Metal–Organic-Framework-Based Materials for Antimicrobial Applications

ACS Nano, Journal Year: 2021, Volume and Issue: 15(3), P. 3808 - 3848

Published: Feb. 25, 2021

To address the serious threat of bacterial infection to public health, great efforts have been devoted development antimicrobial agents for inhibiting growth, preventing biofilm formation, and sterilization. Very recently, metal–organic frameworks (MOFs) emerged as promising materials various applications owing their different functions including controlled/stimulated decomposition components with bactericidal activity, strong interactions membranes, formation photogenerated reactive oxygen species (ROS) well high loading sustained releasing capacities other materials. This review focuses on recent advances in design, synthesis, MOF-based materials, which are classified by roles component-releasing (metal ions, ligands, or both), photocatalytic, chelation carriers or/and synergistic functional (antibiotics, enzymes, metals/metal oxides, carbon etc.). The constituents, fundamental mechanisms, evaluation activities these highlighted present design principles efficient prospects challenges this research field proposed.

Language: Английский

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The recent progress on metal–organic frameworks for phototherapy

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(8), P. 5086 - 5125

Published: Jan. 1, 2021

Some infectious or malignant diseases such as cancers are seriously threatening the health of human beings all over world. The commonly used antibiotic therapy cannot effectively treat these within a short time, and also bring about adverse effects drug resistance immune system damage during long-term systemic treatment. Phototherapy is an emerging antibiotic-free strategy to diseases. Upon light irradiation, phototherapeutic agents can generate cytotoxic reactive oxygen species (ROS) induce temperature increase, which leads death targeted cells. These two kinds killing strategies referred photodynamic (PDT) photothermal (PTT), respectively. So far, many photo-responsive have been developed. Among them, metal-organic framework (MOF) becoming one most promising materials because its structure chemical compositions be easily modulated achieve specific functions. MOFs intrinsic ability under rational design MOF construction, serve carrier therapeutic agents, owing tunable porosity. provide feasibility for various combined therapies targeting methods, improves efficiency phototherapy. In this review, we firstly investigated principles phototherapy, comprehensively summarized recent advances in PDT, PTT synergistic therapy, from construction modification. We expect that our demonstration will shed on future development field, it step closer clinical trials.

Language: Английский

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Highly Effective and Noninvasive Near‐Infrared Eradication of a Staphylococcus aureus Biofilm on Implants by a Photoresponsive Coating within 20 Min

Advanced Science, Journal Year: 2019, Volume and Issue: 6(17)

Published: July 19, 2019

Abstract Biofilms have been related to the persistence of infections on medical implants, and these cannot be eradicated because resistance biofilm structures. Therefore, a biocompatible phototherapeutic system is developed composed MoS 2 , IR780 photosensitizer, arginine–glycine–aspartic acid–cysteine (RGDC) safely eradicate biofilms titanium implants within 20 min. The magnetron‐sputtered film possesses excellent photothermal properties, can produce reactive oxygen species (ROS) with irradiation near‐infrared (NIR, λ = 700–1100 nm) light. Consequently, combination therapy (PTT) photodynamic (PDT), assisted by glutathione oxidation accelerated NIR light, provide synergistic rapid killing bacteria, i.e., 98.99 ± 0.42% eradication ratio against Staphylococcus aureus in vivo min, which much greater than that PTT or PDT alone. With assistance ROS, permeability damaged bacterial membranes increases, become more sensitive heat, thus accelerating leakage proteins from bacteria. In addition, RGDC biosafety osteoconductivity, confirmed animal experiments.

Language: Английский

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Antibacterial and Antiviral Functional Materials: Chemistry and Biological Activity toward Tackling COVID-19-like Pandemics

ACS Pharmacology & Translational Science, Journal Year: 2020, Volume and Issue: 4(1), P. 8 - 54

Published: Dec. 29, 2020

The ongoing worldwide pandemic due to COVID-19 has created awareness toward ensuring best practices avoid the spread of microorganisms. In this regard, research on creating a surface which destroys or inhibits adherence microbial/viral entities gained renewed interest. Although many reports are available antibacterial materials coatings, there is relatively small amount data use antiviral materials. However, with more geared area, new information being added literature every day. combination and chemical represents potentially path-breaking intervention mitigate disease-causing agents. review, we have surveyed various classes such as small-molecule organics, synthetic biodegradable polymers, silver, TiO2, copper-derived chemicals. protection mechanisms against pathogen colonies discussed in detail, highlights key differences that could determine parameters would govern future development advanced surfaces.

Language: Английский

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Uranium extraction from seawater: material design, emerging technologies and marine engineering

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 52(1), P. 97 - 162

Published: Nov. 30, 2022

Uranium extraction from seawater (UES), a potential approach to securing the long-term uranium supply and sustainability of nuclear energy, has experienced significant progress in past decade.

Language: Английский

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Advancing antimicrobial strategies for managing oral biofilm infections

International Journal of Oral Science, Journal Year: 2019, Volume and Issue: 11(3)

Published: Sept. 1, 2019

Abstract Effective control of oral biofilm infectious diseases represents a major global challenge. Microorganisms in biofilms exhibit increased drug tolerance compared with planktonic cells. The present review covers innovative antimicrobial strategies for controlling biofilm-related infections published predominantly over the past 5 years. Antimicrobial dental materials based on agent release, contact-killing and multi-functional have been designed synthesized prevention initial bacterial attachment subsequent formation tooth material surface. Among therapeutic approaches managing clinical practice, photodynamic therapy has emerged as an alternative to regimes mechanical removal biofilms, cold atmospheric plasma shows significant advantages conventional approaches. Nevertheless, more preclinical studies appropriately well-structured multi-center trials are critically needed obtain reliable comparative data. acquired information will be helpful identifying most effective antibacterial solutions optimal circumstances utilize these strategies.

Language: Английский

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Metal organic framework-based antibacterial agents and their underlying mechanisms

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(16), P. 7138 - 7169

Published: Jan. 1, 2022

MOFs can kill the bacteria efficiently by multiple mechanisms, such as releasing metal ions and/or antibacterial micro-molecules; performing catalytically active site; acting photosensitizers; mimicking enzymes; based on gas therapy and so on.

Language: Английский

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Photoresponsive Materials for Antibacterial Applications

Cell Reports Physical Science, Journal Year: 2020, Volume and Issue: 1(11), P. 100245 - 100245

Published: Nov. 1, 2020

Recently, photoactivated sterilization, as a rapid, effective, and antibiotic-free antibacterial method, has attracted increasing attention from researchers. Many outstanding photoresponsive materials, including photocatalysts, photosensitizers (PSs), photothermal have been developed applied to microbial inactivation treat infectious bacterial diseases. This mini-review aims provide insights gathered studying materials systems, (1) reactive oxygen species (ROS)-based photodynamic therapy (PDT) (2) hyperthermia-based (PTT). In addition, potential application fields for these methods, the remaining challenges using inactivation, perspectives future, prospective research directions are discussed in depth.

Language: Английский

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Graphene/CuO₂ Nanoshuttles with Controllable Release of Oxygen Nanobubbles Promoting Interruption of Bacterial Respiration

ACS Applied Materials & Interfaces, Journal Year: 2020, Volume and Issue: 12(32), P. 35813 - 35825

Published: July 15, 2020

An oxygen nanoshuttle based on a reduced graphene oxide/copper peroxide (rGO/CuO2) nanocomposite has been presented to deliver in situ nanobubbles (O2 NBs) for combating bacterial infections. In the presence of rGO, solid source (i.e., CuO2) was decomposed (in response environmental conditions such as pH and temperature) into O2 NBs more controllable long-lasting trend (from 60 144 h). neutral buffer, experienced growth collapse evolutions, creating dynamic micro–nanoenvironment around nanocomposite. addition effective battling against methicillin-resistant Staphylococcus aureus bacteria, demonstrated superior antibacterial properties Gram-positive S. those Gram-negative Escherichia coli especially rGO. fact, rGO contents could provide synergistic effects through harvesting some respiratory electrons (leading striking interruption pathway) one side transferring them NBs, resulting nanoscale reactive species (ROS) generation another side. Moreover, near-infrared laser irradiation induced damage cell membrane due local heat elevation catalyzing release/collapse imposing mechanical disruptions. Our results show that O2-containing nanoshuttles can effectively be used intelligent anti-infection nanorobots upcoming graphene-based nanobiomedical applications.

Language: Английский

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Synergistic Chemotherapy and Photodynamic Therapy of Endophthalmitis Mediated by Zeolitic Imidazolate Framework‐Based Drug Delivery Systems

Small, Journal Year: 2019, Volume and Issue: 15(47)

Published: Oct. 7, 2019

Endophthalmitis, derived from the infections of pathogens, is a common complication during use ophthalmology-related biomaterials and after ophthalmic surgery. Herein, aiming at efficient photodynamic therapy (PDT) bacterial biofilm eradication endophthalmitis, pH-responsive zeolitic imidazolate framework-8-polyacrylic acid (ZIF-8-PAA) material constructed for infection-targeted delivery ammonium methylbenzene blue (MB), broad-spectrum photosensitizer antibacterial agent. Polyacrylic (PAA) incorporated into system to achieve higher pH responsiveness better drug loading capacity. MB-loaded ZIF-8-PAA nanoparticles are modified with AgNO3 /dopamine in situ reduction silver (AgNPs), followed by secondary modification vancomycin/NH2 -polyethylene glycol (Van/NH2 -PEG), leading formation composite nanomaterial, ZIF-8-PAA-MB@AgNPs@Van-PEG. Dynamic light scattering, transmission electron microscopy, UV-vis spectral analysis used explore synthesis, release, related properties. In terms biological performance, vitro studies against three kinds bacteria, i.e., Escherichia coli, Staphylococcus aureus, methicillin-resistant S. suggest an obvious superiority PDT/AgNPs any single strategy. Both retinal pigment epithelium cellular biocompatibility experiments vivo mice endophthalmitis models verify function nanomaterials.

Language: Английский

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