subsequently, the MOFs were further modified Co(II) and hyaluronic acid (HA) fabricate MINCH MISCH, respectively. By introducing octupolar molecules expanding conjugation, MISCH exhibited a larger cross section efficient NIR light improved carrier transfer, leading outstanding photocatalytic hydrogen production. Moreover, HA modification enabled achieve specific therapy cancer cells. This study provides valuable insights into constructing highly photocatalysis, presenting potential platform in tumor treatment.

Language: Английский

Citations

1