Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
137(1)
Published: Aug. 22, 2024
Abstract
Single‐atom
nanozymes
(SAzymes)
with
ultrahigh
atom
utilization
efficiency
have
been
extensively
applied
in
reactive
oxygen
species
(ROS)‐mediated
cancer
therapy.
However,
the
high
energy
barriers
of
reaction
intermediates
on
single‐atom
sites
and
overexpressed
antioxidants
tumor
microenvironment
restrict
amplification
oxidative
stress,
resulting
unsatisfactory
therapeutic
efficacy.
Herein,
we
report
a
multi‐enzyme
mimetic
MoCu
dual‐atom
nanozyme
(MoCu
DAzyme)
various
catalytic
active
sites,
which
exhibits
peroxidase,
oxidase,
glutathione
(GSH)
nicotinamide
adenine
dinucleotide
phosphate
(NADPH)
oxidase
mimicking
activities.
Compared
Mo
SAzyme,
introduction
Cu
atoms,
formation
synergetic
effects
among
enhance
substrate
adsorption
reduce
barrier,
thereby
endowing
DAzyme
stronger
Benefiting
from
above
enzyme‐like
activities,
can
not
only
generate
multiple
ROS,
but
also
deplete
GSH
block
its
regeneration
to
trigger
cascade
stress.
Additionally,
strong
optical
absorption
near‐infrared
II
bio‐window
endows
remarkable
photothermal
conversion
performance.
Consequently,
achieves
high‐efficiency
synergistic
treatment
incorporating
collaborative
therapy
This
work
will
advance
applications
DAzymes
provide
valuable
insights
for
nanocatalytic
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
64(1)
Published: Aug. 22, 2024
Single-atom
nanozymes
(SAzymes)
with
ultrahigh
atom
utilization
efficiency
have
been
extensively
applied
in
reactive
oxygen
species
(ROS)-mediated
cancer
therapy.
However,
the
high
energy
barriers
of
reaction
intermediates
on
single-atom
sites
and
overexpressed
antioxidants
tumor
microenvironment
restrict
amplification
oxidative
stress,
resulting
unsatisfactory
therapeutic
efficacy.
Herein,
we
report
a
multi-enzyme
mimetic
MoCu
dual-atom
nanozyme
(MoCu
DAzyme)
various
catalytic
active
sites,
which
exhibits
peroxidase,
oxidase,
glutathione
(GSH)
nicotinamide
adenine
dinucleotide
phosphate
(NADPH)
oxidase
mimicking
activities.
Compared
Mo
SAzyme,
introduction
Cu
atoms,
formation
synergetic
effects
among
enhance
substrate
adsorption
reduce
barrier,
thereby
endowing
DAzyme
stronger
Benefiting
from
above
enzyme-like
activities,
can
not
only
generate
multiple
ROS,
but
also
deplete
GSH
block
its
regeneration
to
trigger
cascade
stress.
Additionally,
strong
optical
absorption
near-infrared
II
bio-window
endows
remarkable
photothermal
conversion
performance.
Consequently,
achieves
high-efficiency
synergistic
treatment
incorporating
collaborative
therapy
This
work
will
advance
applications
DAzymes
provide
valuable
insights
for
nanocatalytic
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Feb. 20, 2025
The
advent
of
nanozymes
has
revolutionized
approaches
to
cancer
diagnosis
and
therapy,
introducing
innovative
strategies
that
address
the
limitations
conventional
treatments.
Nanozyme
nanostructures
with
enzyme-mimicking
catalytic
abilities
exhibit
exceptional
stability,
biocompatibility,
customizable
functions,
positioning
them
as
promising
tools
for
theranostics.
By
emulating
natural
enzyme
reactions,
can
selectively
target
eradicate
cells,
minimizing
harm
adjacent
healthy
tissues.
Nanozymes
also
be
functionalized
specific
targeting
ligands,
allowing
precise
delivery
regulated
release
therapeutic
agents,
improving
treatment
effectiveness
reducing
adverse
effects.
However,
issues
such
selectivity,
regulatory
compliance
remain
critical
challenges
clinical
application
nanozymes.
This
review
provides
an
overview
nanozymes,
highlighting
their
unique
properties,
various
classifications,
activities,
diverse
applications
in
strategic
oncological
deployment
could
profoundly
impact
future
advancements
personalized
medicine,
recent
progress
prospective
directions
enzyme-mimetic
treatment.
summarizes
Journal of Materials Chemistry B,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
This
review
discusses
the
recent
developments
in
copper-based
nanomaterials
that
utilize
copper-induced
cell
death,
categorized
by
materials
systems,
while
highlighting
limitations
of
current
cuproptosis
related
nanomaterials.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 16, 2025
Abstract
Single‐atom
nanozymes
(SANs)
are
promising
enzyme‐active
catalysts
due
to
their
maximum
atomic
utilization.
However,
it
is
still
a
challenge
precisely
regulate
the
single‐atom
structure,
especially
in
multimetallic
MOFs.
Based
on
Cu‐N
4
structure
of
Zn
Cu
1
,
cascade
competition
strategy
mediated
by
buffer
(polydopamine)
proposed
for
first
time,
which
induces
one‐step
nonthermal
reaction
remove
inactive
site
and
adjust
coordination
environment.
Experimental
results
theoretical
calculations
show
that
nanozyme
with
2
O
(Cu‐N/O)
breaks
strong
steric
restriction,
exposed
active
can
better
adsorb
H
making
have
peroxidase‐like
activity.
Compared
traditional
bimetallic
(Cu
)
monometallic
(Cu‐MoF)
nanozymes,
has
stronger
catalytic
activity
photothermal
properties,
as
well
good
photocatalytic
extremely
stability.
It
successfully
applied
Lateral
flow
immunoassay
achieve
three‐mode
ultrasensitive
detection
Escherichia
coli
O157:H7,
test
strips
after
subjected
broad‐spectrum
sterilization
treatment.
Nano Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 11, 2025
Diabetic
osteoporosis
(DOP)
is
a
chronic
complication
of
diabetes
mellitus
(DM)
that
impairs
bone
health,
and
effective
management
DOP
remains
formidable
challenge.
In
this
study,
we
developed
biocatalytic
cascade
nanoplatform,
GOx@SrCaP-CAT-Tet,
offering
osteogenic,
angiogenic,
anti-inflammatory
activities
for
targeted
management.
The
platform
includes
glucose
oxidase
(GOx)
catalase
(CAT),
encapsulated
in
strontium-doped
calcium
phosphate
(SrCaP),
converting
into
gluconic
acid
hydrogen
peroxide
(H2O2),
alleviating
the
hyperglycemia
promoting
hypoxia-induced
vascularization.
Both
generated
H2O2
any
overabundance
microenvironment
can
be
scavenged
by
CAT,
thus
relieving
inflammation.
Via
surface
modified
with
tetracycline
(Tet)
targeting,
release
Sr2+,
Ca2+,
PO43-
stimulate
osteogenesis
suppress
osteoclastogenesis,
thereby
hastening
formation
reversing
osteoporosis.
This
nanoplatform
shows
promise
managing
both
vitro
vivo.
Our
findings
open
new
horizon
through
reactions.
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 31, 2025
Abstract
Targeted
delivery
of
glucose
oxidase
(GOx)
using
MXene
remains
a
great
challenge
due
to
its
poor
dispersion
and
susceptibility
oxidation,
the
hypoxia
high
glutathione
(GSH)
contents
make
situation
even
more
worrying.
Herein,
bovine
serum
albumin‐mediated
non‐chemical
modification
strategy
is
developed,
endowing
titanium
carbide
with
long‐time
water‐dispersion
further
integrating
it
as
glycolysis‐controllable
therapy
system
without
any
chemotherapeutic
agents.
The
also
constructs
an
effective
O
2
cycling
GSH
degradation
pathway,
which
fundamentally
adjusts
tumor
microenvironment
greatly
elevates
both
in
vivo
vitro
effects.
Reactive
oxygen
species
are
generated
disrupt
balance
oxidative
stress.
Moreover,
reduced
efficiency
mitochondrial
energy
production
significantly
inhibits
level
glycolysis
hinders
supply.
study
presents
cancer
treatment
combining
starvation/photothermal
therapy,
has
superior
anti‐cancer
effects
dual
reducing
levels
diminishing
cellular
capacity.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 5, 2024
Abstract
Chemical
reactions
underpin
biological
processes,
and
imbalances
in
critical
biochemical
pathways
within
organisms
can
lead
to
the
onset
of
severe
diseases.
Within
this
context,
emerging
field
“Nanocatalytic
Medicine”
leverages
nanomaterials
as
catalysts
modulate
fundamental
chemical
specific
microenvironments
This
approach
is
designed
facilitate
targeted
synthesis
localized
accumulation
therapeutic
agents,
thus
enhancing
treatment
efficacy
precision
while
simultaneously
reducing
systemic
side
effects.
The
effectiveness
these
nanocatalytic
strategies
critically
hinges
on
a
profound
understanding
kinetics
intricate
interplay
particular
pathological
ensure
effective
catalytic
actions.
review
methodically
explores
situ
their
associated
biomaterials,
emphasizing
regulatory
that
control
responses.
Furthermore,
discussion
encapsulates
crucial
elements‐reactants,
catalysts,
reaction
conditions/environments‐necessary
for
optimizing
thermodynamics
reactions,
rigorously
addressing
both
biophysical
dimensions
disease
enhance
outcomes.
It
seeks
clarify
mechanisms
underpinning
biomaterials
evaluate
potential
revolutionize
across
various
conditions.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 12, 2024
Abstract
Proteins
have
emerged
as
promising
therapeutics
in
oncology
due
to
their
great
specificity.
Many
treatment
strategies
are
developed
based
on
protein
biologics,
such
immunotherapy,
starvation
therapy,
and
pro‐apoptosis
while
some
biologics
entered
the
clinics.
However,
clinical
translation
is
severely
impeded
by
instability,
short
circulation
time,
poor
transmembrane
transportation,
immunogenicity.
Micro‐
nano‐particles‐based
drug
delivery
platforms
designed
solve
those
problems
enhance
therapeutic
efficacy.
This
review
first
summarizes
different
types
of
proteins
research
stages,
highlighting
administration
limitations.
Next,
various
micro‐
nano‐particles
described
demonstrate
how
they
can
overcome
The
potential
then
explored
efficacy
combinational
therapies.
Finally,
challenges
future
directions
carriers
discussed
for
optimized
delivery.
